专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2013040212A3 UNIQUE TRANSCRIPTIONAL SIGNATURES IN THE BLOOD OF CLINICAL RESPONDERS 审中-公开
标题翻译：临床反应者血液中的独特的转录信号
公开(公告)号：WO2013040212A3
公开(公告)日：2013-10-31
申请号：PCT/US2012055168
申请日：2012-09-13
申请人： BAYLOR RES INST , PALUCKA ANNA KAROLINA , ROSELLO-URGELL JOSE , BANCHEREAU JACQUES F , FAY JOSEPH , CHAUSSABEL DAMIEN
发明人： PALUCKA ANNA KAROLINA , ROSELLO-URGELL JOSE , BANCHEREAU JACQUES F , FAY JOSEPH , CHAUSSABEL DAMIEN
IPC分类号： G01N33/574 , C12N15/11 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/178
摘要： A method for using the blood transcriptional profile of patients with stage IV melanoma to generate networks associated with the possibility of prolonged survival and networks associated with clinical responses to dendritic cell (DC) vaccination as measured by tumor regression are disclosed herein.
摘要翻译：本文公开了使用IV期黑素瘤患者的血液转录谱的方法，以生成与延长存活的可能性相关联的网络，以及通过肿瘤消退测量的与树突状细胞（DC）接种的临床反应相关的网络。

2. 发明申请

WO02072013A8 METHOD OF TREATING MALIGNANCIES THROUGH INDUCTION OF BLOOD IMMUNE RESPONSES 审中-公开
标题翻译：通过诱导血液免疫应答治疗恶性肿瘤的方法
公开(公告)号：WO02072013A8
公开(公告)日：2005-04-28
申请号：PCT/US0207232
申请日：2002-03-11
申请人： BAYLOR RES INST , BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA , FAY JOSEPH , STEINMAN RALPH , DHODAPKAR MADHAV , WITTKOWSKI KNUT M
发明人： BANCHEREAU JACQUES F , PALUCKA ANNA KAROLINA , FAY JOSEPH , STEINMAN RALPH , DHODAPKAR MADHAV , WITTKOWSKI KNUT M
IPC分类号： C12Q1/02 , A61K35/14 , A61K39/00 , A61K48/00 , A61P35/00 , C12N5/06 , C12P21/08 , G01N33/50 , A61K47/00
CPC分类号： G01N33/5011 , A61K39/0011 , A61K2039/5154 , A61K2039/5156 , G01N33/5047
摘要： A method of treating malignancies through induction of immune responses has been found. In one aspect, the present invention is a method for treating malignancy comprising administering an effective amount of a vaccine comprising antigen-presenting cells loaded with at least two or more agents selected from the group consisting of tumor antigens and tumor antigen derived peptides. In another embodiment, the vaccine comprises at least two or more agents selected from the group consisting of tumor antigens and tumor antigen derived peptides which target antigen-presenting cells in the patient. The vaccines can also further comprise antigen-presenting cells loaded with control antigens used to determine the patient's immune competence. The evaluation of vaccine-induced immune responses in blood provides a predictive factor for treatment efficacy.
摘要翻译：已经发现通过诱导免疫应答治疗恶性肿瘤的方法。一方面，本发明是一种治疗恶性肿瘤的方法，包括施用有效量的包含抗原呈递细胞的疫苗，所述抗原呈递细胞装载有选自肿瘤抗原和肿瘤抗原衍生肽中的至少两种以上的药剂。在另一个实施方案中，疫苗包含选自肿瘤抗原和靶向患者抗原呈递细胞的肿瘤抗原衍生肽的至少两种或更多种药剂。疫苗还可以包含负载用于确定患者的免疫能力的对照抗原的抗原呈递细胞。血液中疫苗诱导的免疫应答的评估为治疗效果提供了预测因素。

