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    • 8. 发明申请
    • Pharmaceutical composition comprising a renin inhibitor, a calcium channel blocker and a diuretic
    • 药物组合物,其包含肾素抑制剂,钙通道阻断剂和利尿剂
    • US20050182042A1
    • 2005-08-18
    • US10514683
    • 2003-05-16
    • David FeldmanRandy Webb
    • David FeldmanRandy Webb
    • A61K31/137A61K31/165A61K31/192A61K31/196A61K31/277A61K31/341A61K31/385A61K31/4184A61K31/4409A61K31/4422A61K31/4439A61K31/4545A61K31/455A61K31/495A61K31/4965A61K31/517A61K31/519A61K31/549A61K31/554A61K31/585A61K45/06A61P3/10A61P9/00A61P9/04A61P9/06A61P9/10A61P9/12A61P13/12A61P15/00A61P17/00A61P21/00A61P25/06A61P25/28A61P27/06A61P35/00
    • A61K45/06
    • The invention relates to a pharmaceutical composition comprising (i) a renin inhibitor, (ii) a calcium channel blocker (CCB), and (iii) a diuretic and to a method of treatment of a condition or a disease selected from the group consisting of hypertension, heart failure such as (acute and chronic) congestive heart failure, left ventricular dysfunction and hypertrophic cardiomyopathy, diabetic cardiac myopathy, supraventricular and ventricular arrhythmias, atrial fibrillation, atrial flutter, detrimental vascular remodeling, myocardial infarction and its sequelae, atherosclerosis, angina (whether unstable or stable), renal insufficiency (diabetic and non-diabetic), heart failure, angina pectoris, diabetes, secondary aldosteronism, primary and secondary pulmonary hypertension, renal failure conditions, such as diabetic nephropathy, glomerulonephritis (including IgA nephropathy), renal fibrosis, scleroderma, glomerular sclerosis, proteinuria of renal disease, and also renal vascular hypertension, diabetic retinopathy, the management of other vascular disorders, such as migraine, peripheral vascular disease, Raynaud's disease, luminal hyperplasia, cognitive dysfunction (such as Alzheimer's), glaucoma and stroke, pulmonary and hepatic fibrosis, fibrotic diseases resulting from accumulation of excess extracellular matrix induced by TGF, and proliferative diseases of smooth muscle cells, including uterine fibroids comprising administering a therapeutically effective amount of said pharmaceutical composition to a mammal in need of such treatment.
    • 本发明涉及一种药物组合物,其包含(i)肾素抑制剂,(ii)钙通道阻滞剂(CCB),和(iii)利尿剂和治疗选自以下的疾病或疾病的方法: 高血压,心力衰竭(急性和慢性)充血性心力衰竭,左心室功能障碍和肥大性心肌病,糖尿病性心肌病,室上性心室性心律失常,心房颤动,心房扑动,有害血管重塑,心肌梗塞及其后遗症,动脉粥样硬化,心绞痛 (不稳定或稳定),肾功能不全(糖尿病和非糖尿病),心力衰竭,心绞痛,糖尿病,继发性醛固酮增多症,原发性和继发性肺动脉高压,肾衰竭病症如糖尿病性肾病,肾小球肾炎(包括IgA肾病) 肾纤维化,硬皮病,肾小球硬化,肾脏疾病的蛋白尿,以及肾血管性高血压 糖尿病视网膜病变,其他血管疾病如偏头痛,外周血管疾病,雷诺氏病,管腔增生,认知功能障碍(如阿尔茨海默氏症),青光眼和中风,肺和肝纤维化的管理,由过量积累引起的纤维化疾病 由TGF诱导的细胞外基质和平滑肌细胞的增殖性疾病,包括子宫肌瘤,包括向需要这种治疗的哺乳动物施用治疗有效量的所述药物组合物。
    • 9. 发明授权
    • Method and apparatus for chlorine dioxide manufacture
    • 制造二氧化氯的方法和装置
    • US5234678A
    • 1993-08-10
    • US875883
    • 1992-04-29
    • Aaron RosenblattDavid H. RosenblattDavid FeldmanJoseph E. KnappDiane BattistiBadie Morsi
    • Aaron RosenblattDavid H. RosenblattDavid FeldmanJoseph E. KnappDiane BattistiBadie Morsi
    • C01B11/02
    • C01B11/024
    • A method and apparatus for the generation, use, and disposal of chlorine dioxide is disclosed. A solid sodium chlorite composition having impurities, at least one of which is sodium hydroxide, is contacted with an agent to consume essentially all of the sodium hydroxide. Chlorine dioxide gas is then generated by contacting the resultant composition with chlorine in a humidified inert carrier gas. The resultant chlorine dioxide gas mixture may then be treated to remove chlorine gas present therein by contacting the same with soda-lime in particulate form. After using the chlorine dioxide gas mixture in the desired manner, chlorine dioxide present in the spent effluent gas may be substantially removed via the introduction of the effluent gas into an aqueous solution of sodium thiosulfate having a sufficient amount of an inorganic base to maintain the alkalinity of the solution during consumption of thiosulfate by chlorine dioxide.
    • 公开了用于产生,使用和处理二氧化氯的方法和装置。 具有至少一种氢氧化钠的杂质的固体亚氯酸钠组合物与试剂接触以消耗基本上所有的氢氧化钠。 然后通过使所得组合物与加湿的惰性载气中的氯接触来产生二氧化氯气体。 然后可以将所得二氧化氯气体混合物与颗粒形式的钠钙接触,从而除去其中存在的氯气。 以所需方式使用二氧化氯气体混合物后,废弃废气中存在的二氧化氯可以通过将流出气体引入具有足够量的无机碱的硫代硫酸钠水溶液中而基本上除去,以保持碱度 在二氧化氯消耗硫代硫酸盐时的溶液。