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1. 发明授权

US4239683A Pyrrolo benzodiazepine compounds 失效
标题翻译：吡咯并苯并二氮杂化合物
公开(公告)号：US4239683A
公开(公告)日：1980-12-16
申请号：US42449
申请日：1979-05-25
申请人： Atuyuki Takanabe , Yoshio Arakawa , Yoshio Kagitani , Yasuo Ueda , Daisuke Satoh , Nobuhiko Komatsu
发明人： Atuyuki Takanabe , Yoshio Arakawa , Yoshio Kagitani , Yasuo Ueda , Daisuke Satoh , Nobuhiko Komatsu
IPC分类号： A61K31/55 , A61P35/00 , C07D207/16 , C07D487/04 , C07D498/14
CPC分类号： C07D487/04 , C07D207/16
摘要： Novel perhydro-1H-pyrrolo[2,1-C][1,4]benzodiazepin-5-one compounds having antitumor activity, perhydro-1H-pyrrolo[2,1-C][1,4]-benzodiazepin-5,11-dione, compounds which are synthetic intermediate of the former, and processes for producing these compounds.
摘要翻译：具有抗肿瘤活性的全新的全氢-1H-吡咯并[2,1-C] [1,4]苯并二氮杂-5-酮化合物，全氢-1H-吡咯并[2,1-C] [1,4] - 苯并二氮杂-5， 11-二酮，其为前者的合成中间体的化合物，以及这些化合物的制备方法。

2. 发明授权

US4185016A Pyrrolo benzodiazepine compounds 失效
标题翻译：吡咯并苯并二氮杂化合物
公开(公告)号：US4185016A
公开(公告)日：1980-01-22
申请号：US947418
申请日：1978-10-02
申请人： Atuyuki Takanabe , Yoshio Arakawa , Yoshio Kagitani , Yasuo Ueda , Daisuke Satoh , Nobuhiko Komatsu
发明人： Atuyuki Takanabe , Yoshio Arakawa , Yoshio Kagitani , Yasuo Ueda , Daisuke Satoh , Nobuhiko Komatsu
IPC分类号： A61K31/55 , A61P35/00 , C07D207/16 , C07D487/04 , C07D498/14
CPC分类号： C07D487/04 , C07D207/16
摘要： Novel perhydro-1H-pyrrolo[2,1-C][1,4]benzodiazepin-5-one compounds having antitumor activity, perhydro-1H-pyrrolo[2,1-C][1,4]-benzodiazepin-5,11-dione compounds which are synthetic intermediate of the former, and processes for producing these compounds.
摘要翻译：具有抗肿瘤活性的全新的全氢-1H-吡咯并[2,1-C] [1,4]苯并二氮杂-5-酮化合物，全氢-1H-吡咯并[2,1-C] [1,4] - 苯并二氮杂-5，作为前者的合成中间体的11-二酮化合物，以及这些化合物的制造方法。

3. 发明授权

US4309437A Pyrrolo-benzodiazepine compounds and anti-tumor composition thereof 失效
标题翻译：吡咯并苯并二氮杂化合物及其抗肿瘤组合物
公开(公告)号：US4309437A
公开(公告)日：1982-01-05
申请号：US127984
申请日：1980-03-04
申请人： Yasuo Ueda , Yoshio Kagitani , Eiji Sako , Tadakazu Suyama , Nobuhiko Komatsu , Daisuke Satoh
发明人： Yasuo Ueda , Yoshio Kagitani , Eiji Sako , Tadakazu Suyama , Nobuhiko Komatsu , Daisuke Satoh
IPC分类号： A61K31/55 , A61P35/00 , C07D487/04
CPC分类号： C07D487/04
摘要： Novel 5,10,11,11a-tetrahydro-8-methyl-11-sulfo or sulfino-1H-pyrrolo[2,1-c][1,4]-benzodiazepin-2-acrylamides which have antitumor activity and low toxicity are prepared by reacting corresponding 11-reactive compound with a reactive sulfur compound to form 11-sulfino compounds and, if desired, oxidizing the 11-sulfino compounds to obtain 11-sulfo compound.
摘要翻译：具有抗肿瘤活性和低毒性的新型5,10,11,11a-四氢-8-甲基-11-磺基或亚磺酰基-1H-吡咯并[2,1-c] [1,4] - 苯并二氮杂-2-丙烯酰胺是通过使相应的11-反应性化合物与活性硫化合物反应形成11-亚磺酰基化合物，如果需要，将该11-亚磺酰基化合物氧化得到11-磺基化合物。

