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1. 发明申请

WO02057474A3 PROCESSES FOR ENHANCED PRODUCTION OF PANTOTHENATE 审中-公开
标题翻译：加强生产PANTOTHENATE的方法
公开(公告)号：WO02057474A3
公开(公告)日：2003-10-02
申请号：PCT/US0201842
申请日：2002-01-19
申请人： BASF AG , HERMANN THERON , PATTERSON THOMAS A , PERO JANICE G , YOCUM ROGERS R , BALDENIUS KAI-UWE , BECK CHRISTINE
发明人： HERMANN THERON , PATTERSON THOMAS A , PERO JANICE G , YOCUM ROGERS R , BALDENIUS KAI-UWE , BECK CHRISTINE
IPC分类号： C12N15/09 , A61K31/7088 , A61P43/00 , C12N1/21 , C12N9/10 , C12P13/00 , C12P13/02 , C12P13/04 , C12R1/125 , C12N15/03
CPC分类号： C12P13/04 , C12N9/1022 , C12P13/02
摘要： The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.
摘要翻译：本发明的特征在于利用具有改良泛酸生物合成酶活性的微生物生产泛酸盐和泛酸盐的改进方法。特别地，本发明的特征在于减少副产物形成和提高所需产物的产率和纯度的方法。还具有重组微生物和培养条件。还有这些微生物产生的组合物。

2. 发明申请

WO2004035010A8 METHODS AND ORGANISMS FOR PRODUCTION OF B6 VITAMERS 审中-公开
标题翻译：生产B6维生素的方法和有机体
公开(公告)号：WO2004035010A8
公开(公告)日：2004-06-10
申请号：PCT/US0308880
申请日：2003-03-21
申请人： BASF AG , YOCUM ROGERS R , WILLIAMS MARK K , PERO JANICE G
发明人： YOCUM ROGERS R , WILLIAMS MARK K , PERO JANICE G
IPC分类号： C12N9/00 , C12N15/52 , C12P17/12 , C12P25/00 , C12N1/12 , C12N1/16 , C12N1/20 , C12N9/10
CPC分类号： C12N9/00 , C12N15/52 , C12P17/12
摘要： The present invention features methods of producing B6 vitamers that involve culturing an organism overexpressing an enzyme that catalyzes a step in the biosynthesis of a B6 vitamer under conditions such that a B6 vitamer is produced. The present invention further features methods of producing B6 vitamers that involve culturing recombinant microorganisms having increased activity of at least one B6 vitamer biosynthetic enzyme, e.g., YaaD or YaaE, or a homologue thereof, or Epd, PdxA, PdxJ, PdxF, PdxB, PdxH, and/or Dxs , or a homologue thereof.
摘要翻译：本发明的特征在于生产B6维生素的方法，其涉及培养在产生B6维生素的条件下过量表达催化B6维生素生物合成步骤的酶的生物体的培养。本发明还涉及生产B6维生素的方法，其涉及培养具有增加至少一种B6维生素生物合成酶的活性的重组微生物，例如YaaD或YaaE或其同源物，或Epd，PdxA，PdxJ，PdxF，PdxB，PdxH ，和/或Dxs，或其同源物。

3. 发明申请

WO2004035010A2 METHODS AND ORGANISMS FOR PRODUCTION OF B6 VITAMERS 审中-公开
标题翻译：生产B6维生素的方法和生物
公开(公告)号：WO2004035010A2
公开(公告)日：2004-04-29
申请号：PCT/US0308880
申请日：2003-03-21
申请人： BASF AG , YOCUM ROGERS R , WILLIAMS MARK K , PERO JANICE G
发明人： YOCUM ROGERS R , WILLIAMS MARK K , PERO JANICE G
IPC分类号： C12N9/00 , C12N15/52 , C12P17/12 , A61K
CPC分类号： C12N9/00 , C12N15/52 , C12P17/12
摘要： The present invention features methods of producing B6 vitamers that involve culturing an organism overexpressing an enzyme that catalyzes a step in the biosynthesis of a B6 vitamer under conditions such that a B6 vitamer is produced. The present invention further features methods of producing B6 vitamers that involve culturing recombinant microorganisms having increased activity of at least one B6 vitamer biosynthetic enzyme, e.g., YaaD or YaaE, or a homologue thereof, or Epd, PdxA, PdxJ, PdxF, PdxB, PdxH, and/or Dxs , or a homologue thereof.
摘要翻译：本发明的特征在于生产B6维生素的方法，所述维生素B6涉及在产生B6维生素的条件下培养过表达酶的生物体，所述酶催化B6维生素的生物合成的步骤。本发明进一步特征在于生产B6维生素E的方法，所述方法涉及培养具有增加的至少一种B6维生素生物合成酶（例如YaaD或YaaE）或其同源物或Epd，PdxA，PdxJ，PdxF，PdxB，PdxH ，和/或Dxs或其同系物。

