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1. 发明申请

WO2010130608A2 METHOD FOR PRODUCING (METH)ACRYLIC ACID ESTERS CONTAINING URETHANE GROUPS 审中-公开
标题翻译：用于生产聚氨酯（甲基）丙烯酸酯
公开(公告)号：WO2010130608A2
公开(公告)日：2010-11-18
申请号：PCT/EP2010056079
申请日：2010-05-05
申请人： BASF SE , STUERMER RAINER , DREW DEJANA , HAUER BERNHARD , DAEUWEL JUERGEN , MEISENBURG UWE
发明人： STUERMER RAINER , DREW DEJANA , HAUER BERNHARD , DAEUWEL JUERGEN , MEISENBURG UWE
IPC分类号： C12P7/62
CPC分类号： C12P13/02 , C12P7/62
摘要： Method for producing (meth)acrylic acid esters (U) containing urethane groups by reacting an alcohol (A) containing urethane groups with a (meth)acrylic acid ester of a saturated alcohol (G) in the presence of at least one polymerization inhibitor (P) having an enzyme (E) as a catalyst in a reactor, wherein a) the released saturated alcohol and the optionally used entrainer form an azeotrope with the excess corresponding (meth)acrylic acid ester (G), the azeotrope is separated by distillation at reduced pressure, and b) at least one partial flow from the sump of the reactor is recirculated via the head of the distillation column.
摘要翻译：一种用于通过在反应器中的催化剂的含氨基甲酸酯基的醇（A），其具有在至少一种阻聚剂（P）的存在下的饱和醇（G）的（甲基）丙烯酸酯用一种酶（E）反应来制备含氨基甲酸酯（甲基）丙烯酸酯（U）过程其中a）所释放的饱和醇和夹带剂，如果使用的话，与过量的相应的（甲基）丙烯酸酯（G）形成Azoetrop，共沸物通过蒸馏在减压下除去，并从反应器的底部通过所述头部b）至少一个部分流蒸馏塔再循环。

2. 发明申请

WO2008058951A8 PROCESS FOR ENZYMATIC REDUCTION OF ALKENE DERIVATIVES 审中-公开
标题翻译： METHOD FOR烯衍生物的酶促还原
公开(公告)号：WO2008058951A8
公开(公告)日：2009-12-10
申请号：PCT/EP2007062251
申请日：2007-11-13
申请人： BASF SE , STUERMER RAINER , HAUER BERNHARD , FRIEDRICH THOMAS , FABER KURT , HALL MELANIE
发明人： STUERMER RAINER , HAUER BERNHARD , FRIEDRICH THOMAS , FABER KURT , HALL MELANIE
IPC分类号： C12P7/24 , C12P7/26 , C12P7/46 , C12P41/00
CPC分类号： C12P7/24 , C12P7/26 , C12P7/40 , C12P7/46 , C12P7/62 , C12P13/008 , C12P17/10 , C12P41/002
摘要： Process for enzymatic production of compounds of the general formula (2) from unsaturated alkene derivatives of the general formula (1) by reduction of a compound of the formula (1) in the presence of a reductase comprising at least one of the polypeptide sequences SEQ ID NO: 1, 2, or 3 or having a functionally equivalent polypeptide sequence which has at least 80% sequence identity with SEQ ID NO: 1, 2, or 3.
摘要翻译：处理用于通过还原下式的化合物的酶促制备由通式（1）的不饱和链烯烃衍生物，通式（2）的化合物（1）在包含多肽序列SEQ ID NO中的至少一种的还原酶的存在：1，2，或或3，其具有与SEQ ID NO具有至少80％序列同一性的功能上等同的多肽序列：1，2，或第三

