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1. 发明授权

US08973283B2 System and method for solvent recovery in a batch fluidized bed process 有权
标题翻译：在分批流化床工艺中进行溶剂回收的系统和方法
公开(公告)号：US08973283B2
公开(公告)日：2015-03-10
申请号：US13142061
申请日：2010-02-02
申请人： Arup Nandi , Alan Cheng , John Fredric Billingham
发明人： Arup Nandi , Alan Cheng , John Fredric Billingham
IPC分类号： F26B5/06 , B01D53/00 , B01D53/26 , F26B3/08 , F26B21/14 , F26B25/00
CPC分类号： B01D53/002 , B01D53/265 , B01D2257/2064 , B01D2257/7022 , B01D2257/7027 , B01D2257/704 , B01D2257/708 , B01D2257/80 , F26B3/08 , F26B21/14 , F26B25/006 , Y10T137/0318 , Y10T137/8593
摘要： A system and method for solvent recovery in a batch fluidized bed process is provided. The disclosed embodiment of the fluidized bed system includes a fluidized bed vessel adapted to contain a batch of solvent-containing product; an influent or intake circuit adapted to supply an inert fluidizing gas to the fluidized bed vessel; an effluent circuit adapted to remove the solvent containing inert fluidizing gas from the fluidized bed vessel; a first recycle circuit coupling the effluent circuit to a solvent recovery means; a second recycle circuit directly coupling the effluent circuit to the intake circuit and a flow control valve operatively disposed to divide the effluent between the first recycle circuit and the second recycle circuit based on the operating regime of the fluidized bed process. The disclosed embodiments further include a source of liquid nitrogen coupled to the second recycle circuit to provide the make-up inert gas as well as provide enhanced cooling of the effluent based on the operating regime of the fluidized bed process.
摘要翻译：提供了一种用于分批流化床方法中的溶剂回收的系统和方法。所公开的流化床系统的实施例包括适于容纳一批含溶剂的产物的流化床容器; 适于向流化床容器供应惰性流化气体的进水或进气回路; 流出回路，适于从流化床容器中除去含有惰性流化气体的溶剂; 将流出物回路耦合到溶剂回收装置的第一再循环回路; 将流出物回路直接连接到进气回路的第二回收回路和可操作地设置成基于流化床方法的操作状态在第一再循环回路和第二再循环回路之间分配流出物的流量控制阀。所公开的实施例还包括耦合到第二再循环回路以提供补充惰性气体的液氮源，并且基于流化床方法的操作状态提供对流出物的增强的冷却。

2. 发明申请

US20120030962A1 SYSTEM AND METHOD FOR SOLVENT RECOVERY IN A BATCH FLUIDIZED BED PROCESS 有权
标题翻译：一种批量流化床方法中溶剂回收的系统和方法
公开(公告)号：US20120030962A1
公开(公告)日：2012-02-09
申请号：US13142061
申请日：2010-02-02
申请人： Arup Nandi , Alan Cheng , John Fredric Billingham
发明人： Arup Nandi , Alan Cheng , John Fredric Billingham
IPC分类号： F26B5/06 , F26B21/00 , F15B13/00 , F17D3/00
CPC分类号： B01D53/002 , B01D53/265 , B01D2257/2064 , B01D2257/7022 , B01D2257/7027 , B01D2257/704 , B01D2257/708 , B01D2257/80 , F26B3/08 , F26B21/14 , F26B25/006 , Y10T137/0318 , Y10T137/8593
摘要： A system and method for solvent recovery in a batch fluidized bed process is provided. The disclosed embodiment of the fluidized bed system includes a fluidized bed vessel adapted to contain a batch of solvent-containing product; an influent or intake circuit adapted to supply an inert fluidizing gas to the fluidized bed vessel; an effluent circuit adapted to remove the solvent containing inert fluidizing gas from the fluidized bed vessel; a first recycle circuit coupling the effluent circuit to a solvent recovery means; a second recycle circuit directly coupling the effluent circuit to the intake circuit and a flow control valve operatively disposed to divide the effluent between the first recycle circuit and the second recycle circuit based on the operating regime of the fluidized bed process. The disclosed embodiments further include a source of liquid nitrogen coupled to the second recycle circuit to provide the make-up inert gas as well as provide enhanced cooling of the effluent based on the operating regime of the fluidized bed process.
摘要翻译：提供了一种用于分批流化床方法中的溶剂回收的系统和方法。所公开的流化床系统的实施例包括适于容纳一批含溶剂的产物的流化床容器; 适于向流化床容器供应惰性流化气体的进水或进气回路; 流出回路，适于从流化床容器中除去含有惰性流化气体的溶剂; 将流出物回路耦合到溶剂回收装置的第一再循环回路; 将流出物回路直接连接到进气回路的第二回收回路和可操作地设置成基于流化床方法的操作状态在第一再循环回路和第二再循环回路之间分配流出物的流量控制阀。所公开的实施例还包括耦合到第二再循环回路以提供补充惰性气体的液氮源，并且基于流化床方法的操作状态提供对流出物的增强的冷却。

