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1. 发明申请

US20140045837A1 9-Substituted 8-Oxoadenine Compound 有权
标题翻译： 9-取代的8-氧基腺嘌呤化合物
公开(公告)号：US20140045837A1
公开(公告)日：2014-02-13
申请号：US14058064
申请日：2013-10-21
申请人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
发明人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
IPC分类号： C07D473/18
CPC分类号： C07D473/18 , A61K31/522 , A61K31/5377
摘要： The present invention provides an 8-oxoadenine compound having immunomodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
摘要翻译：本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其药学上可接受的盐。

2. 发明授权

US08575180B2 9-substituted 8-oxoadenine compound 有权
标题翻译： 9-取代的8-氧代腺嘌呤化合物
公开(公告)号：US08575180B2
公开(公告)日：2013-11-05
申请号：US13187260
申请日：2011-07-20
申请人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
发明人： Ayumu Kurimoto , Kazuki Hashimoto , Yoshiaki Isobe , Stephen Brough , Ian Millichip , Hiroki Wada , Roger Bonnert , Thomas Mcinally
IPC分类号： A61K31/52 , C07D473/00
CPC分类号： C07D473/18 , A61K31/522 , A61K31/5377
摘要： The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
摘要翻译：本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其药学上可接受的盐。

3. 发明授权

US08198285B2 Pyrazine derivatives 失效
标题翻译：吡嗪衍生物
公开(公告)号：US08198285B2
公开(公告)日：2012-06-12
申请号：US13008154
申请日：2011-01-18
申请人： Tao Feng , Hitesh Jayantilal Sanganee , Hiroki Wada
发明人： Tao Feng , Hitesh Jayantilal Sanganee , Hiroki Wada
IPC分类号： A61K31/497 , A61P35/00 , A61P19/08 , C07D401/12
CPC分类号： C07D401/12
摘要： The invention concerns pyrazine derivatives of the Formula I or pharmaceutically-acceptable salts thereof; wherein each of n, m and R has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of bone-related disorders or conditions.
摘要翻译：本发明涉及式I的吡嗪衍生物或其药学上可接受的盐; 其中n，m和R中的每一个在描述中具有上文定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于治疗骨相关疾病或病症的药物中的用途。

4. 发明申请

US20090143400A1 PURINE DERIVATIVES HAVING IMMUNO-MODULATING PROPERTIES 审中-公开
标题翻译：具有免疫调节特性的嘌呤衍生物
公开(公告)号：US20090143400A1
公开(公告)日：2009-06-04
申请号：US12066952
申请日：2006-09-12
申请人： Thomas McInally , Stephen Thom , Hiroki Wada
发明人： Thomas McInally , Stephen Thom , Hiroki Wada
IPC分类号： A61K31/496 , C07D473/18 , A61K31/522 , A61P31/12 , A61P35/00 , A61P37/08 , A61P11/00
CPC分类号： C07D473/18
摘要： The present invention provides compounds of formula wherein n, Y, Z, R, R1, R2 and R3 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供下式的化合物，其中n，Y，Z，R，R 1，R 2和R 3如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途。

5. 发明授权

US5289684A Charging pressure control apparatus for an internal combustion engine with a dual turbocharger system 失效
标题翻译：具有双涡轮增压器系统的内燃机的充气压力控制装置
公开(公告)号：US5289684A
公开(公告)日：1994-03-01
申请号：US923251
申请日：1992-07-31
申请人： Mamoru Yoshioka , Kunihiko Nakata , Hiroki Wada
发明人： Mamoru Yoshioka , Kunihiko Nakata , Hiroki Wada
IPC分类号： F02B37/007 , F02B37/18 , F02D41/00 , F02B37/12
CPC分类号： F02B37/007 , F02B37/18 , F02D41/0007 , Y02T10/144
摘要： A charging pressure control apparatus including a first duty control solenoid valve for controlling the opening degree of an exhaust bypass valve to thereby control a charging pressure during "one-turbocharger-operation", and a second duty control solenoid valve for controlling the opening degree of a waste gate valve to thereby control a charging pressure during "two-turbocharger-operation". The operating conditions at high altitudes of the first duty control solenoid valve and the second duty control solenoid valve are made different from those at low altitudes so that the power characteristic of the turbocharged engine is as good at high altitudes as at low altitudes.
摘要翻译：一种充电压力控制装置，包括：第一占空比控制电磁阀，用于控制排气旁路阀的开度，从而控制“单涡轮增压器运行”期间的充气压力，以及第二负荷控制电磁阀，废气闸阀，从而在“双涡轮增压器运转”期间控制充气压力。使第一占空比控制电磁阀和第二占空比控制电磁阀的高空作业条件与低空高度不同，使得涡轮增压发动机的功率特性在高海拔处与低海拔地区一样好。

