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1. 发明授权

US06212434B1 Single pass lead system 失效
公开(公告)号：US06212434B1
公开(公告)日：2001-04-03
申请号：US09120824
申请日：1998-07-22
申请人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W. Goebel , Douglas A. Heitkamp , Randall M. Peterfeso
发明人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W. Goebel , Douglas A. Heitkamp , Randall M. Peterfeso
IPC分类号： A61N105
CPC分类号： A61N1/0573 , A61N1/0563
摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

2. 发明授权

US06321122B1 Single pass defibrillation/pacing lead with passively attached electrode for pacing and sensing 失效
标题翻译：单次除颤/起搏导联带有被动连接的电极用于起搏和感测
公开(公告)号：US06321122B1
公开(公告)日：2001-11-20
申请号：US09121018
申请日：1998-07-22
申请人： Avram Scheiner , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , John E. Heil , William Hsu , Ronald W. Heil, Jr.
发明人： Avram Scheiner , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , John E. Heil , William Hsu , Ronald W. Heil, Jr.
IPC分类号： A61N100
CPC分类号： A61N1/0573
摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The second electrode is adapted for positioning and fixation to the wall of the atrium of the heart. A passive fixation element may be used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and passive fixation of the second electrode.
摘要翻译：适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统的单程心内膜引导电极包括具有周向外表面的引线体。引线包括具有第一导电表面的第一远端电极。引线体还具有具有第二导电表面的第二电极。第二电极适于定位并固定在心脏心房的壁上。被动固定元件可以用作第二电极的一部分。引线体还包括有助于第二电极的定位和被动固定的弯曲部分。

3. 发明授权

US06505082B1 Single pass lead system 失效
公开(公告)号：US06505082B1
公开(公告)日：2003-01-07
申请号：US09643125
申请日：2000-08-21
申请人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W Goebel , Douglas A Heitkamp , Randall M. Peterfeso
发明人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W Goebel , Douglas A Heitkamp , Randall M. Peterfeso
IPC分类号： A61N105
CPC分类号： A61N1/0573 , A61N1/0563
摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

4. 发明授权

US06256541B1 Endocardial lead having defibrillation and sensing electrodes with septal anchoring 失效
标题翻译：具有除颤和感应/起搏电极的心内膜导联
公开(公告)号：US06256541B1
公开(公告)日：2001-07-03
申请号：US09062268
申请日：1998-04-17
申请人： John E. Heil , Ronald W. Heil, Jr. , Avram Scheiner , Yayun Lin , Lyle A. Bye , J. John Lattuca
发明人： John E. Heil , Ronald W. Heil, Jr. , Avram Scheiner , Yayun Lin , Lyle A. Bye , J. John Lattuca
IPC分类号： A61N105
CPC分类号： A61N1/0563 , A61N1/0573
摘要： An endocardial lead comprising an elongate body having a first defibrillation coil electrode, a second defibrillation coil electrode and a first pacing/sensing electrode. The first defibrillation coil electrode has a first end and a second end, where the first end is at or near the distal end of the elongate body and the second end spaced longitudinally from the distal end. The first pacing/sensing electrode is spaced longitudinally along the peripheral surface from the second end of the first defibrillation coil electrode. The second defibrillation coil electrode is spaced longitudinally along the peripheral surface from the first pacing/sensing electrode to afford positioning the first defibrillation coil longitudinally adjacent an apical location of the right ventricle of a heart with the first pacing/sensing electrode within the right ventricle of the heart and the second defibrillation coil within the right atrial chamber or a major vein leading to the right atrial chamber of the heart. The elongate body further includes a curved portion on which the first pacing/sensing electrode is positioned such that the first pacing/sensing electrode extends beyond the peripheral surface of the elongate body to engage the tissue of the heart. The first pacing/sensing electrode further includes a retaining element, where the retaining element is adapted to be embedded in the right ventricle of the heart to secure the first pacing/sensing electrode and the elongate body of the endocardial lead to the right ventricle of the heart.
摘要翻译：一种心内膜，其包括具有第一除颤线圈电极，第二除颤线圈电极和第一起搏感测电极的细长体。第一除颤线圈电极具有第一端和第二端，其中第一端处于细长体的远端处或其附近，并且第二端与远端纵向间隔开。第一起搏感测电极沿着与第一除颤线圈电极的第二端的外周表面纵向间隔开。第二除颤线圈电极沿着与第一起搏/感测电极的外周表面纵向间隔开，以使第一除颤线圈与心脏右心室的顶端位置纵向相邻，其中第一起搏/感测电极位于右心室内右心房中的心脏和第二除颤线圈或通向心脏右心房的主要静脉。细长主体还包括弯曲部分，第一起搏/感测电极定位在弯曲部分上，使得第一起搏/感测电极延伸超出细长体的周边表面以接合心脏的组织。第一起搏/感测电极还包括保持元件，其中保持元件适于嵌入心脏的右心室，以将第一起搏/感测电极和心内膜引导件的细长体固定到右心室心。

