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1. 发明申请

WO03008980A3 METHOD AND SYSTEM FOR SAMPLE ALIQUOT STORAGE 审中-公开
标题翻译：用于样本存储的方法和系统
公开(公告)号：WO03008980A3
公开(公告)日：2003-04-17
申请号：PCT/US0207995
申请日：2002-03-15
申请人： BECKMAN COULTER INC
发明人： QURESHI HUMAYUN , SPIESS BERNARD , WEISS ROBERT A , WERNESS PETER G , WILSON BRIAN D , LASKA RONALD C
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G01N35/0092 , G01N35/1002
摘要： A method and system of sample aliquot storage for automated immunochemistry or chemistry instruments are provided. The method and system provide a sample aliquot storage unit having a sample storage wheel for storing sample vessels containing sample aliquots in a chilled enclosed environment, which are accessible by both a sample pipettor of a sample aliquoting station and a pick-and-place gripper. The pick-and-place gripper transports the sample vessels containing sample aliquots to multiple independent reagent pipetting stations respectively for sample aspiration of subsequent assay, and thereafter transports the sample vessels containing remaining sample aliquots back to the sample storage wheel to be stored in the chilled environment for reflex testing. When all the tests are completed, the pick-and-place gripper transports the sample vessels to a waste storage area.
摘要翻译：提供了用于自动化免疫化学或化学仪器的样品等分试样储存的方法和系统。该方法和系统提供样品等分存储单元，其具有样品储存轮，用于将含有样品等分试样的样品容器储存在冷藏的封闭环境中，所述样品容器可由样品等分试样台的样品移液器和拾取和放置夹具接近。拾取和夹持器将含有样品等分试样的样品容器分别运送到多个独立的试剂移液站，用于随后测定的样品抽吸，然后将含有剩余样品等分试样的样品容器运送回样品储存轮，以储存在冷藏反射测试环境。当所有测试完成后，拾取和放置夹具将样品容器运送到废物储存区域。

2. 发明申请

WO0231357A2 FLUID-MOVING DEVICE WITH INTEGRATED VALVE 审中-公开
标题翻译：带集成阀的流体动力装置
公开(公告)号：WO0231357A2
公开(公告)日：2002-04-18
申请号：PCT/US0131503
申请日：2001-10-10
申请人： BECKMAN COULTER INC
发明人： KITTOCK MARK J , QURESHI HUMAYUN
IPC分类号： F04B7/00 , F04B13/00 , F04B53/10 , F04B53/16 , B01L11/00 , G01N1/00
CPC分类号： F04B13/00 , F04B7/0003 , F04B53/10 , F04B53/16 , Y10T137/7613
摘要： A fluid-moving device with an integrated valve is disclosed. The device includes a housing (1) defining a suction chamber (2) and at least one internal passage-way (3) formed inside the housing (1). A first end (4) of the internal passageway (3) opens to the suction chamber (2) and a second end (5) of the internal passageway connects to an outside surface of the housing. The fluid-moving device of the present invention also includes a pumping structure (5) disposed inside the suction chamber (2) for generating a pressure inside the suction chamber. The device may also include valve passageways formed inside the housing. In one embodiment, a manifold is utilized for connecting the valve passageways to fluid supplies and fluid sinks. The manifold has a casing, at least one input port, at least one output port, and a plurality of internal manifold passageways formed in the manifold casing. A method of making a fluid-moving device with an integrated valve of the present invention is also disclosed.
摘要翻译：公开了一种具有集成阀的流体移动装置。该装置包括限定吸入室（2）的壳体（1）和形成在壳体（1）内部的至少一个内部通道（3）。内部通道（3）的第一端（4）通向吸入室（2），并且内部通道的第二端（5）连接到壳体的外表面。本发明的流体移动装置还包括设置在吸入室（2）内部的用于在吸入室内产生压力的泵送结构（5）。该装置还可以包括形成在壳体内的阀通道。在一个实施例中，歧管用于将阀通道连接到流体供应源和流体槽。歧管具有壳体，至少一个输入端口，至少一个输出端口和形成在歧管壳体中的多个内部歧管通道。还公开了一种制造具有本发明的集成阀的流体移动装置的方法。

