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1. 发明申请

WO2008005859A2 DENDRITIC CELLS GENERATED USING GM-CSF AND INTERFERON ALPHA AND LOADED WITH HEAT-TREATED AND KILLED CANCER CELLS 审中-公开
标题翻译：用GM-CSF和干扰素α产生树突状细胞并加载经热处理和杀死的癌细胞
公开(公告)号：WO2008005859A2
公开(公告)日：2008-01-10
申请号：PCT/US2007072525
申请日：2007-06-29
申请人： BAYLOR RES INST , PALUCKA ANNA KAROLINA , BANCHEREAU JACQUES F , TAQUET NICOLAS , BURKEHOLDER SUSAN
发明人： PALUCKA ANNA KAROLINA , BANCHEREAU JACQUES F , TAQUET NICOLAS , BURKEHOLDER SUSAN
IPC分类号： A61P35/00
CPC分类号： A61K39/0011 , A61K2039/5154 , C12N5/0639 , C12N2501/22 , C12N2501/24 , C12N2501/25
摘要： The present invention includes compositions and methods for making a pharmaceutically effective amount of one or more dendritic cells matured by exposure to IFNa loaded with cancer antigens from cells that are heat shocked and subsequently killed, wherein the one or more IFNa dendritic cells are under conditions to present the one or more cancer antigens are presented within the context of autologous MHC.
摘要翻译：本发明包括用于制备药学有效量的一种或多种树突细胞的组合物和方法，所述树突细胞通过暴露于负载有来自热休克且随后杀死的细胞的癌抗原的IFNa成熟，其中所述一种或多种IFNa树突细胞处于目前一种或多种癌症抗原呈现在自体MHC的情况下。

2. 发明申请

WO2007044450A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2007044450A3
公开(公告)日：2009-04-23
申请号：PCT/US2006038940
申请日：2006-10-06
申请人： BAYLOR RES INST , BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA
发明人： BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA
IPC分类号： A61K39/00 , A61K38/00
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K38/1793 , A61K38/2086 , A61K39/395 , A61K45/06
摘要： The present invention includes compositions and methods for the treatment of cancers by controlling the type of immune response mounted against the tumor, and more particularly, the treatment of tumors with cytokine antagonists to change the type of helper T cell response and inhibition of angiogenesis, prevention of formation of metastasis and prevention of formation of tumor stroma.
摘要翻译：本发明包括通过控制针对肿瘤的免疫应答的类型来治疗癌症的组合物和方法，更具体地，用细胞因子拮抗剂治疗肿瘤以改变辅助性T细胞应答的类型和抑制血管发生，预防形成转移和预防肿瘤基质的形成。

3. 发明申请

WO2008024642A3 GENE EXPRESSION SIGNATURES IN BLOOD LEUKOCYTES PERMIT DIFFERENTIAL DIAGNOSIS OF ACUTE INFECTIONS 审中-公开
标题翻译：基因表达特征在急性白血病患者血清白细胞介素的差异诊断中的价值
公开(公告)号：WO2008024642A3
公开(公告)日：2008-12-04
申请号：PCT/US2007075713
申请日：2007-08-10
申请人： BAYLOR RES INST , UNIV TEXAS , BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA , RAMILO OCTAVIO , CHAUSSABEL DAMIEN
发明人： BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA , RAMILO OCTAVIO , CHAUSSABEL DAMIEN
IPC分类号： C12Q1/68 , C12P19/34 , G01N33/48
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of the extent, type and nature of a host immune response and the nature of the infectious disease using gene expression data.
摘要翻译：本发明包括用于使用基因表达数据早期检测和一致确定宿主免疫应答的程度，类型和性质以及传染病性质的组合物，系统和方法。

