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1. 发明申请

WO2008042637A2 METHOD AND DEVICE FOR TEST SAMPLE LOADING 审中-公开
标题翻译：用于测试样品加载的方法和装置
公开(公告)号：WO2008042637A2
公开(公告)日：2008-04-10
申请号：PCT/US2007079311
申请日：2007-09-24
申请人： BECKMAN COULTER INC , WILSON BRIAN D
发明人： WILSON BRIAN D
IPC分类号： G01N21/00
CPC分类号： G01N35/0099 , G01N35/1083 , G01N2035/00277 , G01N2035/1032 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/2575
摘要： An automated analyzer is configured to receive and analyze samples provided to the automated analyzer in primary sample containers. The automated analyzer comprises a sample retention unit, at least one transport device, and at least one aspiration device. The sample retention unit is configured to receive and retain a plurality of sample retention vessels. The sample retention unit may comprise a sample storage unit, an analytic unit, or other processing unit within the automated analyzer that retains a sample for some purpose. The transport device is configured to receive a first primary sample container containing a first sample and deliver the first primary sample container to the sample retention unit as one of the plurality of sample retention vessels. The aspiration device is configured to receive a second sample from a second primary sample container and deliver the second sample into one of the plurality of sample retention vessels.
摘要翻译：自动分析仪被配置为接收和分析提供给主样本容器中的自动分析仪的样本。该自动分析仪包括样品保持单元，至少一个传送装置和至少一个抽吸装置。样品保持单元被构造成接收并保持多个样品保持容器。样本保留单元可以包括样本存储单元，分析单元或自动分析仪内的其他处理单元，其为了某种目的而保留样本。运输装置构造成接收容纳第一样本的第一主要样本容器并且将第一主要样本容器作为多个样本保留容器中的一个递送至样本保存单元。抽吸装置构造成接收来自第二主要样本容器的第二样本并且将第二样本递送到多个样本保留容器之一中。

2. 发明申请

WO2012012779A3 SYSTEM AND METHOD INCLUDING ANALYTICAL UNITS 审中-公开
标题翻译：包括分析单位的系统和方法
公开(公告)号：WO2012012779A3
公开(公告)日：2013-01-24
申请号：PCT/US2011045107
申请日：2011-07-22
申请人： BECKMAN COULTER INC , WILSON BRIAN D , ALARURI SAMI D , ANDERSON DAVID L , DAVIS MATTHEW S , ERICKSON MATTHEW D , GWYNN ROBERT B , JOHNSON ALAN N , KRAIHANZEL CHARLES S , MAURER GARRICK A , ROSEN MICHAEL J , SAUERBURGER MARK F , SCHMIDT DANIEL R , WAGNER REED B , WILTSIE JOSHUA D , STACHELEK THOMAS M , YANG DAVID L
发明人： WILSON BRIAN D , ALARURI SAMI D , ANDERSON DAVID L , DAVIS MATTHEW S , ERICKSON MATTHEW D , GWYNN ROBERT B , JOHNSON ALAN N , KRAIHANZEL CHARLES S , MAURER GARRICK A , ROSEN MICHAEL J , SAUERBURGER MARK F , SCHMIDT DANIEL R , WAGNER REED B , WILTSIE JOSHUA D , STACHELEK THOMAS M , YANG DAVID L
IPC分类号： G01N35/10 , G01N35/00 , G01N35/04
CPC分类号： G01N35/04 , B01L3/021 , B01L3/0275 , B01L3/50825 , B01L3/5085 , B01L3/50851 , B01L3/52 , B01L3/545 , B01L7/52 , B01L2200/025 , B01L2200/0642 , B01L2200/0668 , B01L2200/12 , B01L2200/147 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/042 , B01L2300/044 , B01L2300/045 , B01L2300/046 , B01L2300/0654 , B01L2300/0851 , B01L2300/123 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , C12M41/12 , C12P19/34 , C12Q1/68 , C12Q1/686 , C12Q3/00 , G01F23/24 , G01F23/26 , G01N1/31 , G01N1/38 , G01N35/00732 , G01N35/0092 , G01N35/0098 , G01N35/1002 , G01N35/1011 , G01N35/1016 , G01N35/1081 , G01N2035/00435 , G01N2035/00752 , G01N2035/00851 , G01N2035/0413 , G01N2035/0415 , G01N2035/0436 , G01N2035/0465 , G01N2035/0475 , G01N2035/1013 , G01N2035/1025 , G01N2035/1048 , G01N2035/1051 , G01N2035/1076 , G05B13/02 , G05B13/0205 , G06F19/10 , Y10T436/113332
摘要： Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.
摘要翻译：公开了用于处理和分析样品的系统和方法。该系统可以使用可在不同处理位置处理的测定盒来处理样品，例如生物流体。在某些情况下，该系统可用于PCR处理。不同的处理位置可以包括可以准备样品的准备位置和可以分析样品的分析位置。为了帮助准备样品，系统还可以包括可以包括加工车道的多个处理站。在样品分析期间，在某些情况下，可以使用热循环仪模块和适当的光学检测系统来检测样品中某些核酸序列的存在或不存在。该系统可用于准确快速地处理样品。

