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1. 发明申请

WO0144476A3 Moss genes from physcomitrella patens encoding proteins involved in the synthesis of carbohydrates 审中-公开
标题翻译：编码参与碳水化合物合成的蛋白质的小麦藓的苔藓基因
公开(公告)号：WO0144476A3
公开(公告)日：2002-04-25
申请号：PCT/EP0012697
申请日：2000-12-14
申请人： LERCHL JENS , RENZ ANDREAS , EHRHARDT THOMAS , REINDL ANDREAS , CIRPUS PETRA , BISCHOFF FRIEDRICH , FRANK MARKUS , FREUND ANNETTE , DUWENIG ELKE , SCHMIDT RALF-MICHAEL , RESKI RALF , BASF PLANT SCIENCE GMBH
发明人： LERCHL JENS , RENZ ANDREAS , EHRHARDT THOMAS , REINDL ANDREAS , CIRPUS PETRA , BISCHOFF FRIEDRICH , FRANK MARKUS , FREUND ANNETTE , DUWENIG ELKE , SCHMIDT RALF-MICHAEL , RESKI RALF
IPC分类号： C07K14/415 , C12N9/00 , C12N15/29 , C07K16/16 , C07K16/40 , C12P19/00 , G01N33/573 , G01N33/68
CPC分类号： C12N9/00 , C07K14/415
摘要： Isolated nucleic acid molecules, designated CMRP nucleic acid molecules, which encode novel CMRPs from Physcomitrella patens are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing CMRP nucleic acid molecules, and host cells and organisms into which the expression vectors have been introduced. The invention still further provides isolated CMRPs, mutated CMRPs, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from transformed cells based on genetic engineering of CMRP genes in this organism.
摘要翻译：描述了编码来自小立碗藓的新型CMRP的分离的核酸分子，命名为CMRP核酸分子。本发明还提供反义核酸分子，含有CMRP核酸分子的重组表达载体，以及引入表达载体的宿主细胞和生物体。本发明还进一步提供了基于该生物体中CMRP基因的遗传工程的分离的CMRP，突变CMRPs，融合蛋白，抗原肽和用于从转化细胞产生所需化合物的方法。

2. 发明申请

WO0144276A2 MOSS GENES FROM PHYSCOMITRELLA PATENS ENCODING PROTEINS INVOLVED IN THE SYNTHESIS OF TOCOPHEROLS AND CAROTENOIDS 审中-公开
标题翻译：来自PHYSCOMITRELLA PATES的MOSS基因编码参与合成植物油和卡诺菌素的蛋白质
公开(公告)号：WO0144276A2
公开(公告)日：2001-06-21
申请号：PCT/EP0012698
申请日：2000-12-14
申请人： BASF PLANT SCIENCE GMBH , LERCHL JENS , RENZ ANDREAS , EHRHARDT THOMAS , REINDL ANDREAS , CIRPUS PETRA , BISCHOFF FRIEDRICH , FRANK MARKUS , FREUND ANNETTE , DUWENIG ELKE , SCHMIDT RALF MICHAEL , RESKI RALF , BADUR RALF
发明人： LERCHL JENS , RENZ ANDREAS , EHRHARDT THOMAS , REINDL ANDREAS , CIRPUS PETRA , BISCHOFF FRIEDRICH , FRANK MARKUS , FREUND ANNETTE , DUWENIG ELKE , SCHMIDT RALF-MICHAEL , RESKI RALF , BADUR RALF
IPC分类号： C12N9/10 , C12N15/52 , C12N15/82 , C07K14/00
CPC分类号： C12N9/1007 , C12N15/52 , C12N15/8243 , C12N15/825
摘要： Isolated nucleic acid molecules, designated TCMRP nucleic acid molecules, which encode novel TCMRPs from e.g. Physcomitrella patens are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TCMRP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated TCMRPs, mutated TCMRPs, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from transformed cells, organisms or plants based on genetic engineering of TCMRP genes in these organisms.
摘要翻译：分离的核酸分子，命名为TCMRP核酸分子，其编码来自例如新鲜的TCMRP。描述了小立碗藓。本发明还提供反义核酸分子，含有TCMRP核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。本发明还进一步提供了分离的TCMRP，突变的TCMRP，融合蛋白，抗原肽和基于这些生物体中TCMRP基因的遗传工程改进从转化细胞，生物体或植物生产所需化合物的方法。

