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2. 发明专利

AU7646598A Substituted aminothiazoles and the use thereof as active antimicrobial substances 未知
公开(公告)号：AU7646598A
公开(公告)日：1998-11-27
申请号：AU7646598
申请日：1998-04-22
申请人： BAYER AG
发明人： BAASNER BERND , MATZKE MICHAEL , MILITZER HANS-CHRISTIAN , SCHALLER KLAUS , LABISCHINSKI HARALD PROF DR , ENDERMANN RAINER , WERLING HANS-OTTO DR
IPC分类号： C07D277/38 , C07D277/48 , C07D417/12 , C07D417/14 , A61K31/425

3. 发明专利

DE19652219A1 未知
公开(公告)号：DE19652219A1
公开(公告)日：1998-06-18
申请号：DE19652219
申请日：1996-12-16
申请人： BAYER AG
发明人： PETERSEN UWE DR , MATZKE MICHAEL DR , JAETSCH THOMAS DR , SCHENKE THOMAS DR , HIMMLER THOMAS DR , BARTEL STEPHAN DR , BAASNER BERND DR , WERLING HANS-OTTO DR , SCHALLER KLAUS PROF DR , LABISCHINSKI HARALD PROF DR , ENDERMANN RAINER DR
IPC分类号： C07D491/048 , A61K31/00 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/5383 , A61K31/5395 , A61P1/04 , A61P31/04 , C07D491/04 , C07D519/00 , C07F9/6561 , A61K31/44 , A61K31/645
摘要： The invention concerns the use of quinolone and naphthyridone carboxylic acid derivatives which are substituted in position 7 by a 1-aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl group and their salts for treating Helicobacter pylori infections and the gastroduodenal diseases associated therewith.