5. 发明授权

US06345204B1 Single pass lead having retractable, actively attached electrode for pacing and sensing 失效
标题翻译：单通引线具有可伸缩的，主动连接的用于起搏和感测的电极
公开(公告)号：US06345204B1
公开(公告)日：2002-02-05
申请号：US09661531
申请日：2000-09-14
申请人： Avram Scheiner , Ronald W. Heil, Jr. , Qingsheng Zhu , Peter T. Kelley , David M. Flynn , John E. Heil
发明人： Avram Scheiner , Ronald W. Heil, Jr. , Qingsheng Zhu , Peter T. Kelley , David M. Flynn , John E. Heil
IPC分类号： A61N105
CPC分类号： A61N1/0573
摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity including a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface which is for positioning within the ventricle of the heart. The lead body also has a second electrode which has a second electrical conducting surface adapted for positioning within the atrium of the heart. Both of the first and the second electrodes are adapted for positioning and fixation to the wall. An active fixation element is used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and fixing of the second electrode. In another embodiment, the main lead body includes a recess into which an atrial lead body and the active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element which can also be moved by turning the terminal pin.
摘要翻译：一种单程心内膜引导电极，其适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统，包括具有周向外表面的引线体。引线包括第一远端电极，其具有用于定位在心脏心室内的第一导电表面。引线体还具有第二电极，该第二电极具有适于定位在心脏心房内的第二导电表面。第一和第二电极都适于定位和固定在墙上。活性固定元件用作第二电极的一部分。引线体还包括有助于第二电极的定位和固定的弯曲部分。在另一实施例中，主引线体包括凹部，其中一个端部的心房引线体和主动固定元件可以从凹部位置到固定在心脏壁上的位置。主动固定元件也可以通过转动端子销来移动。

6. 发明授权

US6152954A Single pass lead having retractable, actively attached electrode for pacing and sensing 失效
标题翻译：单通引线具有可伸缩的，主动连接的用于起搏和感测的电极
公开(公告)号：US6152954A
公开(公告)日：2000-11-28
申请号：US121006
申请日：1998-07-22
申请人： Avram Scheiner , Ronald W. Heil, Jr. , Qingsheng Zhu , Peter T. Kelley , David M. Flynn , John E. Heil
发明人： Avram Scheiner , Ronald W. Heil, Jr. , Qingsheng Zhu , Peter T. Kelley , David M. Flynn , John E. Heil
IPC分类号： A61N1/05
CPC分类号： A61N1/0573
摘要： A single-pass endocardial lead electrode adapted for implantation on or about the heart and for connection to a system for monitoring or stimulating cardiac activity including a lead body with a circumferential outer surface. The lead includes a first distal end electrode which has a first electrical conducting surface which is for positioning within the ventricle of the heart. The lead body also has a second electrode which has a second electrical conducting surface adapted for positioning within the atrium of the heart. Both of the first and the second electrodes are adapted for positioning and fixation to the wall. An active fixation element is used as part of the second electrode. The lead body also includes a curved portion which facilitates the positioning and fixing of the second electrode. In another embodiment, the main lead body includes a recess into which an atrial lead body and the active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element which can also be moved by turning the terminal pin.
摘要翻译：一种单程心内膜引导电极，其适于植入在心脏上或其周围并用于连接到用于监测或刺激心脏活动的系统，包括具有周向外表面的引线体。引线包括第一远端电极，其具有用于定位在心脏心室内的第一导电表面。引线体还具有第二电极，该第二电极具有适于定位在心脏心房内的第二导电表面。第一和第二电极都适于定位和固定在墙上。活性固定元件用作第二电极的一部分。引线体还包括有助于第二电极的定位和固定的弯曲部分。在另一个实施例中，主引线主体包括凹部，其中安装在一端的心房引线主体和主动固定元件可以从凹陷位置行进到用于固定到心脏壁的位置。主动固定元件也可以通过转动端子销来移动。

