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1. 发明申请

US20050209148A1 Methods of treating obesity or diabetes using NT-4/5 审中-公开
标题翻译：使用NT-4/5治疗肥胖或糖尿病的方法
公开(公告)号：US20050209148A1
公开(公告)日：2005-09-22
申请号：US11064309
申请日：2005-02-22
申请人： Arnon Rosenthal , John Lin , Jennifer Stratton , Robert Klein , Jaume Pons
发明人： Arnon Rosenthal , John Lin , Jennifer Stratton , Robert Klein , Jaume Pons
IPC分类号： A61K38/17 , A61K38/18
CPC分类号： A61K38/185
摘要： The invention concerns methods for treating obesity, non-insulin dependent diabetes mellitus, metabolic syndrome, and other related diseases by administering an NT-4/5 polypeptide. The invention also concerns compositions and kits comprising an NT-4/5 polypeptide.
摘要翻译：本发明涉及通过施用NT-4/5多肽来治疗肥胖症，非胰岛素依赖性糖尿病，代谢综合征和其它相关疾病的方法。本发明还涉及包含NT-4/5多肽的组合物和试剂盒。

2. 发明申请

US20070232535A1 GFRalpha3 and its uses 有权
标题翻译： GFRalpha3及其用途
公开(公告)号：US20070232535A1
公开(公告)日：2007-10-04
申请号：US11529680
申请日：2006-09-27
申请人： Frederic de Sauvage , Robert Klein , Heidi Phillips , Arnon Rosenthal
发明人： Frederic de Sauvage , Robert Klein , Heidi Phillips , Arnon Rosenthal
IPC分类号： A61K39/00 , C07K14/00 , G01N33/53
CPC分类号： C07K16/2863 , C07K14/71 , C07K2317/75 , C07K2319/00 , C12Q1/485 , G01N33/573 , G01N33/74 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRα3, a novel α-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an α-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced subunit receptor homo-dimerization or homo-oligomerization.
摘要翻译：本发明涉及核苷酸序列，包括表达序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞，其表达和免疫粘附和抗体对哺乳动物GFRalpha3，GDNF（即GFR）受体家族的新型α-亚单位受体。它进一步涉及通过检测酪氨酸激酶受体活化（即自身磷酸化）或与配体诱导的亚单位受体均二聚化或同型寡聚化相关的其它活性来测量α亚基受体活化的测定法。

3. 发明申请

US20050221330A1 GFRalpha3 and its uses 审中-公开
标题翻译： GFRalpha3及其用途
公开(公告)号：US20050221330A1
公开(公告)日：2005-10-06
申请号：US10621855
申请日：2003-07-16
申请人： Frederic de Sauvage , Robert Klein , Heidi Phillips , Arnon Rosenthal
发明人： Frederic de Sauvage , Robert Klein , Heidi Phillips , Arnon Rosenthal
IPC分类号： G01N33/68 , A61K39/395 , A61K45/00 , A61P1/02 , A61P1/10 , A61P11/06 , A61P17/02 , A61P25/02 , A61P25/06 , A61P27/02 , C07K14/71 , C07K16/28 , C07K19/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/42 , G01N33/573 , C12Q1/68 , C07H21/04
CPC分类号： C07K16/2863 , C07K14/71 , C07K2317/75 , C07K2319/00 , C12Q1/485 , G01N33/573 , G01N33/74 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRα3, a novel α-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an α-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced α-subunit receptor homo-dimerization or homo-oligomerization.
摘要翻译：本发明涉及核苷酸序列，包括表达序列标签（EST），寡核苷酸探针，多肽，载体和表达哺乳动物GFRalpha3的免疫粘附和宿主细胞，以及GDNF（即GFR）受体家族的新型α-亚基受体。它进一步涉及通过检测酪氨酸激酶受体激活（即自身磷酸化）或与配体诱导的α-亚基受体均二聚化或同型寡聚化相关的其他活性来测量α-亚单位受体活化的测定法。