3. 发明专利

JP2014193114A System and method including analytical units 有权
标题翻译：包括分析单位的系统和方法
公开(公告)号：JP2014193114A
公开(公告)日：2014-10-09
申请号：JP2013066089
申请日：2013-03-27
申请人： Beckman Coulter Inc , ベックマンコールター, インコーポレイテッド
发明人： WILSON BRIAN D , ALARURI SAMI D , ANDERSON DAVID L , MATTHEW S DAVIS , MATTHEW D ERICKSON , ROBERT B GWYNN , JOHNSON ALAN N , KRAIHANZEL CHARLES S , MAURER GARRICK A , MICHAEL J ROSEN , MARK F SAUERBURGER , SCHMIDT DANIEL R , REED B WAGNER , WILTSIE JOSHUA D , STACHELEK THOMAS M , YANG DAVID L
IPC分类号： C12M1/00
CPC分类号： G01N35/04 , B01L3/021 , B01L3/0275 , B01L3/50825 , B01L3/5085 , B01L3/50851 , B01L3/52 , B01L3/545 , B01L7/52 , B01L2200/025 , B01L2200/0642 , B01L2200/0668 , B01L2200/12 , B01L2200/147 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/042 , B01L2300/044 , B01L2300/045 , B01L2300/046 , B01L2300/0654 , B01L2300/0851 , B01L2300/123 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , C12M41/12 , C12P19/34 , C12Q1/68 , C12Q1/686 , C12Q3/00 , G01F23/24 , G01F23/26 , G01N1/31 , G01N1/38 , G01N35/00732 , G01N35/0092 , G01N35/0098 , G01N35/1002 , G01N35/1011 , G01N35/1016 , G01N35/1081 , G01N2035/00435 , G01N2035/00752 , G01N2035/00851 , G01N2035/0413 , G01N2035/0415 , G01N2035/0436 , G01N2035/0465 , G01N2035/0475 , G01N2035/1013 , G01N2035/1025 , G01N2035/1048 , G01N2035/1051 , G01N2035/1076 , G05B13/02 , G05B13/0205 , G06F19/10 , Y10T436/113332
摘要： PROBLEM TO BE SOLVED: To provide systems and methods for processing and analyzing samples.SOLUTION: A system can process samples, such as biological fluids, using analyzing cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist in preparation of samples, the system may also include a large number of processing stations which may include processing lanes. In some cases, during analysis of samples, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.
摘要翻译：要解决的问题：提供处理和分析样品的系统和方法。解决方案：系统可以使用可在不同处理位置处理的分析盒来处理样品，如生物流体。在某些情况下，该系统可用于PCR处理。不同的处理位置可以包括可以准备样品的准备位置和可以分析样品的分析位置。为了帮助准备样品，系统还可以包括大量可以包括加工车道的处理站。在一些情况下，在分析样品期间，可以使用热循环仪模块和适当的光学检测系统来检测样品中某些核酸序列的存在或不存在。该系统可用于准确快速地处理样品。

