专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明专利

DE19730847A1 未知
公开(公告)号：DE19730847A1
公开(公告)日：1999-01-28
申请号：DE19730847
申请日：1997-07-18
申请人： BAYER AG
发明人： BARTEL STEPHAN DR , GUARNIERI WALTER DR , RIEDL BERND DR , HAEBICH DIETER DR , STOLLE ANDREAS DR , RUPPELT MARTIN DR , RADDATZ SIEGFRIED DR , ROSENTRETER ULRICH DR , WILD HANNO DR , ENDERMANN RAINER DR , KROLL HEIN-PETER DR
IPC分类号： C07D263/20 , C07D263/24 , C07D413/04 , C07D413/10 , C07D491/04 , C07D491/048 , C07D263/06 , A61K31/42 , C07D471/06 , C07D495/06
摘要： The invention relates to tricyclically substituted oxazolidinones of general formula (I), wherein R represents azido, hydroxy or a group of formula -OR , O-SO2RO , -(CO)aNR R , D-R or -CO-R and A represents a radical of formula (a), (b), (c), (d), (e), or (f) wherein E represents an oxygen or a sulphur atom, or the CO-, CH2-, SO- or SO2 group, or a group of formula -NR , C=NR or -C=N-NR R . The invention also relates to a method for producing the tricyclically substituted oxazolidinones, and to their use as medicaments, especially as antibacterial medicaments.

5. 发明专利

CZ253396A3 HETEROCYCLICALLY SUBSTITUTED PRESUDOPEPTIDES, PROCESS OF THEIR PREPARATION AND MEDICAMENTS CONTAINING THEREOF 未知
公开(公告)号：CZ253396A3
公开(公告)日：1997-03-12
申请号：CZ253396
申请日：1996-08-28
申请人： BAYER AG
发明人： RADDATZ SIEGFRIED DR , WILD HANNO DR , HANSEN JUTTA DR
IPC分类号： A61K31/34 , A61K31/40 , A61P31/12 , C07D405/12 , C07D409/12
摘要： Heterocyclic pseudo-peptides of formula (I) are new where R = a gp. of formula (a) or (b) R , R = a gp. of formula (c), (d) or (e) and R = H or 1-20C acyl opt. substd. with carboxy or 1-6C alkoxycarbonyl.

