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1. 发明申请

WO2021122687A1 INCREASING SPACE-TIME-YIELD, CARBON-CONVERSION-EFFICIENCY AND CARBON SUBSTRATE FLEXIBILITY IN THE PRODUCTION OF FINE CHEMICALS 审中-公开
公开(公告)号：WO2021122687A1
公开(公告)日：2021-06-24
申请号：PCT/EP2020/086342
申请日：2020-12-16
申请人： BASF SE
发明人： SCHROEDER, Hartwig , HAILER, Anne-Catrin , HOFF, Birgit , ZELDER, Oskar , OEDMAN, Peter , WANDREY, Georg, Bejamin , DIETZSCH, Christian , KUMAR, Mukesh , SATORY, Dominik , BLANKSCHIEN, Matthew, David , PLASSMEIER, Jens, Klaus
IPC分类号： C12P19/00 , C12N9/88 , C12Y406/01001
摘要： Increasing space-time-yield, carbon-conversion-efficiency and carbon substrate flexibility in the production of fine chemicals The inventors of the current invention have found a surprising positive effect of increased cAMP levels and / or manipulating the PTS system on the space-time-yield, carbon-conversion-efficiency and carbon substrate flexibility of fine chemical production of a host organism. This was achieved by de-regulating adenylate cyclase cyaa by deleting the C-terminal regulatory region leading to increased cAMP levels or deleting the Crr protein activity (carbohydrate repression resistance) which regulates the carbohydate utilization system. Both lead to increased 2-fucosyllactoe and 6-sialyllactose production (human milk oligosaccharides) and increase carbohydrate usage.

2. 发明申请

WO2017167623A1 FERMENTATIVE PRODUCTION OF N-BUTYLACRYLATE USING ALCOHOL ACYL TRANSFERASE ENZYMES 审中-公开
标题翻译：用乙醇酰胺转移酶发酵生产N-丁基丙烯酸酯
公开(公告)号：WO2017167623A1
公开(公告)日：2017-10-05
申请号：PCT/EP2017/056872
申请日：2017-03-22
申请人： BASF SE
发明人： SAUM, Stephan , KIM, Woncheol , ZELDER, Oskar , JAITZIG, Jennifer , GUO, Zheyuan
IPC分类号： C12N9/10 , C12P7/62 , C08F220/18
摘要： The invention is directed to a recombinant nucleic acid molecule, a recombinant microorganism and to a method for fermentative production of n-butylacrylate and other esters from alcohols and acyl-CoA units using alcohol acyl transferase enzymes.
摘要翻译：本发明涉及重组核酸分子，重组微生物以及使用醇酰基转移酶从醇和酰基-CoA单元发酵产生丙烯酸正丁酯和其它酯的方法。 / p>

3. 发明申请

WO2015169920A1 GENETICALLY MODIFIED MICROORGANISM FOR IMPROVED PRODUCTION OF FINE CHEMICALS ON SUCROSE 审中-公开
标题翻译：用于改善生产精细化学品的遗传改良微生物
公开(公告)号：WO2015169920A1
公开(公告)日：2015-11-12
申请号：PCT/EP2015/060102
申请日：2015-05-07
申请人： BASF SE
发明人： KRAWCZYK, Joanna Martyna , HAEFNER, Stefan , SCHROEDER, Hartwig , ZELDER, Oskar
IPC分类号： C12P7/46 , C12R1/01 , C12N9/12
CPC分类号： C12N15/102 , C07K14/195 , C12N15/74 , C12N2510/02 , C12P7/46 , C12Y207/11
摘要： The present invention relates to a modified microorganism having, compared to its wildtype, -a reduced activity of an enzyme encoded by the ptsA -gene, -a reduced activity of an enzyme encoded by the ptsH -gene or -a reduced activity of an enzyme encoded by the ptsA -gene and a reduced activity of an enzyme encoded by the ptsH -gene, wherein the wildtype from which the modified microorganism has been derived belongs to the family of Pasteurellaceae . The present invention also relates to a method for producing succinic acid and to the use of modified microorganisms.
摘要翻译：本发明涉及一种修饰的微生物，其与野生型相比具有降低的由ptsA基因编码的酶的活性， - 由ptsH基因编码的酶的活性降低或 - 酶活性降低由ptsA基因编码并且由ptsH基因编码的酶的活性降低，其中已经衍生了经修饰的微生物的野生型属于巴氏杆菌科。本发明还涉及生产琥珀酸的方法和使用改性微生物。

