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1. 发明授权

US5116942A Protein having an inflammatory phospholipase A.sub.2 inhibitory activity 失效
标题翻译：具有炎症磷脂酶A2抑制活性的蛋白质
公开(公告)号：US5116942A
公开(公告)日：1992-05-26
申请号：US295724
申请日：1988-12-02
申请人： Keizo Inoue , Atsushi Imaizumi , Takashi Kamimura , Yorimasa Suwa , Masahiro Okada , Yoji Suzuki , Ichiro Kudo
发明人： Keizo Inoue , Atsushi Imaizumi , Takashi Kamimura , Yorimasa Suwa , Masahiro Okada , Yoji Suzuki , Ichiro Kudo
IPC分类号： C12P21/00 , A61K38/00 , A61K38/55 , A61P29/00 , C07K1/20 , C07K14/00 , C07K14/435 , C07K14/47
CPC分类号： C07K14/4703 , A61K38/00
摘要： Protein having inflammatory phospholipase A.sub.2 inhibitory activity wherein said protein has a nature to be induced from cells by administration of glucocorticoid, for example, having a molecular weight of 40 K and the amino acid sequence from the N-terminal consisting of a N-terminal amino acid-Asp-Val-Pro-Ala-Ala-Asp-Leu-Ser-Asp-.
摘要翻译： PCT No.PCT / JP88 / 00318 Sec。 371日期：1988年12月2日 102（e）日期1988年12月2日PCT提交1988年3月30日PCT公布。出版物WO88 / 07552 日期：1988年10月6日。具有炎性磷脂酶A2抑制活性的蛋白质，其中所述蛋白质具有通过施用糖皮质激素（例如分子量为40K）和来自N-末端的氨基酸序列从细胞诱导的性质由N-末端氨基酸-asp-Val-Pro-Ala-Ala-Asp-Leu-Ser-Asp-组成。

2. 发明授权

US5344764A Protein inhibitors of phospholipase A.sub.2 purified from inflammatory sites and production process 失效
标题翻译：从炎症部位纯化的磷脂酶A2蛋白抑制剂和生产工艺
公开(公告)号：US5344764A
公开(公告)日：1994-09-06
申请号：US47379
申请日：1993-04-16
申请人： Yorimasa Suwa , Atsushi Imaizumi , Masahiro Okada , Ichiro Kudo , Keizo Inoue , Yoji Suzuki
发明人： Yorimasa Suwa , Atsushi Imaizumi , Masahiro Okada , Ichiro Kudo , Keizo Inoue , Yoji Suzuki
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C12P21/06 , C07K3/00 , C12N5/00 , C12N15/00
CPC分类号： C07K14/4703 , A61K38/00
摘要： Protein inhibitors of phospholipase A.sub.2 purified from inflammatory sites which have an amino acid sequence given in FIGS. 3-1 through 3-3 or an amino acid sequence physiologically equivalent thereto, a process for preparation of said inhibitory protein wherein serum of mammalian animal is enzymatically treated, and a gene coding said inhibitory protein.
摘要翻译：从具有图1和2中给出的氨基酸序列的炎症部位纯化的磷脂酶A2的蛋白质抑制剂。 3-1至3-3或与其生理等同的氨基酸序列，其中哺乳动物血清被酶处理的所述抑制性蛋白质的制备方法和编码所述抑制性蛋白质的基因。

