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1. 发明申请

WO2009092793A3 VERFAHREN ZUR FERMENTATIVEN HERSTELLUNG VON 1,5-DIAMINOPENTAN 审中-公开
公开(公告)号：WO2009092793A3
公开(公告)日：2009-07-30
申请号：PCT/EP2009/050778
申请日：2009-01-23
申请人： BASF SE , VÖLKERT, Martin , ZELDER, Oskar , ERNST, Burkhard , JEONG, Weol Kyu
发明人： VÖLKERT, Martin , ZELDER, Oskar , ERNST, Burkhard , JEONG, Weol Kyu
IPC分类号： C12P13/00
摘要： Die vorliegende Erfindung betrifft ein Verfahren zur Isolierung von 1,5-Diaminopentan (DAP) aus DAP-haltigen Fermentationsbrühen, ein Verfahren zur fermentativen Herstellung von DAP unter Verwendung dieser Isolierungsmethode sowie ein Verfahren zur Herstellung von DAP-haltigen Polymeren unter Einsatz des in dieser Weise isolierten bzw. fermentativ hergestellten DAPs.

2. 发明申请

WO2008049782A1 METHOD OF INCREASING GENE EXPRESSION USING MODIFIED CODON USAGE 审中-公开
标题翻译：使用改性CODON使用增加基因表达的方法
公开(公告)号：WO2008049782A1
公开(公告)日：2008-05-02
申请号：PCT/EP2007/061152
申请日：2007-10-18
申请人： BASF SE , HEROLD, Andrea , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , ZELDER, Oskar , JEONG, Weol Kyu
发明人： HEROLD, Andrea , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , ZELDER, Oskar , JEONG, Weol Kyu
IPC分类号： C12N15/67 , C12N15/77
CPC分类号： C12N15/67 , C12N15/77
摘要： The present invention relates to a method of increasing the amount of at least one polypeptide in the host cell by expressing a modified nucleotide sequence encoding for a polypeptide in a host cell with said modified.nucleotide sequence being derived from a different non-modified nucleotide sequence encoding for a polypeptide of identical amino acid sequence such that the codon usage of the modified nucleotide sequence is adjusted to the codon usage of abundant proteins in the host cell.
摘要翻译：本发明涉及一种通过在宿主细胞中表达编码多肽的修饰的核苷酸序列来增加宿主细胞中至少一种多肽的量的方法，所述修饰的核苷酸序列衍生自不同的未修饰的核苷酸序列编码相同氨基酸序列的多肽，使得修饰的核苷酸序列的密码子使用被调整为宿主细胞中丰富蛋白质的密码子使用。

3. 发明申请

WO2008049781A1 METHOD OF REDUCING GENE EXPRESSION USING MODIFIED CODON USAGE 审中-公开
标题翻译：使用改性CODON使用减少基因表达的方法
公开(公告)号：WO2008049781A1
公开(公告)日：2008-05-02
申请号：PCT/EP2007/061151
申请日：2007-10-18
申请人： BASF SE , HEROLD, Andrea , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , ZELDER, Oskar , JEONG, Weol Kyu
发明人： HEROLD, Andrea , KLOPPROGGE, Corinna , SCHRÖDER, Hartwig , ZELDER, Oskar , JEONG, Weol Kyu
IPC分类号： C12N15/77
CPC分类号： C12N15/77
摘要： The present invention is directed to a method of reducing the amount of at least one polypeptide in a host cell by expressing a nucleotide sequence encoding for the polypeptide in the host cell wherein the nucleotide sequence uses codons that are rarely used according to the codon usage of the host organism. Furthermore, the present invention relates to nucleotide sequences encoding for a polypeptide with a codon usage that has been adjusted to use codons that are only rarely used according to the codon usage of the host organism. The present invention further relates to the use of such sequences and methods for producing fine chemicals such as amino acids, sugars, lipids, oils, carbohydrates, vitamins, cofactors etc.
摘要翻译：本发明涉及通过在宿主细胞中表达编码多肽的核苷酸序列来减少宿主细胞中至少一种多肽的量的方法，其中所述核苷酸序列使用根据密码子使用的密码子使用的密码子宿主生物体。此外，本发明涉及编码具有密码子用途的多肽的核苷酸序列，其已被调整为使用根据宿主生物的密码子使用很少使用的密码子。本发明还涉及这样的序列和方法用于生产精细化学品如氨基酸，糖，脂质，油，碳水化合物，维生素，辅因子等的用途。