4. 发明申请

WO2015169919A1 IMPROVED MICROORGANISM FOR SUCCINIC ACID PRODUCTION 审中-公开
标题翻译：改进的生物酸生产微生物
公开(公告)号：WO2015169919A1
公开(公告)日：2015-11-12
申请号：PCT/EP2015/060100
申请日：2015-05-07
申请人： BASF SE
发明人： KRAWCZYK, Joanna Martyna , HAEFNER, Stefan , SCHRÖDER, Hartwig , DANTAS COSTA, Esther , ZELDER, Oskar , VON ABENDROTH, Gregory , WITTMANN, Christoph , STELLMACHER, René , BECKER, Judith
IPC分类号： C12P7/46 , C12R1/01
CPC分类号： C12N15/102 , C07K14/195 , C12N15/74 , C12N2510/02 , C12P7/46 , C12Y207/11
摘要： The present invention relates to a modified microorganism. The present invention also relates to a method for producing an organic compount and to the use of modified microorganisms.
摘要翻译：本发明涉及一种修饰微生物。本发明还涉及一种生产有机化合物的方法和使用改性微生物。

5. 发明申请

WO2015135980A1 THE USE OF POLYMERS TO IMPROVE THE RHEOLOGY OF BASE SUSPENSIONS DURING FERMENTATION 审中-公开
标题翻译：聚合物在发酵过程中改善基础悬浮液的流变学的应用
公开(公告)号：WO2015135980A1
公开(公告)日：2015-09-17
申请号：PCT/EP2015/055052
申请日：2015-03-11
申请人： BASF SE
发明人： FRAMBACH, Klaus , DANTAS COSTA, Esther , ZELDER, Oskar , SCHRÖDER, Hartwig , HAEFNER, Stefan , KRAWCZYK, Joanna Martyna , RIEDELE, Christian
IPC分类号： C12P7/40 , C08K5/00
CPC分类号： C12P7/40
摘要： The present invention relates to a process for producing an organic acid by fermentation, comprising the process steps: I) cultivating microorganisms in a culture medium comprising at least one assimilable carbon source to allow the microorganisms to produce the organic acid, thereby ob-taining a fermentation broth comprising the organic acid, wherein the pH of the fer-mentation broth is controlled to be within a range from 3 to 8 by the addition of a basic compoud; II) recovering the organic acid or the salt thereof from the fermentation broth obtained in process step I); wherein in process step I) the basic compound is added in the form an aqueous suspension comprising a) water, b) the basic compound, and c) a polymeric plasticizer The present invention also relates to the use of organic polymers as a polymeric plasticizer inthe fermentative production of an organic acid.
摘要翻译：本发明涉及通过发酵生产有机酸的方法，包括以下步骤：I）在包含至少一种可同化碳源的培养基中培养微生物，以使微生物产生有机酸，从而获得含有有机酸的发酵液，其中通过添加碱性肥料将发酵液的pH控制在3至8的范围内; II）从方法步骤I）中获得的发酵液中回收有机酸或其盐; 其中在方法步骤I）中，碱性化合物以包含a）水，b）碱性化合物和c）聚合物增塑剂的水性悬浮液的形式加入本发明还涉及有机聚合物作为聚合物增塑剂的用途发酵生产有机酸。