4. 发明申请

US20060216289A1 GFRalpha3 and its uses 审中-公开
标题翻译： GFRalpha3及其用途
公开(公告)号：US20060216289A1
公开(公告)日：2006-09-28
申请号：US11448387
申请日：2006-06-06
申请人： Frederic de Sauvage , Robert Klein , Heidi Phillips , Arnon Rosenthal
发明人： Frederic de Sauvage , Robert Klein , Heidi Phillips , Arnon Rosenthal
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/71 , C07K16/28
CPC分类号： C07K16/2863 , C07K14/71 , C07K2317/75 , C07K2319/00 , C12Q1/485 , G01N33/573 , G01N33/74 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRα3, a novel α-subunit receptor of the GDNF (i.e. GFR) receptor family. It further relates to an assay for measuring activation of an α-subunit receptor by detecting tyrosine kinase receptor activation (i.e., autophosphorylation) or other activities related to ligand-induced α-subunit receptor homo-dimerization or homo-oligomerization.
摘要翻译：本发明涉及核苷酸序列，包括表达序列标签（EST），寡核苷酸探针，多肽，载体和宿主细胞，其表达和免疫粘附和抗体对哺乳动物GFRalpha3，GDNF（即GFR）受体家族的新型α-亚单位受体。它进一步涉及通过检测酪氨酸激酶受体激活（即自身磷酸化）或与配体诱导的α-亚基受体均二聚化或同型寡聚化相关的其他活性来测量α-亚单位受体活化的测定法。

5. 发明申请

US20060142196A1 Uses of GDNF and GDNF receptor 有权
公开(公告)号：US20060142196A1
公开(公告)日：2006-06-29
申请号：US11336555
申请日：2006-01-20
申请人： Robert Klein , Mark Moore , Arnon Rosenthal , Anne Ryan
发明人： Robert Klein , Mark Moore , Arnon Rosenthal , Anne Ryan
IPC分类号： A61K38/17 , C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/71 , A01K2217/05 , A61K38/00 , C07K16/22 , C07K2319/00
摘要： GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRα (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to GDNFRα-ligands, for example GDNF, by providing GDNFRα to the cell. Also provided are methods for using GDNFRα, GDNF, or agonists thereof, separately or in complex, to treat kidney diseases.

6. 发明申请

US20060292114A1 Neurturin receptor 有权
公开(公告)号：US20060292114A1
公开(公告)日：2006-12-28
申请号：US11508791
申请日：2006-08-22
申请人： Robert Klein , Arnon Rosenthal , Mary Hynes
发明人： Robert Klein , Arnon Rosenthal , Mary Hynes
IPC分类号： A61K38/20 , A61K38/19 , A61K38/18 , A61K38/22 , A61K39/395
CPC分类号： C07K14/705 , A01K67/0275 , A61K2039/505 , C07K16/22 , G01N33/6863 , G01N33/6872 , Y10S930/12
摘要： NTNRα, NTNRα extracellular domain (ECD), NTNRα variants, chimeric NTNRα (e.g., NTNRα immunoadhesion), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including methods to modulate cell activity and survival by response to NTNRα-ligands, for example NTN, by providing NTNRα to the cell.

7. 发明授权

US08774164B2 Adaptive R99 and HS PS (high speed packet-switched) link diversity for coverage and capacity enhancement of circuit-switched calls 有权
标题翻译：自适应R99和HS PS（高速分组交换）链路分集，用于电路交换呼叫的覆盖和容量增强
公开(公告)号：US08774164B2
公开(公告)日：2014-07-08
申请号：US12392578
申请日：2009-02-25
申请人： Robert Klein , Arthur Brisebois
发明人： Robert Klein , Arthur Brisebois
IPC分类号： H04W36/06 , H04L12/66
CPC分类号： H04W28/0231 , H04W36/06 , H04W36/28 , H04W72/08
摘要： A system and methodology that facilitates adaptive link diversity for enhanced coverage and capacity during user data communication in a UMTS (Universal Mobile Telecommunications System) is provided. Specifically, current radio conditions associated with the user data are monitored and analyzed. Moreover, a switching and/or concurrent transport mechanism is implemented for communication between a NodeB and UE (User Equipment), when the current radio conditions change beyond a predefined level. In particular, a CS (Circuit Switched) over HSPA (High Speed Packet Access) connection is reconfigured to an R99 (Release 99) CS connection, or a concurrent R99 CS connection is provided along with the CS over HSPA connection, when detected that radio conditions have degraded beyond a predefined threshold. In one aspect, the selection between switching to a new transport mechanism and, adding a concurrent transport mechanism is based on an analysis and/or operator defined conditions.
摘要翻译：提供了一种在UMTS（通用移动通信系统）中的用户数据通信期间促进适应性链路分集以增强覆盖和容量的系统和方法。具体来说，监视和分析与用户数据相关联的当前无线电条件。此外，当当前无线电条件改变超出预定义的水平时，实现用于节点B和UE（用户设备）之间的通信的交换和/或并发传输机制。特别地，通过HSPA（高速分组接入）连接的CS（电路交换）重新配置为R99（版本99）CS连接，或者当检测到该无线电时，与CS通过HSPA连接一起提供并发的R99 CS连接条件已经超过预定阈值。在一个方面，切换到新的传输机制和添加并发传输机制之间的选择是基于分析和/或操作符定义的条件。