4. 发明申请

WO2011091319A3 DENDRITIC CELL VACCINES 审中-公开
标题翻译： DENDRITIC细胞疫苗
公开(公告)号：WO2011091319A3
公开(公告)日：2011-11-17
申请号：PCT/US2011022147
申请日：2011-01-21
申请人： BAYLOR RES INST , BANCHEREAU JACQUES F , MONTES MONICA , PALUCKA ANNA KAROLINA , SLOAN LOUIS M , LEVY YVES , AGENCE NATIONALE DE RECH S SUR LE SIDA ET LES HEPATITIS VIRALES
发明人： BANCHEREAU JACQUES F , MONTES MONICA , PALUCKA ANNA KAROLINA , SLOAN LOUIS M , LEVY YVES
IPC分类号： A61K39/12 , A61K31/18 , A61K38/04 , A61K38/16 , A61K39/21 , A61P31/18 , C12N5/0784
CPC分类号： C12N5/0639 , A61K39/12 , A61K39/21 , A61K2039/5154 , A61K2039/545 , A61K2039/6018 , C07K14/005 , C12N2501/052 , C12N2501/22 , C12N2501/24 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334
摘要： Compositions and methods for the prophylaxis and treatment of human immunodeficiency virus (HIV) infections are disclosed herein. More specifically the present invention discloses describes an autologous dendritic cell (DC) vaccine product derived by culturing a patient's monocytes with granulocyte macrophage colony stimulating factor (GM-CSF) and interferon alpha 2b (IFN-a), loading the DC with a mixture of five lipopeptides of Gag, Nef and Pol HIV antigens, and, optionally activating the DC with lipopolysaccharide (LPS).
摘要翻译：本文公开了预防和治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。更具体地，本发明公开了一种通过用粒细胞巨噬细胞集落刺激因子（GM-CSF）和干扰素α2b（IFN-α）培养患者的单核细胞衍生的自体树突状细胞（DC）疫苗产品， 5种Gag，Nef和Pol HIV抗原的脂肽，以及任选地用脂多糖（LPS）活化DC。

5. 发明申请

WO0129192A3 USE OF ALLOGENEIC CELL LINES TO LOAD ANTIGEN-PRESENTING CELLS TO ELICIT OR ELIMINATE IMMUNE RESPONSES 审中-公开
标题翻译：使用同种异体细胞系负载抗原呈递细胞以免疫或免疫免疫应答
公开(公告)号：WO0129192A3
公开(公告)日：2002-01-17
申请号：PCT/US0028670
申请日：2000-10-16
申请人： BAYLOR RES INST , BANCHEREAU JACQUES F , BERARD FREDERIC , BLANCO PATRICK , NEIDHART BERARD EVE MARIE , NOURI SHIRAZI MAHYAR , PALUCKA ANNA KAROLINA
发明人： BANCHEREAU JACQUES F , BERARD FREDERIC , BLANCO PATRICK , NEIDHART-BERARD EVE-MARIE , NOURI-SHIRAZI MAHYAR , PALUCKA ANNA KAROLINA
IPC分类号： A61K35/12 , A61K39/00 , A61P35/00 , C12N5/0784 , C12N5/08
CPC分类号： C12N5/0639 , A61K39/0008 , A61K39/001 , A61K39/0011 , A61K2035/122 , A61K2039/5152 , A61K2039/5154 , A61K2039/5158 , A61K2039/57 , C12N5/064
摘要： Novel antigen-presenting cells, including but not limited to dendritic cells (DC), that are loaded with antigens from dead or dying cells including allogenic cell lines, and the methods for making such antigen-presenting cells are described. These loaded antigen-presenting cells are useful to induce both prophylactic immune responses and therapeutic immune responses in humans. In particular, such loaded antigen-presenting cells are useful in the management of cancer and infectious diseases. Alternatively, the loaded antigen-presenting cells can be used to eliminate undesired immune responses such as autoimmune responses and graft versus host disease or host versus graft reaction, i.e., graft rejection in organ and bone marrow transplantation. Antigen-presenting cells useful in the present invention include but are not limited to dendritic cells at various differentiation stages (precursors, immature dendritic cells and mature dendritic cells), dendritic cells derived from blood precursors including but not limited to monocytes, dendritic cells derived from CD34-hematopoetic progenitor cells, subsets of dentritic cells such as Langerhans cells, interstitial DCs and lymphoid DCs. The antigen-presenting cells and the precursors of cytotoxic cells are derived from healthy volunteers or from tumor-bearing patients. Antigen-loaded dendritic cells prepared as described here can also prime naïve T cells to differentiate into effector cells able to recognize multiple and/or shared tumor antigens that are expressed either on the tumor cells that are used to load the dentritic cells and/or on other tumor cells. The cytotoxic T cells generated by exposure to antigen-loaded dendritic cells prepared as described here can also be used in adoptive therapy. This induction of responses against multiple antigens shared between different cells, for instance tumor cells, as described here is important as it leads to broad immune responses. In the present invention, the T cells that are exposed to dendritic cells loaded with killed cells can be tolerized against the antigen(s) expressed on the killed cells. That can be achieved by manipulation of loaded dentritic cells that allows presentation of the antigen but inhibits the expression of co-stimulatory molecules.
摘要翻译：描述了载有来自死亡或死亡细胞（包括同种异体细胞系）的抗原的新型抗原呈递细胞，包括但不限于树突细胞（DC），以及制备这种抗原呈递细胞的方法。这些负载的抗原呈递细胞可用于诱导人类的预防性免疫应答和治疗性免疫应答。特别地，这种负载的抗原呈递细胞可用于治疗癌症和感染性疾病。或者，加载的抗原呈递细胞可用于消除不期望的免疫应答，例如自身免疫应答和移植物抗宿主病或宿主与移植物反应，即在器官和骨髓移植中的移植排斥反应。可用于本发明的抗原呈递细胞包括但不限于在各种分化阶段的树突状细胞（前体，未成熟树突细胞和成熟树突状细胞），衍生自血液前体的树突状细胞，包括但不限于单核细胞，衍生自 CD34-造血祖细胞，诸如朗格汉斯细胞，间质性DCs和淋巴样DCs的树突状细胞亚群。抗原呈递细胞和细胞毒性细胞的前体衍生自健康志愿者或来自肿瘤的患者。如本文所述制备的抗原负载的树突状细胞也可以使初始的T细胞分化成能够识别多次和/或共享肿瘤抗原的效应细胞，所述多个和/或共有的肿瘤抗原在用于装载树突细胞的肿瘤细胞上表达和/或在其他肿瘤细胞。通过暴露于如本文所述制备的抗原负载的树突状细胞产生的细胞毒性T细胞也可用于过继疗法。如本文所述，这种对不同细胞（例如肿瘤细胞）共有的多种抗原的反应诱导是重要的，因为它导致广泛的免疫应答。在本发明中，暴露于负载有杀死细胞的树突细胞的T细胞可以耐受在杀死的细胞上表达的抗原。这可以通过操作允许呈递抗原但抑制共刺激分子的表达的负载的树突状细胞来实现。