4. 发明专利

JP2013150623A System and method including analytical unit 有权
标题翻译：包括分析单元的系统和方法
公开(公告)号：JP2013150623A
公开(公告)日：2013-08-08
申请号：JP2013066088
申请日：2013-03-27
申请人： Beckman Coulter Inc , ベックマンコールター, インコーポレイテッド
发明人： WILSON BRIAN D , ALARURI SAMI D , ANDERSON DAVID L , DAVIS MATTHEW S , ERICKSON MATTHEW D , GWYNN ROBERT B , JOHNSON ALAN N , KRAIHANZEL CHARLES S , MAURER GARRICK A , ROSEN MICHAEL J , SAUERBURGER MARK F , SCHMIDT DANIEL R , WAGNER REED B , WILTSIE JOSHUA D , STACHELEK THOMAS M , YANG DAVID L
IPC分类号： C12M1/00 , C12Q1/68 , G01N35/02 , G01N35/04
CPC分类号： G01N35/04 , B01L3/021 , B01L3/0275 , B01L3/50825 , B01L3/5085 , B01L3/50851 , B01L3/52 , B01L3/545 , B01L7/52 , B01L2200/025 , B01L2200/0642 , B01L2200/0668 , B01L2200/12 , B01L2200/147 , B01L2300/021 , B01L2300/022 , B01L2300/024 , B01L2300/042 , B01L2300/044 , B01L2300/045 , B01L2300/046 , B01L2300/0654 , B01L2300/0851 , B01L2300/123 , B01L2300/18 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , C12M41/12 , C12P19/34 , C12Q1/68 , C12Q1/686 , C12Q3/00 , G01F23/24 , G01F23/26 , G01N1/31 , G01N1/38 , G01N35/00732 , G01N35/0092 , G01N35/0098 , G01N35/1002 , G01N35/1011 , G01N35/1016 , G01N35/1081 , G01N2035/00435 , G01N2035/00752 , G01N2035/00851 , G01N2035/0413 , G01N2035/0415 , G01N2035/0436 , G01N2035/0465 , G01N2035/0475 , G01N2035/1013 , G01N2035/1025 , G01N2035/1048 , G01N2035/1051 , G01N2035/1076 , G05B13/02 , G05B13/0205 , G06F19/10 , Y10T436/113332
摘要： PROBLEM TO BE SOLVED: To provide systems and methods for processing and analyzing samples.SOLUTION: A system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.
摘要翻译：要解决的问题：提供处理和分析样品的系统和方法。解决方案：系统可以使用可在不同处理位置处理的测定盒来处理样品，如生物流体。在某些情况下，该系统可用于PCR处理。不同的处理位置可以包括可以准备样品的准备位置和可以分析样品的分析位置。为了帮助准备样品，系统还可以包括可以包括加工车道的多个处理站。在样品分析期间，在某些情况下，可以使用热循环仪模块和适当的光学检测系统来检测样品中某些核酸序列的存在或不存在。该系统可用于准确快速地处理样品。