3. 发明申请

WO0136606A3 PROTOPORPHYRINOGEN IX OXIDASE AND THE USE THEREOF 审中-公开
标题翻译：原卟啉原Ⅸ氧化酶及其用途
公开(公告)号：WO0136606A3
公开(公告)日：2001-11-15
申请号：PCT/EP0011100
申请日：2000-11-10
申请人： BASF PLANT SCIENCE GMBH , SCHIFFER HELMUT , LERCHL JENS , GRIMM BERNHARD , LERMONTOVA INNA , VORONETSKAJA VALERIA
发明人： SCHIFFER HELMUT , LERCHL JENS , GRIMM BERNHARD , LERMONTOVA INNA , VORONETSKAJA VALERIA
IPC分类号： C12N9/02 , C12N15/82 , A01H1/00 , C07K14/415
CPC分类号： C12N9/001 , C12N15/8209 , C12N15/8243 , C12N15/8274
摘要： The present invention relates to DNA sequences coding for a polypeptide that is resistant against peroxidising inhibitors of the protoporphyrinogen IX oxidase.
摘要翻译：本发明涉及编码用于要在过氧化Protoporphrinogen-IX氧化酶抑制剂抗性的多肽的DNA序列。

4. 发明申请

WO0138484A3 MOSS GENES FROM PHYSCOMITRELLA PATENS CODING PROTEINS INVOLVED IN THE SYNTHESIS OF POLYUNSATURATED FATTY ACIDS AND LIPIDS 审中-公开
标题翻译：在多糖脂肪酸和脂肪的合成中涉及到的编码蛋白质的来自 PHYSCOMITRELLA PATENS的MOSS基因
公开(公告)号：WO0138484A3
公开(公告)日：2001-11-01
申请号：PCT/EP0011615
申请日：2000-11-22
申请人： BASF PLANT SCIENCE GMBH
发明人： LERCHL JENS , RENZ ANDREAS , EHRHARDT THOMAS , REINDL ANDREAS , CIRPUS PETRA , BISCHOFF FRIEDRICH , FRANK MARKUS , FREUND ANNETTE , DUWENIG ELKE , SCHMIDT RALF-MICHAEL , RESKI RALF
IPC分类号： A01H11/00 , A01H13/00 , C07K14/405 , C07K14/41 , C07K14/415 , C07K16/14 , C07K16/16 , C12N1/11 , C12N1/13 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/02 , C12N15/09 , C12P7/64 , C12R1/13 , C12N15/52 , C12N5/10 , C12N9/00 , C12N15/29 , C12Q1/68 , G01N33/573
CPC分类号： C12P7/6409 , C07K14/415 , C07K2319/00 , C12P7/6427 , C12P7/6463 , C12P7/6472
摘要： Isolated nucleic acid molecules, designated LMRP nucleic acid molecules, which encode novel LMRPs from e.g. Physcomitrella patens are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing LMRP nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated LMRPs, mutated LMRPs, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from transformed cells, organisms or plants based on genetic engineering of LMRP genes in these organisms.
摘要翻译：分离的核酸分子，命名为LMRP核酸分子，其编码来自例如新的LMRP。描述了小立碗藓。本发明还提供反义核酸分子，含有LMRP核酸分子的重组表达载体，以及引入了表达载体的宿主细胞。本发明还进一步提供了基于这些生物体中LMRP基因的遗传工程的分离的LMRP，突变的LMRPs，融合蛋白，抗原肽和用于改进从转化细胞，生物或植物产生所需化合物的方法。