4. 发明申请

WO0121772A9 METHODS AND MICROORGANISMS FOR PRODUCTION OF PANTO-COMPOUNDS 审中-公开
标题翻译：用于生产PANTO化合物的方法和微生物
公开(公告)号：WO0121772A9
公开(公告)日：2002-12-05
申请号：PCT/US0025993
申请日：2000-09-21
申请人： BASF AG
发明人： YOCUM ROGERS R , PATTERSON THOMAS A , HERMANN THERON , PERO JANICE G
IPC分类号： C12N15/09 , C12N1/21 , C12N9/02 , C12N9/12 , C12N9/88 , C12N15/52 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/04 , C12Q1/48 , C12R1/125 , C12N9/00 , C12N9/10 , C12N15/53 , C12N15/54 , C12N15/60 , C12N15/75 , C12P7/42
CPC分类号： C12P13/02 , C12N9/0006 , C12N9/1014 , C12N9/1205 , C12N9/88 , C12N9/93 , C12N15/52 , C12P7/42 , C12P13/06 , C12P17/04
摘要： The present invention features methods of producing panto-compounds e.g. , pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzymeA biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate g(a)-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.
摘要翻译：本发明的特征在于生产泛化合物的方法，例如，泛酸盐），其中已经操纵了泛酸生物合成途径和/或异亮氨酸 - 缬氨酸生物合成途径和/或辅酶A生物合成途径的微生物。提供了酮过氧还原酶过表达微生物以及天冬氨酸g（a） - 脱羧酶过表达微生物的方法。描述了以前体非依赖性方式和高产率生产泛化合物的方法。还提供了用于实践上述方法的重组微生物，载体，分离的核酸分子，基因和基因产物。本发明还具有以前的微生物泛酸激酶基因coaX，以及利用具有改良的泛酸激酶活性的微生物产生泛化合物的方法。重组微生物，载体，分离的coaX核酸分子和纯化的CoaX蛋白。还特征在于利用本发明的重组微生物和/或纯化的CoaX蛋白鉴定泛酸激酶调节剂的方法。

5. 发明专利

SK9022003A3 Processes for enhanced production of pantothenate 未知
公开(公告)号：SK9022003A3
公开(公告)日：2003-12-02
申请号：SK9022003
申请日：2002-01-19
申请人： BASF AG
发明人： HERMANN THERON , PATTERSON THOMAS A , PERO JANICE G , YOCUM ROGERS R , BALDENIUS KAI-UWE , BECK CHRISTINE
IPC分类号： A61K31/7088 , A61P43/00 , C12N1/21 , C12N9/10 , C12P13/00 , C12P13/02 , C12N15/09 , C12P13/04 , C12R1/125 , C12P7/42 , C12P13/06
摘要： The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features methods for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are also are featured. Also featured are compositions produced by such microorganisms.

6. 发明专利

MX2008000480A MICROORGANISMOS RECOMBINANTES QUE PRODUCEN METIONINA. 未知
公开(公告)号：MX2008000480A
公开(公告)日：2008-03-07
申请号：MX2008000480
申请日：2006-07-18
申请人： BASF AG
发明人： PATTERSON THOMAS A , HERMANN THERON , PERO JANICE G , SCHRODER HARTWIG , ZELDER OSKAR , KLOPPROGGE CORINNA , HAEFNER STEFAN , HEROLD ANDREA , YOCUM ROGERS R , WILLIAMS MARK K
IPC分类号： C12P13/12
摘要： Esta invencion se refiere a microorganismos recombinantes productores de metionina. Especificamente, esta invencion se refiere a cepas recombinantes de Corynebacterium que producen niveles incrementados de metionina comparado con sus contrapartes tipo silvestre y ademas a metodos para generar dichos organismos.

