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1. 发明申请

WO2005083093A3 METHOD FOR PRODUCING POLYUNSATURATED FATTY ACIDS IN TRANSGENIC PLANTS 审中-公开
标题翻译： PROCESS转基因植物中多产多不饱和脂肪酸
公开(公告)号：WO2005083093A3
公开(公告)日：2006-02-16
申请号：PCT/EP2005001863
申请日：2005-02-23
申请人： BASF PLANT SCIENCE GMBH , CIRPUS PETRA , BAUER JOERG , QIU XIAO , WU GUOHAI , DATLA NAGAMANI
发明人： CIRPUS PETRA , BAUER JOERG , QIU XIAO , WU GUOHAI , DATLA NAGAMANI
IPC分类号： C11B1/02 , C12N9/02 , C12N9/10 , A01K67/027
CPC分类号： C12N15/82 , C12N15/8247
摘要： The invention relates to a method for producing polyunsaturated fatty acids in seeds of transgenic plants. According to said method, nucleic acids, coding for polypeptides with a ?-3-desaturase, ?-12-desaturase, ?-6-desaturase, ?-6-elongase, ?-5-desaturase, ?-5-elongase and/or ?-4-desaturase activity, preferably for polypeptides with a ?-6-desaturase, ?-6-elongase and ?-5-desaturase activity, are introduced into the organism. The nucleic acid sequences are represented by SEQ ID NO: 11, SEQ ID NO: 27, SEQ ID NO: 193, SEQ ID NO: 197, SEQ ID NO: 199 and SEQ ID NO: 201. Advantageously, said nucleic acid sequences can be expressed in the organism optionally together with other nucleic acid sequences that code for polypeptides of the biosynthesis of the fatty acid or lipid metabolism. Nucleic acid sequences coding for a ?-6-desaturase, ?-5-desaturase, ?-4-desaturase, ?-1 2-desaturase and/or ?-6-elongase activity are especially advantageous. Advantageously, said desaturases and elongases originate from thalassiosira, euglena or ostreococcus. The invention also relates to a method for producing oils and/or triacylglycerides with an increased content of long-chain polyunsaturated fatty acids. In a preferred embodiment, the invention also relates to a method for producing arachidonic acid, eicosapentaenic acid or docosahexaenic acid, and to a method for producing triglycerides with an increased content of unsaturated fatty acids, especially arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid, in transgenic plants, preferably in seeds of the transgenic plants. The invention further relates to the production of a transgenic plant with an increased content of polyunsaturated fatty acids, especially arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid, based on the expression of the elongases and desaturases used in the inventive method. The invention also relates to recombinant nucleic acids molecules containing, together or individually, nucleic acid sequences coding for the polypeptides with a ?-6-desaturase, ?-6-elongase, ?-5-desaturase and ?-5-elongase activity, and transgenic plants containing said recombinant nucleic acid molecules. Another part of the invention relates to oils, lipids and/or fatty acids produced according to the inventive method, and to the use thereof. Furthermore, the invention relates to unsaturated fatty acids and triglycerides with an increased content of unsaturated fatty acids, and to the use of the same.
摘要翻译：本发明涉及一种用于生产由核酸的转基因植物的种子中的多不饱和脂肪酸的方法被引入到生物体中，其与β-3去饱和酶，？-12-去饱和酶，？-6去饱和酶编码多肽，？-6-延伸,? -5去饱和酶，？-5-延伸酶和/或Δ4-去饱和酶优选的多肽具有？-6去饱和酶，？-6延伸酶和？-5- 脱氢酶活性。的核酸序列示于SEQ ID NO：11，SEQ ID NO：27，SEQ ID NO：193，SEQ ID NO：197，SEQ ID NO：199和SEQ ID NO：所示第二百○一序列有利地，这些核酸序列可以在生物体中，任选地与编码所述脂肪酸或脂质的生物合成的多肽的另外的核酸序列表达。特别有利的是编码一个？-6去饱和酶中，α-1 2去饱和酶-6-延伸-5去饱和酶，？4去饱和酶，？和/或核酸序列？有利的是，这些去饱和酶和延伸酶海链藻，裸藻或Ostreococcus。此外，本发明涉及用于生产油和/或三酰基甘油酯与长链多不饱和脂肪酸的升高的内容的处理。本发明中的优选实施例还涉及一种用于生产花生四烯酸，二十碳五烯酸或二十二碳六酸和用于生产甘油三酯的与不饱和脂肪酸含量增加的处理，特别是花生四烯酸，二十碳五烯酸和/或二十碳六烯酸的，有利的是在转基因植物中的转基因的种子植物。本发明涉及生产具有多不饱和脂肪酸，特别是花生四烯酸，二十碳五烯酸和/或二十碳六烯酸，含量增加的转基因植物由于延伸酶的表达和在本发明的去饱和酶处理中使用。本发明还涉及含有核酸序列，其的重组核酸分子编码的多肽具有？-6去饱和酶，？-6-延伸,? -5去饱和酶和β-5-延伸酶，联合或单独，以及含有上述的重组核酸分子的转基因植物。本发明的另一部分涉及通过本发明和它们的使用过程中产生的油，脂质和/或脂肪酸。本发明还涉及到的不饱和脂肪酸和甘油三酯具有不饱和脂肪酸的含量增加及其用途。