6. 发明专利

CZ198895A3 BENZOXAZOLYLOXAZOLIDINONES AND BENZOTHIAZOLYLOXAZOLIDINONES, PROCESS OF THEIR PREPARATION AND USE FOR PREPARING MEDICAMENTS 未知
公开(公告)号：CZ198895A3
公开(公告)日：1996-02-14
申请号：CZ198895
申请日：1995-08-02
申请人： BAYER AG
发明人： HABICH DIETER DR , RIEDL BERND DR , RUPPELT MARTIN DR , STOLLE ANDERAS DR , WILD HANNO DR , ENDERMANN RAINER DR , BREMM KLAUS DIETER DR , KROLL HEIN PETER DR , LABISCHINSKI HARALD PROF DR , SCHALLER KLAUS DR , WERLING HANS OTTO DR
IPC分类号： C07D491/113 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/5377 , A61K31/55 , A61P31/04 , C07D247/02 , C07D263/38 , C07D263/56 , C07D263/58 , C07D413/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D419/12 , C07D491/10
摘要： Benzoxazolyl and benzothiazolyloxazolidinone derivs. of formula (I) and their salts are new. A = O or S(O)a; a = 0-2; R = azido or OSO2R or NR R ; R = H, formyl, carboxy, opt. branched ≤ 6C alkoxy-carbonyl; or is alkenyl or alkenyl of ≤ 8C (which are opt. substd. by OH, halo, or by alkoxy, acyl, alkylthio or alkoxycarbonyl each of ≤ 6C or phenyl which in turn may be substd by halo), 6-10C aryl (opt. substd. with carboxy, halogen, CN, formyl, CF3, NO2, 1-6C alkoxy, 1-6C alkoxycarbonyl, 1-6C alkylthio, 1-6C acyl or 1-6C alkyl), or is NR R , OR , S(O)cR , morpholino or a gp. of formula (a)-(h). R = 1-4C alkyl or Ph (opt. substd. with 1-4C alkyl); R and R = each 3-6C cycloalkyl, H, Ph, 1-8C alkyl or an amino protecting gp; or R or R = COR ; R = 3-6C cycloalkyl, 1-8C alkyl, 1-8C alkoxy, Ph or H; G, L and M = each H, COOH, halogen, CN, formyl, CF3, NO2, 1-6C alkoxy, 1-6C alkoxy-carbonyl, 1-6C alkylthio, 1-6C acyl, 1-6C alkyl (this last opt. substd. with OH , 1-5C alkoxy, 1-5C acyl or NR R ), NR 'R ', 2-8C alkyl phenyl, Ph or a 5-6 membered opt. satd. heterocycle contg. up to 3 heteroatoms chosen from S, N and/or O and opt. itself substd. with CONR R , NR R , NR SO2R , R R N-SO2 or R S(O)b; and/or G, L and M are opt. mono- or di- substd. with carboxy, halogen, CN, formly, CF3, NO2 Ph 1-6C alkoxy, 1-6C alkoxycarbonyl, 1-6C alkylthio, 1-6C acyl, 1-6C alkyl (this last itself opt. substd. with OH, 1-5C alkoxy, 1-5C acyl or NR R ); R and R = each H, 1-4C alkyl or Ph or together with the N to which they are attached form a 5-6 membered satd. heterocycle contg. a further heteroatom chosen from N, S and/or O and opt. substd. on one of the further N with 1-3C alkyl or acyl and/or R and R = NR 'R ', R ' and R ' = as defined for R and R . b = 0-2; R , R , R , R and R = each H, 1-6C alkyl or Ph; R , R 2, R and R = each as defined for R and R ; R and R = each as defined for R ; R = 3-6C cycloalkyl, Ph, 1-6C acyl, 1-8C alkyl (opt. substd. with OH, alkoxy or OH-substd. 1-6C alkoxy, a 5-6 membered aromatic heterocycle contg up to 3 heteroatoms chosen from S, N and/or O or with Ph (itself opt. substd. with OH, CF3, halogen, NO2 or 1-4C alkyl) or alkyl opt. substd. with NR R or a gp. of formula (i)) R = a gp of formula (j) R = OH, 1-4C alkoxy or NR R R and R = each H, 1-5C alkyl, 3-6C cycloalkyl or Ph; R = H 1-7C alkyl (opt. substd. with indolyl, OH, SH, imidazolyl, methylthio, amino, Ph, OH-substd. Ph, CONH2 CO2H or C(NH2)=NH; d = 0-6; T = O, CH2 or NR ; R = H, Ph, 1-6C alkyl (opt. substd. with OH); R = as defined for R or H; R = 1-8C alkyl (opt. substd. with 1-6C alkoxy or OH- or 1-6C alkoxy-substd. 1-6C alkoxy, 3-6C cycloalkyl or a 6-membered aromatic, opt. benzo condensed heterocycle contg. up to 4 N whichis itself opt. mono- or di-substd. with NO2, CF3, halogen, CN, OH, 1-5C alkyl, 1-5C alkoxy or 1-5C acyl; R = a gp of formula (l), Ph or pyridyl; e = as defined for (d) W = as defined for T; C = 0-2; R = 1-16C alkyl or alkenyl (opt. substd. with 1-6C alkoxycarbonyl, Ph or a 5-7 membered aromatic heterocycle contg 1-3 heteroatoms chosen from S, N and O) or 6-10C aryl or 1 5-7 membered aromatic heterocycle contg 1-3 heteroatoms chosen from S, N and O (these cycles being opt. mono or di-substd. with carboxy, halogen, CN, formyl, CF3, NO2, 1-6C alkoxy, 1-6C alkoxy-carbonyl, 1-6C alkylthio, 1-6C acyl or 1-6C alkyl); R and R = as defined for R and R ; R and R together form O or R and R = each H, OH or 1-6C alkyl / opt. substd. with NR R ; f = 0-1; g = 0-6; R = 6-10C acyl or a 5-6 membered aromatic opt. benzo-condensed heterocycle contg. up to 3 heteroatoms chosen from S, N and O (all ring system being opt. mono-, di- or tri-substd. with NO2, CN, OH, Ph, halogen, CF3, 1-5C alkyl, 1-5C alkoxy or 1-5C acetyl (sic)) or morpholino, OH, 1-6C alkoxy, NR R , COR or a gp. of formula (l); R and R = each as defined for R and R ; R = morpholino, OH or 1-6C alkoxy; R and R = each H, Ph, 1-6C alkyl or benzyl; R , R and R = as defined for R ; l = 1-2.

7. 发明专利

DE4425609A1 未知
公开(公告)号：DE4425609A1
公开(公告)日：1996-01-25
申请号：DE4425609
申请日：1994-07-20
申请人： BAYER AG
发明人： RIEDL BERND DR , HAEBICH DIETER DR , STOLLE ANDREAS DR , WILD HANNO DR , ENDERMANN RAINER DR , BREMM KLAUS-DIETER DR , KROLL HEIN-PETER DR , LABISCHINSKI HARALD PROF DR , SCHALLER KLAUS DR , WERLING HANS-OTTO DR
IPC分类号： C07D333/52 , A61K31/42 , A61P31/04 , C07D307/81 , C07D333/70 , C07D413/04 , C07D413/14 , A61K31/495 , A61K31/40 , A61K31/445
摘要： 3-Heteroaryl-2-oxazolidinone derivs. of formula (I) and their salts and S-oxides are new: R1 = azido, OH, OR2, OSO2R3 or NR4R5; R2 = linear or branched 1-8C acyl or a protecting gp.; R3 = e.g. 1-4C alkyl; R4,R5 = e.g. H; A = O or S; D, E, G, L and M = e.g. (a) COOH, halo, CN, SH, CHO, etc., or NR7R8; and/or (b) NR7'R8' ; and/or (c) phenyl, etc.; R7,R8 = H, 1-4C alkyl or phenyl; or NR7R8 = a satd. R- or 6-membered ring opt. contg. another heteroatom (N, S and/or O) and opt. substd. by 1-3C alkyl or acyl; R7', R8' = gps. as defined for R7 and R8; etc..

