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1. 发明申请

WO2007051725A3 MICROORGANISM AND PROCESS FOR THE PREPARATION OF L-METHIONINE 审中-公开
标题翻译：用于制备L-甲硫氨酸的微生物和方法
公开(公告)号：WO2007051725A3
公开(公告)日：2007-06-28
申请号：PCT/EP2006067680
申请日：2006-10-23
申请人： BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE G , YOCUM R ROGERS , PATTERSON THOMAS A , WILLIAMS MARK , HERMAN THERON
发明人： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE G , YOCUM R ROGERS , PATTERSON THOMAS A , WILLIAMS MARK , HERMAN THERON
IPC分类号： A23K1/00 , C12N15/52 , C12P13/12
CPC分类号： C12P13/12 , A23K10/16 , A23K20/142 , A23K40/10 , C12N15/52
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
摘要翻译：本发明涉及用于有效制备L-氨基酸如L-甲硫氨酸的微生物和方法。特别地，本发明涉及微生物和其中甲硫氨酸途径中高山ion素的形成和/或积累减少和/或预防的方法。

2. 发明申请

WO2007011845A3 USE OF A BACILLUS METI GENE TO IMPROVE METHIONINE PRODUCTION IN MICROORGANISMS 审中-公开
标题翻译：使用芽孢杆菌METI基因改善微生物中的蛋氨酸生产
公开(公告)号：WO2007011845A3
公开(公告)日：2007-04-12
申请号：PCT/US2006027617
申请日：2006-07-18
申请人： BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , YOCUM R ROGERS , WILLIAMS MARK K
发明人： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , YOCUM R ROGERS , WILLIAMS MARK K
IPC分类号： C12P13/12 , C07K14/32 , C07K14/34 , C12N5/10
CPC分类号： C12P13/12 , C07K14/32 , C07K14/34 , C12P3/00 , C12P5/023 , C12P7/04 , C12P7/06 , C12P7/16 , C12P7/18 , C12P7/20 , C12P7/28 , C12P7/48 , C12P7/52 , C12P7/54 , C12P7/56 , C12P13/04 , C12P23/00 , Y02E50/10 , Y02E50/17 , Y02E50/343
摘要： The present invention pertains to improved microorganisms and methods for the production of methionine and other sulfur containing fine chemicals using the metl gene from Bacillus subtilis or a gene related to metI. In some embodiments of the present invention, the metI gene or another gene is integrated in a fashion that allows for co-production of a water soluble compound such as methionine or other amino acid and a caortenoid compound.
摘要翻译：本发明涉及使用来自枯草芽孢杆菌的metl基因或与metI有关的基因来生产甲硫氨酸和其他含硫精细化学品的改良微生物和方法。在本发明的一些实施方案中，metI基因或另一基因以允许共同产生水溶性化合物如甲硫氨酸或其他氨基酸和类胡萝卜素化合物的方式整合。

3. 发明申请

WO2007135188A2 PROCESS FOR THE PREPARATION OF L-METHIONINE 审中-公开
标题翻译：制备L-甲硫氨酸的方法
公开(公告)号：WO2007135188A2
公开(公告)日：2007-11-29
申请号：PCT/EP2007055056
申请日：2007-05-24
申请人： BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMANN THERON
发明人： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMANN THERON
IPC分类号： C12P13/12
CPC分类号： C12P13/12
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-methionine. In particular, the present invention relates to processes in which the amount of serine available for the metabolism of the microorganism is increased.
摘要翻译：本发明涉及用于L-甲硫氨酸有效制备的微生物和方法。特别地，本发明涉及其中可用于微生物代谢的丝氨酸量增加的方法。