3. 发明申请

WO02075323A3 METHOD AND SYSTEM FOR AUTOMATED IMMUNOCHEMISTRY ANALYSIS 审中-公开
标题翻译：自动免疫化学分析方法与系统
公开(公告)号：WO02075323A3
公开(公告)日：2003-03-13
申请号：PCT/US0207989
申请日：2002-03-15
申请人： BECKMAN COULTER INC
发明人： QURESHI HUMAYUN , DAVIS GLENN A , KITTOCK MARK J , WERNESS PETER G , WILLENBRING ARMER J , WILSON BRIAN D
IPC分类号： G01N35/00 , G01N35/10
CPC分类号： G01N35/1002 , G01N35/0092 , Y10T436/11 , Y10T436/113332 , Y10T436/115831
摘要： A method and system for automated immunochemistry or chemistry analysis are provided. The method and system provide a sample aliquoting section, a reagent pipetting section (15) having a plurality of independent reagent pipetting stations (4, 5, 6, 7) each operating on a cycle of a first period of time, and an incubate and wash and read section (12, 16) operating on a cycle of a second period of time to match the throughput of the system, where the quotient of the first period of time divided by the second period of time is a whole number, and the number of the independent reagent pipetting stations being equal to the whole number. The respective cycles of the independent reagent pipetting stations are staggered apart by the second time period, such that at least one of the multiple independent pipetting stations is available for working with the incubate and wash and read section ( 12, 16) at each operating cycle of the second period of time.
摘要翻译：提供了一种用于自动化免疫化学或化学分析的方法和系统。该方法和系统提供样品等分部分，试剂吸移部分（15），其具有多个独立的试剂移液站（4,5,6,7），每个独立的试剂移液站以第一时间段的循环操作，并且孵育和洗涤和读取部分（12,16），其在第二时间段的周期上操作以匹配系统的吞吐量，其中第一时间段的商除以第二时间段是整数，并且独立试剂移液站的数量等于整数。独立试剂移液站的各个循环在第二时间段间交错分开，使得多个独立移液站中的至少一个可用于在每个操作循环中与孵化和洗涤和读取部分（12,16）一起工作的第二个时期。

4. 发明申请

WO02075322A2 ROTARY INCUBATION STATION FOR IMMUNOASSAY SYSTEMS 审中-公开
标题翻译：旋转管理系统的旋转管理站
公开(公告)号：WO02075322A2
公开(公告)日：2002-09-26
申请号：PCT/US0207991
申请日：2002-03-15
申请人： BECKMAN COULTER INC
发明人： GJERDINGEN DONALD J , QURESHI HUMAYUN , WERNESS PETER G , WILSON BRIAN D , KITTOCK MARK J
IPC分类号： B01L7/00 , G01N35/00 , G01N35/02 , G01N33/53
CPC分类号： G01N35/025 , B01L7/00 , G01N2035/00376
摘要： A rotary incubation station (10) for an automated analyzer is provided. The rotary incubation station (10) includes a platform (11), a circular ring-shaped outside rotary wheel (14) having a plurality of nesting locations (18) for washing and reading vessels, and a circular disc-shaped inside rotary wheel (12) having a plurality of nesting locations (16) for incubation and storage of vessels. The rotary incubation station (10) also includes a spur gear mechanism for rotating the outside and inside rotary wheels (14, 12), including spur gear drivers (32, 36) respectively engaged with spur gear teeth (30, 40) of the outside and inside rotary wheel (14, 12), providing accurate control of the rotation of the outside and inside rotary wheels (14, 12).
摘要翻译：提供了一种用于自动分析仪的旋转孵育站（10）。旋转孵育站（10）包括平台（11），具有用于洗涤和读取容器的多个嵌套位置（18）的圆环形外部旋转轮（14）和圆盘形内部旋转轮 12）具有用于孵化和储存容器的多个嵌套位置（16）。旋转式孵育站（10）还包括用于使外部和内部旋转的正齿轮机构（14,12），其包括分别与外部的正齿轮齿（30,40）接合的正齿轮驱动器（32,36）和旋转轮（14,12）内部，提供对外部和内部旋转轮（14,12）的旋转的精确控制。