7. 发明授权

US06584363B2 Implantable lead with dissolvable coating for improved fixation and extraction 失效
公开(公告)号：US06584363B2
公开(公告)日：2003-06-24
申请号：US09906571
申请日：2001-07-16
申请人： Ronald W. Heil, Jr. , John E. Heil , Randy Westlund
发明人： Ronald W. Heil, Jr. , John E. Heil , Randy Westlund
IPC分类号： A61N105
CPC分类号： A61N1/0568 , A61N1/056
摘要： A cardiac rhythm management system provides an endocardial cardiac rhythm management lead with an at least partially dissolvable coating at least partially on insulating portions of the lead body at or near its distal end. Upon dissolution, the coating promotes tissue ingrowth to secure the lead in place within fragile vascular structures or elsewhere. Dissolution of one such coating releases a therapeutic agent, such as a steroid that modifies the fibrotic scar tissue content of tissue ingrowth, such that the resulting bond between the tissue and the lead is weak, so that the lead can be easily extracted if desired. One such lead includes an insulating elongate body carrying at least. The lead also includes an at least partially dissolvable coating on an insulating portion of the peripheral distal lead surface. The coating provides one or more of a rough surface, a porous surface, or a swollen surface after being exposed to an aqueous substance.

8. 发明授权

US07218971B2 Implantable lead with dissolvable coating for improved fixation and extraction 失效
标题翻译：可植入铅，可溶解涂层，用于改进固定和提取
公开(公告)号：US07218971B2
公开(公告)日：2007-05-15
申请号：US10608850
申请日：2003-06-24
申请人： Ronald W. Heil, Jr. , John E. Heil , Randy Westlund
发明人： Ronald W. Heil, Jr. , John E. Heil , Randy Westlund
IPC分类号： A61N1/05
CPC分类号： A61N1/0568 , A61N1/056
摘要： A cardiac rhythm management system provides an endocardial cardiac rhythm management lead with an at least partially dissolvable coating at least partially on insulating portions of the lead body at or near its distal end. Upon dissolution, the coating promotes tissue ingrowth to secure the lead in place within fragile vascular structures or elsewhere. Dissolution of one such coating releases a therapeutic agent, such as a steroid that modifies the fibrotic scar tissue content of tissue ingrowth, such that the resulting bond between the tissue and the lead is weak, so that the lead can be easily extracted if desired. One such lead includes an insulating elongate body carrying at least. The lead also includes an at least partially dissolvable coating on an insulating portion of the peripheral distal lead surface. The coating provides one or more of a rough surface, a porous surface, or a swollen surface after being exposed to an aqueous substance.
摘要翻译：心脏节律管理系统提供心内心律管理引线，至少部分地可以在其远端处或其远端处的引线体的绝缘部分上具有至少部分可溶解的涂层。溶解后，涂层促进组织向内生长，以将铅固定在脆弱的血管结构或其他地方。一种这样的涂层的溶解释放治疗剂，例如修饰组织向内生长的纤维化瘢痕组织含量的类固醇，使得组织和引线之间产生的结合较弱，从而如果需要，铅可以容易地提取。一个这样的引线包括至少承载的绝缘细长体。引线还包括在外周远端引线表面的绝缘部分上的至少部分可溶解的涂层。在暴露于含水物质之后，涂层提供粗糙表面，多孔表面或溶胀表面中的一种或多种。