4. 发明申请

WO2007011939A3 USE OF DIMETHYL DISULFIDE FOR METHIONINE PRODUCTION IN MICROORGANISMS 审中-公开
标题翻译：二甲基磺脲在微生物中的生产中的应用
公开(公告)号：WO2007011939A3
公开(公告)日：2007-07-05
申请号：PCT/US2006027855
申请日：2006-07-18
申请人： BASF AG , ZELDER OSKAR , HAEFNER STEFAN , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHRODER HARTWIG , YOCUM R ROGERS , WILLIAMS MARK K
发明人： ZELDER OSKAR , HAEFNER STEFAN , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHRODER HARTWIG , YOCUM R ROGERS , WILLIAMS MARK K
IPC分类号： C12P13/12
CPC分类号： C12P13/12
摘要： The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ?metF organism or a ?metE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/Met? and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ?metF ?metB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.
摘要翻译：本发明的特征在于用于生产甲硫氨酸的改进方法和生物体。本发明证明，metF生物体或αmetE AmetH生物体，例如谷氨酸棒状杆菌或大肠杆菌的突变体可以使用甲基封端的硫化物源，例如二甲基二硫（DMDS）作为硫的来源和甲基，绕过MetH / Met？和MetF活性以及减少硫酸盐的需要，用于合成甲硫氨酸。该专利中还描述了涉及MetY（也称为MetZ）的数据，其作为将甲基封端的硫化物源（例如DMDS）并入甲硫氨酸中的酶。谷氨酸棒状芽孢杆菌的ΔFIFFmetB菌株可以使用甲基封端的硫化物源，例如DMDS，作为硫化物和甲基两者的来源。此外，通过加入甲基封端的硫化物源（例如DMDS），改善过度产生O-乙酰高丝氨酸的工程化原养殖生物体的甲硫氨酸生产。

5. 发明申请

WO2007020295A3 MICROORGANISMS WITH INCREASED EFFICIENCY FOR METHIONINE SYNTHESIS 审中-公开
标题翻译： MICROORGANISMS对提高蛋氨酸合成的效率
公开(公告)号：WO2007020295A3
公开(公告)日：2007-05-03
申请号：PCT/EP2006065460
申请日：2006-08-18
申请人： BASF AG , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMAN THERON
发明人： ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA , SCHROEDER HARTWIG , HAEFNER STEFAN , HEINZLE ELMAR , WITTMANN CHRISTOPH , KROEMER JENS , PERO JANICE , YOCUM ROGERS , PATTERSON THOMAS , WILLIAMS MARK , HERMAN THERON
IPC分类号： C12N15/52 , C12P13/12 , C12R1/13 , C12R1/19
CPC分类号： C12N15/52 , C12P13/12
摘要： The present invention concerns methods for the production of microorganisms with increased efficiency for methionine synthesis. The present invention also concerns microorganisms with increased efficiency for methionine synthesis. Furthermore, the present invention concerns methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.
摘要翻译：本发明涉及生产甲硫氨酸合成效率提高的微生物的方法。本发明还涉及甲硫氨酸合成效率提高的微生物。此外，本发明涉及用于确定与甲硫氨酸合成有关的生物体的最佳代谢通量的方法。

6. 发明专利

BRPI0519165A2 未知
公开(公告)号：BRPI0519165A2
公开(公告)日：2008-12-30
申请号：BRPI0519165
申请日：2005-12-21
申请人： BASF AG
发明人： HAFNER STEFAN , KLOPPROGGE CORINNA , HEROLD ANDREA , SCHROEDER HARTWIG , ZELDER OSKAR
IPC分类号： C12N15/77 , C07K14/34
摘要： An expression unit (A) that contains several promoters is new. A new expression unit (A) comprises several promoters and includes, in the 5' to 3' direction the sequence module (I). 5'-P 1-(A x-P x) n-A y-P y-3' (I) n = integer 0-10; A x and A y = same or different chemical bonds or nucleic acid linker sequences; P 1, P x and P y = same or different promoter sequences, containing at least one RNA-polymerase binding region, and at least P y also includes a ribosome-binding, 3'-terminal segment. Independent claims are also included for: (1) an expression cassette (EC) that contains, in the 5' to 3' direction, the sequence module (II); (2) vector that contains at least one EC; (3) a genetically modified microorganism (GMO) transfected with the vector of (2) or containing EC; and (4) method for preparing biosynthetic products (X) by culturing GMO. 5'-P 1-(A x-P x) n-A y-P y-G-3' (II) G : at least one nucleic acid coding sequence functionally linked to the 5'-upstream regulatory sequence.

