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1. 发明申请

WO2011044541A3 IDENTIFICATION OF MICRORNAS (MIRNAS) IN FECAL SAMPLES AS BIOMARKERS FOR GASTROENTEROLOGICAL CANCERS 审中-公开
标题翻译：识别作为胃肠癌生物标记的FECAL样品中的微阵列（MIRNAS）
公开(公告)号：WO2011044541A3
公开(公告)日：2011-07-28
申请号：PCT/US2010052112
申请日：2010-10-08
申请人： BAYLOR RES INST , GOEL AJAY , BOLAND C RICHARD , LINK ALEXANDER , BALAGUER FRANCESC
发明人： GOEL AJAY , BOLAND C RICHARD , LINK ALEXANDER , BALAGUER FRANCESC
IPC分类号： C12Q1/68 , C12N15/10 , C12N15/11
CPC分类号： C12P19/34 , C12Q1/6806 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178 , C12Q2527/137
摘要： A simple, rapid, inexpensive, and promising commercial biomarker assay method for multiple diseases is described herein. The present invention detects miRNA-based biomarkers in human stool specimens. The method of the present invention amplifies miRNA directly from stool specimens without any prior miRNA extraction. Differential expression of specific microRNAs in stool of colorectal cancer CRC and adenoma patients suggest fecal microRNAs as a novel potential biomarker for colorectal neoplasia detection. The method of the present invention has diagnostic, prognostic, and therapeutic relevance for gastroenterological cancers/colorectal cancer and as well as further acquired or hereditary GI diseases.
摘要翻译：本文描述了用于多种疾病的简单，快速，便宜且有希望的商业生物标志物测定方法。本发明在人粪便标本中检测基于miRNA的生物标志物。本发明的方法从没有任何先前的miRNA提取的粪便标本中直接扩增miRNA。结直肠癌粪便中特异性微小RNA的差异表达CRC和腺瘤患者建议粪便微小RNA作为结肠直肠肿瘤检测的新型潜在生物标志物。本发明的方法具有对胃肠癌/结肠直肠癌以及进一步获得或遗传性GI疾病的诊断，预后和治疗相关性。

2. 发明公开

EP3108012A4 MIR-320E AND COLORECTAL CANCER 审中-公开
公开(公告)号：EP3108012A4
公开(公告)日：2017-10-11
申请号：EP15752265
申请日：2015-02-18
申请人： BAYLOR RES INST
发明人： GOEL AJAY , PEREZ-CARBONELL LUCIA , BOLAND C RICHARD
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61K31/513 , C12N15/113 , C12N2310/14 , C12N2320/30 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178 , G06F19/322 , G06F19/3406 , G16H10/60 , G16H40/63 , Y02A90/22 , Y02A90/26
摘要： Embodiments provide methods and compositions related to determining treatments for colorectal cancer patients by detection and analysis of the expression level of miRNA such as miR-320e in the patients. Embodiments provide predictive, prognostic and/or diagnostics methods by identifying miRNAs that are useful for clinical management of cancer patients, particularly colorectal cancer patients or patients at risk or determined to have colorectal cancer. Methods and compositions are based, in part, on the discovery that expression of certain miRNAs in cancer patients is associated with advancing cancer stages and/or can predict the responsiveness of cancer therapy, and can, therefore, provide basis for designing treatment strategies. In particular embodiments, the miRNA molecule is miR-320, particularly miR-320e.

3. 发明公开

EP2686448A4 CHANGES IN THE EXPRESSION OF MIR-200C/141 CLUSTER OF MICRORNAS AS BIOMARKERS FOR EPITHELIAL-TO-MESENCHYMAL TRANSITION IN HUMAN COLORECTAL CANCER METASTASIS 审中-公开
标题翻译：变动情况的表达ME-200℃/在转移中人类结肠直肠癌的微小RNA作为生物标志物上皮间质转化141簇
公开(公告)号：EP2686448A4
公开(公告)日：2015-08-05
申请号：EP12760610
申请日：2012-02-29
申请人： BAYLOR RES INST
发明人： GOEL AJAY , BOLAND C RICHARD , HUR KEUN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178

