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1. 发明授权

US5116942A Protein having an inflammatory phospholipase A.sub.2 inhibitory activity 失效
标题翻译：具有炎症磷脂酶A2抑制活性的蛋白质
公开(公告)号：US5116942A
公开(公告)日：1992-05-26
申请号：US295724
申请日：1988-12-02
申请人： Keizo Inoue , Atsushi Imaizumi , Takashi Kamimura , Yorimasa Suwa , Masahiro Okada , Yoji Suzuki , Ichiro Kudo
发明人： Keizo Inoue , Atsushi Imaizumi , Takashi Kamimura , Yorimasa Suwa , Masahiro Okada , Yoji Suzuki , Ichiro Kudo
IPC分类号： C12P21/00 , A61K38/00 , A61K38/55 , A61P29/00 , C07K1/20 , C07K14/00 , C07K14/435 , C07K14/47
CPC分类号： C07K14/4703 , A61K38/00
摘要： Protein having inflammatory phospholipase A.sub.2 inhibitory activity wherein said protein has a nature to be induced from cells by administration of glucocorticoid, for example, having a molecular weight of 40 K and the amino acid sequence from the N-terminal consisting of a N-terminal amino acid-Asp-Val-Pro-Ala-Ala-Asp-Leu-Ser-Asp-.
摘要翻译： PCT No.PCT / JP88 / 00318 Sec。 371日期：1988年12月2日 102（e）日期1988年12月2日PCT提交1988年3月30日PCT公布。出版物WO88 / 07552 日期：1988年10月6日。具有炎性磷脂酶A2抑制活性的蛋白质，其中所述蛋白质具有通过施用糖皮质激素（例如分子量为40K）和来自N-末端的氨基酸序列从细胞诱导的性质由N-末端氨基酸-asp-Val-Pro-Ala-Ala-Asp-Leu-Ser-Asp-组成。

2. 发明授权

US4810780A Protein having phospholipase A2 inhibitory activity 失效
标题翻译：具有磷脂酶A2抑制活性的蛋白质
公开(公告)号：US4810780A
公开(公告)日：1989-03-07
申请号：US903549
申请日：1986-09-04
申请人： Atsushi Imaizumi , Takashi Kamimura , Yorimasa Suwa , Masahiro Okada
发明人： Atsushi Imaizumi , Takashi Kamimura , Yorimasa Suwa , Masahiro Okada
IPC分类号： A61K35/24 , A61K38/55 , C07K14/47 , C12P21/02 , C12R1/91 , A61K37/64
CPC分类号： C07K14/4721 , Y10S530/848
摘要： Protein having a phospholipase A.sub.2 inhibitory activity which has the nature to be induced from cells upon administration of glucocorticoid and has a phospholipase A.sub.2 inhibitory activity.
摘要翻译：具有磷脂酶A2抑制活性的蛋白质，其在施用糖皮质激素后具有从细胞诱导的性质并且具有磷脂酶A2抑制活性。

3. 发明授权

US5344764A Protein inhibitors of phospholipase A.sub.2 purified from inflammatory sites and production process 失效
标题翻译：从炎症部位纯化的磷脂酶A2蛋白抑制剂和生产工艺
公开(公告)号：US5344764A
公开(公告)日：1994-09-06
申请号：US47379
申请日：1993-04-16
申请人： Yorimasa Suwa , Atsushi Imaizumi , Masahiro Okada , Ichiro Kudo , Keizo Inoue , Yoji Suzuki
发明人： Yorimasa Suwa , Atsushi Imaizumi , Masahiro Okada , Ichiro Kudo , Keizo Inoue , Yoji Suzuki
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12P21/06 , C07K3/00 , C12N5/00 , C12N15/00
CPC分类号： C07K14/4703 , A61K38/00
摘要： Protein inhibitors of phospholipase A.sub.2 purified from inflammatory sites which have an amino acid sequence given in FIGS. 3-1 through 3-3 or an amino acid sequence physiologically equivalent thereto, a process for preparation of said inhibitory protein wherein serum of mammalian animal is enzymatically treated, and a gene coding said inhibitory protein.
摘要翻译：从具有图1和2中给出的氨基酸序列的炎症部位纯化的磷脂酶A2的蛋白质抑制剂。 3-1至3-3或与其生理等同的氨基酸序列，其中哺乳动物血清被酶处理的所述抑制性蛋白质的制备方法和编码所述抑制性蛋白质的基因。