8. 发明专利

AU9386501A Method for characterizing, identifying and designating microbial mixtures by comparing ir, ft-ir, raman, ft-raman and gc analysis data with data from a reference database 未知
公开(公告)号：AU9386501A
公开(公告)日：2002-04-29
申请号：AU9386501
申请日：2001-10-05
申请人： BAYER AG , SYNTHON KG
发明人： HAFENRICHTER RUDOLF , FROYMAN ROBRECHT , LABISCHINSKI HARALD PROF DR , SCHIFFER GUIDO , SCHMITT JURGEN , UDELHOVEN THOMAS
IPC分类号： G01N21/31 , G01N30/02 , G01N30/62 , G01N30/86 , G01N30/88 , G01N33/00 , G06F17/00 , G01N33/48
摘要： In order to rapidly characterize, identify and designate microbial mixtures, vibrational spectra of samples are measured based on the IR, FT-IR, Raman and FT-Raman spectroscopy or gas chromatograms are recorded. The measurements are conducted in known experimental devices. The characterization and identification of microbial mixtures ensues by comparing the infrared, Raman spectra or the chromatograms of the gas chromatography or gas chromatography/mass spectroscopy of the sample to be examined with a reference database consisting of IR, FT-IR, Raman or FT-Raman spectra or of GC chromatograms/GC mass spectra that are classified into two or more classes according to the composition, to the property or to the state of the measured reference sample. The comparison preferably ensues using methods of pattern recognition such as artificial neural networks, multi-variant statistical models, machine learning, case-based classification and genetic algorithms.

9. 发明专利

AU5853898A Use of 7-(1-aminomethyl-2-oxa-7-aza-bicyclo{3.3.0}oct-7-yl)-quinolone carboxylic acid and naphthyridone carboxylic acid derivatives for treating (helicobacter pylori) infections and the gastroduodenal diseases associated therewith 未知
公开(公告)号：AU5853898A
公开(公告)日：1998-07-15
申请号：AU5853898
申请日：1997-12-03
申请人： BAYER AG
发明人： PETERSEN UWE , MATZKE MICHAEL , JAETSCH THOMAS , SCHENKE THOMAS , HIMMLER THOMAS , BARTEL STEPHAN , BAASNER BERND , WERLING HANS-OTTO DR , SCHALLER KLAUS , LABISCHINSKI HARALD PROF DR , ENDERMANN RAINER
IPC分类号： C07D491/048 , A61K31/00 , A61K31/4375 , A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/5383 , A61K31/5395 , A61P1/04 , A61P31/04 , C07D491/04 , C07D519/00 , C07F9/6561
摘要： The invention relates to the use of quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in position 7 by a 1-aminomethyl-2-oxa-7-azabicyclo[3.3.0]oct-7-yl radical, and of their salts for the therapy of Helicobacter pylori infections and associated gastroduodenal disorders.

10. 发明专利

DE4425612A1 未知
公开(公告)号：DE4425612A1
公开(公告)日：1996-04-04
申请号：DE4425612
申请日：1994-07-20
申请人： BAYER AG
发明人： RIEDL BERND DR , HAEBICH DIETER DR , STOLLE ANDREAS DR , WILD HANNO DR , ENDERMANN RAINER DR , BREMM KLAUS-DIETER DR , KROLL HEIN-PETER DR , LABISCHINSKI HARALD PROF DR , SCHALLER KLAUS DR , WERLING HANS-OTTO DR
IPC分类号： C07D237/20 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/495 , A61K31/50 , A61P31/04 , C07D213/72 , C07D215/38 , C07D215/48 , C07D239/42 , C07D241/44 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , A61K31/55
摘要： Nitrogen-contg. heteroaryl-oxazolidinones of formula (I) and their salts and N-oxides are new. R = N3, OH, OR2, OSO2R or NR R ; R = 1-8C acyl or OH protecting gp.; R = 1-4C alkyl or phenyl opt. substd. by 1-4C alkyl; R , R = H, 3-6C cycloalkyl, phenyl, 1-8C alkyl or NH2 protecting gp.; or R or R = COR ; R = H, 3-6C cycloalkyl, phenyl or 1-8C alkyl; D = (a) 6-membered C-bonded aromatic heterocycle contg. at least 1 N atom; (b) C-bonded bi- or tricyclic aromatic gp. with 6-membered rings of which at least 1 is N-contg, etc.

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