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1. 发明申请

WO02060517A3 MEDICAMENT RESPIRATORY DELIVERY DEVICE AND METHOD 审中-公开
标题翻译：药物呼吸递送装置和方法
公开(公告)号：WO02060517A3
公开(公告)日：2002-11-07
申请号：PCT/US0200578
申请日：2002-01-09
申请人： BECTON DICKINSON CO , CASPER ROBERT A , SNOW JOHN M , GARDNER DAVID L , SULLIVAN VINCENT J , WILLS ANJANA BHUTA , MONAHAN LAWRENCE A , KNORS CHRISTOPHER J
发明人： CASPER ROBERT A , SNOW JOHN M , GARDNER DAVID L , SULLIVAN VINCENT J , WILLS ANJANA BHUTA , MONAHAN LAWRENCE A , KNORS CHRISTOPHER J
IPC分类号： A61J1/06 , A61J7/00 , A61M11/06 , A61M13/00 , A61M15/00 , B05B11/06
CPC分类号： B05B11/061 , A61M11/02 , A61M15/0028 , A61M15/0031 , A61M15/0081 , A61M15/08 , A61M2202/04 , A61M2202/064 , A61M2205/073 , B05B11/062
摘要： A medicament respiratory delivery device including a housing having a chamber including coaxially aligned inlet and outlet, a medicament cartridge located within the chamber having a passage therethrough and membranes sealing the passage having a burst pressure of less than 10 atmospheres, a manually actuatable fluid delivery device having an outlet in fluid communication with the chamber and a manually actuated valve located between the outlet of the fluid delivery device and the chamber inlet for delivery of fluid under pressure to the valve. The medicament respiratory delivery device of this invention may be utilized to deliver a controlled unit dose of an aerosolizable medicament on demand by first pressurizing a pressure chamber in the pressure delivery device upstream of the valve, then opening the valve to open the membranes and express the medicament through the chamber outlet.
摘要翻译： 1。一种药物呼吸递送设备，包括：壳体，其具有包括同轴对准的入口和出口的腔室;位于腔室内的药筒，药筒具有穿过其中的通道和密封通道的膜，所述膜片具有小于10个大气压的爆破压力;手动致动的流体输送装置具有与腔室流体连通的出口和位于流体输送装置的出口与腔室入口之间的手动致动阀，用于将压力下的流体输送至阀。根据需要，本发明的药物呼吸输送装置可用于输送受控制的单位剂量的可气雾化药剂，首先对阀上游的压力输送装置中的压力室加压，然后打开阀打开膜并表达药物通过腔室出口。

2. 发明申请

WO02055133A3 MEDICAMENT RESPIRATORY DELIVERY DEVICE, CARTRIDGE AND METHOD OF MAKING SAME 审中-公开
标题翻译：药物呼吸装置，药盒及其制造方法
公开(公告)号：WO02055133A3
公开(公告)日：2002-11-14
申请号：PCT/US0200437
申请日：2002-01-09
申请人： BECTON DICKINSON CO , SULLIVAN VINCENT J , WILLS ANJANA BHUTA , MONAHAN LAWRENCE A , TRULL MICHAEL W , KNORS CHRISTOPER J
发明人： SULLIVAN VINCENT J , WILLS ANJANA BHUTA , MONAHAN LAWRENCE A , TRULL MICHAEL W , KNORS CHRISTOPER J
IPC分类号： A61J1/06 , A61J7/00 , A61M11/06 , A61M15/00 , B05B11/06
CPC分类号： B05B11/061 , A61M11/003 , A61M11/008 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M2202/064 , A61M2205/073 , A61M2207/00 , B05B11/062
摘要： A medicament respiratory delivery device including a housing having a chamber, an inlet and an outlet generally coaxially aligned with the chamber, wherein the chamber includes a medicament cartridge having a body including a generally cylindrical passage extending through the opposed ends of the cartridge generally coaxially aligned with the inlet and outlet of the housing having thin burstable polyolefin membranes having a burst pressure of between 1.2 and 10 atmospheres stretched taut over the ends of the cartridge, such that fluid delivered to the inlet ruptures the membranes, entraining medicament contained within the cartridge passage which is delivered to the patient's respiratory system through the outlet. The method of forming the cartridge includes stretching out and bending a membrane to one end of the cartridge, preferably by heat bonding, filing the cartridge with a medicament and sealing the opposed end preferably with a second burstable membrane by stretching out a membrane over a convex surface and heat bonding.
摘要翻译：一种药物呼吸输送装置，包括具有腔室，大体上与腔室同轴对准的入口和出口的壳体，其中所述腔室包括药剂盒，所述药剂盒具有主体，该主体包括大体上圆柱形的通道，该通道延伸穿过所述药筒的相对端，壳体的入口和出口具有薄的可爆破的聚烯烃膜，其具有介于盒的端部之间拉伸的介于1.2和10个大气压之间的爆破压力，使得输送到入口的流体破裂膜，夹带在盒通道内的药剂通过出口将其输送到患者的呼吸系统。成型盒的方法包括：将薄膜伸出并弯曲到盒的一端，优选地通过热粘合，用药物填充盒，并且优选用第二可爆膜密封相对端，通过在凸起表面和热粘合。

