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    • 6. 发明申请
    • SPIRO[INDOLIN-3,4'-PIPERIDINE] DERIVATIVES AS GNRH RECEPTOR ANTAGONISTS
    • 作为GNRH受体拮抗剂的SPIRO [吲哚-3,4'-哌啶]衍生物
    • WO2015091315A1
    • 2015-06-25
    • PCT/EP2014/077680
    • 2014-12-15
    • BAYER PHARMA AKTIENGESELLSCHAFT
    • PANKNIN, OlafBÄURLE, StefanRING, SvenSCHWEDE, WolfgangSCHMEES, NorbertNOWAK-REPPEL, KatrinLANGER, Gernot
    • C07D471/10A61K31/438A61P15/00A61P5/24
    • C07D471/10
    • Spiroindoline-piperidine derivatives of formula (I) as gonadotropin- releasing hormone (GnRH) receptor antagonists, process for their preparation and pharmaceutical compositions thereof, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selcted from the group of endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reproductive therapy such as in vitro fertilization). The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (GnRH) receptor antagonists.
    • 式(I)的螺二氢吲哚 - 哌啶衍生物作为促性腺激素释放激素(GnRH)受体拮抗剂,其制备方法及其药物组合物,其用于治疗和/或预防疾病的用途及其用于制备药物的用途 治疗和/或预防男性和女性中特别是性激素相关疾病的治疗和/或预防,特别是从子宫内膜异位症,子宫肌瘤,多囊卵巢疾病,多毛症,早熟性青春期,性腺类固醇依赖性肿瘤等中筛选出的疾病,特别是性激素相关疾病 作为前列腺,乳腺和卵巢的癌症,促性腺垂体腺瘤,睡眠呼吸暂停,肠易激综合征,经前期综合征,良性前列腺肥大,避孕和不孕症(例如,辅助生殖治疗如体外受精)。 本申请特别涉及作为促性腺激素释放激素(GnRH)受体拮抗剂的螺二氢吲哚衍生物。