5. 发明申请

WO0231386A3 FLUID-MOVING DEVICE WITH A CLEARANCE SEAL 审中-公开
标题翻译：带有间隙密封的流体运动装置
公开(公告)号：WO0231386A3
公开(公告)日：2002-08-22
申请号：PCT/US0131502
申请日：2001-10-10
申请人： BECKMAN COULTER INC
发明人： KITTOCK MARK J , QURESHI HUMAYUN
IPC分类号： F04B53/16 , F16J15/44
CPC分类号： F04B53/164 , F16J15/441
摘要： A clearance seal assembly (20) is disclosed. The assembly comprises a stationary member (21) defining a first side, a second side and an opening (23) connecting the first and second side; a moving member (24) moveably disposed through the opening; and a sealing member (25) circumferentially disposed between the stationary member and the moving member. The sealing member has a fluid-tight relationship with the stationary member. The sealing member and the moving member define a continuous and uniform gap (26) having a size that allows the fluid to fill the gap but prevents the fluid from flowing through the gap from the first side to the second side of the opening under an operating pressure differential between the first and the second side. In a preferred embodiment, both the sealing member and the moving member are made of a ceramic material. The sealing assembly may also include a static seal disposed between the stationary member and the sealing to allow a variable clearance therebetween while maintaining the fluid-tight relationship between the sealing member and the stationary member. A pump utilizing the sealing assembly of the present invention is also disclosed.
摘要翻译：公开了一种间隙密封组件（20）。该组件包括限定第一侧，第二侧和连接第一侧和第二侧的开口（23）的固定构件（21）移动部件（24），其可移动地设置穿过所述开口; 以及沿周向设置在静止部件和移动部件之间的密封部件（25）。密封构件与静止构件具有流体密封关系。密封构件和移动构件限定连续且均匀的间隙（26），该间隙具有允许流体填充间隙但防止流体在操作下从开口的第一侧到第二侧流过间隙的尺寸第一和第二侧之间的压力差。在优选实施例中，密封构件和移动构件都由陶瓷材料制成。密封组件还可包括设置在静止构件与密封件之间的静态密封件，以允许其间的可变间隙，同时保持密封构件与静止构件之间的流体密封关系。还公开了利用本发明的密封组件的泵。

6. 发明专利

DE60200880T2 未知
公开(公告)号：DE60200880T2
公开(公告)日：2005-07-28
申请号：DE60200880
申请日：2002-01-22
申请人： BECKMAN COULTER INC
发明人： KITTOCK J , QURESHI HUMAYUN , WILSON D , WILLENBRING J
IPC分类号： B25J15/12 , G01N35/00
摘要： A method and system for picking and placing vessels are provided. The system includes a gripper assembly mounted on a positioning mechanism. The gripper assembly includes a cylinder, a plurality of flexible gripping members extending from the cylinder in a spaced-apart relationship for receiving therebetween a vessel and holding it by friction, a piston slideably inserted inside the cylinder, and a plunger connected to and movable with the piston and extending between the gripping members for engaging the vessel. The method includes the steps of positioning the gripper assembly, picking up and transferring a vessel, and placing, seating and releasing the vessel. The contents of the vessel may also be mixed simultaneously during the transferring of the vessel.