4. 发明申请

WO2011073278A1 PROCESSES AND RECOMBINANT MICROORGANISMS FOR THE PRODUCTION OF CADAVERINE 审中-公开
标题翻译：用于生产CADAVERINE的工艺和重组微生物
公开(公告)号：WO2011073278A1
公开(公告)日：2011-06-23
申请号：PCT/EP2010/069802
申请日：2010-12-15
申请人： BASF SE , SCHRÖDER, Hartwig , JEONG, Weol Kyu , SERWE, Annegret , ZELDER, Oskar
发明人： SCHRÖDER, Hartwig , JEONG, Weol Kyu , SERWE, Annegret , ZELDER, Oskar
IPC分类号： C12N9/88 , C12P13/00 , C12R1/15
CPC分类号： C12N9/88 , C12P13/001
摘要： The present invention relates to the use of recombinant microorganisms comprising DNA molecules in a deregulated form which improve the production of cadaverine, as well as to recombinant DNA molecules and polypeptides used to produce the microorganism, said microorganism comprising an intracellular lysine decarboxylase activity and an enhanced lysine import activity or comprising an intracellular and an extracellular lysine decarboxylase activity or comprising an intracellular and extracellular lysine decarboxylase activity and an enhanced lysine import activity. The present invention also relates to a processes for the production of cadaverine using recombinant microorganisms.
摘要翻译：本发明涉及包含DNA分子的重组微生物在去调节形式中的用途，其改善了尸胺的产生，以及用于产生微生物的重组DNA分子和多肽，所述微生物包含细胞内赖氨酸脱羧酶活性和增强的赖氨酸进入活性或包含细胞内和细胞外赖氨酸脱羧酶活性或包含细胞内和细胞外赖氨酸脱羧酶活性和增强的赖氨酸进口活性。本发明还涉及使用重组微生物生产尸胺的方法。

5. 发明申请

WO2009133114A1 PRODUCTION PROCESS FOR FINE CHEMICALS USING MICROORGANISMS WITH REDUCED ISOCITRATE DEHYDROGENASE ACTIVITY 审中-公开
标题翻译：使用具有降低的异烟肼脱氢酶活性的微生物的精细化学品的生产工艺
公开(公告)号：WO2009133114A1
公开(公告)日：2009-11-05
申请号：PCT/EP2009/055146
申请日：2009-04-28
申请人： BASF SE , HEROLD, Andrea , SCHRÖDER, Hartwig , JEONG, Weol Kyu , KLOPPROGGE, Corinna , ZELDER, Oskar , HAEFNER, Stefan , RICHTER, Ulrike , BECKER, Judith , WITTMANN, Christoph
发明人： HEROLD, Andrea , SCHRÖDER, Hartwig , JEONG, Weol Kyu , KLOPPROGGE, Corinna , ZELDER, Oskar , HAEFNER, Stefan , RICHTER, Ulrike , BECKER, Judith , WITTMANN, Christoph
IPC分类号： C12P13/00 , C12N9/04
CPC分类号： C12P13/001 , C12N9/0006 , C12P13/02 , C12P13/08 , C12P13/12 , C12P13/20
摘要： The present invention is directed to a method utilizing a microorganism with reduced isocitrate dehydrogenase activity for the production of fine chemicals. Said fine chemicals may be amino acids, monomers for polymer synthesis, sugars, lipids, oils, fatty acids or vitamins and are preferably amino acids of the aspartate family, especially methionine or lysine, or derivatives of said amino acids, especially cadaverine. Furthermore, the present invention relates to a recombinant microorganism having a reduced isocitrate dehydrogenase activity in comparison to the initial microorganism and the use of such microorganisms in producing fine chemicals such as aspartate family amino acids and their derivatives.
摘要翻译：本发明涉及利用具有降低的异柠檬酸脱氢酶活性的微生物来生产精细化学品的方法。所述精细化学品可以是氨基酸，用于聚合物合成的单体，糖，脂质，油，脂肪酸或维生素，并且优选天冬氨酸家族的氨基酸，特别是甲硫氨酸或赖氨酸，或所述氨基酸的衍生物，特别是尸胺。此外，本发明涉及与初始微生物相比具有降低的异柠檬酸脱氢酶活性的重组微生物，以及这些微生物在生产精细化学品如天冬氨酸家族氨基酸及其衍生物中的用途。