6. 发明申请

WO2009149382A3 ANTI-CD8 ANTIBODIES BLOCK PRIMING OF CYTOTOXIC EFFECTORS AND LEAD TO GENERATION OF REGULATORY CD8+T CELLS 审中-公开
标题翻译：抗CD8抗体阻断细胞毒性作用的细胞因子并导致调节性CD8 + T细胞的产生
公开(公告)号：WO2009149382A3
公开(公告)日：2010-04-29
申请号：PCT/US2009046464
申请日：2009-06-05
申请人： BAYLOR RES INST , BANCHEREAU JACQUES F , KLECHEVSKY EYNAV , PALUCKA ANNA KAROLINA
发明人： BANCHEREAU JACQUES F , KLECHEVSKY EYNAV , PALUCKA ANNA KAROLINA
IPC分类号： C07K16/28 , A61K39/395 , A61P37/06
CPC分类号： C07K16/2815 , A61K39/001 , A61K2035/122 , A61K2039/505 , C07K2317/73 , C12N5/0636 , C12N5/064 , C12N2501/22 , C12N2501/24 , C12N2501/26 , C12N2501/505
摘要： The present invention includes compositions and methods for inducing tolerance in a subject in need thereof comprising providing the subject with an effective amount of an anti-CD8 antibody sufficient in induce CD8+ T cell immune tolerance to allogeneic antigens.
摘要翻译：本发明包括用于在有需要的受试者中诱导耐受性的组合物和方法，其包括向受试者提供有效量的足以诱导对同种异体抗原的CD8 + T细胞免疫耐受的抗CD8抗体。