5. 发明申请

WO03008980A3 METHOD AND SYSTEM FOR SAMPLE ALIQUOT STORAGE 审中-公开
标题翻译：用于样本存储的方法和系统
公开(公告)号：WO03008980A3
公开(公告)日：2003-04-17
申请号：PCT/US0207995
申请日：2002-03-15
申请人： BECKMAN COULTER INC
发明人： QURESHI HUMAYUN , SPIESS BERNARD , WEISS ROBERT A , WERNESS PETER G , WILSON BRIAN D , LASKA RONALD C
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G01N35/0092 , G01N35/1002
摘要： A method and system of sample aliquot storage for automated immunochemistry or chemistry instruments are provided. The method and system provide a sample aliquot storage unit having a sample storage wheel for storing sample vessels containing sample aliquots in a chilled enclosed environment, which are accessible by both a sample pipettor of a sample aliquoting station and a pick-and-place gripper. The pick-and-place gripper transports the sample vessels containing sample aliquots to multiple independent reagent pipetting stations respectively for sample aspiration of subsequent assay, and thereafter transports the sample vessels containing remaining sample aliquots back to the sample storage wheel to be stored in the chilled environment for reflex testing. When all the tests are completed, the pick-and-place gripper transports the sample vessels to a waste storage area.
摘要翻译：提供了用于自动化免疫化学或化学仪器的样品等分试样储存的方法和系统。该方法和系统提供样品等分存储单元，其具有样品储存轮，用于将含有样品等分试样的样品容器储存在冷藏的封闭环境中，所述样品容器可由样品等分试样台的样品移液器和拾取和放置夹具接近。拾取和夹持器将含有样品等分试样的样品容器分别运送到多个独立的试剂移液站，用于随后测定的样品抽吸，然后将含有剩余样品等分试样的样品容器运送回样品储存轮，以储存在冷藏反射测试环境。当所有测试完成后，拾取和放置夹具将样品容器运送到废物储存区域。

6. 发明申请

WO02075322A2 ROTARY INCUBATION STATION FOR IMMUNOASSAY SYSTEMS 审中-公开
标题翻译：旋转管理系统的旋转管理站
公开(公告)号：WO02075322A2
公开(公告)日：2002-09-26
申请号：PCT/US0207991
申请日：2002-03-15
申请人： BECKMAN COULTER INC
发明人： GJERDINGEN DONALD J , QURESHI HUMAYUN , WERNESS PETER G , WILSON BRIAN D , KITTOCK MARK J
IPC分类号： B01L7/00 , G01N35/00 , G01N35/02 , G01N33/53
CPC分类号： G01N35/025 , B01L7/00 , G01N2035/00376
摘要： A rotary incubation station (10) for an automated analyzer is provided. The rotary incubation station (10) includes a platform (11), a circular ring-shaped outside rotary wheel (14) having a plurality of nesting locations (18) for washing and reading vessels, and a circular disc-shaped inside rotary wheel (12) having a plurality of nesting locations (16) for incubation and storage of vessels. The rotary incubation station (10) also includes a spur gear mechanism for rotating the outside and inside rotary wheels (14, 12), including spur gear drivers (32, 36) respectively engaged with spur gear teeth (30, 40) of the outside and inside rotary wheel (14, 12), providing accurate control of the rotation of the outside and inside rotary wheels (14, 12).
摘要翻译：提供了一种用于自动分析仪的旋转孵育站（10）。旋转孵育站（10）包括平台（11），具有用于洗涤和读取容器的多个嵌套位置（18）的圆环形外部旋转轮（14）和圆盘形内部旋转轮 12）具有用于孵化和储存容器的多个嵌套位置（16）。旋转式孵育站（10）还包括用于使外部和内部旋转的正齿轮机构（14,12），其包括分别与外部的正齿轮齿（30,40）接合的正齿轮驱动器（32,36）和旋转轮（14,12）内部，提供对外部和内部旋转轮（14,12）的旋转的精确控制。