7. 发明专利

DE60104433T2 未知
公开(公告)号：DE60104433T2
公开(公告)日：2005-08-18
申请号：DE60104433
申请日：2001-10-10
申请人： BECKMAN COULTER INC
发明人： KITTOCK J , QURESHI HUMAYUN
IPC分类号： F04B7/00 , F04B13/00 , F04B53/10 , F04B53/16 , G01N1/00 , B01L11/00
摘要： A fluid-moving device with an integrated valve is disclosed. The device includes a housing defining a suction chamber and at least one internal passageway formed inside the housing. A first end of the internal passageway opens to the suction chamber and a second end of the internal passageway connects to an outside surface of the housing. The fluid-moving device of the present invention also includes a pumping structure disposed inside the suction chamber for generating a pressure inside the suction chamber. The device may also include valve passageways formed inside the housing. In one embodiment, a manifold is utilized for connecting the valve passageways to fluid supplies and fluid sinks. The manifold has a casing, at least one input port, at least one output port, and a plurality of internal manifold passageways formed in the manifold casing. A method of making a fluid-moving device with an integrated valve of the present invention is also disclosed.

8. 发明专利

DE60201742T2 未知
公开(公告)号：DE60201742T2
公开(公告)日：2006-02-09
申请号：DE60201742
申请日：2002-03-15
申请人： BECKMAN COULTER INC
发明人： GJERDINGEN J , QURESHI HUMAYUN , WERNESS G , WILSON D , KITTOCK J
IPC分类号： B01L7/00 , G01N33/53 , G01N35/00 , G01N35/02
摘要： A rotary incubation station for an automated analyzer is provided. The rotary incubation station includes a platform, a circular ring-shaped outside rotary wheel having a plurality of nesting locations for washing and reading vessels, and a circular disc-shaped inside rotary wheel having a plurality of nesting locations for incubation and storage of vessels. The rotary incubation station also includes a spur gear mechanism for rotating the outside and inside rotary wheels, including spur gear drivers respectively engaged with spur gear teeth of the outside and inside rotary wheel, providing accurate control of the rotation of the outside and inside rotary wheels.

9. 发明专利

DE60201742D1 未知
公开(公告)号：DE60201742D1
公开(公告)日：2004-12-02
申请号：DE60201742
申请日：2002-03-15
申请人： BECKMAN COULTER INC
发明人： GJERDINGEN J , QURESHI HUMAYUN , WERNESS G , WILSON D , KITTOCK J
IPC分类号： B01L7/00 , G01N35/00 , G01N35/02 , G01N33/53
摘要： A rotary incubation station for an automated analyzer is provided. The rotary incubation station includes a platform, a circular ring-shaped outside rotary wheel having a plurality of nesting locations for washing and reading vessels, and a circular disc-shaped inside rotary wheel having a plurality of nesting locations for incubation and storage of vessels. The rotary incubation station also includes a spur gear mechanism for rotating the outside and inside rotary wheels, including spur gear drivers respectively engaged with spur gear teeth of the outside and inside rotary wheel, providing accurate control of the rotation of the outside and inside rotary wheels.

10. 发明专利

DE60201269T2 未知
公开(公告)号：DE60201269T2
公开(公告)日：2005-10-06
申请号：DE60201269
申请日：2002-03-15
申请人： BECKMAN COULTER INC
发明人： QURESHI HUMAYUN , DAVIS A , KITTOCK J , WERNESS G , WILLENBRING J , WILSON D
IPC分类号： G01N35/00 , G01N35/10
摘要： A method and system of sample aliquot storage for automated immunochemistry or chemistry instruments are provided. The method and system provide a sample aliquot storage unit having a sample storage wheel for storing sample vessels containing sample aliquots in a chilled enclosed environment, which are accessible by both a sample pipettor of a sample aliquoting station and a pick-and-place gripper. The pick-and-place gripper transports the sample vessels containing sample aliquots to multiple independent reagent pipetting stations respectively for sample aspiration of subsequent assay, and thereafter transports the sample vessels containing remaining sample aliquots back to the sample storage wheel to be stored in the chilled environment for reflex testing. When all the tests are completed, the pick-and-place gripper transports the sample vessels to a waste storage area.

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