3. 发明申请

WO2002072013A3 METHOD OF TREATING MALIGNANCIES THROUGH INDUCTION OF BLOOD IMMUNE RESPONSES 审中-公开
公开(公告)号：WO2002072013A3
公开(公告)日：2002-09-19
申请号：PCT/US2002/007232
申请日：2002-03-11
申请人： BAYLOR RESEARCH INSTITUTE , BANCHEREAU, Jacques, F. , PALUCKA, Anna, Karolina , FAY, Joseph , STEINMAN, Ralph , DHODAPKAR, Madhav , WITTKOWSKI, Knut, M.
发明人： BANCHEREAU, Jacques, F. , PALUCKA, Anna, Karolina , FAY, Joseph , STEINMAN, Ralph , DHODAPKAR, Madhav , WITTKOWSKI, Knut, M.
IPC分类号： A61K39/00
摘要： A method of treating malignancies through induction of immune responses has been found. In one aspect, the present invention is a method for treating malignancy comprising administering an effective amount of a vaccine comprising antigen-presenting cells loaded with at least two or more agents selected from the group consisting of tumor antigens and tumor antigen derived peptides. In another embodiment, the vaccine comprises at least two or more agents selected from the group consisting of tumor antigens and tumor antigen derived peptides which target antigen-presenting cells in the patient. The vaccines can also further comprise antigen-presenting cells loaded with control antigens used to determine the patient's immune competence. The evaluation of vaccine-induced immune responses in blood provides a predictive factor for treatment efficacy.

4. 发明专利

GB9522783D0 Wide handle golf putter with variable-set handle 未知
公开(公告)号：GB9522783D0
公开(公告)日：1996-01-10
申请号：GB9522783
申请日：1995-11-07
申请人： FAY JOSEPH G

5. 发明专利

CA256475A CHANGE-SPEED APPARATUS 未知
公开(公告)号：CA256475A
公开(公告)日：1925-12-22
申请号：CA256475D
申请人： FAY JOSEPH G
发明人： FAY JOSEPH G

6. 发明申请

WO1997019986A1 SYNDIOTACTIC VINYLAROMATIC POLYMERS HAVING IMPROVED CRYSTALLIZATION KINETICS 审中-公开
标题翻译：具有改进的结晶动力学的聚氨基乙烯基聚合物
公开(公告)号：WO1997019986A1
公开(公告)日：1997-06-05
申请号：PCT/US1996018064
申请日：1996-11-14
申请人： THE DOW CHEMICAL COMPANY , MAECKER, Norbert, L. , FAY, Joseph, J.
发明人： THE DOW CHEMICAL COMPANY
IPC分类号： C08K05/5333
CPC分类号： C08K5/5333 , C08L25/02
摘要： A polymer composition comprising: (a) a highly syndiotactic vinyl aromatic polymer; and (b) from 0.1 to 5.0 percent, based on the polymer weight of a crystallization modifier selected from the group consisting of alkaline earth metal bis[monoethyl(3,5-di-t-butyl-4-hydroxybenzyl)phosphonate] salts has improved crystal formation properties.
摘要翻译：一种聚合物组合物，其包含：（a）高度间同立构的乙烯基芳族聚合物; 和（b）0.1至5.0％，基于选自碱土金属双[（乙基（3,5-二 - 叔丁基-4-羟基苄基）膦酸酯]盐的结晶改性剂的聚合物重量改善晶体形成性能。