3. 发明授权

US08794012B2 Method and system for controlled rate freezing of biological material 有权
标题翻译：生物材料控制速率冷冻的方法和系统
公开(公告)号：US08794012B2
公开(公告)日：2014-08-05
申请号：US12266760
申请日：2008-11-07
申请人： Alan Cheng
发明人： Alan Cheng
IPC分类号： F25D25/00 , B01D8/00 , F17C7/02 , F25D3/10 , A01N1/02
CPC分类号： F25D3/102 , A01N1/0252 , F25D29/001
摘要： A method and system for controlled rate freezing of biological materials is provided. The presently disclosed system and method provides the ability to rapidly cool the biological materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time.
摘要翻译：提供了生物材料控制速率冷冻的方法和系统。本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的生物材料的能力，其中使用层流和均匀流动的冷冻剂在设置在冷却单元内的多个小瓶附近。生物材料的快速冷却是通过精确地控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。

4. 发明授权

US08015841B2 Cryogenic refrigeration system for lyophilization 有权
标题翻译：用于冷冻干燥的低温制冷系统
公开(公告)号：US08015841B2
公开(公告)日：2011-09-13
申请号：US11897448
申请日：2007-08-30
申请人： Alan Cheng
发明人： Alan Cheng
IPC分类号： F25J1/00
CPC分类号： A01N1/02 , A01N1/0252 , F25D3/10 , F25D17/02 , F25D2400/02 , F26B5/06
摘要： A cryogenic refrigeration system includes a cryogenic heat exchanger system adapted for vaporizing a liquid cryogen and using the gaseous cryogen to cool heat transfer fluid and a heat transfer cooling circuit that cools the lyophilization chamber as well as the condenser. The disclosed heat transfer cooling circuit includes a primary recirculation loop adapted for cooling the lyophilization chamber with the heat transfer fluid, a secondary recirculation loop adapted for cooling a condenser with the heat transfer fluid, and one or more valves operatively coupling the cryogenic heat exchanger system, the primary recirculation loop, and the secondary recirculation loop.
摘要翻译：低温制冷系统包括适于蒸发液体冷冻剂并使用气态冷冻剂冷却传热流体的冷冻热交换器系统和冷冻冻干室以及冷凝器的传热冷却回路。所公开的传热冷却回路包括适于用热传导流体冷冻冻干室的第一再循环回路，适于用传热流体冷却冷凝器的第二再循环回路，以及将低温热交换器系统，初级再循环回路和次级再循环回路。