9. 发明授权

US06304786B1 Implantable lead with dissolvable coating for improved fixation and extraction 有权
标题翻译：可植入铅，可溶解涂层，用于改进固定和提取
公开(公告)号：US06304786B1
公开(公告)日：2001-10-16
申请号：US09280096
申请日：1999-03-29
申请人： Ronald W. Heil, Jr. , John E. Heil , Randy Westlund
发明人： Ronald W. Heil, Jr. , John E. Heil , Randy Westlund
IPC分类号： A61N105
CPC分类号： A61N1/0568 , A61N1/056
摘要： A cardiac rhythm management system provides an endocardial cardiac rhythm management lead with an at least partially dissolvable coating at least partially on insulating portions of the lead body at or near its distal end. Upon dissolution, the coating promotes tissue ingrowth to secure the lead in place within fragile vascular structures or elsewhere. Dissolution of one such coating releases a therapeutic agent, such as a steroid that modifies the fibrotic scar tissue content of tissue ingrowth, such that the resulting bond between the tissue and the lead is weak, so that the lead can be easily extracted if desired. One such lead includes an insulating elongate body carrying at least. The lead also includes an at least partially dissolvable coating on an insulating portion of the peripheral distal lead surface. The coating provides one or more of a rough surface, a porous surface, or a swollen surface after being exposed to an aqueous substance.
摘要翻译：心脏节律管理系统提供心内心律管理引线，其至少部分地可以在其远端处或其远端处的引线体的绝缘部分上具有至少部分可溶解的涂层。溶解后，涂层促进组织向内生长，以将铅固定在脆弱的血管结构或其他地方。一种这样的涂层的溶解释放治疗剂，例如改变组织向内生长的纤维化瘢痕组织含量的类固醇，使得组织和引线之间的所得粘合力较弱，从而如果需要，铅可以容易地提取。一个这样的引线包括至少承载的绝缘细长体。引线还包括在外周远端引线表面的绝缘部分上的至少部分可溶解的涂层。在暴露于含水物质之后，涂层提供粗糙表面，多孔表面或溶胀表面中的一种或多种。

10. 发明授权

US06408213B1 Low profile, ventricular, transvenous, epicardial defibrillation lead 有权
标题翻译：低调，心室，静脉，心外膜除颤引线
公开(公告)号：US06408213B1
公开(公告)日：2002-06-18
申请号：US09407364
申请日：1999-09-29
申请人： Jeffrey T. Bartig , Stuart R. Chastain , Gwen Crevensten , John E. Heil , Curtis C. Lindstrom
发明人： Jeffrey T. Bartig , Stuart R. Chastain , Gwen Crevensten , John E. Heil , Curtis C. Lindstrom
IPC分类号： A61N100
CPC分类号： A61N1/0563 , A61N2001/0585
摘要： A cardiac lead designed for implantation in the vasculature of the left side of the heart comprising a flexible lead body having a central lumen, a removable terminal pin, electrodes electrically coupled to the removable terminal pin, a mechanism for securing the electrodes in the proper position in the vasculature and a mechanism for sealing the central lumen after implantation to prevent body fluids from invading the lumen. The cardiac lead can be implanted or explanted using either a guidewire, a guide catheter or both.
摘要翻译：设计用于植入在心脏左侧脉管系统中的心脏引线，包括具有中心腔的柔性引线体，可移除端子引脚，电耦合到可移除端子引脚的电极，用于将电极固定在适当位置的机构在脉管系统中以及用于在植入后密封中央腔的机构，以防止体液侵入内腔。可以使用导丝，引导导管或两者将植入或移植心脏引线。

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