7. 发明专利

CA2434518A1 METHODS AND MICROORGANISMS FOR THE PRODUCTION OF 3-(2-HYDROXY-3-METHYL-BUTYRYLAMINO)-PROPIONIC ACID (HMBPA) 未知
公开(公告)号：CA2434518A1
公开(公告)日：2002-07-25
申请号：CA2434518
申请日：2002-01-19
申请人： BASF AG
发明人： HERMANN THERON , PATTERSON THOMAS A , YOCUM ROGERS R , BALDENIUS KAI-UWE , PERO JANICE G , BECK CHRISTINE
IPC分类号： C12N15/09 , C12N1/21 , C12N9/02 , C12N9/10 , C12P7/42 , C12P13/02 , C12P13/04 , C12R1/125 , C12N15/03 , C12N15/52
摘要： The present invention features methods of producting 3-(2-hydroxy-3-methyl- butyrylamino)-propionic acid ("HMBPA") and .alpha.-hydroxyisovalerate (".alpha.-HIV") utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. Recombinant microorganisms and conditions fo r culturing same are also featured. Also featured are compositions including HMBPA and compositions including .alpha.-HIV.

8. 发明专利

CA2615416A1 METHIONINE PRODUCING RECOMBINANT MICROORGANISMS 未知
公开(公告)号：CA2615416A1
公开(公告)日：2007-01-25
申请号：CA2615416
申请日：2006-07-18
申请人： BASF AG
发明人： SCHRODER HARTWIG , YOCUM ROGERS R , HAEFNER STEFAN , HERMANN THERON , ZELDER OSKAR , PATTERSON THOMAS A , PERO JANICE G , HEROLD ANDREA , WILLIAMS MARK K , KLOPPROGGE CORINNA
IPC分类号： C12P13/12
摘要： This invention relates to methionine producing recombinant microorganisms. Specifically, this invention relates to recombinant strains of Corynebacterium that produce increased levels of methionine compared to their wild-type counterparts and further to methods of generating such microorganisms.

9. 发明专利

PL356566A1 METHODS AND MICROORGANISMS FOR PRODUCTION OF PANTO-COMPOUNDS 未知
公开(公告)号：PL356566A1
公开(公告)日：2004-06-28
申请号：PL35656600
申请日：2000-09-21
申请人： BASF AG
发明人： YOCUM ROGERS R , PATTERSON THOMAS A , HERMANN THERON , PERO JANICE G
IPC分类号： C12N15/09 , C12N1/21 , C12N9/02 , C12N9/12 , C12N9/88 , C12N15/52 , C12P13/02 , C12P13/04 , C12P13/06 , C12P17/04 , C12Q1/48 , C12R1/125 , C12N9/00 , C12N15/54 , C12P7/42
摘要： The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzyme A biosynthetic pathway has been manipulated. Methods featuring ketopantoate reductase overexpressing microorganisms as well as aspartate ±-decarboxylase overexpressing microorganisms are provided. Methods of producing panto-compounds in a precursor-independent manner and in high yield are described. Recombinant microorganisms, vectors, isolated nucleic acid molecules, genes and gene products useful in practicing the above methodologies are also provided. The present invention also features a previously unidentified microbial pantothenate kinase gene, coaX , as well as methods of producing panto-compounds utilizing microorganisms having modified pantothenate kinase activity. Recombinant microorganisms, vectors, isolated coaX nucleic acid molecules and purified CoaX proteins are featured. Also featured are methods for identifying pantothenate kinase modulators utilizing the recombinant microorganisms and/or purified CoaX proteins of the present invention.

10. 发明专利

CA2434483A1 PROCESSES FOR ENHANCED PRODUCTION OF PANTOTHENATE 未知
公开(公告)号：CA2434483A1
公开(公告)日：2002-07-25
申请号：CA2434483
申请日：2002-01-19
申请人： BASF AG
发明人： BECK CHRISTINE , BALDENIUS KAI-UWE , YOCUM ROGERS R , PERO JANICE G , HERMANN THERON , PATTERSON THOMAS A
IPC分类号： C12N15/09 , A61K31/7088 , A61P43/00 , C12N1/21 , C12N9/10 , C12P13/00 , C12P13/02 , C12P13/04 , C12R1/125 , C07C231/02 , C07C235/12 , C12P7/42 , C12N15/75
摘要： The present invention features improved methods for producing pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities. In particular, the invention features method s for reducing byproduct formation and increasing yields and purity of desired product. Recombinant microorganisms and conditions for culturing same are al so are featured. Also featured are compositions produced by such microorganisms .

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