4. 发明公开

EP2794924A4 IDENTIFICATION OF METASTASIS-SPECIFIC MIRNA AND HYPOMETHYLATION SIGNATURES IN HUMAN COLORECTAL CANCER 失效转让
标题翻译： IDENTIFIZIERUNG VON METASTASENSPEZIFISCHER MIRNA UND HYPOMETHYLIERUNGSSIGNATUREN BEI MENSCHLICHEM KOLOREKTALKARZINOM
公开(公告)号：EP2794924A4
公开(公告)日：2015-12-23
申请号：EP12859326
申请日：2012-12-21
申请人： BAYLOR RES INST
发明人： GOEL AJAY , BOLAND RICHARD C , HUR KEUN
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2525/207 , C12Q2600/154 , C12Q2600/178
摘要： The present invention includes methods and biomarkers for diagnosing or detecting colorectal cancer metastasis in a human subject by comparing the Alu repeat methylation level in the biological sample to an Alu repeat methylation control level from a normal non-cancerous sample from the human subject, wherein a decrease in the Alu repeat methylation level is indicative of colorectal cancer and colorectal cancer metastasis. The invention also includes methods and biomarkers for diagnosing or detecting colorectal cancer (CRC) metastasis in a human subject by determining a level of expression of let-7i, miR-10b, miR-320a, and miR-221 in the sample from the one or more biological samples; and comparing the level of expression of let-7i, miR-10b, miR-320a, and miR-221 in the sample with the level of expression of let-7i, miR-10b, miR-320a, and miR-221 from normal colorectal tissue, wherein high expression of at least on of let-7i or miR-320a is indicative of a good prognosis for the CRC, while the low expression of at least one of miR-10b or miR-221 is indicative of a good prognosis for the CRC or CRC metastasis.
摘要翻译：本发明包括通过将生物样品中的Alu重复甲基化水平与来自人类受试者的正常非癌性样品的Alu重复甲基化对照水平进行比较来诊断或检测人类受试者的结肠直肠癌转移的方法和生物标志物，其中a Alu重复甲基化水平的降低指示结肠直肠癌和结肠直肠癌转移。本发明还包括用于通过测定样品中let-7i，miR-10b，miR-320a和miR-221的表达水平来诊断或检测人受试者中的结肠直肠癌（CRC）转移的方法和生物标志物或更多的生物样品; 并将样品中let-7i，miR-10b，miR-320a和miR-221的表达水平与let-7i，miR-10b，miR-320a和miR-221的表达水平与正常结肠直肠组织，其中至少对let-7i或miR-320a的高表达指示CRC的良好预后，而miR-10b或miR-221中的至少一种的低表达指示良好的预后用于CRC或CRC转移。

5. 发明申请

WO2016149445A8 METHODS AND COMPOSITIONS INVOLVING TRANSMEMBRANE AND COILED-COIL DOMAINS 3 (TMCO3) IN CANCER 审中-公开
标题翻译：涉及跨膜和卷曲螺旋结构域3（TMCO 3）在癌症中的方法和组合物
公开(公告)号：WO2016149445A8
公开(公告)日：2017-04-27
申请号：PCT/US2016022757
申请日：2016-03-17
申请人： BAYLOR RES INST
发明人： GOEL AJAY , SHIGEYASU KUNITOSHI
IPC分类号： A61K31/495 , A61K31/4965 , A61K31/7105 , A61K39/395 , A61P35/00 , C12Q1/68
CPC分类号： A61K31/713 , A61K31/4745 , A61K31/513 , A61K31/519 , A61K31/555 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/57419 , G01N2800/56
摘要： Certain embodiments provide methods and compositions related to clinical management of cancer patients based on the expression level of TMCO3. Further embodiments involve methods and compositions related to treatment of cancer patients or patients determined to have an increased TMCO3 level relative to a control or a reference level that is normal or indicating favorable prognosis.
摘要翻译：基于TMCO 3的表达水平，某些实施方案提供了与癌症患者的临床管理有关的方法和组合物。进一步的实施方案涉及与治疗癌症患者或患者相关的方法和组合物，所述方法和组合物被确定为具有相对于正常或指示有利预后的对照或参照水平增加的TMCO 3水平。