4. 发明授权

US5374713A Peptide inhibitors of phospholipase A.sub.2 purified from inflammatory sites 失效
标题翻译：从炎症部位纯化的磷脂酶A2的肽抑制剂
公开(公告)号：US5374713A
公开(公告)日：1994-12-20
申请号：US861962
申请日：1992-06-18
申请人： Yorimasa Suwa , Atsushi Imaizumi , Masahiro Okada , Chieko Azuma , Ichiro Kudo , Keizo Inoue
发明人： Yorimasa Suwa , Atsushi Imaizumi , Masahiro Okada , Chieko Azuma , Ichiro Kudo , Keizo Inoue
IPC分类号： A61K38/00 , C07K14/47 , A61K37/02 , C07K7/10
CPC分类号： C07K14/4703 , A61K38/00
摘要： Peptide inhibitors of phospholipase A.sub.2 from inflammatory sites having the amino acid sequence given in formula SEQ. I.D. NO: 1 ##STR1##
摘要翻译： PCT No.PCT / JP91 / 01424 371日期：1992年6月18日 102（e）日期1992年6月18日PCT 1991年10月17日PCT公布。第WO92 / 06997号公报日期：1992年4月30日。具有式SEQ。中给出的氨基酸序列的来自炎症部位的磷脂酶A2的肽抑制剂。 ID。 NO：1 [I]

5. 发明授权

US5851983A Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology 失效
标题翻译：弹性蛋白酶抑制多肽及其重组基因技术生产方法
公开(公告)号：US5851983A
公开(公告)日：1998-12-22
申请号：US963538
申请日：1992-10-20
申请人： Takashi Sugiyama , Takashi Kamimura , Kenichi Masuda , Masahiro Okada , Eiko Ohtsuka , Atsushi Imaizumi , Kunihito Watanabe , Tetsuya Suga , Yohichi Matsumoto , Akiko Takeuchi
发明人： Takashi Sugiyama , Takashi Kamimura , Kenichi Masuda , Masahiro Okada , Eiko Ohtsuka , Atsushi Imaizumi , Kunihito Watanabe , Tetsuya Suga , Yohichi Matsumoto , Akiko Takeuchi
IPC分类号： A61K38/00 , C07K14/81 , A61K38/16 , C12N15/41
CPC分类号： C07K14/811 , A61K38/00 , C07K2319/50
摘要： The present invention provides an elastase inhibitory polypeptide comprising a C-terminal half of a human secretory leukocyte protease inhibitor (SLPI) and having an elastase inhibitory activity wherein inhibitory activity of a trypsin-like serine protease does not exceed 1/10 of elastase inhibitory activity, and polypeptides having the above-mentioned biological activity wherein one or more than one amino acid is added, one or more than one amino acid is deleted and/or one or more than one amino acid is replaced. The present invention also provides a process for the production of the above-mentioned protein or other protein via a corresponding fused protein.
摘要翻译：本发明提供了包含人分泌型白细胞蛋白酶抑制剂（SLPI）的C末端一半并且具有弹性蛋白酶抑制活性的弹性蛋白酶抑制性多肽，其中胰蛋白酶样丝氨酸蛋白酶的抑制活性不超过+ E， + EE的弹性蛋白酶抑制活性，以及具有上述生物活性的多肽，其中加入一个或多于一个氨基酸，一个或多于一个氨基酸被缺失和/或一个或多于一个氨基酸被替换。本发明还提供了通过相应的融合蛋白生产上述蛋白质或其它蛋白质的方法。

6. 发明授权

US06434675B1 Method and apparatus for updating data stored in plural storage means in an information processing system 有权
公开(公告)号：US06434675B1
公开(公告)日：2002-08-13
申请号：US09785003
申请日：2001-02-15
申请人： Jun Hasegawa , Toshitada Saito , Masahiro Okada , Toshio Fujisawa
发明人： Jun Hasegawa , Toshitada Saito , Masahiro Okada , Toshio Fujisawa
IPC分类号： G06F1212
摘要： A storage means control apparatus of this invention includes a first processing unit for performing write processing in a first storage unit, a second processing unit for performing write processing in a second storage unit, a tag data control unit for managing tag data representing storage areas where the first processing unit has performed write processing in the first storage unit (101), another tag data control unit for managing another tag data representing storage areas where the second processing unit has performed write processing in the second storage unit, a priority data control unit for managing priority data representing a priority of each of the first and second processing units in units of storage areas of the second storage unit, a prevention data control unit for managing prevention data for preventing write processing in each storage area of the second storage unit using the priority data and the tag data, and a processing data updating unit for writing the data written in the first storage unit (101) in the second storage unit on the basis of the prevention data. With this arrangement, when each write control unit in a plurality of processing units performs write processing in the storage unit of the self processing unit, matching of stored contents among the units can be ensured.

