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1. 发明申请

WO2004031266A3 CELL ADHESION RESISTING SURFACES 审中-公开
标题翻译：细胞粘附电阻表面
公开(公告)号：WO2004031266A3
公开(公告)日：2004-12-23
申请号：PCT/US0330479
申请日：2003-09-29
申请人： BECTON DICKINSON CO , LIEBMANN-VINSON ANDREA , CLARKE RICHARD P , XU RUILING , HEIDARAN MOHAMMAD A
发明人： LIEBMANN-VINSON ANDREA , CLARKE RICHARD P , XU RUILING , HEIDARAN MOHAMMAD A
IPC分类号： C12N5/00 , H05H1/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/00
CPC分类号： C12N5/0068 , C12N2533/80 , Y10T428/13 , Y10T428/1352
摘要： A coated surface that resists cell adhesion comprising hyaluronic acid directly bound to a plasma-treated polymer surface. A process for producing the coated surface is disclosed as are further modifications of the hyaluronic acid by attaching ligand-binding polypeptides (antibodies or antibody binding proteins).
摘要翻译：一种抗细胞粘附的涂层表面，其包含与等离子体处理的聚合物表面直接结合的透明质酸。通过连接配体结合多肽（抗体或抗体结合蛋白），透明质酸的进一步修饰也被公开。

2. 发明申请

WO2004020034A3 MICROABRADER WITH CONTROLLED ABRASION FEATURES 审中-公开
标题翻译：具有控制磨损特性的微控制器
公开(公告)号：WO2004020034A3
公开(公告)日：2004-09-23
申请号：PCT/US0326811
申请日：2003-08-27
申请人： BECTON DICKINSON CO , LASTOVICH ALEXANDER G , MARTIN FRANK E , HAIDER ISHAQ M , CLARKE RICHARD P , ALARCON JASON B , MIKSZTA JOHN A , DEKKER JOHN P III , HARDING WESTON
发明人： LASTOVICH ALEXANDER G , MARTIN FRANK E , HAIDER ISHAQ M , CLARKE RICHARD P , ALARCON JASON B , MIKSZTA JOHN A , DEKKER JOHN P III , HARDING WESTON
IPC分类号： A61B10/02 , A61B17/00 , A61B17/20 , A61B17/32 , A61F2/82 , A61M31/00 , A61M37/00
CPC分类号： A61M37/0015 , A61B17/205 , A61B2017/320004 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61M2037/0023 , A61M2037/0038 , A61M2037/0046 , A61M2037/0053
摘要： An abrader device for delivering a substance into skin via an abrasion process includes a housing adapted to be pressed against the skin at a desired delivery site, an applicator head disposed, in an upper opening of the housing and movable across a lower opening of the housing to abrade the delivery site in at least one furrow, and an abrader surface attached to the applicator head whereby the housing remains firm and stationary at the delivery site and structure of the housing and the applicator head controls parameters of the abrasion process. In particular, the amount of force or pressure applied to the abrader surface, the speed at which the abrader surface moves across the skin and the number of lateral passes of the abrader surface across the skin are controlled so that the abrader device provides a furrow with a length of substantially the same depth thereby providing reproducible results, even though different technicians are applying the abrader device against a patient's skin.
摘要翻译：用于通过磨损过程将物质输送到皮肤中的磨料装置包括适于在期望的输送部位压紧皮肤的壳体，设置在壳体的上部开口中并可移动穿过壳体的下部开口在至少一个沟槽中研磨输送部位，以及附着到施用器头部的磨料表面，由此壳体在输送位置处保持坚固和固定，并且壳体的结构和施加器头部控制磨损过程的参数。特别地，控制施加到研磨器表面的力或压力的量，磨损表面移动穿过皮肤的速度和磨擦表面穿过皮肤的横向通过次数，使得研磨器装置提供沟槽长度基本相同的深度，从而提供可重复的结果，即使不同的技术人员将磨擦装置应用于患者的皮肤。