5. 发明申请

WO02057465A3 METHOD FOR PRODUCING POLYUNSATURATED FATTY ACIDS, NOVEL BIOSYNTHESIS GENES AND NOVEL PLANT EXPRESSION CONSTRUCTS 审中-公开
标题翻译：用于生产多不饱和脂肪酸，合成新的和新工厂的表达构建
公开(公告)号：WO02057465A3
公开(公告)日：2003-06-12
申请号：PCT/EP0200462
申请日：2002-01-18
申请人： BASF PLANT SCIENCE GMBH , LERCHL JENS , RENZ ANDREAS , HEINZ ERNST , DOMERGUE FREDERIC , ZAEHRINGER ULRICH
发明人： LERCHL JENS , RENZ ANDREAS , HEINZ ERNST , DOMERGUE FREDERIC , ZAEHRINGER ULRICH
IPC分类号： A01H5/00 , A01K67/027 , A23D9/007 , A23L1/30 , A61K8/30 , A61K8/34 , A61K8/37 , A61K31/201 , A61K31/202 , A61K31/231 , A61K31/232 , A61K31/7088 , A61K36/00 , A61K39/395 , A61K45/00 , A61P3/06 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/02 , C12N15/09 , C12N15/53 , C12N15/82 , C12P7/64 , C12Q1/02 , C12Q1/26 , G01N33/15 , G01N33/50 , C11B1/00 , C12N15/11 , C12P7/62 , C12Q1/68 , G01N33/573
CPC分类号： C12N9/0083 , C12N15/8247 , C12P7/6427 , C12P7/6472
摘要： The invention relates to a method for producing unsaturated fatty acids comprising at least two double bonds, and a method for producing triglycerides having an increased content of polyunsaturated fatty acids comprising at least two double bonds. The invention also relates to the advantageous use of the nucleic acid sequences of SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 9, SEQ ID NO: 11 or SEQ ID NO: 18 in the inventive methods, and for producing a transgenic organism, preferably a transgenic plant or a transgenic micro-organism having an increased content of fatty acids, oils or lipids containing unsaturated C18, C20, or C22 fatty acids. The invention further relates to novel desaturases comprising the sequences of SEQ ID NO. 1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 11, or the homologues, derivatives or analogues thereof, and gene constructs comprising said genes or the homologues, derivatives or analogues thereof, in addition to the use of the same, either alone or combined with biosynthesis genes of polyunsaturated fatty acids, as advantageously represented in SEQ ID NO: 7 and SEQ ID NO: 9. Furthermore, the invention relates to isolated nucleic acid sequences, expression cassettes containing said nucleic acid sequences, vectors, and transgenic organisms containing at least one nucleic acid sequence or an expression cassette. The invention also relates to unsaturated fatty acids comprising at least two double bonds and triglycerides having an increased content of unsaturated fatty acids comprising at least two double bonds, and the use of the same. Finally, the invention relates to multi-expression cassettes for seed-specific expression, in addition to vectors or organisms comprising a desaturase gene, either alone or combined with other desaturases having the sequence of SEQ ID NO: 7 and/or elongase genes having the sequence of ID NO: 9 or the homologues, derivatives or analogues of the same, expressed by means of the above-mentioned expression cassettes.
摘要翻译：本发明涉及一种用于制备具有至少两个双键和/或用于生产甘油三酯的具有多不饱和脂肪酸与多不饱和脂肪酸具有至少两个双键的至少höhtem含量增加的内容的方法的不饱和脂肪酸的方法。本发明还涉及有利地使用的核酸序列的SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5，SEQ ID NO：9，SEQ ID NO：11或SEQ ID NO：18中的过程和用于生产的转基因生物体，优选转基因植物或具有脂肪酸，油或脂类具有不饱和C18，C20，C22或脂肪酸含量增加的转基因微生物。本发明还涉及新的去饱和酶与序列SEQ ID号 1，SEQ ID NO：3，SEQ ID NO：5和SEQ ID NO：11或它的同系物，衍生物或它们的类似物，和包含所述基因的基因构建体或他们的同系物，衍生物或类似物，并单独或与生物合成基因组合使用它们polyungesätigter 脂肪酸，例如有利地在SEQ ID NO：9：7和SEQ ID NO。本发明还涉及分离的核酸序列; 表达盒包含Nukleinesäuresequenzen。载体，以及含有至少一种核酸序列或表达盒的转基因生物。本发明还涉及一种具有至少两个双键和具有具有至少两个双键和其用途的不饱和脂肪酸含量增加的甘油三酯不饱和脂肪酸。本发明还涉及用于种子特异性表达，其包括单独或与具有SEQ ID NO：1的序列的其它去饱和酶组合的去饱和酶基因的多表达盒和载体或生物体：7和/或延长酶基因与去SEQ ID NO：9或它的同系物，衍生物或类似物包括使用vesagter的表达盒。