4. 发明授权

US4587052A 1H-pyrrolo-[2,1-C][1,4]benzodiazepine-2-acrylamide compounds having antitumor activity 失效
标题翻译：具有抗肿瘤活性的1H-吡咯并[2,1-C] [1,4]苯并二氮杂-2-丙烯酰胺化合物
公开(公告)号：US4587052A
公开(公告)日：1986-05-06
申请号：US578032
申请日：1984-02-08
申请人： Yasuo Ueda , Yusei Shiraga , Satoshi Morimoto , Yoshio Kagitani , Satoshi Funakoshi , Tadakazu Suyama
发明人： Yasuo Ueda , Yusei Shiraga , Satoshi Morimoto , Yoshio Kagitani , Satoshi Funakoshi , Tadakazu Suyama
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Benzodiazepine derivative represented by the following general formula or pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 is --COR.sup.4 (R.sup.4 is a carboxylic acid residue) or an alkyl or aralkyl group (these groups have a substituent selected from a carboxyl group, an amino group and a cyano group), R.sup.2 is a lower alkyl group and R.sup.3 is a hydrogen atom or a lower alkyl group.The above compound is low in toxicity and has an antitumor activity.
摘要翻译：由下列通式表示的苯并二氮杂衍生物或其药学上可接受的盐：其中R 1为-COR 4（R 4为羧酸残基）或烷基或芳烷基（这些基团具有选自羧基，氨基基和氰基），R2是低级烷基，R3是氢原子或低级烷基。上述化合物的毒性低，具有抗肿瘤活性。

5. 发明授权

US4701325A Injectable aqueous solution containing hydrogensulfite and/or sulfite and anticancerous benzodiazepine compound 失效
标题翻译：含有亚硫酸氢盐和/或亚硫酸盐和抗癌苯并二氮杂化合物的可注射水溶液
公开(公告)号：US4701325A
公开(公告)日：1987-10-20
申请号：US580183
申请日：1984-02-15
申请人： Yasuo Ueda , Yoshio Kagitani , Shirou Komeda , Satoshi Funakoshi
发明人： Yasuo Ueda , Yoshio Kagitani , Shirou Komeda , Satoshi Funakoshi
IPC分类号： A61K33/04 , A61P43/00 , A61K31/55
CPC分类号： A61K33/04
摘要： An alkali metal hydrogensulfite or sulfite is effective for controlling a local injury such as inflammation and vein injury occurring on the injection of an antitumor benzodiazepine compound of the formula ##STR1## wherein R.sub.1 denotes hydrogen atom, or acyl, carbamyl, or alkoxycarbonyl group; R.sub.2 denotes hydrogen atom or acyl group; and R.sub.3 denotes sulfinic acid rest, SO.sub.2 X, or sulfonic acid rest, SO.sub.3 X, X meaning hydrogen, alkali metal or alkaline earth metal. An aqueous solution containing the both can be administered by injection.
摘要翻译：碱式金属亚硫酸氢盐或亚硫酸盐可有效地控制局部损伤，例如在注射式IMA IMA的抗肿瘤苯并二氮杂化合物时发生的炎症和静脉损伤，其中R1表示氢原子，或酰基，氨基甲酰基或烷氧基羰基; R2表示氢原子或酰基; R3表示亚硫酸基，SO2X或磺酸基，SO3X，X表示氢，碱金属或碱土金属。可以通过注射施用含有这两者的水溶液。