6. 发明专利

DE19544106A1 未知
公开(公告)号：DE19544106A1
公开(公告)日：1996-10-24
申请号：DE19544106
申请日：1995-11-27
申请人： BAYER AG
发明人： STOLLE ANDREAS DR , HAEBICH DIETER DR , BARTEL STEPHAN DR , RIEDL BERND DR , RUPPELT MARTIN DR , WILD HANNO DR , ENDERMANN RAINER DR , BREMM KLAUS-DIETER DR , KROLL HEIN-PETER DR , LABISCHINSKI HARALD PROF , SCHALLER KLAUS DR , WERLING HANS-OTTO DR
IPC分类号： A61K31/425 , C07D263/58 , C07D413/04 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/14 , C07D419/04 , C07F9/6558 , C07F9/6584 , C07D291/08 , C07F9/6581 , C07F9/6564 , C07F9/6539 , A61K31/42
摘要： A compound of formula (I) and its interchangeable isomeric form, isomer and salts thereof: wherein R1 represents triazo, hydroxyl, or formula-OR2, O-SO2R3 or -NR4R5 groups, in which R2 represents straight or branched acyl having no more than 8 carbon atoms, or hydroxyl protected groups, R3 represents straight or branched alkyl having no more than 4 carbon atoms, or phenyl substitutable by straight or branched alkyl having no more than 4 carbon atoms, R4 and R5 are the same or different from each other and represent cycloalkyl having 3-6 carbon atoms, hydrogen, phenyl, straight or branched alkyl having no more than 8 carbon atoms or alkoxy or amino protected group, or R4 or R5 represents -CO-R6, P(O)(OR7)(OR8) or -SO2-R9 group, in which R6 represents cycloalkyl having 3-6 carbon atoms or halogen-substituted cycloalkyl; trifluoromethyl, straight or branched alkoxy having no more than 8 carbon atoms, phenyl, benzyloxy or hydrogen, or R6 represents straight or branched alkyl or alkenyl having no more than 8 carbon atoms, randomly substituted by cyano, halogen or trifluoromethyl, or represents under each condition thioalkyl or acyl having no more than 6 carbon atoms, or -NR10R11 group, in which R10 and R11 are the same or different and represent hydrogen, phenyl or straight or branched alkyl having no more than 6 carbon atoms, or R6 represents 5-member aryl heteroring having no more than 3 heteroatoms selected from S, N and/or O, randomly substituted by straight or branched alkyl having no more than 3 carbon atoms; R7 and R8 are the same or different and represent hydrogen or straight or branched alkyl having no more than 4 carbon atoms; R9 represents straight or branched alkyl or phenyl having no more than 4 carbon atoms. A represents the following group: in which G, L, and M are the same or different, and represent hydrogen, halogen, cyano, trifluoromethyl, straight or branched alkyl having no more than 6 atoms, or -CO-NR17R18 group, in which R17 and R18 are the same or different and represent hydrogen, straight or branched alkyl having no more than 4 carbon atoms, or phenyl, R12 represents hydrogen, cycloalkylcarbonyl or cycloalkyl having 3-6 carbon atoms or straight or branched oxo-carbonyl having no more than 6 carbon atoms, or straight or branched alkyl or alkenyl having no more than 10 carbon atoms, which can be randomly substituted by the following groups: cyano, azido, trifluoromethyl, pyridyl, halogen, hydroxyl, carboxyl, straight or branched carbonyl having no more than 6 atoms, benzyloxycarbonyl, aryl having no more than 6-10 carbon atoms, cycloalkyl having 3-6 carbon atoms and/or group R25-S(O)d, in which d denotes number 0 or 2, R25 represents straight or branched alkyl having no more than 4 carbon atoms, benzyl, phenyl or methylphenyl, or R12 represents the following groups, or represents -COOCl3 or straight or branched acyl having no more than 6 carbon atoms and randomly substituted by the following groups: trifluoromethyl, trichloromethyl or -OR26 group, in which R26 represents hydrogen or straight or branched alkyl having no more than 6 carbon atoms which can be randomly substituted by aryl having no more than 10 carbon atoms or R12 represents groups of formula -(CO)c-NR27R28, -NR29-SO2R30, R31R32-N-SO2- or R33-S(O)f, in which is number 0 or 1, R27, R28 and R29 are defined the same as R17 and R18 above and can be the same or different, or form together with nitrogen atom 5-6 member saturated hetero ring containing other heteroatoms randomly selected from N, S and/or O, and can be randomly substituted by straight or branched alkyl or acyl having no more than 3 carbon atoms, which even substitutes other nitrogen atom, R31 and R32 are defined the same as R17 and R18 and can be the same or different, R30 and R33 under all circumstances are defined the same as R25 above and can be the same or different, D represents O or S, E represents O or S or -NH, T represents O or -NH, R13 and R 14 are defined the same as R12 above and can be the same or different, or T represents S, in the proviso: R13 and R14 are defined the same as R12 above, but do not represent hydrogen, or under the condition where R12, R13 and R14 do not represent hydrogen, E and/or T represent -NR34, in which R34 is defined the same as R12 above except for hydrogen and can be the same or different, or R34 represents cyano or -CO2R35, in which R35 represents benzyl or phenyl and is randomly substitutable by nitro or halogen, and W are defined the same as D above or represents N-R14 above and can the same or different, a denotes number 1 or 2, b denotes number 0 or 1, R15 and R16 are defined the same as R12 above and the same as or different from R12.