7. 发明授权

US06219762B1 Method and apparatus for assigning priority to update data stored in plural storage means 失效
标题翻译：用于分配优先级以更新存储在多个存储装置中的数据的方法和装置
公开(公告)号：US06219762B1
公开(公告)日：2001-04-17
申请号：US08892490
申请日：1997-07-14
申请人： Jun Hasegawa , Toshitada Saito , Masahiro Okada , Toshio Fujisawa
发明人： Jun Hasegawa , Toshitada Saito , Masahiro Okada , Toshio Fujisawa
IPC分类号： G06F1318
CPC分类号： G06F12/0817
摘要： A storage means control apparatus of this invention includes a first processing unit for performing write processing in a first storage unit, a second processing unit for performing write processing in a second storage unit, a revealing data control unit for managing revealing data representing storage areas where the first processing unit has performed write processing in the first storage unit (101), another revealing data control unit for managing another revealing data representing storage areas where the second processing unit has performed write processing in the second storage unit, a priority data control unit for managing priority data representing a priority of each of the first and second processing units in units of storage areas of the second storage unit, a inhibition data control unit for managing inhibition data for inhibiting write processing in each storage area of the second storage unit using the priority data and the revealing data, and a processing data reflection unit for writing the data written in the first storage unit (101) in the second storage unit on the basis of the inhibition data. With this arrangement, when each write control unit in a plurality of processing units performs write processing in the storage unit of the self processing unit, matching of stored contents among the units can be ensured.
摘要翻译：本发明的存储装置控制装置包括用于在第一存储单元中执行写入处理的第一处理单元，用于在第二存储单元中执行写入处理的第二处理单元，用于管理表示存储区域的显示数据的显示数据控制单元，第一处理单元在第一存储单元（101）中执行写入处理，另一个显示数据控制单元，用于管理表示第二处理单元在第二存储单元中执行写入处理的存储区域的另一显示数据，优先级数据控制单元用于以第二存储单元的存储区域为单位管理表示第一处理单元和第二处理单元的优先级的优先级数据;禁止数据控制单元，用于管理用于禁止第二存储单元的每个存储区域中的写入处理的禁止数据，所述禁止数据使用优先级数据和显示数据，以及处理数据反映单元，用于基于禁止数据写入写入第二存储单元中的第一存储单元（101）中的数据。利用这种布置，当多个处理单元中的每个写入控制单元在自身处理单元的存储单元中执行写入处理时，可以确保各单元之间存储的内容的匹配。

8. 发明授权

US4965170A Silver halide photographic material and method for forming super high contrast images therewith 失效
标题翻译：卤化银照相材料和用于形成超高对比度图像的方法
公开(公告)号：US4965170A
公开(公告)日：1990-10-23
申请号：US489872
申请日：1990-03-06
申请人： Toshinao Ukai , Kazuhiro Shirasu , Koki Nakamura , Keizo Koya , Masahiro Okada , Kazunobu Katoh
发明人： Toshinao Ukai , Kazuhiro Shirasu , Koki Nakamura , Keizo Koya , Masahiro Okada , Kazunobu Katoh
IPC分类号： G03C1/06 , G03C1/83 , G03C7/305
CPC分类号： G03C1/83 , G03C1/061 , G03C7/30547 , Y10S430/156 , Y10S430/159
摘要： A silver halide photographic material comprising a support having thereon at least one silver halide emulsion layer, said emulsion layer or at least one of other hydrophilic colloid layers containing a compound represented by formula (I):PWR--Time--.sub.T LA (I)wherein PWR represents a group which undergoes reduction to release (Time).sub.t LA; Time represents a group which release LA upon reaction following release of (Time).sub.t LA from PWR; t represents an integer of 0 or 1; and LA represents a group having a maximum light absorption in a wavelength range of 310 nm or more. In a preferred embodiment, one of said other hydrophilic colloid layers substantially free of the compound represented by formula (I) is provided between said at least one silver halide emulsion layer in said silver halide photographic material and one of said other hydrophilic colloid layers containing the compound represented by formula (I), and at least one of these hydrophilic colloid layers or at least one other of said other hydrophilic colloid layers contains a hydrazine derivative. A process for the formation of an ultrahigh contrast image, which comprises exposing the above-described silver halide photographic material to light, and then developing the silver halide photographic material with a developing solution having a pH of 11.0 to 12.3 and containing 0.15 mol/l or more of sulfite ions.

