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1. 发明申请

WO2006094945A3 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOLS BY MEANS OF ENZYMATIC REDUCTION 审中-公开
标题翻译：工艺生产光学活性醇BY酶还原
公开(公告)号：WO2006094945A3
公开(公告)日：2007-03-15
申请号：PCT/EP2006060452
申请日：2006-03-03
申请人： BASF AG , STUERMER RAINER , DAEUWEL JUERGEN , KESSELER MARIA , ACHATZ BRIGITTE , BREUER MICHAEL
发明人： STUERMER RAINER , DAEUWEL JUERGEN , KESSELER MARIA , ACHATZ BRIGITTE , BREUER MICHAEL
IPC分类号： C12P17/00 , C07C27/00 , C07D333/16 , C12P7/02 , C12P7/04
CPC分类号： C12P7/02 , C07D333/16 , C12P17/00 , C12P41/002
摘要： The invention concerns a method for producing optically active alcohols of formula (I) by means of enzymatic reduction of the corresponding ketones, in particular, the production of (1S)-3-methylamino-1-(2-thienyl)-propane-1-ol and (1S)-3-chlorine-1-(2-thienyl)-propane-1-ol.
摘要翻译：一种用于制备式（I）通过酶促还原相应的酮的旋光活性的链烷醇，特别是（1S）的制备-3-甲基氨基-1-（2-噻吩基）丙-1-醇和过程（1S） -3-氯-1-（2-噻吩基）丙-1-醇。

2. 发明申请

WO2005033094A3 METHODS FOR THE PRODUCTION OF 3-METHYLAMINO-1-(THIENE-2-YL)-PROPANE-1-OL 审中-公开
标题翻译： PROCESS FOR 3-甲基氨基-1-（噻吩-2-基）丙-1-醇的制备
公开(公告)号：WO2005033094A3
公开(公告)日：2005-11-24
申请号：PCT/EP2004010939
申请日：2004-09-30
申请人： BASF AG , STUERMER RAINER , KESSELER MARIA , HAUER BERNHARD , FRIEDRICH THOMAS , BREUER MICHAEL
发明人： STUERMER RAINER , KESSELER MARIA , HAUER BERNHARD , FRIEDRICH THOMAS , BREUER MICHAEL
IPC分类号： C07D333/16 , C07D333/20 , C12N9/04 , C12N15/53 , C12N15/63 , C12P7/04
CPC分类号： C07D333/16
摘要： The invention relates to enzymatic and non-enzymatic methods for the production of 3-methylamino-1-(thiene-2-yl)-propane-1-ol; in addition to enzymes for carrying out said method; nucleic acid sequences coding for said enzymes, expression cassettes containing them, vectors and recombinant hosts.
摘要翻译：本发明涉及酶和非酶方法对3-甲基氨基-1-（噻吩-2-基）丙-1-醇的制备; 和酶用于实施这些方法。用于编码包含这些表达盒，载体和重组宿主核酸序列的这些酶。

3. 发明申请

WO2005108590A3 METHOD FOR PRODUCING OPTICALLY ACTIVE ALCOHOLS FROM ALKANONES USING A DEHYDROGENASE OF AZOARCUS 审中-公开
标题翻译：工艺生产光学活性醇：TK脱氢酶固氮弓的烷ONES
公开(公告)号：WO2005108590A3
公开(公告)日：2006-04-06
申请号：PCT/EP2005004872
申请日：2005-05-04
申请人： BASF AG , STUERMER RAINER , KESSELER MARIA , HAUER BERNHARD , FRIEDRICH THOMAS , BREUER MICHAEL , SCHROEDER HARTWIG
发明人： STUERMER RAINER , KESSELER MARIA , HAUER BERNHARD , FRIEDRICH THOMAS , BREUER MICHAEL , SCHROEDER HARTWIG
IPC分类号： C12P7/02 , C07D333/16 , C12N9/04 , C12P20060101 , C12P13/00 , C12P17/00
CPC分类号： C07D333/22 , C07D333/16 , C12P17/00
摘要： The invention relates to a method for producing the optically active alkanols of formula (I), wherein n is an integer of from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, carbocylic or heterocyclic ring, and R
摘要翻译：一种用于制备式（I）其中n是从0至5的整数的光学活性链烷醇过程; Cyc为任选取代的单核或多核的，饱和或不饱和的，碳环或杂环，且R