8. 发明专利

CZ198895A3 BENZOXAZOLYLOXAZOLIDINONES AND BENZOTHIAZOLYLOXAZOLIDINONES, PROCESS OF THEIR PREPARATION AND USE FOR PREPARING MEDICAMENTS 未知
公开(公告)号：CZ198895A3
公开(公告)日：1996-02-14
申请号：CZ198895
申请日：1995-08-02
申请人： BAYER AG
发明人： HABICH DIETER DR , RIEDL BERND DR , RUPPELT MARTIN DR , STOLLE ANDERAS DR , WILD HANNO DR , ENDERMANN RAINER DR , BREMM KLAUS DIETER DR , KROLL HEIN PETER DR , LABISCHINSKI HARALD PROF DR , SCHALLER KLAUS DR , WERLING HANS OTTO DR
IPC分类号： C07D491/113 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/5377 , A61K31/55 , A61P31/04 , C07D247/02 , C07D263/38 , C07D263/56 , C07D263/58 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D419/12 , C07D491/10
摘要： Benzoxazolyl and benzothiazolyloxazolidinone derivs. of formula (I) and their salts are new. A = O or S(O)a; a = 0-2; R = azido or OSO2R or NR R ; R = H, formyl, carboxy, opt. branched ≤ 6C alkoxy-carbonyl; or is alkenyl or alkenyl of ≤ 8C (which are opt. substd. by OH, halo, or by alkoxy, acyl, alkylthio or alkoxycarbonyl each of ≤ 6C or phenyl which in turn may be substd by halo), 6-10C aryl (opt. substd. with carboxy, halogen, CN, formyl, CF3, NO2, 1-6C alkoxy, 1-6C alkoxycarbonyl, 1-6C alkylthio, 1-6C acyl or 1-6C alkyl), or is NR R , OR , S(O)cR , morpholino or a gp. of formula (a)-(h). R = 1-4C alkyl or Ph (opt. substd. with 1-4C alkyl); R and R = each 3-6C cycloalkyl, H, Ph, 1-8C alkyl or an amino protecting gp; or R or R = COR ; R = 3-6C cycloalkyl, 1-8C alkyl, 1-8C alkoxy, Ph or H; G, L and M = each H, COOH, halogen, CN, formyl, CF3, NO2, 1-6C alkoxy, 1-6C alkoxy-carbonyl, 1-6C alkylthio, 1-6C acyl, 1-6C alkyl (this last opt. substd. with OH , 1-5C alkoxy, 1-5C acyl or NR R ), NR 'R ', 2-8C alkyl phenyl, Ph or a 5-6 membered opt. satd. heterocycle contg. up to 3 heteroatoms chosen from S, N and/or O and opt. itself substd. with CONR R , NR R , NR SO2R , R R N-SO2 or R S(O)b; and/or G, L and M are opt. mono- or di- substd. with carboxy, halogen, CN, formly, CF3, NO2 Ph 1-6C alkoxy, 1-6C alkoxycarbonyl, 1-6C alkylthio, 1-6C acyl, 1-6C alkyl (this last itself opt. substd. with OH, 1-5C alkoxy, 1-5C acyl or NR R ); R and R = each H, 1-4C alkyl or Ph or together with the N to which they are attached form a 5-6 membered satd. heterocycle contg. a further heteroatom chosen from N, S and/or O and opt. substd. on one of the further N with 1-3C alkyl or acyl and/or R and R = NR 'R ', R ' and R ' = as defined for R and R . b = 0-2; R , R , R , R and R = each H, 1-6C alkyl or Ph; R , R 2, R and R = each as defined for R and R ; R and R = each as defined for R ; R = 3-6C cycloalkyl, Ph, 1-6C acyl, 1-8C alkyl (opt. substd. with OH, alkoxy or OH-substd. 1-6C alkoxy, a 5-6 membered aromatic heterocycle contg up to 3 heteroatoms chosen from S, N and/or O or with Ph (itself opt. substd. with OH, CF3, halogen, NO2 or 1-4C alkyl) or alkyl opt. substd. with NR R or a gp. of formula (i)) R = a gp of formula (j) R = OH, 1-4C alkoxy or NR R R and R = each H, 1-5C alkyl, 3-6C cycloalkyl or Ph; R = H 1-7C alkyl (opt. substd. with indolyl, OH, SH, imidazolyl, methylthio, amino, Ph, OH-substd. Ph, CONH2 CO2H or C(NH2)=NH; d = 0-6; T = O, CH2 or NR ; R = H, Ph, 1-6C alkyl (opt. substd. with OH); R = as defined for R or H; R = 1-8C alkyl (opt. substd. with 1-6C alkoxy or OH- or 1-6C alkoxy-substd. 1-6C alkoxy, 3-6C cycloalkyl or a 6-membered aromatic, opt. benzo condensed heterocycle contg. up to 4 N whichis itself opt. mono- or di-substd. with NO2, CF3, halogen, CN, OH, 1-5C alkyl, 1-5C alkoxy or 1-5C acyl; R = a gp of formula (l), Ph or pyridyl; e = as defined for (d) W = as defined for T; C = 0-2; R = 1-16C alkyl or alkenyl (opt. substd. with 1-6C alkoxycarbonyl, Ph or a 5-7 membered aromatic heterocycle contg 1-3 heteroatoms chosen from S, N and O) or 6-10C aryl or 1 5-7 membered aromatic heterocycle contg 1-3 heteroatoms chosen from S, N and O (these cycles being opt. mono or di-substd. with carboxy, halogen, CN, formyl, CF3, NO2, 1-6C alkoxy, 1-6C alkoxy-carbonyl, 1-6C alkylthio, 1-6C acyl or 1-6C alkyl); R and R = as defined for R and R ; R and R together form O or R and R = each H, OH or 1-6C alkyl / opt. substd. with NR R ; f = 0-1; g = 0-6; R = 6-10C acyl or a 5-6 membered aromatic opt. benzo-condensed heterocycle contg. up to 3 heteroatoms chosen from S, N and O (all ring system being opt. mono-, di- or tri-substd. with NO2, CN, OH, Ph, halogen, CF3, 1-5C alkyl, 1-5C alkoxy or 1-5C acetyl (sic)) or morpholino, OH, 1-6C alkoxy, NR R , COR or a gp. of formula (l); R and R = each as defined for R and R ; R = morpholino, OH or 1-6C alkoxy; R and R = each H, Ph, 1-6C alkyl or benzyl; R , R and R = as defined for R ; l = 1-2.