5. 发明申请

US20090133411A1 METHOD AND SYSTEM FOR CONTROLLED RATE FREEZING OF BIOLOGICAL MATERIAL 有权
标题翻译：生物材料控制速率冻结的方法与系统
公开(公告)号：US20090133411A1
公开(公告)日：2009-05-28
申请号：US12266760
申请日：2008-11-07
申请人： Alan Cheng
发明人： Alan Cheng
IPC分类号： F25D25/00 , B01D8/00
CPC分类号： F25D3/102 , A01N1/0252 , F25D29/001
摘要： A method and system for controlled rate freezing of biological materials is provided. The presently disclosed system and method provides the ability to rapidly cool the biological materials contained in vials or other containers within a cooling unit via forced convective cooling using a laminar and uniform flow of cryogen in proximity to the plurality of vials disposed within the cooling unit. The rapid cooling of the biological materials is achieved by precisely controlling and adjusting the temperature of the cryogen being introduced to the system as a function of time.
摘要翻译：提供了生物材料控制速率冷冻的方法和系统。本公开的系统和方法提供了通过强制对流冷却来快速冷却包含在冷却单元内的小瓶或其他容器中的生物材料的能力，其中使用层流和均匀流动的冷冻剂在设置在冷却单元内的多个小瓶附近。生物材料的快速冷却是通过精确地控制和调节作为时间的函数引入到系统中的冷冻剂的温度来实现的。

6. 发明授权

US07461649B2 Portable gas operating inhaler 有权
标题翻译：便携式气体操作吸入器
公开(公告)号：US07461649B2
公开(公告)日：2008-12-09
申请号：US10845411
申请日：2004-05-14
申请人： Stephan C. F. Gamard , Bryan R. Bielec , Royce S. Fishman , Alan Cheng
发明人： Stephan C. F. Gamard , Bryan R. Bielec , Royce S. Fishman , Alan Cheng
IPC分类号： A61M11/00 , A61M15/00 , A61M16/00
CPC分类号： A61M15/0045 , A61M11/002 , A61M15/0008 , A61M15/005 , A61M15/007 , A61M15/0086 , A61M15/0088 , A61M15/009 , A61M2202/025 , A61M2202/064
摘要： An inhaler comprising a compressed gas, such as Heliox gas is provided. The disclosed inhaler includes a first chamber containing a compressed gas which is in communication with an equalization chamber having pressure lower than the pressure of the gas in the first chamber. The inhaler also includes a drug storage chamber which is detachably coupled to the equalization chamber and operable such that a portion of the compressed gas from the equalization chamber fluidizes and aerosolizes the drug to produce a drug cloud. The drug cloud is directed into a spacer where it can be inhaled by a user.
摘要翻译：提供了包括诸如Heliox气体的压缩气体的吸入器。所公开的吸入器包括第一室，其包含压缩气体，压缩气体与具有低于第一室中的气体压力的均压室连通。吸入器还包括药物储存室，其可拆卸地联接到均衡室并且可操作使得来自均衡室的压缩气体的一部分使药物流化并使其雾化以产生药物云。药物云被引导到间隔物中，其可以被使用者吸入。

7. 外观设计

USD539243S1 Television 有权
公开(公告)号：USD539243S1
公开(公告)日：2007-03-27
申请号：US29220370
申请日：2004-12-28
申请人： Chaucer Chiu , Alan Cheng , Lulu Ma
设计人： Chaucer Chiu , Alan Cheng , Lulu Ma