6. 发明申请

WO2009098046A1 METHOD FOR THE PRODUCTION OF DIPICOLINATE 审中-公开
标题翻译：生产DIPICOLINATE的方法
公开(公告)号：WO2009098046A1
公开(公告)日：2009-08-13
申请号：PCT/EP2009/000758
申请日：2009-02-04
申请人： BASF SE , ZELDER, Oskar , JEONG, Weol Kyu , KLOPPROGGE, Corinna , HEROLD, Andrea , SCHRÖDER, Hartwig
发明人： ZELDER, Oskar , JEONG, Weol Kyu , KLOPPROGGE, Corinna , HEROLD, Andrea , SCHRÖDER, Hartwig
IPC分类号： C12P17/12 , C12N9/02
CPC分类号： C12P17/12 , C12N9/001
摘要： The present invention relates to a novel method for the fermentative production of dipicolinate by cultivating a recombinant microorganism expressing an enzyme having dipicolinate synthetase activity. The present invention also relates to corresponding recombinant hosts, recombinant vectors, expression cassettes and nucleic acids suitable for preparing such hosts as well as a method of preparing polyester or polyamide copolymers making use of dipicolinate as obtained by fermentative production.
摘要翻译：本发明涉及通过培养表达具有吡啶二羧酸合成酶活性的酶的重组微生物来发酵吡啶硫酸盐的新方法。本发明还涉及适用于制备这种宿主的相应的重组宿主，重组载体，表达盒和核酸以及使用通过发酵生产得到的吡啶二酸盐制备聚酯或聚酰胺共聚物的方法。

7. 发明申请

WO2007113127A1 PROCESS FOR THE PRODUCTION OF CADAVERINE 审中-公开
标题翻译：生产CADAVERINE的过程
公开(公告)号：WO2007113127A1
公开(公告)日：2007-10-11
申请号：PCT/EP2007/052783
申请日：2007-03-23
申请人： BASF AKTIENGESELLSCHAFT , ZELDER, Oskar , JEONG, Weol Kyu , KLOPPROGGE, Corinna , HEROLD, Andrea , SCHRÖDER, Hartwig
发明人： ZELDER, Oskar , JEONG, Weol Kyu , KLOPPROGGE, Corinna , HEROLD, Andrea , SCHRÖDER, Hartwig
IPC分类号： C12P13/00 , C12P13/02 , C12R1/15
CPC分类号： C12P13/02 , C12N9/88 , C12P13/001
摘要： Process for the production of cadaverine by constructing a recombinant microorganism which has a deregulated lysine decarboxylase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahy- drodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl- diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehy¬ drogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate car¬ boxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1 ,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA syn¬ thetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.
摘要翻译：通过构建具有失调的赖氨酸脱羧酶基因和选自由天冬氨酸激酶，天冬氨酸二醛脱氢酶，二氢吡啶二羧酸合成酶，二氢吡啶二羧酸还原酶，四氢吡啶二羧酸琥珀酰基酶组成的组（i）中的至少一种去调节基因的重组微生物来生产尸胺的方法，琥珀酰基 - 氨基 - 酮基庚酸酯转氨酶，琥珀酰基 - 二氨基 - 庚二酸酯去糖基酶，二氨基庚二酸差向异构酶，二氨基庚二酸脱氢酶，精氨酰-tRNA合成酶，二氨基庚二酸脱羧酶，丙酮酸酯酶，磷酸烯醇丙酮酸羧化酶，葡萄糖-6-磷酸脱氢酶，转酮醇酶，转醛醇酶如果天冬氨酸激酶被释放为基因（i）至少第二个基因（i），除了天冬氨酸激酶以外的其他基因（i），所述第二基因（i）不是天冬氨酸激酶，不得不放松管制，而且cul。抚平所述微生物。

8. 发明申请

WO2007101867A1 PROCESS FOR THE PRODUCTION OF β-LYSINE 审中-公开
标题翻译：生产β-赖氨酸的方法
公开(公告)号：WO2007101867A1
公开(公告)日：2007-09-13
申请号：PCT/EP2007/052138
申请日：2007-03-07
申请人： BASF AKTIENGESELLSCHAFT , ZELDER, Oskar , JEONG, Weol Kyu , KLOPPROGGE, Corinna , HEROLD, Andrea , SCHRÖDER, Hartwig
发明人： ZELDER, Oskar , JEONG, Weol Kyu , KLOPPROGGE, Corinna , HEROLD, Andrea , SCHRÖDER, Hartwig
IPC分类号： C12P13/08 , C12P13/00 , C12N15/63 , C12N15/77
CPC分类号： C12P13/08 , C12P13/005 , C12P13/02
摘要： Process for the production of -lysine by constructing a recombinant microorganism which has a deregulated lysine 2,3-aminomutase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diaminopimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.
摘要翻译：通过构建具有失调的赖氨酸2,3-氨基变位酶基因的重组微生物和选自由天冬氨酸激酶，天冬氨酸二甲二醇脱氢酶，二氢吡啶二羧酸合酶，二氢吡啶二羧酸还原酶，二氢吡啶二羧酸还原酶组成的组中的至少一种去调节基因的生产赖氨酸的方法，四氢吡啶二羧酸琥珀酰基酶，琥珀酰 - 氨基 - 酮基庚酸酯转氨酶，琥珀酰 - 二氨基 - 庚二酸二琥珀酰酶，二氨基庚酸酯差向异构酶，二氨基庚二酸脱氢酶，精氨酰-tRNA合成酶，二氨基庚二酸脱羧酶，丙酮酸羧化酶，磷酸烯醇丙酮酸羧化酶，葡萄糖-6-磷酸脱氢酶，转酮酶，转醛醇酶，磷酸葡糖糖苷酶，果糖1,6-二磷酸酶，高丝氨酸脱氢酶，磷酸烯醇丙酮酸羧激酶，琥珀酰辅酶A合成酶，甲基丙二酰-CoA变位酶，条件是如果天冬氨酸激酶被解除调控为基因（i）至少第二个基因（i）除了天冬氨酸激酶必须放松管制，培养说微生物。