9. 发明专利

DE4425609A1 未知
公开(公告)号：DE4425609A1
公开(公告)日：1996-01-25
申请号：DE4425609
申请日：1994-07-20
申请人： BAYER AG
发明人： RIEDL BERND DR , HAEBICH DIETER DR , STOLLE ANDREAS DR , WILD HANNO DR , ENDERMANN RAINER DR , BREMM KLAUS-DIETER DR , KROLL HEIN-PETER DR , LABISCHINSKI HARALD PROF DR , SCHALLER KLAUS DR , WERLING HANS-OTTO DR
IPC分类号： C07D333/52 , A61K31/42 , A61P31/04 , C07D307/81 , C07D333/70 , C07D413/04 , C07D413/14 , A61K31/495 , A61K31/40 , A61K31/445
摘要： 3-Heteroaryl-2-oxazolidinone derivs. of formula (I) and their salts and S-oxides are new: R1 = azido, OH, OR2, OSO2R3 or NR4R5; R2 = linear or branched 1-8C acyl or a protecting gp.; R3 = e.g. 1-4C alkyl; R4,R5 = e.g. H; A = O or S; D, E, G, L and M = e.g. (a) COOH, halo, CN, SH, CHO, etc., or NR7R8; and/or (b) NR7'R8' ; and/or (c) phenyl, etc.; R7,R8 = H, 1-4C alkyl or phenyl; or NR7R8 = a satd. R- or 6-membered ring opt. contg. another heteroatom (N, S and/or O) and opt. substd. by 1-3C alkyl or acyl; R7', R8' = gps. as defined for R7 and R8; etc..

10. 发明专利

AU650800B2 5,6-Dihydro-dibenz(b,e)azepine-6,11-dione-11-oximes 未知
公开(公告)号：AU650800B2
公开(公告)日：1994-06-30
申请号：AU2859792
申请日：1992-11-24
申请人： BAYER AG
发明人： WILD HANNO DR , ROEBEN WOLFGANG DR , AICHINGER GERD DR , PAESSENS ARNOLD DR , GEHR JORG PETERSEN-VON DR
IPC分类号： A61K31/00 , A61K31/55 , A61P31/12 , A61P43/00 , C07D223/20 , C07D405/12 , C12N9/99
摘要： The invention relates to 5,6-dihydrodibenz[b,e]azepine-6,11-dione-11-oximes of the formula I, a process for their preparation and their use as inhibitors of reverse transcriptase and in particular as retroviral agents.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式