4. 发明申请

WO2011009849A3 METHOD FOR PREPARING OPTICALLY ACTIVE HYDROXY ACID ESTERS 审中-公开
标题翻译：制备光学活性羟酸酯的方法
公开(公告)号：WO2011009849A3
公开(公告)日：2011-04-07
申请号：PCT/EP2010060458
申请日：2010-07-20
申请人： BASF SE , MAX PLANCK GESELLSCHAFT , STUERMER RAINER , SCHNEIDER NINA , BOY MATTHIAS , ACHATZ BRIGITTE , RABUS RALF , HEIDER JOHANN
发明人： STUERMER RAINER , SCHNEIDER NINA , BOY MATTHIAS , ACHATZ BRIGITTE , RABUS RALF , HEIDER JOHANN
IPC分类号： C12P7/62 , C12N9/04 , C12P7/64
CPC分类号： C12P7/62 , C12N9/0008 , C12P7/6436
摘要： The invention relates to a method for preparing optically active 2-hydroxy acid ester derivatives of the formula R1-C(OH)-C(O)-O-R2 (I),comprising the bringing into contact of 2-oxo acid ester derivatives of the formula R1-C(O)-C(O)-O-R2 (II) with an enzyme (E) selected from the class of dehydrogenases, in the presence of reduction equivalents, where the compound of the formula (II) is enzymatically reduced to the compound of the formula (I), and the reduction equivalents consumed in the course of the reaction are regenerated again by converting a reducing agent (RA) to the corresponding oxidation product (OP) with the help of the enzyme (E). The invention further comprises a dehydrogenase which reduces 2-oxo acid esters in the presence of reduction equivalents to the corresponding S- 2-hydroxy acid esters, and also a nucleic acid encoding the dehydrogenase.
摘要翻译：本发明涉及制备式R 1 -C（OH）-C（O）-O-R 2（I）的光学活性2-羟基酸酯衍生物的方法，包括使2-氧代酸酯衍生物在式（II）化合物的存在下，式R 1 -C（O）-C（O）-O-R 2（II））与选自脱氢酶类的酶（E）被酶还原成式（I）的化合物，并且在反应过程中消耗的还原等价物通过在酶的帮助下将还原剂（RA）转化成相应的氧化产物（OP）再次再生（ E）。本发明还包括在相应的S- 2-羟基酸酯的还原当量存在下还原2-氧代酸酯的脱氢酶，以及编码脱氢酶的核酸。

5. 发明申请

WO2010130608A2 METHOD FOR PRODUCING (METH)ACRYLIC ACID ESTERS CONTAINING URETHANE GROUPS 审中-公开
标题翻译：用于生产聚氨酯（甲基）丙烯酸酯
公开(公告)号：WO2010130608A2
公开(公告)日：2010-11-18
申请号：PCT/EP2010056079
申请日：2010-05-05
申请人： BASF SE , STUERMER RAINER , DREW DEJANA , HAUER BERNHARD , DAEUWEL JUERGEN , MEISENBURG UWE
发明人： STUERMER RAINER , DREW DEJANA , HAUER BERNHARD , DAEUWEL JUERGEN , MEISENBURG UWE
IPC分类号： C12P7/62
CPC分类号： C12P13/02 , C12P7/62
摘要： Method for producing (meth)acrylic acid esters (U) containing urethane groups by reacting an alcohol (A) containing urethane groups with a (meth)acrylic acid ester of a saturated alcohol (G) in the presence of at least one polymerization inhibitor (P) having an enzyme (E) as a catalyst in a reactor, wherein a) the released saturated alcohol and the optionally used entrainer form an azeotrope with the excess corresponding (meth)acrylic acid ester (G), the azeotrope is separated by distillation at reduced pressure, and b) at least one partial flow from the sump of the reactor is recirculated via the head of the distillation column.
摘要翻译：一种用于通过在反应器中的催化剂的含氨基甲酸酯基的醇（A），其具有在至少一种阻聚剂（P）的存在下的饱和醇（G）的（甲基）丙烯酸酯用一种酶（E）反应来制备含氨基甲酸酯（甲基）丙烯酸酯（U）过程其中a）所释放的饱和醇和夹带剂，如果使用的话，与过量的相应的（甲基）丙烯酸酯（G）形成Azoetrop，共沸物通过蒸馏在减压下除去，并从反应器的底部通过所述头部b）至少一个部分流蒸馏塔再循环。