9. 发明申请

WO2007099029A2 VERFAHREN ZUR REINIGUNG VON CAPROLACTAM, HERGESTELLT AUS LYSIN 审中-公开
标题翻译：清洗由赖氨酸制造的CAPROLACTAM的方法
公开(公告)号：WO2007099029A2
公开(公告)日：2007-09-07
申请号：PCT/EP2007/051377
申请日：2007-02-13
申请人： BASF AKTIENGESELLSCHAFT , PREISHUBER-PFLÜGL, Peter , SCHNELLER, Arnold , YAMAMOTO, Motonori , SIEGEL, Wolfgang , WITTENBECHER, Lars , WARZELHAN, Volker , SCHEIBITZ, Matthias , ZELDER, Oskar , EIBECK, Peter , JEONG, Weol Kyu
发明人： PREISHUBER-PFLÜGL, Peter , SCHNELLER, Arnold , YAMAMOTO, Motonori , SIEGEL, Wolfgang , WITTENBECHER, Lars , WARZELHAN, Volker , SCHEIBITZ, Matthias , ZELDER, Oskar , EIBECK, Peter , JEONG, Weol Kyu
CPC分类号： C07D201/16
摘要： Verfahren zur Reinigung von Caprolactam, hergestellt aus Lysin, indem man Caprolactam mit einer Säure oder einem sauren Ionenaustauscher behandelt sowie die Verwendung zur Herstellung von hochmolekularem Polyamid (Polyamid 6).
摘要翻译：
一种用于净化己内酰胺的方法，由己内酰胺从赖氨酸制备与S＆AUML ;.用酸或酸性离子交换剂和高分子量的聚酰胺的制备中的用途处理好的（聚酰胺6）

10. 发明申请

WO2009095440A1 TRANSPARENTE POLYAMID[5,10] FORMMASSEN 审中-公开
标题翻译：透明聚酰胺[5,10]模塑料
公开(公告)号：WO2009095440A1
公开(公告)日：2009-08-06
申请号：PCT/EP2009/051006
申请日：2009-01-29
申请人： BASF SE , YAMAMOTO, Motonori , JEONG, Weol Kyu , SCHNELLER, Arnold , GRÜTZNER, Rolf-Egbert , GRUBER, Freddy , DEININGER, Jürgen
发明人： YAMAMOTO, Motonori , JEONG, Weol Kyu , SCHNELLER, Arnold , GRÜTZNER, Rolf-Egbert , GRUBER, Freddy , DEININGER, Jürgen
IPC分类号： C08G69/26 , C08G69/28 , C08L77/06 , C08K3/00 , C08K7/02 , C08K7/14 , C08K3/34 , C08K5/00
CPC分类号： C08G69/26 , C08G69/28 , C08K5/0083 , C08L77/06
摘要： Die vorliegende Erfindung betrifft transparente Polyamid[5,10]-Formmasse mit einer Transmission gemessen nach ASTM D1003 an 1 mm dicken, spritzgegossenen Platten von größer oder gleich 80 % und ein Verfahren und Masterbatches zur Herstellung derartiger Formmassen, die Verwendung derartiger Formmassen zur Herstellung von Formkörpern jeglicher Art und die hierbei erhältlichen Formkörper, vorzugsweise Kfz-Karosserieteile jeglicher Art oder Elektronikbauteile, Folien und Fasern.
摘要翻译：本发明涉及透明聚酰胺[5,10]如通过ASTM D1003在1mm厚的注射成型的大于或等于板测得为80％，用于制造这种模塑材料的方法，和母料，使用这种模塑组合物用于生产具有传输模塑组合物任何类型的模制品，并将得到的模制品，任何类型的优选汽车车身板，或电子元件，薄膜和纤维。

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