6. 发明授权

US4587122A Fibronectin-dextran-drug complex and method of preparation thereof 失效
标题翻译：纤连蛋白 - 葡聚糖 - 药物复合物及其制备方法
公开(公告)号：US4587122A
公开(公告)日：1986-05-06
申请号：US726321
申请日：1985-04-23
申请人： Yoshio Kagitani , Yasuo Ueda , Kozi Munechika , Satoshi Morimoto , Shirou Komeda , Kenji Tanaka , Kazumasa Yokoyama
发明人： Yoshio Kagitani , Yasuo Ueda , Kozi Munechika , Satoshi Morimoto , Shirou Komeda , Kenji Tanaka , Kazumasa Yokoyama
IPC分类号： A61K47/48 , C08B37/02 , A61K31/72 , A61K35/16 , A61K37/04
CPC分类号： C08B37/0021 , A61K47/48292 , Y10S530/813
摘要： The drug such as antitumor agents or antibiotics can preferentially be carried to a morbid part, for example, injured tissue and tumor site by administering its complex with fibronectin combined through an oxidized dextran to repair the morbid part. The complex is prepared by reacting the drug, an oxidized dextran having a cleaved structure of aldohexopyranose ring, and fibronectin.
摘要翻译：药物如抗肿瘤剂或抗生素可优先通过将其与通过氧化葡聚糖结合的纤维连接蛋白的复合物施用于病态部分，例如损伤的组织和肿瘤部位来修复病态部分。该复合物通过使药物，具有解离结构的羟基己糖吡喃糖环的氧化葡聚糖与纤连蛋白反应来制备。

7. 发明授权

US4560556A Fibronectin-physiologically active substance complex and method of preparation thereof 失效
标题翻译：纤连蛋白 - 生理活性物质复合物及其制备方法
公开(公告)号：US4560556A
公开(公告)日：1985-12-24
申请号：US572750
申请日：1984-01-23
申请人： Yoshio Kagitani , Kenji Tanaka , Yasuo Ueda , Yusei Shiraga , Tunetaka Nakajima , Takuji Doi , Takao Ohmura , Satoshi Funakoshi , Tadakazu Suyama
发明人： Yoshio Kagitani , Kenji Tanaka , Yasuo Ueda , Yusei Shiraga , Tunetaka Nakajima , Takuji Doi , Takao Ohmura , Satoshi Funakoshi , Tadakazu Suyama
IPC分类号： C07K14/705 , A61K31/40 , A61K31/43 , A61K31/545 , A61K31/70 , A61K38/00 , A61K38/16 , A61K38/22 , A61K47/48 , C07K14/435 , C07K14/78 , C07K19/00 , A61K35/16 , A61K37/04
CPC分类号： C07K14/78 , A61K47/48292 , A61K38/00 , Y10S530/829 , Y10S530/83
摘要： Physiologically active substances such as antibiotics can preferentially be carried to a morbid part, for example, injured tissue and neoplastic cell proliferation site by administering its complex with fibronectin to repair the morbid part. The complex is prepared by the reaction between the physiologically active substance and the fibronectin with or without intervention of a protein cross-linking agent.
摘要翻译：生理活性物质如抗生素可以优先通过给予其与纤连蛋白的复合物来修复病态部分而被携带到病态部分，例如损伤组织和肿瘤细胞增殖部位。该复合物通过蛋白质交联剂的介导或不涉及生理活性物质与纤连蛋白之间的反应来制备。

8. 发明授权

US08125874B2 Optical pickup device 有权
标题翻译：光学拾取装置
公开(公告)号：US08125874B2
公开(公告)日：2012-02-28
申请号：US13020557
申请日：2011-02-03
申请人： Yasuo Ueda , Yoshiyuki Hashimoto , Noriaki Terahara , Toshiaki Takasu , Toshiyasu Tanaka
发明人： Yasuo Ueda , Yoshiyuki Hashimoto , Noriaki Terahara , Toshiaki Takasu , Toshiyasu Tanaka
IPC分类号： G11B7/00 , G11B7/135
CPC分类号： G11B7/1374 , G11B7/1365 , G11B7/1395 , G11B2007/0006
摘要： An optical pickup device has a DVD/CD laser diode for emitting a DVD/CD laser beam as linear polarized light, and a BD laser diode for emitting a BD laser beam. The optical pickup device has a dichroic mirror that regularly reflects a part of the DVD/CD laser beam, transmits a part of the DVD/CD laser beam, and transmits return light of the BD laser beam. The dichroic mirror is formed so that a product of reflectance of outward light of the DVD/CD laser beam and transmittance of return light of the DVD/CD laser beam becomes 20% or more to 25% or less. A light receiving element receives the return light of the DVD/CD laser beam transmitted through the dichroic mirror or the return light of the BD laser beam transmitted through the dichroic mirror.
摘要翻译：光拾取装置具有用于发射DVD / CD激光束作为线性偏振光的DVD / CD激光二极管和用于发射BD激光束的BD激光二极管。光拾取装置具有规则地反映DVD / CD激光束的一部分的二向色镜，透射DVD / CD激光束的一部分，并透射BD激光束的返回光。分色镜被形成为使得DVD / CD激光束的向外光的反射率与DVD / CD激光束的返回光的透射率的乘积为20％以上至25％以下。光接收元件接收通过分色镜透射的DVD / CD激光束的返回光或透过分色镜的BD激光束的返回光。