3. 发明授权

US5374713A Peptide inhibitors of phospholipase A.sub.2 purified from inflammatory sites 失效
标题翻译：从炎症部位纯化的磷脂酶A2的肽抑制剂
公开(公告)号：US5374713A
公开(公告)日：1994-12-20
申请号：US861962
申请日：1992-06-18
申请人： Yorimasa Suwa , Atsushi Imaizumi , Masahiro Okada , Chieko Azuma , Ichiro Kudo , Keizo Inoue
发明人： Yorimasa Suwa , Atsushi Imaizumi , Masahiro Okada , Chieko Azuma , Ichiro Kudo , Keizo Inoue
IPC分类号： A61K38/00 , C07K14/47 , A61K37/02 , C07K7/10
CPC分类号： C07K14/4703 , A61K38/00
摘要： Peptide inhibitors of phospholipase A.sub.2 from inflammatory sites having the amino acid sequence given in formula SEQ. I.D. NO: 1 ##STR1##
摘要翻译： PCT No.PCT / JP91 / 01424 371日期：1992年6月18日 102（e）日期1992年6月18日PCT 1991年10月17日PCT公布。第WO92 / 06997号公报日期：1992年4月30日。具有式SEQ。中给出的氨基酸序列的来自炎症部位的磷脂酶A2的肽抑制剂。 ID。 NO：1 [I]

4. 发明授权

US07834114B2 Polycyclic ester containing cyano group and lactone skeleton 有权
公开(公告)号：US07834114B2
公开(公告)日：2010-11-16
申请号：US12628874
申请日：2009-12-01
申请人： Keizo Inoue , Takahiro Iwahama , Masamichi Nishimura , Kiyoharu Tsutsumi
发明人： Keizo Inoue , Takahiro Iwahama , Masamichi Nishimura , Kiyoharu Tsutsumi
IPC分类号： C08F24/00 , C08F34/02
CPC分类号： C07D307/93 , C08F220/36
摘要： Disclosed is a polycyclic ester containing a cyano group and a lactone skeleton, represented by following Formula (1): wherein Ra represents, for example, a hydrogen atom or an alkyl group having one to six carbon atoms which may have a halogen atom; R1s each represent, for example, a halogen atom or an alkyl or haloalkyl group having one to six carbon atoms; “m” is the number of R1s; “n” is the number of cyano groups; and CH2═C(Ra)COO— group may have either of an endo conformation and an exo conformation. Accordingly, there is provided a novel polycyclic ester containing a cyano group and a lactone skeleton which is useful typically as a monomeric component for highly functional polymers. A polymer, for example, derived from this compound is highly soluble in an organic solvent while remaining stable typically to chemicals and exhibits improved hydrolyzability and/or improved solubility in water after hydrolysis.

5. 发明授权

US07074970B2 Process for producing vinyl ether compounds 失效
标题翻译：制备乙烯基醚化合物的方法
公开(公告)号：US07074970B2
公开(公告)日：2006-07-11
申请号：US10231115
申请日：2002-08-30
申请人： Yasutaka Ishii , Tatsuya Nakano , Keizo Inoue
发明人： Yasutaka Ishii , Tatsuya Nakano , Keizo Inoue
IPC分类号： C07C43/00
CPC分类号： C07D313/10 , C07C41/16 , C07C43/162 , C07C49/753 , C07C69/757 , C07C2601/14 , C07C2603/74 , C07C2603/86 , C07D307/33 , C07D307/93 , Y02P20/55 , C07C43/16 , C07C43/168 , C07C43/178 , C07C43/188 , C07C43/215
摘要： A process produces vinyl ether compounds and includes allowing a vinyl ester compound represented by following Formula (1): wherein R1, R2, R3 and R4 are the same or different and are each a hydrogen atom or an organic group, to react with a hydroxy compound represented by following Formula (2): R5OH (2) wherein R5 is an organic group, in the presence of at least one transition element compound to thereby yield a vinyl ether compound represented by following Formula (3): wherein R2, R3, R4 and R5 have the same meanings as defined above. Such transition element compounds include iridium compounds and other compounds containing Group VIII elements.
摘要翻译：一种方法制备乙烯基醚化合物，包括使下式（1）表示的乙烯基酯化合物：其中R 1，R 2，R 3， >和R 4相同或不同，并且各自为氢原子或有机基团，与下式（2）表示的羟基化合物反应：<？在线式描述= “在线公式”end =“lead”？> 5 OH（2）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R 在至少一种过渡元素化合物的存在下，有机基团是有机基团，从而得到下式（3）表示的乙烯基醚化合物：其中R 2，R R 4，R 4和R 5具有与上述相同的含义。这种过渡元素化合物包括铱化合物和含有VIII族元素的其它化合物。