6. 发明申请

WO0005354A2 ENZYME-CONTAINING POLYMERS 审中-公开
标题翻译：有机聚合物
公开(公告)号：WO0005354A2
公开(公告)日：2000-02-03
申请号：PCT/EP9904590
申请日：1999-07-02
申请人： BASF AG , STUERMER RAINER
发明人： STUERMER RAINER
IPC分类号： C12N9/96 , C08G18/83 , C12N11/08 , C12P41/00 , C12N11/00
CPC分类号： C12N11/08
摘要： The present invention relates to novel enzyme-containing polymers, having at least one of the following structural elements (1 and 2), wherein the abbreviations and symbols have the following meaning: E stands for enzyme; X , X independently represent oxygen, sulfur or NH from a functional group of the enzyme; Q represents hydrogen or group (a); A , A , A , A independently represent oxygen or sulfur; p is 0 or 1 with the proviso that A , A , A and A represent oxygen when p = 0; w is 1-4; q is 1-4; v is 1-100; R represents an optionally substituted or functionalized hydrocarbon group with two to five bonds; R represents an optionally substituted or functionalized hydrocarbon group with two to five bonds; R and R independently represent hydrogen, a C1-C4-alkyl, aryl or alkylaryl group. The invention further relates to a method for the production of said enzyme-containing polymers, their utilization as catalysts in chemical reactions and their use for separating enantiomer mixtures.
摘要翻译：本发明涉及含有所述结构元件中的至少一个新颖的含酶的聚合物（1或2）其中的缩写和符号的含义如下：E：酶X <1>中，X <2>：独立地为氧，硫或NH从该酶的官能团Q：氢或基团（a），A 1，A 2，A 3，A 4：独立地为氧或硫，p：0或1，与当p = 0时，提供A 1，A 2，A 3，A 4氧，w：1-4，q：1-4，v：1-100，R 1：2至5元任选取代或官能化的烃基，R 2：2至5元任选取代或官能化的烃基，R 4和R 5独立地为彼此氢，C1-C4烷基，芳基或烷芳基。此外，本发明涉及一种用于制备含酶的聚合物，含酶的聚合物作为化学反应的催化剂和用于对映体混合物的分离中使用的含酶的聚合物的应用。

7. 发明申请

WO2007036501A3 GRAFT COPOLYMER AND USE OF THE SAME 审中-公开
标题翻译：接枝共聚物和它们的使用
公开(公告)号：WO2007036501A3
公开(公告)日：2007-06-14
申请号：PCT/EP2006066674
申请日：2006-09-25
申请人： BASF AG , FRIEDRICH THOMAS , SCHAEDLER ANDREAS , STUERMER RAINER
发明人： FRIEDRICH THOMAS , SCHAEDLER ANDREAS , STUERMER RAINER
IPC分类号： C08F291/00 , C08F265/00 , C08L51/00 , C09D151/00 , C09J151/00
CPC分类号： C08F265/00 , C08F265/04 , C08F291/00 , C08L51/003 , C08L2666/02 , C09D151/003 , C09J151/003
摘要： The invention relates to a graft copolymer, the use thereof, and a method for the bonding or coating of surfaces.
摘要翻译：本发明涉及一种接枝共聚物，它的使用和用于接合或涂层的表面的方法。

