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1. 发明授权

US08383421B2 Cartridge for automatic measurement and measuring device using the same 有权
标题翻译：墨盒用于自动测量和测量装置使用
公开(公告)号：US08383421B2
公开(公告)日：2013-02-26
申请号：US11332269
申请日：2006-01-17
申请人： Atsushi Yanagida , Takashi Kurihara , Hiroyuki Yokoi , Atsushi Koyata , Yoshikazu Okamura , Daishi Miyamoto
发明人： Atsushi Yanagida , Takashi Kurihara , Hiroyuki Yokoi , Atsushi Koyata , Yoshikazu Okamura , Daishi Miyamoto
IPC分类号： G01N1/10
CPC分类号： B01L3/50851 , B01L3/527 , B01L2300/021 , B01L2300/0809 , B01L2300/1883 , G01N35/026 , Y10T436/25 , Y10T436/2575
摘要： An object of the present invention is to provide a cartridge for automatic measurement used in an automatic measuring device, capable of automatically performing measurement including heat treatment of a sample, and a measuring device using the cartridge.The present invention relates to a cartridge for use in measuring a component to be measured contained in a sample, comprising: at least a heat-treatment well for performing heat treatment of the sample; and a reaction well for reacting the component to be measured in the sample with a material specifically reacting therewith.
摘要翻译：本发明的目的是提供一种用于自动测量的自动测量盒，能够自动执行包括样品的热处理的测量以及使用该盒的测量装置。本发明涉及一种用于测量样品中包含的待测组分的盒，包括：至少一个用于对样品进行热处理的热处理孔; 以及用于使样品中待测量的组分与其特异性反应的材料反应的反应。

2. 发明申请

US20060183217A1 Cartridge for automatic measurement and measuring device using the same 有权
公开(公告)号：US20060183217A1
公开(公告)日：2006-08-17
申请号：US11332269
申请日：2006-01-17
申请人： Atsushi Yanagida , Takashi Kurihara , Hiroyuki Yokoi , Atsushi Koyata , Yoshikazu Okamura , Daishi Miyamoto
发明人： Atsushi Yanagida , Takashi Kurihara , Hiroyuki Yokoi , Atsushi Koyata , Yoshikazu Okamura , Daishi Miyamoto
IPC分类号： C12M1/34
CPC分类号： B01L3/50851 , B01L3/527 , B01L2300/021 , B01L2300/0809 , B01L2300/1883 , G01N35/026 , Y10T436/25 , Y10T436/2575
摘要： An object of the present invention is to provide a cartridge for automatic measurement used in an automatic measuring device, capable of automatically performing measurement including heat treatment of a sample, and a measuring device using the cartridge. The present invention relates to a cartridge for use in measuring a component to be measured contained in a sample, comprising: at least a heat-treatment well for performing heat treatment of the sample; and a reaction well for reacting the component to be measured in the sample with a material specifically reacting therewith.

3. 发明授权

US07749722B2 Measuring method using whole blood 有权
标题翻译：使用全血的测量方法
公开(公告)号：US07749722B2
公开(公告)日：2010-07-06
申请号：US11300867
申请日：2005-12-15
申请人： Yoshikazu Okamura , Takashi Kurihara , Hiroyuki Yokoi , Junichi Ogawa
发明人： Yoshikazu Okamura , Takashi Kurihara , Hiroyuki Yokoi , Junichi Ogawa
IPC分类号： G01N33/53 , G01N1/00
CPC分类号： G01N33/581 , G01N2333/916 , Y10T436/25125 , Y10T436/25375
摘要： A method for measuring an analyte in a whole blood sample comprising the steps of (1) bringing the whole blood sample into contact with a first substance which is carried on an insoluble carrier and specifically binds to the analyte to be measured and a second substance which is labeled with an alkaline phosphatase and specifically binds to the analyte to be measured, and (2) measuring a resulting complex on the basis of an enzyme reaction of the alkaline phosphatase, the measuring step (2) being carried out in the presence of an inhibitor of endogenous alkaline phosphatases, is disclosed.
摘要翻译：一种测定全血样品中的分析物的方法，包括以下步骤：（1）使全血样品与携带在不溶性载体上的第一物质接触并且特异性结合待测量的分析物和第二物质，用碱性磷酸酶标记并且特异性地结合待测量的分析物，和（2）基于碱性磷酸酶的酶反应测量所得的复合物，测量步骤（2）在存在下进行公开了内源性碱性磷酸酶抑制剂。