6. 发明申请

WO02057464A3 METHOD FOR THE EXPRESSION OF BIOSYNTHETIC GENES IN PLANT SEEDS USING MULTIPLE EXPRESSION CONSTRUCTS 审中-公开
标题翻译：为了表达蔬菜种子的生物合成基因的方法是在使用多个表达构建
公开(公告)号：WO02057464A3
公开(公告)日：2003-02-27
申请号：PCT/EP0200461
申请日：2002-01-18
申请人： BASF PLANT SCIENCE GMBH , LERCHL JENS , DUWENIG ELKE , BISCHOFF FRIEDRICH , HEINZ ERNST , DREXLER HJOERDIS , SCHEFFLER JODI
发明人： LERCHL JENS , DUWENIG ELKE , BISCHOFF FRIEDRICH , HEINZ ERNST , DREXLER HJOERDIS , SCHEFFLER JODI
IPC分类号： C12N9/02 , C12N9/10 , C12N15/29 , C12N15/53 , C12N15/54 , C12N15/82 , A01H5/00 , C12N15/81 , C12P7/64
CPC分类号： C12N9/0083 , C12N9/1029 , C12N15/8247
摘要： The invention relates to expression cassettes, combinations thereof and vectors containing said expression cassettes, containing plant promoters with an expression specificity for plant seeds, in particular linseed and the use of said expression cassettes or vectors for the recombinant expression of heterologous genes in plants. The invention further relates to transgenic plants, transformed by means of said expression cassettes, or vectors, cultures, parts or transgenic propagations derived therefrom and the use of the above as foodstuff, animal feedstuff, seedstuff, pharmaceuticals, fine chemicals or industrial raw material.
摘要翻译：本发明涉及一种表达盒，其组合以及含有包含植物启动子用表达特异性植物种子，特别是亚麻子和异源基因在植物中的重组表达使用这些表达盒或载体的表达盒的载体。这些表达盒或转化的培养物从，部件或转基因繁殖材料衍生的转基因植物的载体，并且其用作食品，饲料或种子，医药品，精细化学品或工业原料本发明进一步涉及。

7. 发明专利

CA2541141A1 TRANS-2-ENOYL-COA REDUCTASE GENE OF EUGLENA GRACILIS 未知
公开(公告)号：CA2541141A1
公开(公告)日：2005-05-06
申请号：CA2541141
申请日：2004-10-08
申请人： BASF PLANT SCIENCE GMBH
发明人： OSWALD OLIVER , LERCHL JENS , MARTIN WILLIAM FRANK , CIRPUS PETRA , HOFFMEISTER MEIKE
IPC分类号： C12N9/02 , A01H5/00 , C12N15/82 , C12P7/64

8. 发明专利

NO20043592L 未知
公开(公告)号：NO20043592L
公开(公告)日：2004-10-29
申请号：NO20043592
申请日：2004-08-27
申请人： BASF PLANT SCIENCE GMBH
发明人： HEINZ ERNST , ZANK THORSTEN , LERCHL JENS
IPC分类号： A23D9/00 , A23K1/16 , A61K8/30 , A61K8/36 , A61K31/201 , A61K31/202 , A61P9/00 , A01H5/00 , A61P29/00 , C12N9/00 , C12N9/10 , C12N15/09 , C12N15/82 , C12P7/64 , C12N9/02 , A61K31/20 , A23L1/30 , A23K1/00 , C12N1/00
摘要： The invention relates to a novel elongase gene with the sequence SEQ ID NO: 1 or its homologs, derivatives or analogs, to a gene construct comprising this gene or its homologs, derivatives and analogs, and to its use. The invention also relates to vectors or organisms comprising an elongase gene with the sequence SEQ ID No: 1 or its homologs, derivatives or analogs. Furthermore, the invention relates to a process for the preparation of polyunsaturated fatty acids and to a process for introducing DNA into organisms which produce large amounts of oils and, in particular, oils with a high content of unsaturated fatty acids. Moreover, the invention relates to an oil and/or a fatty acid preparation with a higher content of polyunsaturated fatty acids with at least two double bonds and/or a triacyiglycerol preparation with a higher content of polyunsaturated fatty acids with at least two double bonds.