3. 发明申请

WO2009074524A2 METHOD FOR THE ENZYMATIC REDUCTION OF ALPHA- AND BETA-DEHYDROAMINO ACIDS 审中-公开
标题翻译：方法α和βdehydroaminoacids的酶还原
公开(公告)号：WO2009074524A2
公开(公告)日：2009-06-18
申请号：PCT/EP2008066977
申请日：2008-12-08
申请人： BASF SE , STUERMER RAINER , HAUER BERNHARD , FRIEDRICH THOMAS , FABER KURT , HALL MELANIE , MACHEROUX PETER , STUECKLER CLEMENS
发明人： STUERMER RAINER , HAUER BERNHARD , FRIEDRICH THOMAS , FABER KURT , HALL MELANIE , MACHEROUX PETER , STUECKLER CLEMENS
IPC分类号： C12P13/04
CPC分类号： C12P13/04
摘要： The invention relates to a method for production of amino acids of general formula (3) or (4) from alpha-dehydroamino acids of general formula (1) or (2), where R1 and R2 independently = H, C1-C6 alkyl, C2-C6 alkenyl, optionally substituted carbo- or heterocyclic, aromatic or non-aromatic or alkylaryl, or a carboxyl ( -COOR) group, R3 = H, formyl, acetyl, propionyl, benzyl, benzyloxycarbonyl, BOC, or Alloc and R = H, C1-C6 alkyl or aryl, by reduction of a compound of formula (1) or (2) in the presence of a reductase.
摘要翻译：工艺的通式（3）或（4）通式（1）或由α-脱氢酸（2）其中R1，R2独立地为H，C1-C6烷基，C2-C6链烯基的氨基酸的酶制剂，任选取代的碳环或杂环芳族或非芳族基团，或一个Alkylaryrest，或羧基（ - COOR），R 3是H，甲酰基，乙酰基，丙酰基，苄基，苄氧羰基，BOC，的Alloc，R为H，C1 -C6-烷基，芳基，通过还原式（1）或（2）在一个还原酶的存在。

4. 发明申请

WO2006094945A3 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOLS BY MEANS OF ENZYMATIC REDUCTION 审中-公开
标题翻译：工艺生产光学活性醇BY酶还原
公开(公告)号：WO2006094945A3
公开(公告)日：2007-03-15
申请号：PCT/EP2006060452
申请日：2006-03-03
申请人： BASF AG , STUERMER RAINER , DAEUWEL JUERGEN , KESSELER MARIA , ACHATZ BRIGITTE , BREUER MICHAEL
发明人： STUERMER RAINER , DAEUWEL JUERGEN , KESSELER MARIA , ACHATZ BRIGITTE , BREUER MICHAEL
IPC分类号： C12P17/00 , C07C27/00 , C07D333/16 , C12P7/02 , C12P7/04
CPC分类号： C12P7/02 , C07D333/16 , C12P17/00 , C12P41/002
摘要： The invention concerns a method for producing optically active alcohols of formula (I) by means of enzymatic reduction of the corresponding ketones, in particular, the production of (1S)-3-methylamino-1-(2-thienyl)-propane-1-ol and (1S)-3-chlorine-1-(2-thienyl)-propane-1-ol.
摘要翻译：一种用于制备式（I）通过酶促还原相应的酮的旋光活性的链烷醇，特别是（1S）的制备-3-甲基氨基-1-（2-噻吩基）丙-1-醇和过程（1S） -3-氯-1-（2-噻吩基）丙-1-醇。

5. 发明申请

WO2005033094A3 METHODS FOR THE PRODUCTION OF 3-METHYLAMINO-1-(THIENE-2-YL)-PROPANE-1-OL 审中-公开
标题翻译： PROCESS FOR 3-甲基氨基-1-（噻吩-2-基）丙-1-醇的制备
公开(公告)号：WO2005033094A3
公开(公告)日：2005-11-24
申请号：PCT/EP2004010939
申请日：2004-09-30
申请人： BASF AG , STUERMER RAINER , KESSELER MARIA , HAUER BERNHARD , FRIEDRICH THOMAS , BREUER MICHAEL
发明人： STUERMER RAINER , KESSELER MARIA , HAUER BERNHARD , FRIEDRICH THOMAS , BREUER MICHAEL
IPC分类号： C07D333/16 , C07D333/20 , C12N9/04 , C12N15/53 , C12N15/63 , C12P7/04
CPC分类号： C07D333/16
摘要： The invention relates to enzymatic and non-enzymatic methods for the production of 3-methylamino-1-(thiene-2-yl)-propane-1-ol; in addition to enzymes for carrying out said method; nucleic acid sequences coding for said enzymes, expression cassettes containing them, vectors and recombinant hosts.
摘要翻译：本发明涉及酶和非酶方法对3-甲基氨基-1-（噻吩-2-基）丙-1-醇的制备; 和酶用于实施这些方法。用于编码包含这些表达盒，载体和重组宿主核酸序列的这些酶。