6. 发明申请

WO2015092576A1 IMPROVED PROCESS FOR THE PRODUCTION OF GAMMA-AMINOBUTYRIC ACID (GABA) 审中-公开
标题翻译：改善γ-氨基丁酸（GABA）的生产方法
公开(公告)号：WO2015092576A1
公开(公告)日：2015-06-25
申请号：PCT/IB2014/066288
申请日：2014-11-24
申请人： BASF SE , BASF (CHINA) COMPANY LIMITED
发明人： ZELDER, Oskar , HAEFNER, Stefan , SCHRÖDER, Hartwig , THUMMER, Robert , JEONG, Weol Kyu , RADDATZ, Aline , SCHEIN-ALBRECHT, Karin , HYUN, Hyung-Hwan
IPC分类号： C12N9/88 , C12N15/60 , C12N15/52 , C12P13/00
CPC分类号： C12Y401/01015 , C12N9/1096 , C12N9/88 , C12P13/005 , C12Y206/01019
摘要： The present invention provides an improved method for the fermentative production of gamma-aminobutyric acid (GABA) by cultivating a recombinant microorganism expressing an enzyme having a glutamate decarboxylase activity, wherein the recombinant microorganism has an amended expression of certain enzymes influencing the GABA production and/or yield. The present invention also provides corresponding recombinant cells and methods for preparing polyamides, pyrrolidone and vinylpyrrolidone making use of GABA as obtained fermentative production.
摘要翻译：本发明提供了一种通过培养表达具有谷氨酸脱羧酶活性的酶的重组微生物发酵生产γ-氨基丁酸（GABA）的改进方法，其中重组微生物具有影响GABA产生的某些酶的修饰表达和/ 或产量。本发明还提供相应的重组细胞和制备使用GABA作为获得的发酵生产的聚酰胺，吡咯烷酮和乙烯基吡咯烷酮的方法。

7. 发明申请

WO2014080316A1 GENE CLUSTER FOR BIOSYNTHESIS OF CORNEXISTIN AND HYDROXYCORNEXISTIN 审中-公开
标题翻译：金丝桃素和羟基喹诺酮的生物合成基因组
公开(公告)号：WO2014080316A1
公开(公告)日：2014-05-30
申请号：PCT/IB2013/060093
申请日：2013-11-13
申请人： BASF SE , BASF (CHINA) COMPANY LIMITED
发明人： ZELDER, Oskar , HOFF, Birgit , SCHRöDER, Hartwig , MOLT, Andrea , HARTMANN, Holger , DITRICH, Klaus , BREUER, Michael , REINGRUBER, Rüdiger , WEBER, Jakob
IPC分类号： C12N15/11 , C12N15/63 , C12N15/67 , A01N37/00 , C07D307/77 , C07D62/00
CPC分类号： C12P17/04 , A01N37/42 , A01N37/46 , A01N63/04 , C07D307/93 , C07K14/37 , C12N15/52 , C12N15/67 , C12N15/80
摘要： The invention pertains to the field of production of natural products and, in particular, in the field of production of cornexistin and hydroxycornexistin. It provides polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising such polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using such polynucleotides and polpeptides encoded therein, as well as vectors and recombinant microorganisms comprising such polynucleotides and polypeptides.
摘要翻译：本发明涉及天然产物的生产领域，尤其涉及在玉米corn霉素和羟基角质素的生产领域。它提供了编码涉及Cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含这种多核苷酸的载体和重组微生物。还提供了生产天然产物的方法，特别是使用这样的多核苷酸和其中编码的多肽以及包含这种多核苷酸和多肽的载体和重组微生物来生产玉米corn霉素和羟基角质柔比星的方法。

