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1. 发明授权

US08012964B2 9-substituted 8-oxoadenine compound 有权
标题翻译： 9-取代的8-氧代腺嘌呤化合物
公开(公告)号：US08012964B2
公开(公告)日：2011-09-06
申请号：US10593691
申请日：2005-03-24
申请人： Ayumu Kurimoto , Yoshiaki Isobe , Stephen Brough , Hiroki Wada , Roger Bonnert , Thomas McInally
发明人： Ayumu Kurimoto , Yoshiaki Isobe , Stephen Brough , Hiroki Wada , Roger Bonnert , Thomas McInally
IPC分类号： C07D473/18 , A61K31/522 , A61P37/06 , A61P37/08 , A61P11/06
CPC分类号： C07D473/18 , A61K31/522 , A61K31/5377
摘要： The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
摘要翻译：本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其药学上可接受的盐。

2. 发明申请

US20060264435A1 Novel compounds 失效
公开(公告)号：US20060264435A1
公开(公告)日：2006-11-23
申请号：US10551783
申请日：2004-04-06
申请人： Roger Bonnert , Stephen Brough , Andrew Davies , Timothy Luker , Thomas McInally , Ian Millichip , Garry Pairaudeau , Anil Patel , Rukshana Rasul , Stephen Thom
发明人： Roger Bonnert , Stephen Brough , Andrew Davies , Timothy Luker , Thomas McInally , Ian Millichip , Garry Pairaudeau , Anil Patel , Rukshana Rasul , Stephen Thom
IPC分类号： A61K31/5377 , A61K31/4706 , A61K31/44 , A61K31/513 , A61K31/506
CPC分类号： C07C59/68 , C07C59/70 , C07C65/24 , C07C69/94 , C07C205/35 , C07C205/37 , C07C217/80 , C07C235/42 , C07C255/55 , C07C271/28 , C07C275/32 , C07C311/29 , C07C317/22 , C07C323/18 , C07C2601/02 , C07D205/04 , C07D207/02 , C07D213/61 , C07D213/72 , C07D215/12 , C07D233/52 , C07D239/26 , C07D239/34 , C07D239/42 , C07D277/52 , C07D285/10 , C07D295/192 , C07D295/26 , C07D307/80 , C07D317/54 , C07D333/56 , C07D403/04 , C07D417/04
摘要： The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.

3. 发明授权

US08158820B2 Compounds 失效
标题翻译：化合物
公开(公告)号：US08158820B2
公开(公告)日：2012-04-17
申请号：US10551783
申请日：2004-04-06
申请人： Roger Bonnert , Stephen Brough , Andrew Davies , Timothy Luker , Thomas McInally , Ian Millichip , Garry Pairaudeau , Anil Patel , Rukhsana Rasul , Stephen Thom
发明人： Roger Bonnert , Stephen Brough , Andrew Davies , Timothy Luker , Thomas McInally , Ian Millichip , Garry Pairaudeau , Anil Patel , Rukhsana Rasul , Stephen Thom
IPC分类号： C07C63/33 , A61K31/19
CPC分类号： C07C59/68 , C07C59/70 , C07C65/24 , C07C69/94 , C07C205/35 , C07C205/37 , C07C217/80 , C07C235/42 , C07C255/55 , C07C271/28 , C07C275/32 , C07C311/29 , C07C317/22 , C07C323/18 , C07C2601/02 , C07D205/04 , C07D207/02 , C07D213/61 , C07D213/72 , C07D215/12 , C07D233/52 , C07D239/26 , C07D239/34 , C07D239/42 , C07D277/52 , C07D285/10 , C07D295/192 , C07D295/26 , C07D307/80 , C07D317/54 , C07D333/56 , C07D403/04 , C07D417/04
摘要： The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
摘要翻译：本发明涉及取代的苯氧基乙酸（I）作为治疗呼吸系统疾病的有用的药物化合物，含有它们的药物组合物及其制备方法。