6. 发明公开

EP2686451A4 LINE-1 HYPOMETHYLATION AS A BIOMARKER FOR EARLY-ONSET COLORECTAL CANCER 审中-公开
标题翻译： LINE-1甲基化作为生物标志物早发大肠癌
公开(公告)号：EP2686451A4
公开(公告)日：2014-12-24
申请号：EP12761423
申请日：2012-03-13
申请人： BAYLOR RES INST
发明人： GOEL AJAY , BOLAND C RICHARD , BALAGUER FRANCESC
IPC分类号： C12Q1/68 , G01N33/48
CPC分类号： C12Q1/6886 , C12Q2600/154

7. 发明公开

EP2686452A4 LONG INTERSPERSED NUCLEAR ELEMENTS (LINE-1) AND ALU HYPOMETHYLATION AS BIOMARKERS FOR COLORECTAL CANCER METASTASIS 审中-公开
标题翻译：在铝HYPO甲基LINE-1 DNA序列的生物标记物KOLOREKTALKREBSMETASTASEN
公开(公告)号：EP2686452A4
公开(公告)日：2014-12-17
申请号：EP12761497
申请日：2012-02-29
申请人： BAYLOR RES INST
发明人： GOEL AJAY , BOLAND C RICHARD , HUR KEUN
IPC分类号： C12Q1/68 , G01N33/50
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/154

8. 发明公开

EP2971149A4 ULCERATIVE COLITIS (UC)-ASSOCIATED COLORECTAL NEOPLASIA MARKERS 有权转让
标题翻译：标志物与溃疡性结肠炎（UC）相关的大肠腺瘤病
公开(公告)号：EP2971149A4
公开(公告)日：2016-11-23
申请号：EP14768369
申请日：2014-03-13
申请人： BAYLOR RES INST
发明人： GOEL AJAY , TOIYAMA YUJI , BOLAND C RICHARD , OKUGAWA YOSHINAGA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , A61B1/31 , A61B10/0038 , A61B10/0051 , A61B10/007 , A61B10/04 , C12Q2600/154
摘要： Embodiments provide methods and compositions related to detecting neoplasia in ulcerative colitis patients by detection and analysis of the methylation state of miR-1, -9, -124, miR-137 and/or miR-34b/c in samples from UC patients.

9. 发明公开

EP2971132A4 TISSUE AND BLOOD-BASED MIRNA BIOMARKERS FOR THE DIAGNOSIS, PROGNOSIS AND METASTASIS-PREDICTIVE POTENTIAL IN COLORECTAL CANCER 有权转让
标题翻译：用于诊断，预测和预测彩色直肠癌转移灶潜能的织物和基于血液的MIRNA生物标记物
公开(公告)号：EP2971132A4
公开(公告)日：2016-10-19
申请号：EP14764952
申请日：2014-03-17
申请人： BAYLOR RES INST
发明人： GOEL AJAY , HUR KEUN , TOIYAMA YUJI , BOLAND RICHARD C
IPC分类号： C12Q1/68 , C12P19/34 , C40B40/06
CPC分类号： C12Q1/6886 , A61B1/31 , C12Q2600/178
摘要： Methods and compositions for the diagnosis, prognosis and classification of cancer, especially colorectal cancer, are provided. For example, in certain aspects methods for cancer prognosis using expression or methylation analysis of selected biomarkers are described. Particular aspects of the present invention may include methods and biomarkers for diagnosing or detecting colorectal cancer or metastasis in a subject by measuring a level of expression of biomarker miRNA such as miR-885-5p in the sample from the subject and evaluating the risk of developing cancer or metastasis in the subject.

10. 发明公开

EP2625293A4 MICRORNAS (MIRNA) AS BIOMAKERS FOR THE IDENTIFICATION OF FAMILIAL AND NON-FAMILIAL COLORECTAL CANCER 审中-公开
标题翻译：微小RNA（自然资源部）作为生物标志物用于识别家庭与条件不熟悉有条件结直肠癌
公开(公告)号：EP2625293A4
公开(公告)日：2014-03-19
申请号：EP11831689
申请日：2011-10-07
申请人： BAYLOR RES INST , HOSPITAL CLINIC BARCELONA , CT DE INVESTIGACION EN RED DE ENFERMEDADES HEPATICAS Y DIGESTIVAS
发明人： GOEL AJAY , BOLAND RICHARD C , BALAGUER FRANCESC , GIRONELLA I COS MERITXELL , CASTELLS I GARANGOU ANTONI , MOREIRA RUIZ LETICIA , LOZANO SALVATELLA JUAN JOSE
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/178

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