8. 发明申请

WO9816564A2 CATALYTIC PATTERNS CONTAINING METAL COMPLEXES WITH AN ADAMANTANE-LIKE STRUCTURE 审中-公开
标题翻译：催化剂体系包含金属配合物的ADAMANTANÄHNLICHER结构
公开(公告)号：WO9816564A2
公开(公告)日：1998-04-23
申请号：PCT/EP9705201
申请日：1997-09-23
申请人： BASF AG , GEPRAEGS MICHAEL , STUERMER RAINER , WEISS HORST , STEIGER SUSANNE
发明人： GEPRAEGS MICHAEL , STUERMER RAINER , WEISS HORST , STEIGER SUSANNE
IPC分类号： B01J31/22 , C08F4/602 , C08F4/642 , C08F4/645 , C08F10/00 , C08F12/00 , C08F12/04 , C08F210/02
CPC分类号： C08F10/00 , C08F12/08 , C08F210/02 , C08F4/64072 , C08F212/08
摘要： The present invention relates to catalytic patterns, the active components of which are A) metal complexes of general formula (I), in which the substituents have the following notation: M is a metal of the subgroup III, IV, V or VI in the periodic table of the elements or a metal of the lanthanide series; Y is a negative nucleofuge atom or a negative leaving group; X and X are neutral atoms or negatively loaded atoms from the main group IV, V or VI in the periodic table of the elements; Z is hydrogen, C1- to C10-alkyl, C3- to C10-cycloalkyl, C1- to C10-alkoxy, C1- to C10-alkylthiolat or dialkylamide with, in each case, 1 to 4 C-atoms in the alkyl residues; R to R are hydrogen, organocarbon or organosilicon residues, n is 0, 1 or 2, the valence of M is (2+n), and B) a metallocenium-ionizing compound.
摘要翻译：包含作为活性成分A）（I）通式的金属配合物，其中取代基具有以下含义的催化剂体系：M是金属，V或III的VI，IV ... 元素或镧系的金属的周期表的子组; Y是负离去原子或负离去基团; X和X <1>为IV的带负电荷的或中性原子。，V。和VI。元素的周期表主族; Z是氢，C1-C10烷基，C3至C10环烷基，C1至C10烷氧基，C1至C10烷基硫醇或烷基，R <1>至R <1至4个碳原子的二烷基酰胺具有 11>氢，碳 - 有机或有机硅基团，n为0，1或2，M（2 + n）和B）形成茂金属离子的化合物的化合价。