3. 发明申请

WO02056950A3 MEDICAMENT RESPIRATORY DELIVERY DEVICE 审中-公开
标题翻译：药物呼吸器递送装置
公开(公告)号：WO02056950A3
公开(公告)日：2002-10-24
申请号：PCT/US0200570
申请日：2002-01-09
申请人： BECTON DICKINSON CO , LOCKHART ARTIS R , SULLIVAN VINCENT J , MONAHAN LAWRENCE A , WILLS ANJANA BHUTA
发明人： LOCKHART ARTIS R , SULLIVAN VINCENT J , MONAHAN LAWRENCE A , WILLS ANJANA BHUTA
IPC分类号： A61J1/06 , A61J7/00 , A61M11/06 , A61M13/00 , A61M15/00 , B05B11/06
CPC分类号： B05B11/061 , A61M11/003 , A61M11/008 , A61M15/0028 , A61M15/003 , A61M15/0031 , A61M15/0033 , A61M2202/064 , A61M2205/073 , A61M2207/00 , B05B11/062
摘要： A medicament respiratory delivery device including a housing formed of opposed thermoformed polymeric sheets bonded together having formed therebetween a chamber having a medicament cartridge encapsulated between the sheets, an inlet aligned with a passage through the cartridge having a pierceable closure and an outlet aligned with the passage outlet having a burstable membrane. The device includes a pressure actuator formed as a blister between the sheets and a piercing element having a bow-shaped actuator portion and a shaft which pierces the pierceable closure upon actuation of the pressure actuator, delivering fluid under pressure to the cartridge passage, rupturing the membrane and expressing the medicament.
摘要翻译：一种药物呼吸输送装置，包括由相对的热成型聚合物片材形成的壳体，所述壳体在其间形成有腔室，所述腔室具有封装在所述片材之间的药剂盒，与通过所述药筒的通道对准的入口具有可刺穿的封闭件和与所述通道对准的出口出口具有可爆破的膜。该装置包括形成为片材之间的泡罩的压力致动器和具有弓形致动器部分的穿孔元件和在致动压力致动器时刺穿可刺破的封闭件的轴，将压力下的流体输送到药筒通道，膜并表达药物。

4. 发明申请

WO02055142B1 INHALER WITH FRANGIBLE MEMBRANES 审中-公开
标题翻译：吸入与可变膜
公开(公告)号：WO02055142B1
公开(公告)日：2003-02-13
申请号：PCT/US0200436
申请日：2002-01-09
申请人： BECTON DICKINSON CO , CONNELLY ROBERT I , SULLIVAN VINCENT J , SHERMER CHARLES D , WILLS ANJANA BHUTA , PETTIS RONALD J
发明人： CONNELLY ROBERT I , SULLIVAN VINCENT J , SHERMER CHARLES D , WILLS ANJANA BHUTA , PETTIS RONALD J
IPC分类号： A61J1/06 , A61J7/00 , A61M11/06 , A61M15/00 , B05B11/06
CPC分类号： A61M15/0028 , A61M11/002 , A61M11/003 , A61M11/02 , A61M15/0025 , A61M15/0031 , A61M15/0033 , A61M15/004 , A61M15/0041 , A61M15/0068 , A61M2202/064 , A61M2205/075 , A61M2207/00 , B05B11/061 , B05B11/062
摘要： A medicament delivery device for administering a medicament to a user includes a medicament reservoir and an entrance port and an exit port each disposed adjacent the reservoir. A gas chamber disposed adjacent the entrance port. The device includes a pressurizing mechanism operable to pressurize said gas chamber to at least a prescribed pressure. A first frangible membrane extends across the entrance port and separates the reservoir from the gas chamber. A second frangible membrane extends across the exit port. When the pressurizing mechanism is attached, at least one of the first and second membranes is responsive t the prescribed pressure in the gas chamber to burst to allow gas to flow through the entrance port and the reservoir and to carry the medicament through the exit port.
摘要翻译：用于向使用者施用药物的药物输送装置包括药物储存器和每个设置在储存器附近的入口和出口。邻近入口设置的气室。该装置包括可操作以将所述气室加压至少规定压力的加压机构。第一个易碎膜延伸穿过入口端口，并将储存器与气室隔开。第二个易碎膜延伸穿过出口。当附加加压机构时，第一和第二膜中的至少一个响应于气室中的规定压力而爆裂，以允许气体流过入口和储存器，并将药物运送通过出口。