2. 发明申请

WO2007017419A3 METHOD FOR PRODUCING ARACHIDONIC ACID AND/OR EICOSAPENTAENOIC ACID IN USEFUL TRANSGENIC PLANTS 审中-公开
标题翻译：在转基因植物中生产阿拉酸和/或艾考酸的方法
公开(公告)号：WO2007017419A3
公开(公告)日：2007-05-10
申请号：PCT/EP2006064922
申请日：2006-08-01
申请人： BASF PLANT SCIENCE GMBH , CIRPUS PETRA , BAUER JOERG , QIU XIAO , WU GUOHAI , DATLA NAGAMANI , TRUKSA MARTIN
发明人： CIRPUS PETRA , BAUER JOERG , QIU XIAO , WU GUOHAI , DATLA NAGAMANI , TRUKSA MARTIN
IPC分类号： C12N15/82 , C07K14/415 , C11B1/02 , C12N9/02
CPC分类号： C12N15/8247 , A23K20/158 , A23L33/12 , A61K8/361 , A61Q19/00 , C12N9/0083 , C12N9/1029
摘要： The invention relates to a method for producing arachidonic acid and/or eicosapentaenoic acid in useful transgenic plants, according to which nucleic acids, which encode polypeptides with ?-6-desaturase activity, ?-6-elongase activity or ?-5-desaturase activity, are introduced into the plants. As an added advantage, a gene that encodes a ?-3-desaturase is expressed in the useful plants. In an additional embodiment of the method, additional nucleic acid sequences, which encode polypeptides involved in the biosynthesis of the fatty acid or lipid metabolism, can be expressed in the plants. Particularly advantageous nucleic acid sequences are those that encode ?-8-desaturase activity, ?-12-desaturase activity, ?-15-desaturase activity, ?-4-desaturase activity, ?-9-elongase activity and/or ?-5-elongase activity. The invention also relates to the use of the oils, lipids and/or fatty acids that have been produced by said method in animal feed or foodstuffs, cosmetics or pharmaceutical products.
摘要翻译：本发明涉及用于生产花生四烯酸和/或通过核酸的转基因作物植物的二十碳五烯酸的方法被引入到编码的多肽具有其中植物？-6去饱和酶，？-6-延伸酶或？-5去饱和酶活性，有利的是，编码α-3-去饱和酶的基因还在农作物中表达。在该方法的另一个有利的实施方案中，可以在植物中表达编码脂肪酸或脂质代谢的生物合成的多肽的其他核酸序列。这是编码的8去饱和酶特别有利的核酸序列 - “ - ？-9-延伸12去饱和酶，-15去饱和酶，-4-去饱和酶，和/或???? - 编码5-延伸酶活性。本发明的另一部分涉及使用的在饲料或食品，化妆品或药品中的本发明方法的油，脂质和/或脂肪酸的制造。

3. 发明申请

WO2008022963A2 ISOLATION AND CHARACTERIZATION OF A NOVEL PYTHIUM OMEGA 3 DESATURASE WITH SPECIFICITY TO ALL OMEGA 6 FATTY ACIDS LONGER THAN 18 CARBON CHAINS 审中-公开
标题翻译：一个新的磷酸三钙脱硫剂的分离和表征对所有欧米茄6脂肪酸长18个碳链具有特异性
公开(公告)号：WO2008022963A2
公开(公告)日：2008-02-28
申请号：PCT/EP2007058528
申请日：2007-08-16
申请人： BASF PLANT SCIENCE GMBH , BIORIGINAL FOOD & SCIENCE CORP , BAUER JOERG , WU GUOHAI , QIU XIAO
发明人： BAUER JOERG , WU GUOHAI , QIU XIAO
IPC分类号： C12N9/02 , A01K67/027 , C07K14/37 , C07K16/14 , C07K16/40 , C12N5/10 , C12N15/53 , C12N15/63 , C12N15/81 , C12N15/82 , C12P7/64
CPC分类号： C12P7/6472 , A61K8/64 , A61K8/922 , A61K31/202 , A61K2800/10 , A61Q19/00 , C12N9/0006 , C12N9/0083 , C12N9/0093 , C12N15/52 , C12P7/6427 , C12P7/6436
摘要： The present invention relates to a polynucleotide encoding an omega 3 (?-3) desaturase from Pythium irregulare with specificity to long chain polyunsaturated omega 6 (?- 6) fatty acids as well as a vector containing said polynucleotide, and a host cell containing the vector or the polynucleotide. Moreover, the present invention pertains to a polypeptide encoded by the said polynucleotide, antibodies against the polypeptide as well as a method for the manufacture of the polypeptide. Further, encompassed by the present invention are transgenic non-human organisms. Finally, the present invention relates to methods for the manufacture of compounds and oil- fatty acid- or lipid- containing compositions.
摘要翻译：本发明涉及编码具有对长链多不饱和ω-6（α-6）脂肪酸的特异性的不锈钢的ω3（α-3）去饱和酶的多核苷酸，以及含有所述多核苷酸的载体和含有载体或多核苷酸。此外，本发明涉及由所述多核苷酸编码的多肽，针对多肽的抗体以及制备多肽的方法。此外，本发明包括转基因非人生物体。最后，本发明涉及制备化合物和含油脂肪酸或脂质的组合物的方法。