4. 发明申请

US20110166117A1 Novel Compounds 审中-公开
标题翻译：新型化合物
公开(公告)号：US20110166117A1
公开(公告)日：2011-07-07
申请号：US12982435
申请日：2010-12-30
申请人： Roger Bonnert , Stephen Brough , Andrew Davies , Timothy Luker , Thomas McInally , Ian Millichip , Garry Pairaudeau , Anil Patel , Rukhsana Rasul , Stephen Thom
发明人： Roger Bonnert , Stephen Brough , Andrew Davies , Timothy Luker , Thomas McInally , Ian Millichip , Garry Pairaudeau , Anil Patel , Rukhsana Rasul , Stephen Thom
IPC分类号： A61K31/506 , C07C59/70 , A61K31/192 , A61P11/06 , A61P11/02 , C07D215/06 , A61K31/47 , C07C255/54 , A61K31/277 , C07C205/37 , C07D239/26 , A61K31/505 , C07D213/71 , A61K31/4418 , C07D239/42 , C07D413/04 , A61K31/5377 , A61K31/397
CPC分类号： C07C59/68 , C07C59/70 , C07C65/24 , C07C69/94 , C07C205/35 , C07C205/37 , C07C217/80 , C07C235/42 , C07C255/55 , C07C271/28 , C07C275/32 , C07C311/29 , C07C317/22 , C07C323/18 , C07C2601/02 , C07D205/04 , C07D207/02 , C07D213/61 , C07D213/72 , C07D215/12 , C07D233/52 , C07D239/26 , C07D239/34 , C07D239/42 , C07D277/52 , C07D285/10 , C07D295/192 , C07D295/26 , C07D307/80 , C07D317/54 , C07D333/56 , C07D403/04 , C07D417/04
摘要： The invention relates to substituted phenoxyacetic acids (I) as useful pharmaceutical compounds for treating respiratory disorders, pharmaceutical compositions containing them, and processes for their preparation.
摘要翻译：本发明涉及取代的苯氧基乙酸（I）作为治疗呼吸系统疾病的有用的药物化合物，含有它们的药物组合物及其制备方法。

5. 发明申请

US20090082332A1 PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL OR ALLERGIC DISEASES AND CANCERS 审中-公开
标题翻译：用于治疗病毒或过敏性疾病和癌症的嘌呤衍生物
公开(公告)号：US20090082332A1
公开(公告)日：2009-03-26
申请号：US12067536
申请日：2006-09-20
申请人： Philip Abbot , Roger Victor Bonnert , Stephen Brough , Kamaldeep Chohan , Thomas McInally , Stephen Thom , Yoshiaki Isobe , Kei Nakamura , Shingo Tojo
发明人： Philip Abbot , Roger Victor Bonnert , Stephen Brough , Kamaldeep Chohan , Thomas McInally , Stephen Thom , Yoshiaki Isobe , Kei Nakamura , Shingo Tojo
IPC分类号： A61K31/397 , C07D473/02 , A61P31/12 , A61P35/00 , A61P37/08 , A61K31/522
CPC分类号： C07D473/34
摘要： The present invention provides compounds of formula (I) wherein R1, Y1, X1, Z1, X2, Y2, A, Y3, n, R and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供式（I）化合物，其中R1，Y1，X1，Z1，X2，Y2，A，Y3，n，R和R2如说明书中所定义，其制备方法，含有它们的药物组合物及其制备方法用于治疗。

6. 发明授权

US06958350B2 Chemical compounds 失效
标题翻译：化合物
公开(公告)号：US06958350B2
公开(公告)日：2005-10-25
申请号：US10468179
申请日：2002-02-18
申请人： Stephen Brough , Thomas McInally , Matthew Perry , Brian Springthorpe
发明人： Stephen Brough , Thomas McInally , Matthew Perry , Brian Springthorpe
IPC分类号： A61K31/4545 , A61P1/00 , A61P1/04 , A61P3/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/00 , A61P21/04 , A61P29/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/454 , A61K31/4535
CPC分类号： C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention provides a compound of formula (I): wherein R1, R2, R3, R4, R5, N, X and Y are as defined in the specification, processes, for their preparation, pharmaceutical compositions containing them, and their use in therapy, especially for the treatment of chemokine receptor related diseases and conditions.
摘要翻译：本发明提供式（I）化合物：其中R 1，R 2，R 3，R 4， R 5，N，X和Y如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是用于治疗趋化因子受体相关疾病和条件。