8. 发明申请

US20140047851A1 BULK FREEZING OF BIOPHARMACEUTICALS 审中-公开
标题翻译：生物吸收的大容量冷冻
公开(公告)号：US20140047851A1
公开(公告)日：2014-02-20
申请号：US14008455
申请日：2012-03-27
申请人： Ying Zhou , Alan Cheng , Nigel Grinter , Zachary Fowler , Robert Sever , Ranko Bursac
发明人： Ying Zhou , Alan Cheng , Nigel Grinter , Zachary Fowler , Robert Sever , Ranko Bursac
IPC分类号： F25D3/10
CPC分类号： F25D3/10 , A01N1/0252 , A23L3/364 , F25D15/00 , F25D17/06 , F25D2400/38
摘要： A system and method for bulk freezing is provided. In one embodiment, the system and method for bulk freezing includes a bulk freezing container adapted to hold at least one and preferably a plurality of bags holding a biopharmaceutical liquid. The bulk freezing container includes at least a first and second shelf having corrugations wherein the second shelf is vertically arranged above the first shelf with the bags disposed between the shelves. The bags and the corrugations of the first and second shelves define a plurality of substantially parallel flow channels through which a cryogenic cold fluid or a warming fluid is passed to freeze and/or thaw the biopharmaceutical fluid. In another embodiment, the bulk freezing system and method includes a bulk freezing container with a plurality of adjacent elongated chambers adapted for holding the biopharmaceutical fluid. The adjacent elongated chambers have side walls defining a plurality of substantially parallel flow channels between the plurality of adjacent elongated chambers through which a heat transfer medium is passed for heat exchange through the side walls of the elongated chambers to the fluid within the elongated chambers.
摘要翻译：提供一种用于大容量冷冻的系统和方法。在一个实施例中，用于体积冷冻的系统和方法包括适于容纳至少一个并且优选地多个保持生物药物液体的袋的体积冷冻容器。散装冷冻容器至少包括具有波纹的第一和第二搁架，其中第二搁板垂直地布置在第一搁板的上方，袋子设置在搁架之间。第一和第二搁架的袋和波纹限定了多个基本平行的流动通道，低温冷流体或加温流体通过该流动通道冷冻和/或解冻生物药物流体。在另一个实施方案中，本体冷冻系统和方法包括具有适于保持生物药物流体的多个相邻细长室的体积冷冻容器。相邻的细长室具有在多个相邻的细长室之间限定多个基本平行的流动通道的侧壁，通过该多个相邻的细长室之间传热介质通过细长室的侧壁进行热交换，使其在细长室内的流体。

9. 发明申请

US20090101144A1 PORTABLE GAS OPERATING INHALER 审中-公开
标题翻译：便携式气体操作吸入器
公开(公告)号：US20090101144A1
公开(公告)日：2009-04-23
申请号：US12257579
申请日：2008-10-24
申请人： Stephan C. F. Gamard , Bryan R. Bielec , Alan Cheng , Royce S. Fishman
发明人： Stephan C. F. Gamard , Bryan R. Bielec , Alan Cheng , Royce S. Fishman
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M11/002 , A61M15/0008 , A61M15/005 , A61M15/007 , A61M15/0086 , A61M15/0088 , A61M15/009 , A61M2202/025 , A61M2202/064
摘要： The invention relates to an inhaler comprising a compressed gas, such as Heliox gas in a first chamber which is in communication with an equalization chamber having pressure lower than the pressure of the gas in the first compressed chamber and having a drug storage chamber which is detachably coupled to the equalization chamber operable such that a portion of the compressed gas from the equalization chamber fluidizes and aerosolizes the drug to produce a drug cloud and which can then be injected into a spacer where it can be inhaled by a user.
摘要翻译：本发明涉及一种吸入器，其包括在与第一压缩室内的压力低于第一压缩室中的气体压力的均衡室连通的第一室中的诸如氦气之类的压缩气体，并具有可拆卸的药物储存室耦合到所述均衡室，其可操作使得来自所述均衡室的压缩气体的一部分使所述药物流化并使其雾化以产生药物云，并且然后可以将其注入间隔器中，在该隔离物中可由用户吸入。

10. 发明授权

US06319861B1 Method of improving deposition 有权
标题翻译：改善沉积的方法
公开(公告)号：US06319861B1
公开(公告)日：2001-11-20
申请号：US09562529
申请日：2000-05-02
申请人： Hsueh-Hao Shih , Alan Cheng , Juan-Yuan Wu
发明人： Hsueh-Hao Shih , Alan Cheng , Juan-Yuan Wu
IPC分类号： H01L2131
CPC分类号： H01L21/02046 , H01L21/02049
摘要： A method for improving the quality of a deposited layer over a silicon substrate in a selective deposition where the silicon substrate has a native oxide layer thereon. A plasma reaction using a halogen compound as a reactive agent is performed so that the native oxide layer is transformed into a silicon halide layer and then removed at low pressure. A layer of the desired material is formed over the native oxide free silicon substrate surface by selective deposition.
摘要翻译：一种用于在选择性沉积中提高硅衬底上的沉积层的质量的方法，其中硅衬底上具有自然氧化物层。进行使用卤素化合物作为反应剂的等离子体反应，使得天然氧化物层转变成卤化硅层，然后在低压下除去。通过选择性沉积在所述自然无氧化物硅衬底表面上形成所需材料层。

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