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1. 发明申请

WO0166001A2 SUTURE CLIPS, DELIVERY DEVICES AND METHODS 审中-公开
标题翻译： SUTURE CLIPS，交付设备和方法
公开(公告)号：WO0166001A2
公开(公告)日：2001-09-13
申请号：PCT/US0107349
申请日：2001-03-05
申请人： BARD INC C R , GAMBALE RICHARD A , WEISER MICHAEL F , PAGE EDWARD CARLTON
发明人： GAMBALE RICHARD A , WEISER MICHAEL F , PAGE EDWARD CARLTON
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B2017/045 , A61B2017/0454 , A61B2017/0464 , A61B2017/0488
摘要： A catheter (1) comprises a collet cage (2) with a plurality of flexible collet fingers (4) that captivate a suture clip ring (8) and a suture clip plug (3) for assembly with a suture (7). An outer sliding sleeve (30) constrains the collet fingers (4) when distally advanced to minimize potential trauma during delivery and assembly of the suture clip (3a) in close proximity to the stitched tissue. Proximal retraction of the sliding sleeve (30) coupled with the distal advancement of a pusher (24) against cam surfaces of the inner walls of the collet fingers causes the collet fingers to open. The catheter is designed to hold and assemble the suture clip (3) in a first position and release the suture clip and sever the suture ends proximal to the suture clip in a second position.
摘要翻译：导管（1）包括具有多个柔性夹头（4）的夹头保持器（2），其夹紧缝合夹环（8）和缝合夹塞（3），用于与缝合线（7）组装。外滑动套管（30）在向远侧推进时约束夹头（4），以使缝合夹（3a）在紧邻缝合组织的递送和组装期间的潜在创伤最小化。与推动器（24）的远端前进联接的滑动套管（30）的近端缩回抵靠夹头爪的内壁的凸轮表面使得夹头打开。导管被设计成将缝合夹（3）保持并组装在第一位置，并且释放缝合夹并且在第二位置将缝合线端部接近缝合夹。

2. 发明申请

WO0166001A3 SUTURE CLIPS, DELIVERY DEVICES AND METHODS 审中-公开
标题翻译：缝合夹，递送装置和方法
公开(公告)号：WO0166001A3
公开(公告)日：2001-12-20
申请号：PCT/US0107349
申请日：2001-03-05
申请人： BARD INC C R , GAMBALE RICHARD A , WEISER MICHAEL F , PAGE EDWARD CARLTON
发明人： GAMBALE RICHARD A , WEISER MICHAEL F , PAGE EDWARD CARLTON
IPC分类号： A61B17/04
CPC分类号： A61B17/0487 , A61B2017/045 , A61B2017/0454 , A61B2017/0464 , A61B2017/0488
摘要： A catheter (1) comprises a collet cage (2) with a plurality of flexible collet fingers (4) that captivate a suture clip ring (8) and a suture clip plug (3) for assembly with a suture (7). An outer sliding sleeve (30) constrains the collet fingers (4) when distally advanced to minimize potential trauma during delivery and assembly of the suture clip (3a) in close proximity to the stitched tissue. Proximal retraction of the sliding sleeve (30) coupled with the distal advancement of a pusher (24) against cam surfaces of the inner walls of the collet fingers causes the collet fingers to open. The catheter is designed to hold and assemble the suture clip (3) in a first position and release the suture clip and sever the suture ends proximal to the suture clip in a second position.
摘要翻译：导管（1）包括具有多个柔性夹头指状件（4）的夹头笼（2），该多个柔性夹头指状件（4）捕获缝合线夹环（8）和用于与缝合线（7）组装的缝合线夹塞（3）。当向远侧推进时，外部滑动套筒（30）约束了夹头爪（4），以最小化缝合夹（3a）在紧密接近缝合组织的递送和组装过程中的潜在创伤。与推动器（24）的远侧推进相结合的滑动套筒（30）的近侧缩回抵靠夹头指状物的内壁的凸轮表面导致夹头指状物打开。导管被设计成将缝线夹（3）保持和组装在第一位置，并释放缝线夹，并在第二位置将缝线夹近端的缝线端断开。