9. 发明授权

US5942249A Composition for oral administration containing pyridazinone compounds 失效
标题翻译：含有哒嗪酮化合物的口服组合物
公开(公告)号：US5942249A
公开(公告)日：1999-08-24
申请号：US14563
申请日：1998-01-28
申请人： Toru Iwao , Tomoyo Seki , Nobuo Kondo , Yasuo Ueda
发明人： Toru Iwao , Tomoyo Seki , Nobuo Kondo , Yasuo Ueda
IPC分类号： A61K9/20 , A61K47/12 , A61K31/53
CPC分类号： A61K31/501 , A61K47/12 , A61K9/2013 , Y10S514/96 , Y10S514/97
摘要： A composition for oral administration which contains a pyridazinone compound of the formula (I) ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are each independently a hydrogen atom or a lower alkyl, X is a halogen atom, a cyano or a hydrogen atom, Y is a halogen atom, a trifluoromethyl or a hydrogen atom, and A is a C.sub.1 -C.sub.8 alkylene optionally substituted by hydroxy, or a pharmacologically acceptable salt thereof, and an organic acid. According to the present invention, a composition for oral administration which is stable to heat, light, moisture and the like and which shows improved dissolution and absorption of a pyridazinone compound can be provided.
摘要翻译：一种口服给药的组合物，其含有式（I）的哒嗪酮化合物，其中R 1，R 2和R 3各自独立地为氢原子或低级烷基，X为卤素原子，氰基或氢原子，Y为卤素原子，三氟甲基或氢原子，A是任选被羟基取代的C1-C8亚烷基，或其药学上可接受的盐和有机酸。根据本发明，可以提供一种口服给药的组合物，该组合物对于热，光，水分等是稳定的并且表现出改善的哒嗪酮化合物的溶解和吸收。

10. 发明授权

US4455609A Apparatus for realtime fast reconstruction and display of dose distribution 失效
标题翻译：用于实时快速重建和显示剂量分布的装置
公开(公告)号：US4455609A
公开(公告)日：1984-06-19
申请号：US301012
申请日：1981-09-10
申请人： Kiyonari Inamura , Yasuo Ueda , Nobumasa Furushima , Keisuke Shigaki
发明人： Kiyonari Inamura , Yasuo Ueda , Nobumasa Furushima , Keisuke Shigaki
IPC分类号： G06Q50/24 , A61N5/10 , G01T1/02 , G06Q50/22 , G01T1/16
CPC分类号： A61N5/1048 , G01T1/02 , A61N5/103
摘要： Apparatus for realtime fast reconstruction and display of dose distribution which calculates the dose of absorbed radiation in an irradiated area defined by coordinates and displays the results of the calculation. The apparatus comprises an input unit capable of setting parameters in the form of time-continuous quantities; a dedicated digital computer serving to control the input by the input unit; and a dedicated fast reconstructer for calculating the absorbed dose for each coordinate in the exposed area at a high speed by decomposing calculation formulae necessary for obtaining isodose curves on the basis of the parameter set in the input unit and effecting parallel calculation of the decomposed formulae, thereby obtaining the isodose curves; and video display for storing and displaying the isodose curves classified in terms of different isodose levels. The calculation is normally cyclically repeated to provide a motion picture of the dose distribution when the magnitude of the parameters is varied.
摘要翻译：用于实时快速重构和显示剂量分布的装置，其计算由坐标定义的照射区域中的吸收辐射的剂量并显示计算结果。该装置包括能够以时间连续量的形式设定参数的输入单元; 专用数字计算机，用于控制输入单元的输入; 以及专用快速重构器，用于通过根据输入单元中设置的参数分解获得等剂量曲线所需的计算公式，并且对分解公式进行并行计算，计算高速曝光区域中每个坐标的吸收剂量，从而获得等剂量曲线; 和用于存储和显示根据不同等剂量水平分类的等剂量曲线的视频显示。通常循环重复计算，以在参数的大小变化时提供剂量分布的运动图像。

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