7. 发明申请

US20090099216A1 NOVEL ADENINE COMPOUND 审中-公开
标题翻译：新颖的化合物
公开(公告)号：US20090099216A1
公开(公告)日：2009-04-16
申请号：US12067781
申请日：2006-09-22
申请人： Ian Millichip , Thomas McInally , Roger Bonnert
发明人： Ian Millichip , Thomas McInally , Roger Bonnert
IPC分类号： A61K31/522 , C07D473/18
CPC分类号： C07D473/18
摘要： A novel adenine compound represented by the formula (1): wherein Z represents (un)substituted alkylene, a single bond, etc.; R1 represents an (un)substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, or heteroaryl group; R2 represents hydrogen or (un)substituted alkyl; R3, R4 and R5 each independently represents an (un)substituted alkyl, alkenyl, alkynyl, aryl, or heteroaryl group, provided that R3 and R5 may be bonded to each other to form a 3- to 7-membered, saturated carbocycle or heterocycle in cooperation with the adjacent carbon atom; and X represents oxygen, sulfur, SO2, NR6 (R6 represents hydrogen or alkyl), or a single bond, or a pharmaceutically acceptable salt of the compound. The compound and salt are useful as a medicine.
摘要翻译：由式（1）表示的新型腺嘌呤化合物：其中Z表示（un）取代的亚烷基，单键等; R1表示（un）取代的烷基，烯基，炔基，环烷基，芳基或杂芳基; R2代表氢或（未）取代的烷基; R 3，R 4和R 5各自独立地表示（未）取代的烷基，烯基，炔基，芳基或杂芳基，条件是R 3和R 5可以彼此键合以形成3-至7-元饱和碳环或杂环与邻近的碳原子合作; X表示氧，硫，SO 2，NR 6（R 6表示氢或烷基）或单键或该化合物的药学上可接受的盐。化合物和盐可用作药物。

8. 发明授权

US06946478B2 Compounds 失效
标题翻译：化合物
公开(公告)号：US06946478B2
公开(公告)日：2005-09-20
申请号：US10339261
申请日：2003-01-09
申请人： Andrew Baxter , Stephen Brough , Nicholas Kindon , Thomas McInally , Bryan Roberts , Stephen Thom
发明人： Andrew Baxter , Stephen Brough , Nicholas Kindon , Thomas McInally , Bryan Roberts , Stephen Thom
IPC分类号： C07D295/18 , A61K31/427 , A61K31/4375 , A61K31/445 , A61K31/4468 , A61K31/4523 , A61K31/454 , A61K31/4545 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/541 , A61P1/00 , A61P3/10 , A61P9/10 , A61P11/00 , A61P17/00 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P29/00 , A61P31/00 , A61P31/18 , A61P37/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D20060101 , C07D211/14 , C07D211/22 , C07D211/32 , C07D211/36 , C07D211/40 , C07D211/46 , C07D211/58 , C07D217/14 , C07D241/04 , C07D295/192 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/02 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
CPC分类号： C07D401/12 , C07D211/32 , C07D211/46 , C07D211/58 , C07D217/14 , C07D295/192 , C07D401/14 , C07D405/04 , C07D409/04 , C07D413/12 , C07D417/12 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07D513/04
摘要： The invention provides compounds of general formula wherein R1, m, Q, T, n, R2, R3, V, W, X and R4 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供通式的化合物其中R 1，m，Q，T，n，R 2，R 3，V，W， X和R 4如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

9. 发明申请

US20090143400A1 PURINE DERIVATIVES HAVING IMMUNO-MODULATING PROPERTIES 审中-公开
标题翻译：具有免疫调节特性的嘌呤衍生物
公开(公告)号：US20090143400A1
公开(公告)日：2009-06-04
申请号：US12066952
申请日：2006-09-12
申请人： Thomas McInally , Stephen Thom , Hiroki Wada
发明人： Thomas McInally , Stephen Thom , Hiroki Wada
IPC分类号： A61K31/496 , C07D473/18 , A61K31/522 , A61P31/12 , A61P35/00 , A61P37/08 , A61P11/00
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula wherein n, Y, Z, R, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供下式的化合物，其中n，Y，Z，R，R 1，R 2和R 3如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

10. 发明授权

US07358376B2 Substituted Thiophene compounds 失效
标题翻译：取代噻吩化合物
公开(公告)号：US07358376B2
公开(公告)日：2008-04-15
申请号：US09868884
申请日：2001-02-07
申请人： Andrew Baxter , Stephen Brough , Alan Faull , Craig Johnstone , Thomas McInally
发明人： Andrew Baxter , Stephen Brough , Alan Faull , Craig Johnstone , Thomas McInally
IPC分类号： A61K31/381 , C07D333/20
CPC分类号： C07D409/04 , C07D333/38 , C07D413/04 , C07D417/04
摘要： The invention relates to heteroaromatic carboxamides of formula (I), wherein A, R1, R2 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明涉及式（I）的杂芳族甲酰胺，其中A，R 1，R 2和X如说明书中所定义，其制备中使用的方法和中间体，含有它们的药物组合物及其在治疗中的用途。

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