6. 发明授权

US06949615B2 Monomer having electron-withdrawing group and process for preparing the same 失效
标题翻译：具有吸电子基团的单体及其制备方法
公开(公告)号：US06949615B2
公开(公告)日：2005-09-27
申请号：US10181830
申请日：2001-10-31
申请人： Keizo Inoue
发明人： Keizo Inoue
IPC分类号： C07C33/44 , C07C35/52 , C07C41/01 , C07C41/06 , C07C41/58 , C07C43/192 , C07C43/196 , C07C43/313 , C07C49/755 , C07D307/30 , C07D307/93 , C07D313/10 , C07D317/42 , C07D339/06 , C08F24/00 , G03F7/004 , G03F7/039 , C08F114/18
CPC分类号： C07C41/58 , C07C33/44 , C07C35/52 , C07C41/06 , C07C41/54 , C07C41/56 , C07C43/313 , C07C43/317 , C07C49/755 , C07C2602/42 , C07C2603/74 , C07D307/30 , C07D307/93 , C07D313/10 , C07D317/42 , C07D339/06 , C08F24/00 , G03F7/0046 , G03F7/0397 , C07C43/1786 , C07C43/196
摘要： A monomer containing an electron-withdrawing group of the present invention is represented by following Formula (a), (b) or (c): wherein A1, A2, and A3 are each a ring; Ra, Rb, Rc, and Ru are the same or different and are each a hydrogen atom or organic group; at least one of Rs, Rw and Rv, at least one of Rt and Rw1, and at least one of the two Rw2s are each an electron-withdrawing group, and the others are each a hydrogen atom or organic group; W1 is a single bond or linkage group; and n denotes an integer of 2 to 25, where at least two of Ra, Rb, Rc, Rs, Rt, Ru, Rv, Rw, Rw1, Rw2, W1, and carbon atoms constituting ring A1, carbon atoms constituting ring A2, and carbon atoms constituting ring A3 may be combined to form a ring, respectively. The electron-withdrawing groups in Rs, Rt, Rv, Rw, Rw1, and Rw2 are, for example, groups each containing a fluorine atom. The monomer is useful as a raw material for photoresist polymeric compounds.
摘要翻译：含有本发明吸电子基团的单体由下式（a），（b）或（c）表示：其中A 1，A 2，和A <3>各自为环; R a，R b，R c和R u相同或不同，各自为氢原子或有机基团; R 0和R 2中的至少一个，R 0和R 2中的至少一个，R 0和R 2， SUP> w1，并且两个R 2 w 2中的至少一个各自为吸电子基团，其余各自为氢原子或有机基团; W 1是单键或连接基团; n表示2〜25的整数，其中R a，R b，R b，R c，R i，R b， R 1，R 2，R 2，R 2，R 2，R 2，R 2，R 2， W 2，W 1，和构成环A 1的碳原子，构成环A 2的碳原子，并且构成环A 3的碳原子可以分别结合形成环。 R“，”R“，”R“，”R“，”R“，”R“中的吸电子基团， w1，w2，...，w2都是例如各自含有氟原子的基团。该单体可用作光致抗蚀剂聚合物的原料。