6. 发明授权

US08895570B2 Purine derivatives 有权
标题翻译：嘌呤衍生物
公开(公告)号：US08895570B2
公开(公告)日：2014-11-25
申请号：US13994321
申请日：2011-12-14
申请人： Phillip Abbott , Roger Victor Bonnert , Thomas McInally , Stephen Thom , Hiroki Wada , Satoshi Onuma
发明人： Phillip Abbott , Roger Victor Bonnert , Thomas McInally , Stephen Thom , Hiroki Wada , Satoshi Onuma
IPC分类号： A61K31/52 , C07D473/18
CPC分类号： C07D473/18
摘要： The invention provides the compound of formula (I) and pharmaceutically acceptable salt thereof, pharmaceutical compositions containing the compound and the use of the compound in therapy.
摘要翻译：本发明提供式（I）化合物及其药学上可接受的盐，其含有该化合物的药物组合物和该化合物在治疗中的用途。

7. 发明授权

US08436178B2 Imidazoquinolines with immuno-modulating properties 有权
标题翻译：具有免疫调节性质的咪唑喹啉
公开(公告)号：US08436178B2
公开(公告)日：2013-05-07
申请号：US12596817
申请日：2008-05-06
申请人： Roger Victor Bonnert , Thomas McInally , Stephen Thom , Hiroki Wada
发明人： Roger Victor Bonnert , Thomas McInally , Stephen Thom , Hiroki Wada
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： The present invention provides compounds of formula (I) wherein Ra, R1, R2, R3, X1, Y1, Z1, A, n and m are as defined in the specification, and pharmaceutically acceptable salts thereof, as well as processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
摘要翻译：本发明提供了其中Ra，R1，R2，R3，X1，Y1，Z1，A，n和m如说明书中所定义的式（I）化合物及其药学上可接受的盐，以及其制备方法，含有它们的药物组合物及其在治疗中的用途。

8. 发明授权

US08012964B2 9-substituted 8-oxoadenine compound 有权
标题翻译： 9-取代的8-氧代腺嘌呤化合物
公开(公告)号：US08012964B2
公开(公告)日：2011-09-06
申请号：US10593691
申请日：2005-03-24
申请人： Ayumu Kurimoto , Yoshiaki Isobe , Stephen Brough , Hiroki Wada , Roger Bonnert , Thomas McInally
发明人： Ayumu Kurimoto , Yoshiaki Isobe , Stephen Brough , Hiroki Wada , Roger Bonnert , Thomas McInally
IPC分类号： C07D473/18 , A61K31/522 , A61P37/06 , A61P37/08 , A61P11/06
CPC分类号： C07D473/18 , A61K31/522 , A61K31/5377
摘要： The present invention provides an 8-oxoadenine compound having immunemodulating activities such as an interferon inducing activity and useful as an antiviral agent and antiallergic agent, which is represented by the following formula (1): [wherein the ring A represents a 6-10 membered aromatic carbocyclic ring and the like, R represents a halogen atom, an alkyl group and the like, n represents an integer of 0-2, Z1 represents alkylene, X2 represents oxygen atom, sulfur atom, SO2, NR5, CO, CONR5, NR5CO and the like, Y1, Y2 and Y3 represent independently a single bond or an alkylene group, X1 represents oxygen atom, sulfur atom, NR4 (R4 is hydrogen atom or an alkyl group) or a single bond, R2 represents a substituted or unsubstituted alkyl group, R1 represents hydrogen atom, hydroxy group, an alkoxy group, an alkoxycarbonyl group or a haloalkyl group] or its pharmaceutically acceptable salt.
摘要翻译：本发明提供具有免疫调节活性的8-氧代腺嘌呤化合物，例如干扰素诱导活性，可用作抗病毒剂和抗变应性剂，其由下式（1）表示：[其中环A表示6-10元芳香族碳环等，R表示卤素原子，烷基等，n表示0-2的整数，Z1表示亚烷基，X2表示氧原子，硫原子，SO2，NR5，CO，CONR5，NR5CO 等等，Y1，Y2和Y3独立地表示单键或亚烷基，X1表示氧原子，硫原子，NR4（R4是氢原子或烷基）或单键，R2表示取代或未取代的烷基基团，R 1表示氢原子，羟基，烷氧基，烷氧基羰基或卤代烷基]或其药学上可接受的盐。