8. 发明申请

WO2014030096A2 GENES AND PROCESSES FOR THE PRODUCTION OF CLAVINE-TYPE ALKALOIDS 审中-公开
标题翻译：用于生产CLAVINE型碱性磷酸酶的基因和方法
公开(公告)号：WO2014030096A2
公开(公告)日：2014-02-27
申请号：PCT/IB2013/056604
申请日：2013-08-13
申请人： BASF SE , EVOLVA SA , BASF (CHINA) COMPANY LIMITED
发明人： NAESBY, Michael , FOLLY, Christophe , NIELSEN, Curt Aimé Friis , HATSCH, Anaelle , SCHWAB, Markus , ZELDER, Oskar , HAEFNER, Stefan , SCHRöDER, Hartwig , HOFF, Birgit , MOLT, Andrea , DITRICH, Klaus , BREUER, Michael , HARTMANN, Holger , KöRBER, Karsten
CPC分类号： C12P17/12 , C07D209/90 , C07D487/06 , C07K16/40 , C12N9/0004 , C12N9/001 , C12N9/1007 , C12N9/1085 , C12N9/90 , C12N15/52 , C12P17/10 , C12P17/182 , C12Y205/01
摘要： The invention in principle pertains to the field of recombinant manufacture of clavine-type alkaloids such as cycloclavine, festuclavine, agroclavine, chanoclavine and chanoclavine aldehyde. It provides microorganisms and processes for the manufacture of clavine-type alkaloids as well as polypeptides, polynucleotides and vectors comprising such polynucleotides which can be applied in a method for the manufacture of clavine-type alkaloids.
摘要翻译：本发明原则上涉及重要生产诸如环圈菌素，festuclavine，agroclavine，chanoclavine和chanoclavine醛的克拉克型生物碱的领域。它提供了用于制造棒状生物碱的微生物和方法，以及包含这样的多核苷酸的多肽，多核苷酸和载体，其可以用于制造棒状生物碱的方法。

9. 发明申请

WO2009092793A3 VERFAHREN ZUR FERMENTATIVEN HERSTELLUNG VON 1,5-DIAMINOPENTAN 审中-公开
公开(公告)号：WO2009092793A3
公开(公告)日：2009-07-30
申请号：PCT/EP2009/050778
申请日：2009-01-23
申请人： BASF SE , VÖLKERT, Martin , ZELDER, Oskar , ERNST, Burkhard , JEONG, Weol Kyu
发明人： VÖLKERT, Martin , ZELDER, Oskar , ERNST, Burkhard , JEONG, Weol Kyu
IPC分类号： C12P13/00
摘要： Die vorliegende Erfindung betrifft ein Verfahren zur Isolierung von 1,5-Diaminopentan (DAP) aus DAP-haltigen Fermentationsbrühen, ein Verfahren zur fermentativen Herstellung von DAP unter Verwendung dieser Isolierungsmethode sowie ein Verfahren zur Herstellung von DAP-haltigen Polymeren unter Einsatz des in dieser Weise isolierten bzw. fermentativ hergestellten DAPs.

10. 发明申请

WO2015177674A1 GENE CLUSTER FOR BIOSYNTHESIS OF CORNEXISTIN AND HYDROXYCORNEXISTIN 审中-公开
标题翻译：金丝桃素和羟基喹诺酮的生物合成基因组
公开(公告)号：WO2015177674A1
公开(公告)日：2015-11-26
申请号：PCT/IB2015/053442
申请日：2015-05-11
申请人： BASF SE , BASF (CHINA) COMPANY LIMITED
发明人： ZELDER, Oskar , HOFF, Birgit , SCHRÖDER, Hartwig , MOLT, Andrea , HARTMANN, Holger , VOGT, Florian
IPC分类号： C12N15/63 , C12N15/67 , C12P17/04 , A01N37/00 , C12N15/11 , C12N15/80 , C07D307/77 , C12R1/79
CPC分类号： C12P17/04 , A01N37/42 , A01N37/46 , A01N63/00 , A01N63/04 , C12N15/52
摘要： Provided are polynucleotides encoding polypeptides involved in the biosynthesis of cornexistin and hydroxycornexistin as well as vectors and recombinant microorganisms comprising the polynucleotides. Also provided are methods for the production of natural products, in particular methods for the production of cornexistin and hydroxycornexistin, using said polynucleotides and polypeptides encoded therein, as well as vectors and recombinant microorganisms comprising said polynucleotides and polypeptides.
摘要翻译：提供了编码涉及cornexistin和羟基角质素的生物合成的多肽的多核苷酸以及包含多核苷酸的载体和重组微生物。还提供了使用所述多核苷酸和其中编码的多肽以及包含所述多核苷酸和多肽的载体和重组微生物来生产天然产物的方法，特别是用于生产玉米corn霉素和羟基角质柔比星的方法。

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