4. 发明申请

WO2010023202A3 NUCLEIC ACIDS ENCODING DESATURASES AND MODIFIED PLANT OIL 审中-公开
标题翻译：核酸编码和改性植物油
公开(公告)号：WO2010023202A3
公开(公告)日：2010-06-24
申请号：PCT/EP2009060923
申请日：2009-08-25
申请人： BASF PLANT SCIENCE GMBH , BIORIGINAL FOOD & SCIENCE CORP , BAUER JOERG , SENGER TORALF , ZANK THORSTEN , QIU XIAO , WU GUOHAI
发明人： BAUER JOERG , SENGER TORALF , ZANK THORSTEN , QIU XIAO , WU GUOHAI
IPC分类号： C12N15/82 , C12N9/00
CPC分类号： C12N15/8247 , C12N5/14 , C12N9/00 , C12N9/0004
摘要： The present invention relates to nucleic acids derived from Drechslera tritici-repentis, Cylindorcarpon herteronema, Diploida natalensis, Stagonospora nodorum, Microdochium nivalae and Periplaneta americana. The invention also relates to the individual coding sequences and to proteins encoded by these sequences in combination with other sequences as well as to a process for converting oleic acid to linoleic acid to Iinoleic acid and the production of arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid in a plant.
摘要翻译：本发明涉及来自Drechslera tritici-repentis，Cylindorcarpon herteronema，Diploida natalensis，Stagonospora nodorum，Microdochium nivalae和Periplaneta americana的核酸。本发明还涉及个体编码序列和由这些序列与其它序列组合编码的蛋白质以及将油酸转化为亚油酸至亚油酸的方法，以及花生四烯酸，二十碳五烯酸和/或二十二碳六烯酸的生产酸在植物中。

5. 发明申请

WO2009077478A3 PROMOTERS FROM BRASSICA NAPUS FOR SEED SPECIFIC GENE EXPRESSION 审中-公开
标题翻译：来自芸苔属植物的用于种子特异性基因表达的启动子
公开(公告)号：WO2009077478A3
公开(公告)日：2009-12-10
申请号：PCT/EP2008067492
申请日：2008-12-15
申请人： BASF PLANT SCIENCE GMBH , BIORIGINAL FOOD & SCIENCE CORP , BAUER JOERG , WETJEN TOM , QIU YIAO , WU GUOHAI
发明人： BAUER JOERG , WETJEN TOM , QIU YIAO , WU GUOHAI
IPC分类号： C12N15/82
CPC分类号： C12N15/8234
摘要： The present invention is concerned with means and methods for allowing tissue specific and, in particular, seed specific expression of genes. The present invention, accordingly, relates to a polynucleotide comprising an expression control sequence which allows seed specific expression of a nucleic acid of interest being operatively linked thereto. Moreover, the present invention contemplates vectors, host cells, non-human transgenic organisms comprising the aforementioned polynucleotide as well as methods and uses of such a polynucleotide.
摘要翻译：本发明涉及用于使组织特异性，特别是基因的种子特异性表达的手段和方法。因此，本发明涉及包含表达控制序列的多核苷酸，所述表达控制序列允许目的核酸的种子特异性表达与其可操作地连接。此外，本发明考虑包含上述多核苷酸的载体，宿主细胞，非人转基因生物以及这种多核苷酸的方法和用途。