7. 发明申请

WO2008151948A3 ANTIMICROBIAL POLYOLEFIN AND POLYESTER COMPOSITIONS 审中-公开
标题翻译：抗微生物聚烯烃和聚酯组合物
公开(公告)号：WO2008151948A3
公开(公告)日：2009-02-19
申请号：PCT/EP2008056694
申请日：2008-05-30
申请人： CIBA HOLDING INC , LEUKEL JOERG , RIEFFEL THI THOA , DEISENROTH TED , LIN I-CHYANG , FAY JOSEPH JAMES
发明人： LEUKEL JOERG , RIEFFEL THI THOA , DEISENROTH TED , LIN I-CHYANG , FAY JOSEPH JAMES
IPC分类号： C08K13/02 , A01N25/10 , A01N25/30 , A01N55/02 , C08K3/00 , C08K5/00 , C08K5/098 , C08K5/42 , C08L23/00 , C08L23/04 , C08L23/10 , C08L67/00 , C08L67/03
CPC分类号： C08K5/06 , A01N59/16 , C08K3/005 , C08K3/015 , C08K5/0058 , A01N25/10 , A01N25/30 , A01N2300/00
摘要： Disclosed are polyolefin or polyester fibers, films and molded parts that have excellent durable antimicrobial activity. The polyolefins and polyesters have incorporated therein one or more silver antimicrobial additives and one or more wettability additives. The silver antimicrobials are for example silver supported on a zeolite, silver supported on a glass, elemental silver, micro or nano scaled elemental silver, elemental silver dispersed in silocone oil, silver chloride, silver nitrate, silver sulfate, silver phosphate, silver zirconate or silver apatite. The wettability additives are for instance ethoxylated alcohols CH3CH2(CH2CH2)aCH2CH2(OCH 2CH 2) bOH where a is 6 to 25 and b is 1 to 100 or are alkyl metal sulfonates of formula RSO 3M, where M is Na, K or Li and R is straight or branched chain alkyl of 6 to 32 carbon atoms or is straight or branched chain alkenyl of 6 to 32 carbon atoms. The present compositions retain antimicrobial activity after repeated insults.
摘要翻译：公开了具有优异耐久抗菌活性的聚烯烃或聚酯纤维，薄膜和模制件。聚烯烃和聚酯在其中掺入了一种或多种银抗微生物添加剂和一种或多种润湿性添加剂。银抗微生物剂例如为负载在沸石上的银，负载在玻璃上的银，元素银，微米或纳米级元素银，分散在矽卡醇油中的元素银，氯化银，硝酸银，硫酸银，磷酸银，锆酸银或银磷灰石润湿性添加剂例如是乙氧基化醇CH 3 CH 2（CH 2 CH 2）a CH 2 CH 2（OCH 2 CH 2）bOH，其中a为6至25，b为1至100，或为式RSO 3M的烷基金属磺酸盐，其中M为Na，K或Li， R是6〜32个碳原子的直链或支链烷基，或者是6〜32个碳原子的直链或支链链烯基。本发明的组合物在反复侮辱后保持抗微生物活性。

8. 发明申请

WO2002072013A2 METHOD OF TREATING MALIGNANCIES THROUGH INDUCTION OF BLOOD IMMUNE RESPONSES 审中-公开
标题翻译：通过诱导血液免疫应答治疗恶性肿瘤的方法
公开(公告)号：WO2002072013A2
公开(公告)日：2002-09-19
申请号：PCT/US2002/007232
申请日：2002-03-11
申请人： BAYLOR RESEARCH INSTITUTE , BANCHEREAU, Jacques, F. , PALUCKA, Anna, Karolina , FAY, Joseph , STEINMAN, Ralph , DHODAPKAR, Madhav , WITTKOWSKI, Knut, M.
发明人： BANCHEREAU, Jacques, F. , PALUCKA, Anna, Karolina , FAY, Joseph , STEINMAN, Ralph , DHODAPKAR, Madhav , WITTKOWSKI, Knut, M.
IPC分类号： A61K
CPC分类号： G01N33/5011 , A61K39/0011 , A61K2039/5154 , A61K2039/5156 , G01N33/5047
摘要： A method of treating malignancies through induction of immune responses has been found. In one aspect, the present invention is a method for treating malignancy comprising administering an effective amount of a vaccine comprising antigen-presenting cells loaded with at least two or more agents selected from the group consisting of tumor antigens and tumor antigen derived peptides. In another embodiment, the vaccine comprises at least two or more agents selected from the group consisting of tumor antigens and tumor antigen derived peptides which target antigen-presenting cells in the patient. The vaccines can also further comprise antigen-presenting cells loaded with control antigens used to determine the patient's immune competence. The evaluation of vaccine-induced immune responses in blood provides a predictive factor for treatment efficacy.
摘要翻译：已经发现通过诱导免疫应答治疗恶性肿瘤的方法。一方面，本发明是一种治疗恶性肿瘤的方法，包括施用有效量的包含抗原呈递细胞的疫苗，所述抗原呈递细胞装载有选自肿瘤抗原和肿瘤抗原衍生肽中的至少两种以上的药剂。在另一个实施方案中，疫苗包含选自肿瘤抗原和靶向患者抗原呈递细胞的肿瘤抗原衍生肽的至少两种或更多种药剂。疫苗还可以包含负载用于确定患者的免疫能力的对照抗原的抗原呈递细胞。血液中疫苗诱导的免疫应答的评估为治疗效果提供了预测因素。