7. 发明申请

WO02075323A3 METHOD AND SYSTEM FOR AUTOMATED IMMUNOCHEMISTRY ANALYSIS 审中-公开
标题翻译：自动免疫化学分析方法与系统
公开(公告)号：WO02075323A3
公开(公告)日：2003-03-13
申请号：PCT/US0207989
申请日：2002-03-15
申请人： BECKMAN COULTER INC
发明人： QURESHI HUMAYUN , DAVIS GLENN A , KITTOCK MARK J , WERNESS PETER G , WILLENBRING ARMER J , WILSON BRIAN D
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G01N35/1002 , G01N35/0092 , Y10T436/11 , Y10T436/113332 , Y10T436/115831
摘要： A method and system for automated immunochemistry or chemistry analysis are provided. The method and system provide a sample aliquoting section, a reagent pipetting section (15) having a plurality of independent reagent pipetting stations (4, 5, 6, 7) each operating on a cycle of a first period of time, and an incubate and wash and read section (12, 16) operating on a cycle of a second period of time to match the throughput of the system, where the quotient of the first period of time divided by the second period of time is a whole number, and the number of the independent reagent pipetting stations being equal to the whole number. The respective cycles of the independent reagent pipetting stations are staggered apart by the second time period, such that at least one of the multiple independent pipetting stations is available for working with the incubate and wash and read section ( 12, 16) at each operating cycle of the second period of time.
摘要翻译：提供了一种用于自动化免疫化学或化学分析的方法和系统。该方法和系统提供样品等分部分，试剂吸移部分（15），其具有多个独立的试剂移液站（4,5,6,7），每个独立的试剂移液站以第一时间段的循环操作，并且孵育和洗涤和读取部分（12,16），其在第二时间段的周期上操作以匹配系统的吞吐量，其中第一时间段的商除以第二时间段是整数，并且独立试剂移液站的数量等于整数。独立试剂移液站的各个循环在第二时间段间交错分开，使得多个独立移液站中的至少一个可用于在每个操作循环中与孵化和洗涤和读取部分（12,16）一起工作的第二个时期。

8. 发明申请

WO2006083647A3 METHOD AND APPARATUS FOR WASHING A PROBE OR THE LIKE USING ULTRASONIC ENERGY 审中-公开
标题翻译：用于冲洗探针或类似超声波能量的方法和装置
公开(公告)号：WO2006083647A3
公开(公告)日：2007-10-11
申请号：PCT/US2006002611
申请日：2006-01-24
申请人： BECKMAN COULTER INC
发明人： WILSON BRIAN D
IPC分类号： B08B3/12
CPC分类号： B06B3/02
摘要： An apparatus and corresponding method for ultrasonically washing a probe or the like are disclosed. The apparatus comprises an ultrasonic wave generator (15) and an ultrasonic wave concentrator (20). The ultrasonic wave concentrator (20) includes a body portion having a wash cavity (25). The wash cavity 25 is shaped to generally conform to an exterior portion of the probe (30). A first end of the ultrasonic wave concentrator is adapted to receive ultrasonic energy produced by the ultrasonic wave generator. The ultrasonic energy received at the first end of the concentrator is focused into the wash cavity where it is used to wash the probe (or other object). A second end of the ultrasonic wave concentrator includes an aperture (35) that is open to the wash cavity and is adapted to receive the probe and allow it to enter the wash cavity (25).
摘要翻译：公开了一种用于超声波清洗探针等的装置和相应的方法。该装置包括超声波发生器（15）和超声波收集器（20）。超声波聚光器（20）包括具有洗涤腔（25）的主体部分。洗涤腔25的形状大体上符合探针（30）的外部部分。超声波收集器的第一端适于接收由超声波发生器产生的超声波能量。在集中器的第一端处接收到的超声能量被聚焦到洗涤腔中，在其中用于洗涤探针（或其它物体）。超声波聚光器的第二端包括对洗涤腔开放的孔（35），并且适于接纳探针并允许其进入洗涤腔（25）。