4. 发明申请

US20070141645A1 Measuring method using whole blood 有权
标题翻译：使用全血的测量方法
公开(公告)号：US20070141645A1
公开(公告)日：2007-06-21
申请号：US11300867
申请日：2005-12-15
申请人： Yoshikazu Okamura , Takashi Kurihara , Hiroyuki Yokoi , Junichi Ogawa
发明人： Yoshikazu Okamura , Takashi Kurihara , Hiroyuki Yokoi , Junichi Ogawa
IPC分类号： G01N33/542
CPC分类号： G01N33/581 , G01N2333/916 , Y10T436/25125 , Y10T436/25375
摘要： A method for measuring an analyte in a whole blood sample comprising the steps of (1) bringing the whole blood sample into contact with a first substance which is carried on an insoluble carrier and specifically binds to the analyte to be measured and a second substance which is labeled with an alkaline phosphatase and specifically binds to the analyte to be measured, and (2) measuring a resulting complex on the basis of an enzyme reaction of the alkaline phosphatase, the measuring step (2) being carried out in the presence of an inhibitor of endogenous alkaline phosphatases, is disclosed.
摘要翻译：一种测定全血样品中的分析物的方法，包括以下步骤：（1）使全血样品与携带在不溶性载体上的第一物质接触并且特异性结合待测量的分析物和第二物质，用碱性磷酸酶标记并且特异性地结合待测量的分析物，和（2）基于碱性磷酸酶的酶反应测量所得的复合物，测量步骤（2）在存在下进行公开了内源性碱性磷酸酶抑制剂。

5. 发明授权

US08557599B2 Method for automatic determination of sample 有权
标题翻译：样品自动测定方法
公开(公告)号：US08557599B2
公开(公告)日：2013-10-15
申请号：US13323561
申请日：2011-12-12
申请人： Atsushi Koyata , Hiroyuki Yokoi
发明人： Atsushi Koyata , Hiroyuki Yokoi
IPC分类号： G01N21/00 , G01N21/75 , G01N33/48
CPC分类号： G01N33/5302 , G01N21/59 , G01N35/00603 , G01N35/10 , G01N2035/1062
摘要： A method of determining a kind of a sample, in a method for analyzing a substance by the steps of supplying the sample to be analyzed to a reaction system by a supplying means comprising a transparent region composed of a transparent material, reacting a reagent for detecting the substance with the sample in the reaction system, and analyzing a signal derived from a product obtained by the reaction, characterized by irradiating the transparent region with light in the supplying step, and analyzing an optical intensity of the light.
摘要翻译：一种确定样品种类的方法，在通过以下步骤分析物质的方法中，所述方法是通过包括由透明材料构成的透明区域的供应装置将待分析样品供应到反应系统，将检测试剂所述物质与所述反应体系中的样品一起分析，并且分析由所述反应获得的产物得到的信号，其特征在于，在所述供给步骤中对所述透明区域进行光照射，并分析光的光强度。

6. 发明申请

US20080096285A1 Method for Automatic Determination of Sample 审中-公开
标题翻译：自动测定样品的方法
公开(公告)号：US20080096285A1
公开(公告)日：2008-04-24
申请号：US11572749
申请日：2005-07-27
申请人： Atsushi Koyata , Hiroyuki Yokoi
发明人： Atsushi Koyata , Hiroyuki Yokoi
IPC分类号： G01N21/00 , B01J19/00 , G01N21/01
CPC分类号： G01N33/5302 , G01N21/59 , G01N35/00603 , G01N35/10 , G01N2035/1062
摘要： A method of determining a kind of a sample, in a method for analyzing a substance by the steps of supplying the sample to be analyzed to a reaction system by a supplying means comprising a transparent region composed of a transparent material, reacting a reagent for detecting the substance with the sample in the reaction system, and analyzing a signal derived from a product obtained by the reaction, characterized by irradiating the transparent region with light in the supplying step, and analyzing an optical intensity of the light.
摘要翻译：一种确定样品种类的方法，在通过以下步骤分析物质的方法中，所述方法是通过包括由透明材料构成的透明区域的供应装置将待分析样品供应到反应系统，将检测试剂所述物质与所述反应体系中的样品一起分析，并且分析由所述反应获得的产物得到的信号，其特征在于，在所述供给步骤中对所述透明区域进行光照射，并分析光的光强度。

7. 发明申请

US20120309025A1 METHOD OF ANALYZING HUMAN sCD14-ST 审中-公开
标题翻译：分析人sCD14-ST的方法
公开(公告)号：US20120309025A1
公开(公告)日：2012-12-06
申请号：US13575604
申请日：2011-01-28
申请人： Yoshikazu Okamura , Hiroyuki Yokoi
发明人： Yoshikazu Okamura , Hiroyuki Yokoi
IPC分类号： G01N21/76
CPC分类号： G01N33/566 , G01N2333/70596 , G01N2800/26
摘要： An analysis method capable of accurately measuring human sCD14-ST when using a whole blood sample is provided. In the analysis method, human sCD14-ST in a whole blood sample is analyzed within 6 hours of the collection of the sample.
摘要翻译：提供了一种能够在使用全血样品时精确测量人sCD14-ST的分析方法。在分析方法中，在收集样品的6小时内分析全血样品中的人sCD14-ST。