7. 发明授权

US5081245A Carboxylic acid derivatives 失效
标题翻译：羧酸衍生物
公开(公告)号：US5081245A
公开(公告)日：1992-01-14
申请号：US395524
申请日：1989-08-18
申请人： Hiroaki Nomura , Hiroshi Akimoto , Eiko Imamiya , Keizo Inoue
发明人： Hiroaki Nomura , Hiroshi Akimoto , Eiko Imamiya , Keizo Inoue
IPC分类号： C07C43/13 , C07C43/178 , C07C45/29 , C07C45/67 , C07C49/175 , C07C49/255 , C07C217/08 , C07C229/10 , C07C309/66 , C07D213/30 , C07D239/34 , C07D401/12 , C07D521/00
CPC分类号： C07D213/30 , C07C217/08 , C07C229/10 , C07C309/66 , C07C43/135 , C07C43/1785 , C07C45/29 , C07C45/673 , C07C49/175 , C07C49/255 , C07D231/12 , C07D233/56 , C07D239/34 , C07D249/08 , C07D401/12
摘要： A compound represented by the formula: ##STR1## wherein R represents a hydrogen atom or a lower alkyl group;R.sup.1 represents a higher alkyl group which may be substituted;R.sup.2 represents a hydrogen atom or a lower alkyl group, a lower alkanoyl group or a nitrogen-containing 5- to 7-membered heterocyclic group each of which may be substituted; X represents a divalent group represented by the formula:--(OCH.sub.2 CH.sub.2).sub.p -- wherein p represents an integer of 1 to 5, a divalent group represented by the formula:--O(CH.sub.2).sub.q -- wherein q represents an integer of 3 to 8, or a divalent group represented by the formula:--(OCH.sub.2 CH.sub.2).sub.p --J--(CH.sub.2).sub.q -- wherein J represents an oxygen atom or a group represented by the formula: --S(O).sub.r -- (wherein r represents 0, 1 or 2), and p and q are the same as defined above; Y represents a divalent group containing tertiary or quaternary nitrogen atom(s); and Z represents an alkylene group which may be substituted and/or interrupted, or a group represented by the formula:--Q--T-- or --T--W-- wherein Q and W represent an alkylene group which may be substituted, and T represents a phenhylene group, a naphthylene group, a cycloalkylene group; and a salt thereof exhibit excellent antitumor action including differentiation inducing action and are useful as pharmaceuticals.

8. 发明授权

US4778912A Phospholipid derivatives 失效
标题翻译：磷脂衍生物
公开(公告)号：US4778912A
公开(公告)日：1988-10-18
申请号：US933210
申请日：1986-11-21
申请人： Keizo Inoue , Hiroaki Normura , Tetsuya Okutani
发明人： Keizo Inoue , Hiroaki Normura , Tetsuya Okutani
IPC分类号： A61K31/685 , A61P35/00 , C07F9/10 , C07F9/58
CPC分类号： C07F9/581 , C07F9/10 , Y02P20/55
摘要： Phospholipid derivatives of the formula: ##STR1## wherein R.sup.1 is a higher alkyl, acylmethyl or alkylcarbamoyl group which may be substituted by cycloalkyl; R.sup.2 is a lower alkyl which may be substituted by carboxy, formyl or lower acyl, a carbamoyl or thiocarbamoyl group which is substituted by lower alkyl, or an acetoacetyl group; R.sup.3, R.sup.4 and R.sup.5 are independently hydrogen or lower alkyl, or ##STR2## represents a cyclic ammonio group; and n represents an integer of 8 to 14, and salts thereof have antitumor activity.
摘要翻译：下式的磷脂衍生物：其中R1是可被环烷基取代的高级烷基，酰基甲基或烷基氨基甲酰基; R2是可被羧基，甲酰基或低级酰基取代的低级烷基，被低级烷基或乙酰乙酰基取代的氨基甲酰基或硫代氨基甲酰基; R3，R4和R5独立地为氢或低级烷基，或者“IMAGE”表示环氨基; n表示8〜14的整数，其盐具有抗肿瘤活性。