6. 发明申请

WO2005108590A3 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOLS FROM ALKANONES USING A DEHYDROGENASE OF AZOARCUS 审中-公开
标题翻译：工艺生产光学活性醇：TK脱氢酶固氮弓的烷ONES
公开(公告)号：WO2005108590A3
公开(公告)日：2006-04-06
申请号：PCT/EP2005004872
申请日：2005-05-04
申请人： BASF AG , STUERMER RAINER , KESSELER MARIA , HAUER BERNHARD , FRIEDRICH THOMAS , BREUER MICHAEL , SCHROEDER HARTWIG
发明人： STUERMER RAINER , KESSELER MARIA , HAUER BERNHARD , FRIEDRICH THOMAS , BREUER MICHAEL , SCHROEDER HARTWIG
IPC分类号： C12P7/02 , C07D333/16 , C12N9/04 , C12P20060101 , C12P13/00 , C12P17/00
CPC分类号： C07D333/22 , C07D333/16 , C12P17/00
摘要： The invention relates to a method for producing the optically active alkanols of formula (I), wherein n is an integer of from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, carbocylic or heterocyclic ring, and R
摘要翻译：一种用于制备式（I）其中n是从0至5的整数的光学活性链烷醇过程; Cyc为任选取代的单核或多核的，饱和或不饱和的，碳环或杂环，且R

7. 发明申请

WO0218560A2 BUTINOL I ESTERASE 审中-公开
标题翻译：丁炔醇酯酶我
公开(公告)号：WO0218560A2
公开(公告)日：2002-03-07
申请号：PCT/EP0110040
申请日：2001-08-30
申请人： BASF AG , HAUER BERNHARD , FRIEDRICH THOMAS , NUEBLING CHRISTOPH , STUERMER RAINER
发明人： HAUER BERNHARD , FRIEDRICH THOMAS , NUEBLING CHRISTOPH , STUERMER RAINER
IPC分类号： C12N15/09 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/16 , C12N9/18 , C12N15/55 , C12P7/62 , C12P41/00
CPC分类号： C12N9/16 , C12P41/00
摘要： The invention relates to novel proteins exhibiting esterase activity, in particular butinol I esterase activity, obtained from Pseudomonas glumae and to nucleic acid sequences that code therefor, expression cassettes, vectors and recombinant microorganisms. The invention also relates to a method for producing said proteins and to the use thereof for the enzymatic, in particular, enantioselective ester hydrolysis or interesterification of organic esters.
摘要翻译：本发明涉及具有酯酶活性的新颖的蛋白，特别是丁炔醇我酯酶活性，来自假单胞菌glumae，核酸编码序列，表达盒，载体和重组微生物; 一种用于生产这些蛋白质的以及它们用于酶的使用，映体选择性酶酯水解或酯交换特别是有机酯的方法。

8. 发明申请

WO2011009849A3 METHOD FOR PREPARING OPTICALLY ACTIVE HYDROXY ACID ESTERS 审中-公开
标题翻译：制备光学活性羟酸酯的方法
公开(公告)号：WO2011009849A3
公开(公告)日：2011-04-07
申请号：PCT/EP2010060458
申请日：2010-07-20
申请人： BASF SE , MAX PLANCK GESELLSCHAFT , STUERMER RAINER , SCHNEIDER NINA , BOY MATTHIAS , ACHATZ BRIGITTE , RABUS RALF , HEIDER JOHANN
发明人： STUERMER RAINER , SCHNEIDER NINA , BOY MATTHIAS , ACHATZ BRIGITTE , RABUS RALF , HEIDER JOHANN
IPC分类号： C12P7/62 , C12N9/04 , C12P7/64
CPC分类号： C12P7/62 , C12N9/0008 , C12P7/6436
摘要： The invention relates to a method for preparing optically active 2-hydroxy acid ester derivatives of the formula R1-C(OH)-C(O)-O-R2 (I),comprising the bringing into contact of 2-oxo acid ester derivatives of the formula R1-C(O)-C(O)-O-R2 (II) with an enzyme (E) selected from the class of dehydrogenases, in the presence of reduction equivalents, where the compound of the formula (II) is enzymatically reduced to the compound of the formula (I), and the reduction equivalents consumed in the course of the reaction are regenerated again by converting a reducing agent (RA) to the corresponding oxidation product (OP) with the help of the enzyme (E). The invention further comprises a dehydrogenase which reduces 2-oxo acid esters in the presence of reduction equivalents to the corresponding S- 2-hydroxy acid esters, and also a nucleic acid encoding the dehydrogenase.
摘要翻译：本发明涉及制备式R 1 -C（OH）-C（O）-O-R 2（I）的光学活性2-羟基酸酯衍生物的方法，包括使2-氧代酸酯衍生物在式（II）化合物的存在下，式R 1 -C（O）-C（O）-O-R 2（II））与选自脱氢酶类的酶（E）被酶还原成式（I）的化合物，并且在反应过程中消耗的还原等价物通过在酶的帮助下将还原剂（RA）转化成相应的氧化产物（OP）再次再生（ E）。本发明还包括在相应的S- 2-羟基酸酯的还原当量存在下还原2-氧代酸酯的脱氢酶，以及编码脱氢酶的核酸。