9. 发明申请

WO2006034812A3 METHOD FOR PRODUCING AN OPTICALLY ACTIVE 2-METHYL-ALKANE-1-OL FROM THE CORRESPONDING 2-METHYLALK-2-EN-1-AL, COMPRISING CARBONYL-SELECTIVE REDUCTION, ENANTIOSELECTIVE HYDRATION AND LIPASE-CATALYZED, STEREOSELECTIVE ACYLATION IN ORDER TO ENRICH THE DES 审中-公开
标题翻译：用于生产光学活性的2-甲基-1- OLS的烷从相关2- methylalk-2-CN-1-AL，包括CARBONYLSELEKTIVE REDUCTION，A对映选择性氢化以及脂肪酶催化，STEREO选择性酰化ZWEC
公开(公告)号：WO2006034812A3
公开(公告)日：2006-07-20
申请号：PCT/EP2005010240
申请日：2005-09-22
申请人： BASF AG , JAEKEL CHRISTOPH , HEYDRICH GUNNAR , STUERMER RAINER , PACIELLO ROCCO
发明人： JAEKEL CHRISTOPH , HEYDRICH GUNNAR , STUERMER RAINER , PACIELLO ROCCO
IPC分类号： C07C29/141 , C07C29/17 , C12P7/04 , C12P41/00
CPC分类号： C12P7/04 , C07B2200/07 , C07C29/14 , C07C29/141 , C07C29/172 , C12C11/02 , C07C33/025 , C07C31/125
摘要： The invention relates to a method for producing optically active 2-methylalkane-1-ol of general formula (III), comprising the following steps: (i) carbonyl-selective reduction of 2-methylalk-2-en-1-al of general formula (I) to 2-methylalk-2-en-1-ol of general formula (II), (ii) enantioselective hydration of 2-methylalk-2-en-1-ol to give the compound of general formula (III), (iii) increasing the optical yield of the optically active 2-methylalkane-1-ol (III) obtained in step (ii) by way of a lipase-catalyzed acylation reaction, whereby R represents C 1 -C 10 alkyl.
摘要翻译：一种制备光学活性的2-甲基的通式（III）的烷-1-醇，其包括以下步骤：（ⅰ）carbonylselektive还原的2- methylalk -2-烯-1-醛的通式（I）的2- methylalk -2-烯-1-醇，通式（II），（II）通式（III）的2- methylalk -2-烯-1-醇的对映选择性氢化的，（iii）增加的步骤的光学收率（ii）所述得到的光学活性2-甲基烷烃-1-醇（III）由脂肪酶催化酰化反应（式I - IV），其中R表示C _{1 -C _{10 具有烷基。}}

10. 发明申请

WO2006015727A3 METHOD FOR ENANTIOSELECTIVELY OPENING 3-SUBSTITUTED OXETAN-2-ONES UNDER THE ACTION OF LIPASES OF CANDIDA ANTARCTICA OR BURKHOLDERIA PLANTARRII 审中-公开
标题翻译：脂肪酶南极洲念珠菌OR伯克霍尔德氏菌的影响下的3-取代氧杂环丁烷-2-酮类方法对映选择性OPENING
公开(公告)号：WO2006015727A3
公开(公告)日：2006-07-13
申请号：PCT/EP2005008190
申请日：2005-07-28
申请人： BASF AG , HABICHER TILO , STUERMER RAINER
发明人： HABICHER TILO , STUERMER RAINER
IPC分类号： C12P7/24 , C12P7/40 , C12P7/62 , C12P17/02 , C12P41/00
CPC分类号： C12P41/001 , C12P7/24 , C12P7/40 , C12P7/62 , C12P17/02 , C12P41/003
摘要： The invention relates to a method for producing, in essence, enantiomer-pure 3-hydroxycarboxylic acids or esters of general formula (III) by reacting racemic oxetan-2-ones of general formula (I) with compounds R3-OH of general formula (II) in the presence of a lipase from Candida antarctica or Burkholderia plantarii, and separating the obtained products of formula (III) and (IV) from one another, and the radicals have the following meanings: R 1 , R 2 and R 3 , independent of one another, represent H, C 1 -C 10 -substituted or unsubstituted alkyl, and substituted or unsubstituted aryl or hetaryl, whereby R 1 and R 2 cannot have the same meaning at the same time.
摘要翻译：一种用于基本制备方法由通式（I）的化合物中，R通式3 -OH的外消旋氧杂环丁烷-2-酮反应，对映体纯的3-羟基羧酸或通式（III）的酯（II）中的脂肪酶的来自存在南极假丝酵母或植物伯克霍尔德氏菌）式的（）中的产品III和反应（IV）中获得中隔离，其中，所述基团具有以下含义：R t ^{1 ，R ^{2 ，R ^{3 独立地表示H; ç_{1 -C _{10 - 取代或未取代的烷基，取代或未取代的芳基或杂芳基，其中R ^{1 和R ^{2 可能没有在同一时间相同的含义。}}}}}}}

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