3. 发明申请

WO2005091922A3 METHODS AND DEVICES FOR IMPROVING DELIVERY OF A SUBSTANCE TO SKIN 审中-公开
标题翻译：改善皮肤物质输送的方法和装置
公开(公告)号：WO2005091922A3
公开(公告)日：2006-06-08
申请号：PCT/US2005006660
申请日：2005-03-03
申请人： BECTON DICKINSON CO , PETTITS RONALD J , SUTTER DIANE E , CLARKE RICHARD P
发明人： PETTITS RONALD J , SUTTER DIANE E , CLARKE RICHARD P
IPC分类号： A61M31/00 , A61M5/145 , A61M5/46 , A61M5/48
CPC分类号： A61M5/46 , A61M5/1452 , A61M5/484 , A61M2205/3351
摘要： A method of delivery of a substance to a human subject's skin comprising deposition into a specific compartment of the skin, wherein the delivery occurs at a controlled rate and pressure. The methods of the invention provide accurate deposition of pre-selected volume of the substance e.g., greater than 90% of the pre-selected volume. The methods of the invention encompass varying one or more parameters including but not limited to configurations of the delivery device, volume, pressure, and flow rate of delivery, to enhance the efficacy of delivery of the substance to the human skin. Substances delivered in accordance with the methods of the invention result to the human skin. Substances delivered in accordance with the methods of the invention result in a more efficacious deposition of the substance into the targeted compartment, improved delivery performance, i.e., completeness of delivery as measured by quantification of the substance not delivered or the amount of the substance leaked out from the injection site, and enhanced safety as measured by the occurrence of minimal adverse cutaneous events at the site of injection.
摘要翻译：将物质递送至人受试者的皮肤的方法，包括沉积到皮肤的特定隔室中，其中递送以受控的速率和压力发生。本发明的方法提供物质的预选体积的精确沉积，例如大于预选体积的90％。本发明的方法包括改变一个或多个参数，包括但不限于递送装置的配置，体积，压力和输送流速，以增强物质递送至人体皮肤的功效。根据本发明的方法输送的物质导致人的皮肤。根据本发明的方法输送的物质导致物质进入目标隔室的更有效的沉积，改善的输送性能，即通过定量未输送的物质或泄露的物质的量测量的递送的完整性从注射部位，并通过在注射部位的最小不良皮肤事件的发生所测量的增强的安全性。

4. 发明专利

CA2498027C METHOD AND APPARATUS FOR EPIDERMAL DELIVERY OF A SUBSTANCE 未知
公开(公告)号：CA2498027C
公开(公告)日：2012-03-27
申请号：CA2498027
申请日：2003-09-10
申请人： BECTON DICKINSON CO
发明人： HAIDER M ISHAQ , CLARKE RICHARD P , FENTRESS JAMES K , MIKSZTA JOHN A , MARTIN FRANK E
IPC分类号： A61B17/20 , A61M5/32 , A61M5/142 , A61M5/148 , A61M5/158 , A61M5/46 , A61M37/00
摘要： A methbd and apparatus for epidermal and/or intradermal delivery of a substance is provided. A needle having at least one side port is used to penetrate the skin of a subject. The needle may be of any size. A substance is delivered through the side port and into the skin. The side port can be of any size or shape and be arranged at any location on the needle.

5. 发明专利

AU2003268205A1 MICROABRADER WITH CONTROLLED ABRASION FEATURES 未知
公开(公告)号：AU2003268205A1
公开(公告)日：2004-03-19
申请号：AU2003268205
申请日：2003-08-27
申请人： BECTON DICKINSON CO
发明人： LASTOVICH ALEXANDER G , MARTIN FRANK E , HAIDER ISHAQ M , CLARKE RICHARD P , ALARCON JASON B
IPC分类号： A61B10/02 , A61B17/00 , A61B17/20 , A61B17/32 , A61F2/82 , A61M31/00 , A61M37/00

6. 发明专利

DE69314458T2 未知
公开(公告)号：DE69314458T2
公开(公告)日：1998-04-23
申请号：DE69314458
申请日：1993-12-15
申请人： BECTON DICKINSON CO
发明人： TROPSHA YELENA , CLARKE RICHARD P , ANTOON MITCHELL K
IPC分类号： G01N33/48 , A61B5/15 , A61B5/154 , A61L31/00 , B01L3/14 , B65D23/08 , C08J7/04 , G01N1/00 , G01N1/10 , A61B5/14 , C09D127/08
摘要： The present invention is a plastic container coated with a barrier coating. The barrier coating has a first layer including an inorganic material and a second layer on said first layer including a polymer.