9. 发明授权

US08236971B2 Polycyclic ester containing cyano group and lactone skeleton 有权
标题翻译：含有氰基和内酯骨架的多环酯
公开(公告)号：US08236971B2
公开(公告)日：2012-08-07
申请号：US12900776
申请日：2010-10-08
申请人： Keizo Inoue , Takahiro Iwahama , Masamichi Nishimura , Kiyoharu Tsutsumi
发明人： Keizo Inoue , Takahiro Iwahama , Masamichi Nishimura , Kiyoharu Tsutsumi
IPC分类号： C07D307/93 , C08G61/04
CPC分类号： C07D307/93 , C08F220/36
摘要： A polycyclic ester containing a cyano group and a lactone skeleton, represented by following Formula (1): wherein Ra represents, for example, a hydrogen atom or an alkyl group having one to six carbon atoms which may have a halogen atom; R1s each represent, for example, a halogen atom or an alkyl or haloalkyl group having one to six carbon atoms; “m” is the number of R1s; “n” is the number of cyano groups; and CH2═C(Ra)COO— group may have either of an endo conformation and an exo conformation. Accordingly, there is provided a novel polycyclic ester containing a cyano group and a lactone skeleton which is useful typically as a monomeric component for highly functional polymers. A polymer, for example, derived from this compound is highly soluble in an organic solvent while remaining stable typically to chemicals and exhibits improved hydrolyzability and/or improved solubility in water after hydrolysis.
摘要翻译：由下式（1）表示的含有氰基和内酯骨架的多环酯：其中，Ra表示例如可以具有卤素原子的氢原子或碳原子数1〜6的烷基， R 1各自表示例如卤素原子或具有1〜6个碳原子的烷基或卤代烷基; “m”是R1的数量; “n”是氰基的数目; 和CH 2 = C（Ra）COO-基团可以具有内部构象和外部构象。因此，提供了含有氰基和内酯骨架的新型多环酯，其通常用作高官能聚合物的单体组分。例如衍生自该化合物的聚合物高度可溶于有机溶剂，同时通常保持稳定化学品，并且在水解后表现出改善的水解性和/或改善的在水中的溶解性。

10. 发明申请

US20110065044A1 POLYMER FOR LITHOGRAPHIC PURPOSES AND METHOD FOR PRODUCING SAME 失效
标题翻译：用于平版印刷用途的聚合物及其生产方法
公开(公告)号：US20110065044A1
公开(公告)日：2011-03-17
申请号：US12992423
申请日：2009-06-01
申请人： Arimichi Okumura , Keizo Inoue , Kazuki Okamoto
发明人： Arimichi Okumura , Keizo Inoue , Kazuki Okamoto
IPC分类号： G03F7/004 , G03F7/20 , C08G63/08
CPC分类号： G03F7/0397 , C08F216/125 , C08F220/06 , C08F220/18 , C08F220/28
摘要： A polymer for lithographic purposes has at least a repeating structural unit represented by following General Formula (I). In Formula (I), R1, R3, R4, and R6 each independently represent hydrogen atom, a halogen atom, cyano group, an alkyl group, or a haloalkyl group; R2 and R5 each independently represent hydrogen atom, cyano group, etc.; X1 and X2 each independently represent single bond, or a substituted or unsubstituted bivalent alkylene, alkenylene, or cycloalkylene group, etc.; X3 and X4 each independently represent single bond or —CO—; R7, R8, R9, and R10 each independently represent hydrogen atom, an alkyl group, or a cycloalkyl group. The polymer for lithographic purposes shows good balance between line edge roughness (LER) and etching resistance and allows very fine and uniform patterning.
摘要翻译：用于光刻目的的聚合物至少具有由以下通式（I）表示的重复结构单元。在式（I）中，R 1，R 3，R 4和R 6各自独立地表示氢原子，卤素原子，氰基，烷基或卤代烷基; R2和R5各自独立地表示氢原子，氰基等; X1和X2各自独立地表示单键，或取代或未取代的二价亚烷基，亚烯基或亚环烷基等; X 3和X 4各自独立地表示单键或-CO-; R 7，R 8，R 9和R 10各自独立地表示氢原子，烷基或环烷基。用于光刻目的的聚合物在线边缘粗糙度（LER）和耐蚀刻性之间具有良好的平衡，并且允许非常精细和均匀的图案化。

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