5. 发明申请

WO02055142A3 INHALER WITH FRANGIBLE MEMBRANES 审中-公开
标题翻译：吸入与可变膜
公开(公告)号：WO02055142A3
公开(公告)日：2002-12-19
申请号：PCT/US0200436
申请日：2002-01-09
申请人： BECTON DICKINSON CO , CONNELLY ROBERT I , SULLIVAN VINCENT J , SHERMER CHARLES D , WILLS ANJANA BHUTA , PETTIS RONALD J
发明人： CONNELLY ROBERT I , SULLIVAN VINCENT J , SHERMER CHARLES D , WILLS ANJANA BHUTA , PETTIS RONALD J
IPC分类号： A61J1/06 , A61J7/00 , A61M11/06 , A61M15/00 , B05B11/06
CPC分类号： A61M15/0028 , A61M11/002 , A61M11/003 , A61M11/02 , A61M15/0025 , A61M15/0031 , A61M15/0033 , A61M15/004 , A61M15/0041 , A61M15/0068 , A61M2202/064 , A61M2205/075 , A61M2207/00 , B05B11/061 , B05B11/062
摘要： A medicament delivery device for administering a medicament to a user includes a medicament reservoir and an entrance port and an exit port each disposed adjacent the reservoir. A gas chamber disposed adjacent the entrance port. The device includes a pressurizing mechanism operable to pressurize said gas chamber to at least a prescribed pressure. A first frangible membrane extends across the entrance port and separates the reservoir from the gas chamber. A second frangible membrane extends across the exit port. When the pressurizing mechanism is attached, at least one of the first and second membranes is responsive t the prescribed pressure in the gas chamber to burst to allow gas to flow through the entrance port and the reservoir and to carry the medicament through the exit port.
摘要翻译：用于向使用者施用药物的药物输送装置包括药物储存器和每个设置在储存器附近的入口和出口。邻近入口设置的气室。该装置包括可操作以将所述气室加压至少规定压力的加压机构。第一个易碎膜延伸穿过入口端口，并将储存器与气室隔开。第二个易碎膜延伸穿过出口。当附加加压机构时，第一和第二膜中的至少一个响应于气室中的规定压力而爆裂，以允许气体流过入口和储存器，并将药物运送通过出口。

6. 发明专利

AT326995T 未知
公开(公告)号：AT326995T
公开(公告)日：2006-06-15
申请号：AT02701918
申请日：2002-01-09
申请人： BECTON DICKINSON CO
发明人： CONNELLY ROBERT I , SULLIVAN VINCENT J , SHERMER CHARLES D , WILLS ANJANA BHUTA , PETTIS RONALD J
IPC分类号： A61J1/06 , A61J7/00 , A61M11/06 , A61M15/00 , B05B11/06
摘要： A medicament delivery device for administering a medicament to a user includes a medicament reservoir and an entrance port and an exit port each disposed adjacent the reservoir. A gas chamber disposed adjacent the entrance port. The device includes a pressurizing mechanism operable to pressurize said gas chamber to at least a prescribed pressure. A first frangible membrane extends across the entrance port and separates the reservoir from the gas chamber. A second frangible membrane extends across the exit port. When the pressurizing mechanism is attached, at least one of the first and second membranes is responsive to the prescribed pressure in the gas chamber to burst to allow gas to flow through the entrance port and the reservoir and to carry the medicament through the exit port.

7. 发明专利

BR0214279A 未知
公开(公告)号：BR0214279A
公开(公告)日：2005-12-20
申请号：BR0214279
申请日：2002-11-19
申请人： BECTON DICKINSON CO
发明人： HWANG C ROBIN , SULLIVAN VICENT J , HUANG JUAN , WANG ZHAOLIN , MIKSZTA JOHN A , MONTGOMERY DAVID B , FORD BRANDI , WILLS ANJANA BHUTA
IPC分类号： A61J3/02 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/18 , A61K9/19 , A61K9/22 , A61K31/7088 , A61K35/76 , A61K38/00 , A61K38/28 , A61K39/00 , A61K39/145 , A61K47/26 , A61K47/36 , A61K48/00 , A61P31/12
摘要： A method of preparing a pharmaceutical composition is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles at about atmospheric pressure to produce a powder, wherein said drying is performed in the presence of vibration, internals, mechanical stirring, or a combination thereof. Another method is described, comprising 1) atomizing a liquid formulation of a therapeutic agent to produce an atomized formulation; 2) freezing said atomized formulation to form solid particles; and 3) drying said solid particles to produce a powder; wherein the atomized formulation comprises droplets having an average mean diameter of between about 35μ and about 300μ, and/or the powder comprises dried particles having an average mean diameter of between about 35μ and about 300μ. Compositions made by the above methods, and methods of using the compositions, are also described.

