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    • 3. 发明专利
    • Method for producing purified collagen hydrolyzate
    • 生产纯化的胶原水解产物的方法
    • JP2011201837A
    • 2011-10-13
    • JP2010072994
    • 2010-03-26
    • Asahi Kagaku Kogyo KkAsahi Kasei Chemicals Corp旭化成ケミカルズ株式会社旭陽化学工業株式会社
    • NAKAZAWA YUKIOYOSHIYAMA HIDEKISHIKI SATOSHITADERA YASUHIRODOI MASAHIRO
    • C07K14/78B01D61/14B01D65/02B01D69/08B01D71/44B01D71/68C07K1/34C12P21/00
    • PROBLEM TO BE SOLVED: To provide a method for capable of producing a sufficiently purified collagen hydrolysate excellent in production efficiency and having the less contamination of crushed materials such as microorganisms.SOLUTION: This method for producing the purified collagen hydrolysate comprising an inside pressure filtration process of passing the collagen hydrolysate-containing solution through a porous hollow fiber membrane of which tubular wall is constituted by a blended material of a hydrophobic polymer with a hydrophilic polymer, is provided with that in the case of equally dividing the tubular wall by three, into three regions in the wall thickness direction, the porous hollow fiber membrane has a higher containing ratio of the hydrophilic polymer in an outer circumferential region including an outside surface than the containing ratio of the hydrophilic polymer in an inner circumferential region including an inside surface, and the larger mean hole diameter of the inside surface than the mean hole diameter of the outside surface.
    • 要解决的问题:提供一种能够生产生产效率优异,污染微生物等破碎材料的污染少的胶原蛋白水解产物的方法。解决方案:该纯化胶原蛋白水解产物的制造方法包括内压过滤方法 使含有胶原蛋白水解物的溶液通过疏水性聚合物与亲水性聚合物的混合材料构成的管状壁的多孔中空纤维膜,在将管状壁等分三次的情况下,设置成 三个区域的壁厚方向,多孔中空纤维膜在包括外表面的外周区域中的亲水性聚合物的含有比包含内表面的内周区域中的亲水性聚合物的含有率高, insi的平均孔径较大 表面比外表面的平均孔径。