9. 发明申请

WO0005354A2 ENZYME-CONTAINING POLYMERS 审中-公开
标题翻译：有机聚合物
公开(公告)号：WO0005354A2
公开(公告)日：2000-02-03
申请号：PCT/EP9904590
申请日：1999-07-02
申请人： BASF AG , STUERMER RAINER
发明人： STUERMER RAINER
IPC分类号： C12N9/96 , C08G18/83 , C12N11/08 , C12P41/00 , C12N11/00
CPC分类号： C12N11/08
摘要： The present invention relates to novel enzyme-containing polymers, having at least one of the following structural elements (1 and 2), wherein the abbreviations and symbols have the following meaning: E stands for enzyme; X , X independently represent oxygen, sulfur or NH from a functional group of the enzyme; Q represents hydrogen or group (a); A , A , A , A independently represent oxygen or sulfur; p is 0 or 1 with the proviso that A , A , A and A represent oxygen when p = 0; w is 1-4; q is 1-4; v is 1-100; R represents an optionally substituted or functionalized hydrocarbon group with two to five bonds; R represents an optionally substituted or functionalized hydrocarbon group with two to five bonds; R and R independently represent hydrogen, a C1-C4-alkyl, aryl or alkylaryl group. The invention further relates to a method for the production of said enzyme-containing polymers, their utilization as catalysts in chemical reactions and their use for separating enantiomer mixtures.
摘要翻译：本发明涉及含有所述结构元件中的至少一个新颖的含酶的聚合物（1或2）其中的缩写和符号的含义如下：E：酶X <1>中，X <2>：独立地为氧，硫或NH从该酶的官能团Q：氢或基团（a），A 1，A 2，A 3，A 4：独立地为氧或硫，p：0或1，与当p = 0时，提供A 1，A 2，A 3，A 4氧，w：1-4，q：1-4，v：1-100，R 1：2至5元任选取代或官能化的烃基，R 2：2至5元任选取代或官能化的烃基，R 4和R 5独立地为彼此氢，C1-C4烷基，芳基或烷芳基。此外，本发明涉及一种用于制备含酶的聚合物，含酶的聚合物作为化学反应的催化剂和用于对映体混合物的分离中使用的含酶的聚合物的应用。

10. 发明申请

WO2007036501A3 GRAFT COPOLYMER AND USE OF THE SAME 审中-公开
标题翻译：接枝共聚物和它们的使用
公开(公告)号：WO2007036501A3
公开(公告)日：2007-06-14
申请号：PCT/EP2006066674
申请日：2006-09-25
申请人： BASF AG , FRIEDRICH THOMAS , SCHAEDLER ANDREAS , STUERMER RAINER
发明人： FRIEDRICH THOMAS , SCHAEDLER ANDREAS , STUERMER RAINER
IPC分类号： C08F291/00 , C08F265/00 , C08L51/00 , C09D151/00 , C09J151/00
CPC分类号： C08F265/00 , C08F265/04 , C08F291/00 , C08L51/003 , C08L2666/02 , C09D151/003 , C09J151/003
摘要： The invention relates to a graft copolymer, the use thereof, and a method for the bonding or coating of surfaces.
摘要翻译：本发明涉及一种接枝共聚物，它的使用和用于接合或涂层的表面的方法。

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