7. 发明申请

WO2008100352A3 DIAGNOSIS OF METASTATIC MELANOMA AND MONITORING INDICATORS OF IMMUNOSUPPRESSION THROUGH BLOOD LEUKOCYTE MICROARRAY ANALYSIS 审中-公开
标题翻译：通过血液白细胞分析法分析嗜铬细胞瘤和监测免疫抑制指标
公开(公告)号：WO2008100352A3
公开(公告)日：2008-12-11
申请号：PCT/US2007083555
申请日：2007-11-03
申请人： BAYLOR RES INST , PALUCKA ANNA KAROLINA , BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN
发明人： PALUCKA ANNA KAROLINA , BANCHEREAU JACQUES F , CHAUSSABEL DAMIEN
IPC分类号： G06F19/00 , C12Q1/68 , G11C17/00
CPC分类号： G06F19/20 , C12Q1/6837 , C12Q1/6886 , C12Q2600/158 , G06F19/18
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of metastatic melanoma and/or immunosuppression using microarrays by calculating one or more expression vectors from the expression of one or more genes.
摘要翻译：本发明包括通过从一种或多种基因的表达计算一种或多种表达载体来使用微阵列进行早期检测和一致确定转移性黑素瘤和/或免疫抑制的组合物，系统和方法。

8. 发明申请

WO2013040212A3 UNIQUE TRANSCRIPTIONAL SIGNATURES IN THE BLOOD OF CLINICAL RESPONDERS 审中-公开
标题翻译：临床反应者血液中的独特的转录信号
公开(公告)号：WO2013040212A3
公开(公告)日：2013-10-31
申请号：PCT/US2012055168
申请日：2012-09-13
申请人： BAYLOR RES INST , PALUCKA ANNA KAROLINA , ROSELLO-URGELL JOSE , BANCHEREAU JACQUES F , FAY JOSEPH , CHAUSSABEL DAMIEN
发明人： PALUCKA ANNA KAROLINA , ROSELLO-URGELL JOSE , BANCHEREAU JACQUES F , FAY JOSEPH , CHAUSSABEL DAMIEN
IPC分类号： G01N33/574 , C12N15/11 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/178
摘要： A method for using the blood transcriptional profile of patients with stage IV melanoma to generate networks associated with the possibility of prolonged survival and networks associated with clinical responses to dendritic cell (DC) vaccination as measured by tumor regression are disclosed herein.
摘要翻译：本文公开了使用IV期黑素瘤患者的血液转录谱的方法，以生成与延长存活的可能性相关联的网络，以及通过肿瘤消退测量的与树突状细胞（DC）接种的临床反应相关的网络。

9. 发明申请

WO2008024642A8 GENE EXPRESSION SIGNATURES IN BLOOD LEUKOCYTES PERMIT DIFFERENTIAL DIAGNOSIS OF ACUTE INFECTIONS 审中-公开
标题翻译：白血病基因表达标志允许急性感染的差异性诊断
公开(公告)号：WO2008024642A8
公开(公告)日：2011-02-17
申请号：PCT/US2007075713
申请日：2007-08-10
申请人： BAYLOR RES INST , UNIV TEXAS , BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA , RAMILO OCTAVIO , CHAUSSABEL DAMIEN
发明人： BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA , RAMILO OCTAVIO , CHAUSSABEL DAMIEN
IPC分类号： C12Q1/68 , C12P19/34 , G01N33/48
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： The present invention includes compositions, systems and methods for the early detection and consistent determination of the extent, type and nature of a host immune response and the nature of the infectious disease using gene expression data.
摘要翻译：本发明包括使用基因表达数据早期检测和一致确定宿主免疫应答的程度，类型和性质以及感染性疾病的性质的组合物，系统和方法。

10. 发明申请

WO2008115750A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：用于治疗癌症的组合物和方法
公开(公告)号：WO2008115750A3
公开(公告)日：2008-11-06
申请号：PCT/US2008056726
申请日：2008-03-12
申请人： BAYLOR RES INST , PALUCKA ANNA KAROLINA , BANCHEREAU JACQUES F
发明人： PALUCKA ANNA KAROLINA , BANCHEREAU JACQUES F
IPC分类号： C07K16/24 , C12N5/06 , C12P21/06
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331
摘要： The present invention includes compositions and methods for the treatment, diagnosis and prognosis of cancers by detecting the level of IL- 13 expression in cancerous cells in the tissue microenvironment as an indicator of controlling the type of immune response mounted against the cancer.
摘要翻译：本发明包括通过检测组织微环境中癌细胞中IL-13表达水平作为控制针对癌症的免疫反应类型的指标来治疗，诊断和预后癌症的组合物和方法。

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