3. 发明申请

WO0166018B1 ENDOSCOPIC TISSUE APPOSITION DEVICE WITH MULTIPLE SUCTION PORTS 审中-公开
标题翻译：具有多个吸气口的内窥镜组织检查装置
公开(公告)号：WO0166018B1
公开(公告)日：2003-10-16
申请号：PCT/US0106835
申请日：2001-03-02
申请人： BARD INC C R , GAMBALE RICHARD A , WEISER MICHAEL F , PAGE EDWARD C , LUKIN PETER J
发明人： GAMBALE RICHARD A , WEISER MICHAEL F , PAGE EDWARD C , LUKIN PETER J
IPC分类号： A61B18/20 , A61B1/00 , A61B17/00 , A61B17/04 , A61B17/06 , A61B17/068 , A61B17/08 , A61B17/10 , A61B17/11 , A61B17/12 , A61B17/32 , A61B18/00 , A61B18/04 , A61B18/18 , A61M37/00
CPC分类号： A61B17/0401 , A61B17/00234 , A61B17/0469 , A61B17/0482 , A61B17/0625 , A61B17/068 , A61B17/08 , A61B18/1492 , A61B18/22 , A61B2017/00827 , A61B2017/0409 , A61B2017/0417 , A61B2017/0458 , A61B2017/047 , A61B2017/0472 , A61B2017/061 , A61B2017/081 , A61B2017/306 , A61B2018/00291
摘要： An improved endoscopic tissue apposition device (50) having multiple suction ports (86) permits multiple folds of tissue to be captured in the suction ports (86) with a single positioning of the device (50) and attached together by a tissue securement mechanism such as a suture (14), staple or other form of tissue bonding. The improvement reduces the number of intubations required during an endoscopic procedure to suture tissue or join areas of tissue together. The suction ports (86) may be arranged in a variety of configurations on the apposition device (50) to best suit the desired resulting tissue orientation. The tissue apposition device (50) may also incorporate tissue abrasion means (852) to activate the healing process on surfaces of tissue areas that are to be joined by operation of the device to promote a more secure attachment by permanent tissue bonding.
摘要翻译：具有多个吸入口（86）的改进的内窥镜组织安置装置（50）允许组织的多个折叠通过装置（50）的单个定位被捕获在吸入口（86）中，并且通过组织固定机构作为缝合线（14），钉或其他形式的组织粘合。该改进减少了在内窥镜过程中将缝合组织或将组织区域连接在一起的插管数量。吸入口（86）可以以各种配置布置在接合装置（50）上，以最适合所需的组织取向。组织安置装置（50）还可以包括组织磨损装置（852），以通过装置的操作来激活要连接的组织区域的表面上的愈合过程，以通过永久性组织粘合促进更安全的附接。

4. 发明申请

WO0069504A8 AGENT DELIVERY SYSTEMS 审中-公开
标题翻译：代理交付系统
公开(公告)号：WO0069504A8
公开(公告)日：2001-11-08
申请号：PCT/US0013119
申请日：2000-05-12
申请人： BARD INC C R , GAMBALE RICHARD A , SHAH CHIRAG B , WEISER MICHAEL F , FORCUCCI STEPHEN J , FORDE SEAN
发明人： GAMBALE RICHARD A , SHAH CHIRAG B , WEISER MICHAEL F , FORCUCCI STEPHEN J , FORDE SEAN
IPC分类号： A61M36/04 , A61F2/00 , A61F2/02 , A61M31/00
CPC分类号： A61M37/0069 , A61F2/2493 , A61F2250/0067
摘要： The present invention provides a system for delivering a therapeutic agent into tissue in combination with an implant device (2). Preferably the therapeutic substance is contained within a pellet form (14) that is deliverable into the interior of the device (2) after it has been implanted. In a preferred embodiment the implant device (2) comprises a flexible coiled spring body, the coils (4) of which have a diameter and spacing to contain the pellet (14) within the interior of the device (2). A cavity (18) provided by the interior of the device (2) permits blood to pool around the pellet (14) and mix with the therapeutic agent. In treatment of ischemic tissue such as the of the myocardium of the heart, the mechanical irritation of the tissue caused by the implanted device (2) can help to provide an angiogenic effect. Several delivery systems have provided for delivering the implant and pellet (14) sequentially or simultaneously.
摘要翻译：本发明提供了一种用于将治疗剂与植入装置（2）组合递送到组织中的系统。优选地，治疗物质包含在颗粒形式（14）中，其在植入之后可输送到装置（2）的内部。在优选实施例中，植入装置（2）包括柔性螺旋弹簧体，其线圈（4）具有直径和间距以在装置（2）的内部内容纳颗粒（14）。由装置（2）的内部提供的空腔（18）允许血液围绕颗粒（14）聚集并与治疗剂混合。在治疗缺血组织如心脏的心肌时，由植入装置（2）引起的组织的机械刺激有助于提供血管生成作用。已经提供了几个递送系统来顺序地或同时地递送植入物和颗粒（14）。