9. 发明授权

US07098828B2 Complex band-pass ΔΣ AD modulator for use in AD converter circuit 失效
标题翻译：用于AD转换器电路的复合带通DeltaSigma AD调制器
公开(公告)号：US07098828B2
公开(公告)日：2006-08-29
申请号：US11157848
申请日：2005-06-22
申请人： Hao San , Haruo Kobayashi , Hiroki Wada , Atsushi Wada
发明人： Hao San , Haruo Kobayashi , Hiroki Wada , Atsushi Wada
IPC分类号： H03M3/00 , H03M1/00 , H04B14/06
CPC分类号： H03M3/34 , H03M1/0665 , H03M3/40 , H03M3/424 , H03M3/464
摘要： A complex band-pass ΔΣ AD modulator is provided with a subtracter device, a complex band-pass filter, first and second AD converters, and first and second DA converters. The first and second DA converters and first and second logic circuits are sandwiched by first and second multiplexers. At a first timing of a clock signal, the first multiplexer inputs and outputs the first and second digital signals as they are, and at a second timing thereof, the first multiplexer inputs the first and second digital signals, and outputs the first digital signal as a second digital signal and outputs the second digital signal as a first digital signal. The second multiplexer inputs and outputs first and second analog signals similarly. The first and second logic circuits substantially noise-shapes non-linearities of the first and second DA converters by realizing complex digital and analog filters, using high-pass and low-pass element rotation methods.
摘要翻译：复数带通DeltaSigma AD调制器具有减法器件，复带通滤波器，第一和第二AD转换器以及第一和第二DA转换器。第一和第二DA转换器和第一和第二逻辑电路夹在第一和第二多路复用器之间。在时钟信号的第一定时，第一多路复用器原样输入并输出第一和第二数字信号，并且在其第二定时，第一多路复用器输入第一和第二数字信号，并将第一数字信号作为第二数字信号并输出第二数字信号作为第一数字信号。第二多路复用器类似地输入和输出第一和第二模拟信号。通过使用高通和低通元素旋转方法实现复杂的数字和模拟滤波器，第一和第二逻辑电路基本上噪声地形成第一和第二DA转换器的非线性。

10. 发明授权

US4450810A Device for controlling spark timing and fuel injection of an internal combustion engine 失效
标题翻译：用于控制内燃机的火花正时和燃料喷射的装置
公开(公告)号：US4450810A
公开(公告)日：1984-05-29
申请号：US415993
申请日：1982-09-08
申请人： Hiroki Wada , Yasuhiro Ikuta
发明人： Hiroki Wada , Yasuhiro Ikuta
IPC分类号： F02D41/22 , F02D37/02 , F02D43/00 , F02D45/00 , F02P5/152 , F02P5/153
CPC分类号： F02P5/152 , F02D37/02 , Y02T10/46
摘要： A knock control device of an internal combustion engine incorporated with a device for controlling the spark timing and the fuel injection.The device for controlling the spark timing and the fuel injection comprises an electronic control unit. A knock sensor is mounted on the cylinder block for sensing knocking. When the output of the knock sensor is above a first predetermined level, retardation of spark timing is caused. When the output of the knock sensor is above a second level above the first level, retardation of spark timing is caused and the amount of fuel to be injected is increased.
摘要翻译：一种内燃机的爆震控制装置，其结合有用于控制火花正时和燃料喷射的装置。用于控制火花正时和燃料喷射的装置包括电子控制单元。爆震传感器安装在气缸体上，用于感应爆震。当爆震传感器的输出高于第一预定水平时，引起火花正时的延迟。当爆震传感器的输出高于高于第一水平的第二水平时，引起火花正时的延迟并且喷射的燃料量增加。

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