9. 发明申请

WO2006047026A3 IMPROVED GANTRY ASSEMBLY SUITABLE FOR USE IN A LABORATORY ENVIRONMENT 审中-公开
标题翻译：改进的甘草组合适用于实验室环境
公开(公告)号：WO2006047026A3
公开(公告)日：2007-04-12
申请号：PCT/US2005034229
申请日：2005-09-23
申请人： BECKMAN COULTER INC
发明人： MATTILA ROBERT J , WILSON BRIAN D
IPC分类号： G01N1/00 , G01N35/00
CPC分类号： G01N35/0099 , B25J9/023 , B25J9/104 , Y10T436/2575
摘要： An assembly suitable for use in a laboratory instrument is set forth. The assembly comprises a plurality of guide rods that are disposed generally parallel with one another and a plurality of carriage assemblies connected for movement along the plurality of guide rods. A sub-carriage assembly is disposed on at least one of the carriage assemblies and is connected to the carriage assembly for movement in a direction transverse to the plurality of guide rods. A plurality of carriage drive mechanisms are employed to move the plurality of carriage assemblies independently along said plurality of guide rods and a sub-carriage drive mechanism is provided to move the sub-carriage assembly in a direction transverse to said plurality of guide rods.
摘要翻译：阐述适用于实验室仪器的组件。该组件包括多个彼此平行布置的导向杆，以及多个支架组件，其连接用于沿多个导杆移动。子托架组件设置在至少一个托架组件上，并且连接到托架组件以沿横向于多个导杆的方向运动。使用多个托架驱动机构来沿着所述多个导杆独立地移动多个托架组件，并且提供副托架驱动机构以沿横向于所述多个导杆的方向移动副托架组件。

10. 发明申请

WO02090996A2 SAMPLE PRESENTATION UNIT 审中-公开
标题翻译：样品演示单元
公开(公告)号：WO02090996A2
公开(公告)日：2002-11-14
申请号：PCT/US0207988
申请日：2002-03-15
申请人： BECKMAN COULTER INC
发明人： NGO DANG M , WILSON BRIAN D , MATTILA ROBERT J
IPC分类号： G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/026 , G01N2035/00643 , G01N2035/0465 , G01N2035/0491
摘要： A sample presentation unit (SPU) for an automated analyzer is provided. The SPU has a sample rack onload section having an elongated rail, and an onload moving mechanism movable along the rail for moving the sample racks placed on the rail towards a sample rack presentation section. The sample rack presentation section of the SPU has a transfer area connected to the proximal end of the rail of the sample rack onload section for receiving the sample racks from the sample rack onload section, a sample presentation area adjacent to the automated analyzer for presenting sample racks for aspiration, and a presentation moving mechanism movable between the transfer area and the presentation area for moving sample racks from the transfer area to the presentation area for a sample aspiration and subsequently moving the sample racks from the presentation area back to the transfer area after sample aspiration. The SPU also has a sample rack offload section having an offload area connected to the transfer area of the sample rack presentation section for receiving the sample racks from the sample rack presentation section after sample aspiration, and an offload moving mechanism for moving the sample racks received from the sample rack presentation section to a sample rack offload tray. The SPU further has a plurality of strategically located sensors for detection of motion errors or motor jams.
摘要翻译：提供了一种用于自动分析仪的样品呈现单元（SPU）。 SPU具有带有细长导轨的样品架负载部分，以及可沿轨道移动的负载移动机构，用于将放置在轨道上的样品架移动到样品架呈现部分。 SPU的样品架呈现部分具有连接到样品架负载部分的轨道的近端的传送区域，用于从样品架载荷部分接收样品架，与自动分析器相邻的样品呈现区域用于呈现样品以及呈现移动机构，其可在传送区域和呈现区域之间移动，用于将样品架从传送区域移动到呈现区域用于样品抽吸，并随后将样品架从展示区域移回到传送区域。样品抽吸。 SPU还具有样品架卸载部，其具有连接到样品架呈现部的传送区域的卸载区域，用于在样本抽吸之后从样品架呈现部分接收样品架，以及卸载移动机构，用于移动接收到的样品架从样品架展示部分到样品架卸载托盘。 SPU还具有多个策略性位置传感器，用于检测运动错误或电机卡纸。

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