5. 发明申请

WO0069504A9 AGENT DELIVERY SYSTEMS 审中-公开
标题翻译：代理交付系统
公开(公告)号：WO0069504A9
公开(公告)日：2002-02-21
申请号：PCT/US0013119
申请日：2000-05-12
申请人： BARD INC C R , GAMBALE RICHARD A , SHAH CHIRAG B , WEISER MICHAEL F , FORCUCCI STEPHEN J , FORDE SEAN
发明人： GAMBALE RICHARD A , SHAH CHIRAG B , WEISER MICHAEL F , FORCUCCI STEPHEN J , FORDE SEAN
IPC分类号： A61M36/04 , A61F2/00 , A61F2/02 , A61M31/00
CPC分类号： A61M37/0069 , A61F2/2493 , A61F2250/0067
摘要： The present invention provides a system for delivering a therapeutic agent into tissue in combination with an implant device (2). Preferably the therapeutic substance is contained within a pellet form (14) that is deliverable into the interior of the device (2) after it has been implanted. In a preferred embodiment the implant device (2) comprises a flexible coiled spring body, the coils (4) of which have a diameter and spacing to contain the pellet (14) within the interior of the device (2). A cavity (18) provided by the interior of the device (2) permits blood to pool around the pellet (14) and mix with the therapeutic agent. In treatment of ischemic tissue such as the of the myocardium of the heart, the mechanical irritation of the tissue caused by the implanted device (2) can help to provide an angiogenic effect. Several delivery systems have provided for delivering the implant and pellet (14) sequentially or simultaneously.
摘要翻译：本发明提供了一种用于将治疗剂与植入装置（2）组合递送到组织中的系统。优选地，治疗物质包含在颗粒形式（14）中，其在植入之后可输送到装置（2）的内部。在优选实施例中，植入装置（2）包括柔性螺旋弹簧体，其线圈（4）具有直径和间距以在装置（2）的内部内容纳颗粒（14）。由装置（2）的内部提供的空腔（18）允许血液围绕颗粒（14）聚集并与治疗剂混合。在治疗缺血组织如心脏的心肌时，由植入装置（2）引起的组织的机械刺激有助于提供血管生成作用。已经提供了几个递送系统来顺序地或同时地递送植入物和颗粒（14）。

6. 发明专利

JPH11244392A STENT FOR RECONSTRUCTING BLOOD VESSELS IN TRANSHEART MUSCLE AND ITS GUIDING SYSTEM 失效
公开(公告)号：JPH11244392A
公开(公告)日：1999-09-14
申请号：JP16411698
申请日：1998-05-07
申请人： BARD INC C R
发明人： GAMBALE RICHARD A
IPC分类号： A61B17/00 , A61F2/02 , A61F2/82 , A61F2/94 , A61M29/00
摘要： PROBLEM TO BE SOLVED: To provide a device and a method for reconstructing the blood vessels of myocardial tissues in a heart by using stents. SOLUTION: In order to reconstruct the blood vessels, by implanting plural stents 12, 20 and 24 into myocardial tissues temporarily asleep, the blood from the left ventricle of the heart is made to be flown into the tissue directly. Various types of scents are shown here; when they provides the bloods, the stents steer and also intrude into the tissues, and, after being implanted, the stents protest against the movement outward the tissue. The stents can also be inserted into the myocardial tissue by a steering type of proving device. It is preferable that the stent is provided for the left ventricle of the heart by a catheter of which shape is suitable for holding plural stents and that can be inserted through the skin and be guided. The stents are pushed inside the myocardial tissues directly through the catheter.