7. 发明专利

DE69314458D1 未知
公开(公告)号：DE69314458D1
公开(公告)日：1997-11-13
申请号：DE69314458
申请日：1993-12-15
申请人： BECTON DICKINSON CO
发明人： TROPSHA YELENA , CLARKE RICHARD P , ANTOON MITCHELL K
IPC分类号： G01N33/48 , A61B5/15 , A61B5/154 , A61L31/00 , B01L3/14 , B65D23/08 , C08J7/04 , G01N1/00 , G01N1/10 , A61B5/14 , C09D127/08
摘要： The present invention is a plastic container coated with a barrier coating. The barrier coating has a first layer including an inorganic material and a second layer on said first layer including a polymer.

8. 发明专利

CA2195048A1 Blood Collection Tube Assembly 未知
公开(公告)号：CA2195048A1
公开(公告)日：1997-07-31
申请号：CA2195048
申请日：1997-01-14
申请人： BECTON DICKINSON CO
发明人： HARVEY NOEL G , TROPSHA YELENA G , BURKETT SUSAN L , CLARKE RICHARD P , WONG BRYAN SOO
IPC分类号： A61B5/15 , A61J1/05 , B01L3/14 , B05D7/02 , B32B1/02 , B32B7/02 , B32B9/00 , B32B27/30 , B32B27/38 , B65D23/08 , C08J7/04 , C23C16/40 , A61J1/10
摘要： The present invention is a plastic container coated with a multi-layer barrier coating. The multi-layer barrier coating is useful for providing an effective barrier against gas permeability in containers and for extending shelf-life of containers, especially plastic evacuated blood collection devices.

9. 发明专利

AU2003273306B2 Method and apparatus for epidermal delivery of a substance 未知
公开(公告)号：AU2003273306B2
公开(公告)日：2009-04-30
申请号：AU2003273306
申请日：2003-09-10
申请人： BECTON DICKINSON CO
发明人： MIKSZTA JOHN A , FENTRESS JAMES K , HAIDER M ISHAQ , MARTIN FRANK E , CLARKE RICHARD P
IPC分类号： A61B17/20 , A61M5/142 , A61M5/148 , A61M5/158 , A61M5/32 , A61M5/46 , A61M37/00
摘要： A method and apparatus for epidermal and/or intradermal delivery of a substance is provided. A needle having at least one side port is used to penetrate the skin of a subject. The needle may be of any size. A substance is delivered through the side port and into the skin. The side port can be of any size or shape and be arranged at any location on the needle.

10. 发明专利

ES2287517T3 METODO Y APARATO PARA LA ADMINISTRACION EPIDERMICA DE UNA SUSTANCIA. 未知
公开(公告)号：ES2287517T3
公开(公告)日：2007-12-16
申请号：ES03755805
申请日：2003-09-10
申请人： BECTON DICKINSON CO
发明人： HAIDER M ISHAQ , CLARKE RICHARD P , FENTRESS JAMES K , MIKSZTA JOHN A , MARTIN FRANK E
IPC分类号： A61B17/20 , A61M5/32 , A61M5/142 , A61M5/148 , A61M5/158 , A61M5/46 , A61M37/00
摘要： Una aguja (10), para la administración de una sustancia a la piel de un paciente, que tiene una superficie en contacto con la piel (22) y que comprende: un vástago (11) que tiene una pared (12) que define un agujero o ánima (15) que se extiende longitudinalmente, un primer extremo (16) que está abierto para recibir la sustancia en el agujero (15), y un segundo extremo (17) adaptado a penetrar la piel de un sujeto, en la que el segundo extremo (17) comprende una punta afilada (18) y en la que la punta (18) está biselada, teniendo el vástago (11) una longitud de penetración (A) que se extiende desde la superficie de aplicación a la piel (22) hasta un extremo distal del segundo extremo (17) de menos de 4, 5 mm, y teniendo el vástago al menos una lumbrera lateral (19) que se extiende a través de la pared (12) y que se comunica con el agujero (15), que se caracteriza porque la lumbrera lateral (19) está dispuesta de 0, 025 mm a 2, 5 mm de la superficie de contacto con la piel (22), en la que, cuando la aguja (10) es hecha penetrar totalmente en la piel, la superficie de contacto con la piel (22) hace contacto con la piel, y la sustancia sale bajo presión de la lumbrera lateral (19) directamente dentro de la piel.

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