8. 发明授权

US08409872B2 Cartridge for automatic measurement and measuring method using it 有权
标题翻译：墨盒用于自动测量和测量方法
公开(公告)号：US08409872B2
公开(公告)日：2013-04-02
申请号：US10281252
申请日：2002-10-28
申请人： Hiroyuki Yokoi , Takashi Kurihara
发明人： Hiroyuki Yokoi , Takashi Kurihara
IPC分类号： G01N1/38 , G01N35/00
CPC分类号： B01L3/50855 , B01L3/5085 , G01N1/38 , G01N35/026 , G01N2035/0403 , G01N2035/1032 , Y10T436/25 , Y10T436/25625 , Y10T436/2575
摘要： A cartridge for use in measuring a component to be measured contained in a sample includes a diluting well for diluting a predetermined amount of the sample to a desired dilution, and a reaction well in which the component to be measured contained in the sample and a substance specifically reacting therewith are allowed to react. A diluting solution is filled in the diluting well in a predetermined amount to provide the desired dilution based on a type of the component to be measured when the predetermined amount of the sample is dispensed in the diluting well by a uniform operation.
摘要翻译：用于测量样品中包含的待测组分的筒包括用于将预定量的样品稀释至所需稀释度的稀释孔，以及其中待测样品中包含的待测组分和物质的反应特别是与之反应的反应。稀释液以预定量填充稀释液，以通过均匀的操作将预定量的样品分配在稀释井中时，基于待测量的组分的类型提供所需的稀释度。

9. 发明授权

US10191038B2 Immunological measuring method and measuring kit for whole blood sample 有权
公开(公告)号：US10191038B2
公开(公告)日：2019-01-29
申请号：US14007412
申请日：2012-03-27
申请人： Keiichi Shoji , Hiroyuki Yokoi
发明人： Keiichi Shoji , Hiroyuki Yokoi
IPC分类号： G01N33/543 , G01N33/53
摘要： In a known method of measuring a target substance, comprising: providing a sample solution containing the target substance, a first reaction solution, and a second reaction solution; sequentially aspirating the sample solution and the first reaction solution, using a measuring apparatus equipped with a dispensing unit, into the dispensing unit; discharging them at a time from the dispensing unit, to bring them into contact with the second reaction solution, and to form a complex of the target substance and a first partner which is contained in at least one of the first reaction solution or the second reaction solution and reacts specifically with the target substance; and analyzing the resulting complex, an improved method capable of inhibiting a reaction which adversely affects measurement results is provided. In this improved method, the specific gravity of the sample solution is different from the specific gravity of the first reaction solution; and the sample solution and the first reaction solution are aspirated into the dispensing unit in an overlaid state.

10. 发明申请

US20140127661A1 SYRINGE OPERATION PRACTICE DEVICE 审中-公开
标题翻译： SYRINGE操作实践设备
公开(公告)号：US20140127661A1
公开(公告)日：2014-05-08
申请号：US13813332
申请日：2012-07-20
申请人： Hiroyuki Yokoi
发明人： Hiroyuki Yokoi
IPC分类号： G01F3/04 , G09B23/28
CPC分类号： G01F3/04 , G09B19/24 , G09B23/285
摘要： Provided is a syringe operation detection device 1 for detecting a drawing or injecting operation of a plunger 120 in a syringe 100. A female joint part 52 is joined to a barrel tip 116 of the syringe 100, a male joint part 60 is joined to a needle hub 132 of a syringe needle 130, and a coupling container 70 is placed between the female joint part 52 and the male joint part 60, for allowing them to be continuous with each other while being closed externally. A detector for detecting a pressure, flow velocity, or flow rate of a fluid moving therein is placed in any one of the coupling container 70, the female joint part 52, and the male joint part 60. As a result, there is provided the syringe operation detection device capable of being applied to a syringe actually used and evaluating a drawing or injecting state in objective terms.
摘要翻译：提供了一种用于检测注射器100中的柱塞120的拉拔或注射操作的注射器操作检测装置1.阴连接部52连接到注射器100的筒状末端116，阳接头部60连接到注射器针头130的针座132和联接容器70放置在阴接头部52和阳接头部60之间，以允许它们在外部被封闭的同时彼此连续。用于检测其中移动的流体的压力，流速或流速的检测器被放置在联接容器70，阴接头部分52和阳接头部分60中的任一个中。结果，注射器操作检测装置能够实际应用于实际使用的注射器，并且以客观方式评价绘图或注射状态。

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