9. 发明授权

US4809529A Flaring apparatus for flaring a rim element 失效
标题翻译：用于燃烧轮辋元件的扩口装置
公开(公告)号：US4809529A
公开(公告)日：1989-03-07
申请号：US110346
申请日：1987-10-20
申请人： Yusaku Shinozawa , Atuyoshi Komatu , Masahiro Okada , Hiroshi Yamada , Masatoshi Fujita
发明人： Yusaku Shinozawa , Atuyoshi Komatu , Masahiro Okada , Hiroshi Yamada , Masatoshi Fujita
IPC分类号： B21D53/30 , B21C51/00
CPC分类号： B21D53/30 , Y10T29/49529
摘要： A flaring apparatus including at least one of die member positional adjustment apparatus and a defective rim element ejecting apparatus. The positional adjustment apparatus includes a connecting shaft provided between a die member mounting block and a link mechanism for moving the mounting block. The connecting shaft has shaft portions, axes of which are radially offset from each other. By rotating the connecting shaft, the die member position can be adjusted. Therefore, there is no need to provide a shim between the die member and the mounting block. The defective rim element ejecting apparatus includes a pressure sensing switch which can detect an increase in pressure within a space defined by a rim element and the die members during flaring. When the pressure sensing switch does not detect a predetermined increase in the pressure of the space, for example, when the rim is cracked, a conveyor path device opens and the defective rim element will drop into an ejecting duct thereby ejecting the defective rim element from the manufacturing line.
摘要翻译：包括模具构件位置调节装置和缺陷边缘元件排出装置中的至少一个的扩口装置。位置调整装置包括设置在模具安装块和用于移动安装块的连杆机构之间的连接轴。连接轴具有轴部，轴部的轴线彼此径向偏移。通过旋转连接轴，可以调整模具构件的位置。因此，不需要在模具构件和安装块之间设置垫片。有缺陷的轮辋元件弹出装置包括压力检测开关，该压力检测开关可以在扩口期间检测由轮辋元件和骰子构件限定的空间内的压力增加。当压力感测开关没有检测到空间压力的预定增加时，例如当轮辋破裂时，输送路径装置打开，并且有缺陷的轮辋元件将落入排出管道中，从而将缺陷轮辋元件从生产线。

10. 发明申请

US20100173158A1 Ceramic particle group and method for production thereof and use thereof 有权
公开(公告)号：US20100173158A1
公开(公告)日：2010-07-08
申请号：US12659688
申请日：2010-03-17
申请人： Tsutomu Furuzono , Masahiro Okada
发明人： Tsutomu Furuzono , Masahiro Okada
IPC分类号： C04B35/447 , B32B5/16
CPC分类号： C01B25/32 , A61F2002/30968 , A61F2310/00293 , A61K6/0008 , A61K6/0085 , A61K6/0215 , A61K6/023 , A61L24/0063 , B01J20/048 , B01J20/282 , B82Y30/00 , C04B35/447 , C04B35/6264 , C04B35/63424 , C04B2235/3208 , C04B2235/3212 , C04B2235/781 , C04B2235/783 , C04B2235/784 , C04B2235/785 , Y10T428/2982 , A61K6/083 , C08L81/06 , C08L33/08 , C08L33/10 , A61K6/087 , C08L77/04 , C08L33/26 , C08L71/02
摘要： A ceramic particle group dispersed in a solvent in a state of primary particles of single crystal, a method for production thereof and a use thereof are disclosed. In one embodiment a method is disclosed for producing a sintered particle (ceramic particle) group of hydroxyapatite (HAp), which includes a step of subjecting a system wherein calcium carbonate is present between primary particles of hydroxyapatite (HAp) to sintering and then dissolving calcium carbonate with water to remove calcium carbonate. A hydroxyapatite (HAp) sintered particle group produced by the above method is a nanometer size particle group having a particle diameter of about 70 to about 120 nm, and is a particle group having a uniform particle diameter (coefficient of variation: 12%), and further 96% of the particle group is dispersed as a single crystal particle.

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