7. 发明专利

CA1323814C GUIDE WIRE EXTENSION 未知
公开(公告)号：CA1323814C
公开(公告)日：1993-11-02
申请号：CA518521
申请日：1986-09-18
申请人： GAMBALE RICHARD A
发明人： GAMBALE RICHARD A , CRITTENDEN JAMES F , RYAN JAMES P
IPC分类号： A61M25/00 , A61M25/01 , A61M25/09 , B21F15/06
摘要： A guide wire system for use in catheter exchanges avoids the need foe a separate exchange wire. Instead of the conventional practice in which the initial guide wire is removed and replaced with a longer exchange wire, a guide wire extension is attached to the proximal end of the initial guide wire thereby increasing its effective length so that it may be used to perform a catheter exchange. The initial guide wire remains in place in the patient's vasculature. The proximal end of the guide wire and the distal end of the exchange wire are formed to define a connection which may be crimped to effect the connection between the two wires. A crimping tool is provided to hold the mating ends of the guide wire and extension wire together while effecting the crimp.

8. 发明公开

EP1207932A4 CATHETER POSITIONING SYSTEMS 审中-公开
标题翻译：导管定位系统
公开(公告)号：EP1207932A4
公开(公告)日：2008-01-23
申请号：EP00950836
申请日：2000-07-28
申请人： BARD INC C R
发明人： GAMBALE RICHARD A , FORCUCCI STEPHEN J , SHAH CHIRAG B , WEISER MICHAEL F , FORDE SEAN
IPC分类号： A61M25/00 , A61M25/01 , A61M25/04 , A61M29/00
CPC分类号： A61M25/04 , A61B2017/3488 , A61M25/0084 , A61M2025/0087

9. 发明公开

EP1098597A1 IMPLANT ANCHOR SYSTEMS 审中-公开
标题翻译：系统用于固定植入物
公开(公告)号：EP1098597A1
公开(公告)日：2001-05-16
申请号：EP00932376
申请日：2000-05-12
申请人： BARD INC C R
发明人： WEISER MICHAEL F , GAMBALE RICHARD A , FORCUCCI STEPHEN J , FORDE SEAN , KWAN KELLYWAN
IPC分类号： A61F2/00 , A61B17/064 , A61B17/068 , A61B17/08
CPC分类号： A61B17/064 , A61B17/068 , A61B2017/0649
摘要： The present invention provides anchoring mechanisms for tissue implants. The anchors (4) are integrated as part of the structure of the implant, and serve to resist migration of the implant from highly dynamic muscle tissue such as the myocardium of the heart. In implant devices configured as a flexible coil (8), various attributes of the coil may be altered to increase the anchoring capability of the device. The flexibility of the device may be increased to resist migration by changing the coil filament thickness, and pitch or filament material. Alternatively, the end coil may be altered to have a broader cross-sectional profile in engagement with the tissue or may include an anchoring barb. Additionally, methods of implanting a tissue implant device are provided.

10. 发明公开

EP1542598A4 TISSUE CAPTURING DEVICES 审中-公开
标题翻译：布FASS DEVICES
公开(公告)号：EP1542598A4
公开(公告)日：2012-04-25
申请号：EP03754464
申请日：2003-09-08
申请人： BARD INC C R
发明人： GAMBALE RICHARD A , WEISER MICHAEL F
IPC分类号： A61B17/04 , A61B17/08 , A61B20060101 , A61B17/00 , A61B17/06 , A61B17/064 , A61B17/11 , A61B17/30
CPC分类号： A61B17/0469 , A61B17/0487 , A61B17/1114 , A61B2017/00349 , A61B2017/00827 , A61B2017/00867 , A61B2017/0409 , A61B2017/0414 , A61B2017/0417 , A61B2017/0443 , A61B2017/0458 , A61B2017/0464 , A61B2017/06171 , A61B2017/0649 , A61B2017/1103 , A61B2017/1142 , A61B2017/308

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