6. 发明专利

CA2659993C ISOLATION AND CHARACTERIZATION OF A NOVEL PYTHIUM OMEGA 3 DESATURASE WITH SPECIFICITY TO ALL OMEGA 6 FATTY ACIDS LONGER THAN 18 CARBON CHAINS 未知
公开(公告)号：CA2659993C
公开(公告)日：2016-01-05
申请号：CA2659993
申请日：2007-08-16
申请人： BASF PLANT SCIENCE GMBH , BIORIGINAL FOOD & SCIENCE CORP
发明人： BAUER JOERG , WU GUOHAI , QIU XIAO
IPC分类号： C12N9/02 , A01K67/027 , C07K14/37 , C07K16/14 , C07K16/40 , C12N5/10 , C12N15/53 , C12N15/63 , C12N15/81 , C12N15/82 , C12P7/64
摘要： The present invention relates to a polynucleotide encoding an omega 3 (.omega.-3) desaturase from Pythium irregulare with specificity to long chain polyunsaturated omega 6 (.omega.- 6) fatty acids as well as a vector containing said polynucleotide, and a host cell containing the vector or the polynucleotide. Moreover, the present invention pertains to a polypeptide encoded by the said polynucleotide, antibodies against the polypeptide as well as a method for the manufacture of the polypeptide. Further, encompassed by the present invention are transgenic non-human organisms. Finally, the present invention relates to methods for the manufacture of compounds and oil- fatty acid- or lipid- containing compositions.

7. 发明专利

AU2013202498A2 Isolation and characterization of a novel Pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains 未知
公开(公告)号：AU2013202498A2
公开(公告)日：2013-08-29
申请号：AU2013202498
申请日：2013-04-04
申请人： BIORIGINAL FOOD & SCIENCE CORP , BASF PLANT SCIENCE GMBH
发明人： BAUER JOERG , WU GUOHAI , QIU XIAO
IPC分类号： C12N9/02 , A01K67/027 , C07K14/37 , C07K16/14 , C07K16/40 , C12N5/10 , C12N15/53 , C12N15/63 , C12N15/81 , C12N15/82 , C12P7/64
摘要： The present invention relates to a polynucleotide encoding an omega 3 (w-3) desaturase from Pythium irregulare with specificity to long chain polyunsaturated omega 6 (w- 6) fatty acids as well as a vector containing said polynucleotide, and a host cell containing the vector or the polynucleotide. Moreover, the present invention pertains to a polypeptide encoded by the said polynucleotide, antibodies against the polypeptide as well as a method for the manufacture of the polypeptide. Further, encompassed by the present invention are transgenic non-human organisms. Finally, the present invention relates to methods for the manufacture of compounds and oil- fatty acid- or lipid- containing compositions.

9. 发明专利

AU2016200386B2 Nucleic acids encoding desaturases and modified plant oil 未知
公开(公告)号：AU2016200386B2
公开(公告)日：2017-08-17
申请号：AU2016200386
申请日：2016-01-22
申请人： BASF PLANT SCIENCE GMBH , BIORIGINAL FOOD & SCIENCE CORP
发明人： BAUER JOERG , SENGER TORALF , ZANK THORSTEN , QIU XIAO , WU GUOHAI
IPC分类号： C12N15/82 , C12N9/00
摘要： The present invention relates to nucleic acids derived from Drechslera tritici-repentis, Cylindorcarpon herteronema, Diploida natalensis, Stagonospora nodorum, 5 Microdochium nivalae and Periplaneta americana. The invention also relates to the individual coding sequences and to proteins encoded by these sequences in combination with other sequences as well as to a process for converting oleic acid to linoleic acid to linoleic acid and the production of arachidonic acid, eicosapentaenoic acid and/or docosahexaenoic acid in a plant. 7338395_1 (GHMatters) P86456.AU.1 AMANDAM

10. 发明专利

AU2013202498A1 Isolation and characterization of a novel Pythium omega 3 desaturase with specificity to all omega 6 fatty acids longer than 18 carbon chains 未知
公开(公告)号：AU2013202498A1
公开(公告)日：2013-06-13
申请号：AU2013202498
申请日：2013-04-04
申请人： BIORIGINAL FOOD & SCIENCE CORP , BASF PLANT SCIENCE GMBH
发明人： BAUER JOERG , WU GUOHAI , QIU XIAO
IPC分类号： C12N9/02 , A01K67/027 , C07K14/37 , C07K16/14 , C07K16/40 , C12N5/10 , C12N15/53 , C12N15/63 , C12N15/81 , C12N15/82 , C12P7/64
摘要： The present invention relates to a polynucleotide encoding an omega 3 (w-3) desaturase from Pythium irregulare with specificity to long chain polyunsaturated omega 6 (w- 6) fatty acids as well as a vector containing said polynucleotide, and a host cell containing the vector or the polynucleotide. Moreover, the present invention pertains to a polypeptide encoded by the said polynucleotide, antibodies against the polypeptide as well as a method for the manufacture of the polypeptide. Further, encompassed by the present invention are transgenic non-human organisms. Finally, the present invention relates to methods for the manufacture of compounds and oil- fatty acid- or lipid- containing compositions.

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