9. 发明申请

WO2013040212A2 UNIQUE TRANSCRIPTIONAL SIGNATURES IN THE BLOOD OF CLINICAL RESPONDERS 审中-公开
标题翻译：在临床应答者血液中的唯一转录签名
公开(公告)号：WO2013040212A2
公开(公告)日：2013-03-21
申请号：PCT/US2012/055168
申请日：2012-09-13
申请人： BAYLOR RESEARCH INSTITUTE , PALUCKA, Anna, Karolina , ROSELLO-URGELL, Jose , BANCHEREAU, Jacques, F. , FAY, Joseph , CHAUSSABEL, Damien
发明人： PALUCKA, Anna, Karolina , ROSELLO-URGELL, Jose , BANCHEREAU, Jacques, F. , FAY, Joseph , CHAUSSABEL, Damien
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/178
摘要： A method for using the blood transcriptional profile of patients with stage IV melanoma to generate networks associated with the possibility of prolonged survival and networks associated with clinical responses to dendritic cell (DC) vaccination as measured by tumor regression are disclosed herein.
摘要翻译：利用IV期黑素瘤患者的血液转录特征来生成与长期存活的可能性相关的网络和通过肿瘤消退测量的与对树突细胞（DC）疫苗接种的临床反应有关的网络的方法在此公开。

10. 发明申请

WO2008151948A2 ANTIMICROBIAL POLYOLEFIN AND POLYESTER COMPOSITIONS 审中-公开
标题翻译：抗微生物聚烯烃和聚酯组合物
公开(公告)号：WO2008151948A2
公开(公告)日：2008-12-18
申请号：PCT/EP2008/056694
申请日：2008-05-30
申请人： CIBA HOLDING INC. , LEUKEL, Joerg , RIEFFEL, Thi Thoa , DEISENROTH, Ted , LIN, I-Chyang , FAY, Joseph James
发明人： LEUKEL, Joerg , RIEFFEL, Thi Thoa , DEISENROTH, Ted , LIN, I-Chyang , FAY, Joseph James
IPC分类号： C08K13/02 , A01N25/10 , A01N25/30 , A01N55/02
CPC分类号： C08K5/06 , A01N59/16 , C08K3/015 , C08K5/0058 , A01N25/10 , A01N25/30 , A01N2300/00
摘要： Disclosed are polyolefin or polyester fibers, films and molded parts that have excellent durable antimicrobial activity. The polyolefins and polyesters have incorporated therein one or more silver antimicrobial additives and one or more wettability additives. The silver antimicrobials are for example silver supported on a zeolite, silver supported on a glass, elemental silver, micro or nano scaled elemental silver, elemental silver dispersed in silocone oil, silver chloride, silver nitrate, silver sulfate, silver phosphate, silver zirconate or silver apatite. The wettability additives are for instance ethoxylated alcohols CH 3 CH 2 (CH 2 CH 2 ) a CH 2 CH 2 (OCH 2 CH 2 ) b OH where a is 6 to 25 and b is 1 to 100 or are alkyl metal sulfonates of formula RSO 3 M, where M is Na, K or Li and R is straight or branched chain alkyl of 6 to 32 carbon atoms or is straight or branched chain alkenyl of 6 to 32 carbon atoms. The present compositions retain antimicrobial activity after repeated insults.
摘要翻译：公开了具有优异耐久抗菌活性的聚烯烃或聚酯纤维，薄膜和模制件。聚烯烃和聚酯在其中掺入了一种或多种银抗微生物添加剂和一种或多种润湿性添加剂。银抗微生物剂例如为负载在沸石上的银，负载在玻璃上的银，元素银，微米或纳米级元素银，分散在矽卡醇油中的元素银，氯化银，硝酸银，硫酸银，磷酸银，锆酸银或银磷灰石润湿性添加剂例如是乙氧基化醇CH 3 CH 2（CH 2 CH 2）a CH 2 CH 2（OCH 2 CH 2）bOH，其中a为6至25，b为1至100，或为式RSO 3M的烷基金属磺酸盐，其中M为Na，K或Li， R是6〜32个碳原子的直链或支链烷基，或者是6〜32个碳原子的直链或支链链烯基。本发明的组合物在反复侮辱后保持抗微生物活性。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式