9. 发明专利

BR0206598A 未知
公开(公告)号：BR0206598A
公开(公告)日：2004-06-22
申请号：BR0206598
申请日：2002-01-18
申请人： BASF PLANT SCIENCE GMBH
发明人： LERCHL JENS , RENZ ANDREAS , HEINZ ERNST , DOMERGUE FREDERIC , ZOHRINGER ULRICH
IPC分类号： A01H5/00 , A01K67/027 , A23D9/007 , A23L1/30 , A61K8/30 , A61K8/34 , A61K8/37 , A61K31/201 , A61K31/202 , A61K31/231 , A61K31/232 , A61K31/7088 , A61K36/00 , A61K39/395 , A61K45/00 , A61P3/06 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/02 , C12N15/09 , C12N15/53 , C12N15/82 , C12P7/64 , C12Q1/02 , C12Q1/26 , G01N33/15 , G01N33/50 , C12N15/11 , C12P7/62 , C12Q1/68 , G01N33/573 , C11B1/00
摘要： The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds. The invention furthermore relates to the use of nucleic acid sequences SEQ ID NO: 1, 3, 5, 9, and 11 encoding polypeptides having desaturase or elongase activity in the method and for generating a transgenic organism, preferably a transgenic plant or a transgenic microorganism, with an increased content of fatty acids, oils or lipids with unsaturated C18-, C20-, or C22-fatty acids, and to their homologs or derivatives, to gene constructs encompassing these genes, and to their use alone or in combination with biosynthesis genes of polyunsaturated fatty acids. The invention also relates to multiexpression cassettes for seed-specific expression, and to vectors or organisms which encompass a desaturase gene alone or in combination with further desaturases and/or elongase genes or homologs using said expression cassettes.

10. 发明专利

CA2419020A1 PYRUVATE:NADP+ OXIDOREDUCTASE AND USES THEREOF 未知
公开(公告)号：CA2419020A1
公开(公告)日：2002-02-21
申请号：CA2419020
申请日：2001-08-11
申请人： BASF PLANT SCIENCE GMBH
发明人： ROTTE CARMEN , MARTIN WILLIAM , LERCHL JENS , CIRPUS PETRA
IPC分类号： A01H5/00 , A61K31/7088 , A61K39/395 , A61K45/00 , A61K48/00 , A61P33/00 , C07K16/40 , C07K16/44 , C12N1/21 , C12N5/10 , C12N7/00 , C12N9/02 , C12N15/09 , C12N15/53 , C12N15/82 , C12P7/64 , C12P19/32 , C12P23/00 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53
摘要： Provided are polynucleotides encoding Pyruvate:NADP+ oxidoreductases (PNO) a s well as methods for obtaining the same. Furthermore, vectors comprising said polynucleotides are described, wherein the polynucleotides are operatively linked to expression control sequences allowing the expression in prokaryoti c and/or eukaryotic host cells. In addition, polypeptides encoded by said polynucleotides, antibodies to said polypeptides and methods for their production are provided. Further described are methods for increasing the acetyl CoA synthesis as well as methods for the production of fatty acids, carotenoids, isoprenoids, vitamins, lipids, wax esters, (poly)saccharides and/or polyhydroxyalkanoates, or its metabolism products, in particular, steroid hormones, prostaglandin, cholesterol, triacylglycerols, bile acids o r ketone bodies, comprising the expression of the polynucleotide or polypeptid e described herein in a host cell or plant cell, plant tissue or plant. Method s for the identification of compounds being capable of activating or inhibitin g PNO are described as well. Further, a pharmaceutical composition comprising the afore-mentioned inhibiting compounds and antibodies is described. Furthermore, transgenic plants, plant tissues, and plant cells containing th e above described polynucleotides and vectors are described as well as the use of the mentioned polynucleotides, vectors, polypeptides, antibodies, and/or compounds identified by the method of the invention in the production of acetyl CoA metabolism products, e.g., fatty acids, carotenoids, isoprenoids, vitamins, lipids, (poly)saccharides, wax esters, and/or polyhydroxyalkanoate s, and/or its metabolism products, in particular, steroid hormones, prostaglandin, cholesterol, triacylglycerols, bile acids and/or ketone bodie s and pharmaceutical compositions.

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