8. 发明专利

ES2244762T3 DISPOSITIVO DE ADMINISTRACION RESPIRATORIA DE MEDICAMENTOS, CARTUCHO Y METODO DE FABRICAR EL MISMO. 未知
公开(公告)号：ES2244762T3
公开(公告)日：2005-12-16
申请号：ES02714711
申请日：2002-01-09
申请人： BECTON DICKINSON CO
发明人： SULLIVAN VINCENT J , WILLS ANJANA BHUTA , MONAHAN LAWRENCE A , TRULL MICHAEL W , KNORS CHRISTOPER J
IPC分类号： A61J1/06 , A61J7/00 , A61M11/06 , A61M15/00 , B05B11/06 , A61M1/00
摘要： Cartucho para un dispositivo de administración respiratoria de medicamentos que comprende un cuerpo que tiene extremos opuestos, un conducto a través de dicho cuerpo a través de dichos extremos opuestos, un medicamento almacenado en dicho conducto y membranas poliméricas rompibles que cubren y sellan dicho conducto en dichos extremos opuestos de dicho cuerpo.

9. 发明专利

ES2265486T3 INHALADOR CON MEMBRANAS FRANGIBLES. 未知
公开(公告)号：ES2265486T3
公开(公告)日：2007-02-16
申请号：ES02701918
申请日：2002-01-09
申请人： BECTON DICKINSON CO
发明人： CONNELLY ROBERT I , SULLIVAN VINCENT J , SHERMER CHARLES D , WILLS ANJANA BHUTA , PETTIS RONALD J
IPC分类号： A61J1/06 , A61M15/00 , A61J7/00 , A61M11/06 , B05B11/06
摘要： Un dispositivo (101, 901, 1001, 1101, 1201, 1301) de suministro de medicamentos para administrar un medicamento (5) a un usuario, comprendiendo dicho dispositivo: a) un depósito (166, 866) del medicamento; b) un orificio de entrada (114, 714) y un orificio de salida (118, 418), cada uno de ellos dispuesto adyacente a dicho depósito (166, 866); c) una cámara de gas (112, 612) dispuesta adyacente a dicho orificio de entrada (114, 714); d) un mecanismo compresor (110, 610) accionable para comprimir dicha cámara de gas (112, 612) hasta al menos una presión preestablecida; e) una primera membrana frangible (152, 252, 352, 552, 652, 752} que se extiende a través de dicho orificio de entrada (114, 714) y que separa dicho depósito (166, 866) y dicha cámara de gas (112, 612); caracterizado por f) una segunda membrana frangible (154, 254, 354, 454, 554, 654, 754) que se extiende a través de dicho orificio de salida (118, 418); g) en el que, cuando se acciona dicho mecanismo compresor (110, 610), al menos una de dichas primera y segunda membranas es sensible a dicha presión preestablecida existente en dicha cámara de gas (112, 612) de modo que estalla para dejar que fluya el gas (111) a través de dicho orificio de entrada (114, 714) y de dicho depósito (166, 866) y arrastre el medicamento (5) por dicho orificio de salida (118, 418).

10. 发明专利

DK1351735T3 未知
公开(公告)号：DK1351735T3
公开(公告)日：2006-09-11
申请号：DK02701918
申请日：2002-01-09
申请人： BECTON DICKINSON CO
发明人： CONNELLY ROBERT I , SHERMER CHARLES D , SULLIVAN VINCENT J , WILLS ANJANA BHUTA , PETTIS RONALD J
IPC分类号： A61J1/06 , A61M15/00 , A61J7/00 , A61M11/06 , B05B11/06
摘要： A medicament delivery device for administering a medicament to a user includes a medicament reservoir and an entrance port and an exit port each disposed adjacent the reservoir. A gas chamber disposed adjacent the entrance port. The device includes a pressurizing mechanism operable to pressurize said gas chamber to at least a prescribed pressure. A first frangible membrane extends across the entrance port and separates the reservoir from the gas chamber. A second frangible membrane extends across the exit port. When the pressurizing mechanism is attached, at least one of the first and second membranes is responsive to the prescribed pressure in the gas chamber to burst to allow gas to flow through the entrance port and the reservoir and to carry the medicament through the exit port.

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