7. 发明专利

CA2626909A1 MICROORGANISM AND PROCESS FOR THE PREPARATION OF L-METHIONINE 未知
公开(公告)号：CA2626909A1
公开(公告)日：2007-05-10
申请号：CA2626909
申请日：2006-10-23
申请人： BASF AG
发明人： HAEFNER STEFAN , HERMAN THERON , PERO JANICE G , WILLIAMS MARK , YOCUM R ROGERS , KROEMER JENS , WITTMANN CHRISTOPH , HEINZLE ELMAR , HEROLD ANDREA , KLOPPROGGE CORINNA , PATTERSON THOMAS A , ZELDER OSKAR , SCHROEDER HARTWIG
IPC分类号： C12N1/21 , C12N1/20 , C12N15/52 , C12N15/54 , C12N15/60 , C12N15/63 , C12P13/12
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.

8. 发明专利

CA2615315A1 USE OF DIMETHYL DISULFIDE FOR METHIONINE PRODUCTION IN MICROORGANISMS 未知
公开(公告)号：CA2615315A1
公开(公告)日：2007-01-25
申请号：CA2615315
申请日：2006-07-18
申请人： BASF AG
发明人： YOCUM R ROGERS , SCHRODER HARTWIG , KLOPPROGGE CORINNA , HAEFNER STEFAN , HEROLD ANDREA , WILLIAMS MARK K , ZELDER OSKAR
IPC分类号： C12P13/12
摘要： The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a &Dgr;metF organism or a &Dgr;metE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A &Dgr;metF &Dgr;metB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.

9. 发明专利

CA2591311A1 MULTIPLE PROMOTERS AND THE USE THEREOF FOR GENE EXPRESSION 未知
公开(公告)号：CA2591311A1
公开(公告)日：2006-07-06
申请号：CA2591311
申请日：2005-12-21
申请人： BASF AG
发明人： HAEFNER STEFAN , HEROLD ANDREA , ZELDER OSKAR , KLOPPROGGE CORINNA , SCHROEDER HARTWIG
IPC分类号： C12N15/77 , C07K14/34
摘要： An expression unit (A) that contains several promoters is new. A new expression unit (A) comprises several promoters and includes, in the 5' to 3' direction the sequence module (I). 5'-P 1-(A x-P x) n-A y-P y-3' (I) n = integer 0-10; A x and A y = same or different chemical bonds or nucleic acid linker sequences; P 1, P x and P y = same or different promoter sequences, containing at least one RNA-polymerase binding region, and at least P y also includes a ribosome-binding, 3'-terminal segment. Independent claims are also included for: (1) an expression cassette (EC) that contains, in the 5' to 3' direction, the sequence module (II); (2) vector that contains at least one EC; (3) a genetically modified microorganism (GMO) transfected with the vector of (2) or containing EC; and (4) method for preparing biosynthetic products (X) by culturing GMO. 5'-P 1-(A x-P x) n-A y-P y-G-3' (II) G : at least one nucleic acid coding sequence functionally linked to the 5'-upstream regulatory sequence.

10. 发明专利

BRPI0513552A 未知
公开(公告)号：BRPI0513552A
公开(公告)日：2008-05-06
申请号：BRPI0513552
申请日：2005-07-20
申请人： BASF AG
发明人： SAUER UWE , MAMPEL J RG , DER HARTWIG SCHR , HAEFNER STEFAN , ZELDER OSKAR , HEROLD ANDREA , KLOPPROGGE CORINNA
IPC分类号： C12P13/12 , C12N15/00 , C12P1/00 , C12P11/00 , C12R1/00
摘要： The present invention relates to microorganisms and methods for producing at least one sulfur-containing compound.

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