8. 发明申请

US20100273664A1 Method For The Determination Of Intra- And Intermolecular Interactions In Aqueous Solution 审中-公开
标题翻译：水溶液中分子间和分子间相互作用的测定方法
公开(公告)号：US20100273664A1
公开(公告)日：2010-10-28
申请号：US12446659
申请日：2007-10-20
申请人： Gudrun Lange , Robert Klein , Juergen Albrecht , Matthias Rarey , Ingo Reulecke
发明人： Gudrun Lange , Robert Klein , Juergen Albrecht , Matthias Rarey , Ingo Reulecke
IPC分类号： C40B30/02 , G01N33/68 , G01N33/92 , G01N33/53 , C12Q1/00 , G06F19/00
CPC分类号： G16C10/00 , G16B15/00 , Y10T436/143333
摘要： The present invention relates to the determination of intra- or intermolecular interaction between molecules in aqueous solution, said method comprising the steps of: (a) determining the dehydration (ΔGdehydration) of all atoms in the intermolecular interface, (b) adding the vacuum hydrogen bond energy (εH-bond), and (c) further adding the change in the free enthalpy of the interacting partners upon their interaction. The obtained results can be used for the prediction if and to what extent two molecules of various origin fit to each other.
摘要翻译：本发明涉及确定水溶液中分子之间或分子间相互作用的方法，所述方法包括以下步骤：（a）测定分子间界面中所有原子的脱水（＆Dgr。Gralration），（b）真空氢键能（H键），（c）进一步增加相互作用的物体在相互作用下的自由焓的变化。获得的结果可以用于预测各种来源的两个分子如何以及在何种程度上相互适应。

9. 发明申请

US20100246544A1 INDOOR COMPETITIVE SURVEY OF WIRELESS NETWORKS 有权
标题翻译：室内无线网络的竞争性调查
公开(公告)号：US20100246544A1
公开(公告)日：2010-09-30
申请号：US12413970
申请日：2009-03-30
申请人： Arthur Richard Brisebois , Robert Klein
发明人： Arthur Richard Brisebois , Robert Klein
IPC分类号： H04W4/00
CPC分类号： H01L41/12 , H04L45/00 , H04L45/02 , H04W16/20 , H04W24/00 , H04W48/16
摘要： System(s) and method(s) are provided to collect network operation data within a confined indoor wireless environment for generation of competitive intelligence and strategic network planning. Scanner component(s) survey and compare signals transported in a set of electromagnetic frequency bands, and in accordance with a set of radio technologies associated with competing networks. Collected data can be aggregated and delivered to femto gateway node(s), which can supply the data to an analysis component that generates network operations NetOp intelligence. A report component can manage received and aggregated network operation data and convey a portion thereof to planning tool(s) that can produce competitive intelligence and develop strategic network planning. Planning tool(s) can request specific network operation data or NetOp intelligence. Aggregated network operation data can be employed to identify service provider indoor coverage strengths or weaknesses relative to competitors to focus sales activities related to network services, and network improvement efforts.
摘要翻译：提供系统和方法来收集有限的室内无线环境中的网络运行数据，以产生竞争情报和战略网络规划。扫描器组件调查和比较在一组电磁频带中传输的信号，并且根据与竞争网络相关联的一组无线电技术。收集的数据可以聚合并传送到毫微微网关节点，该节点可以将数据提供给生成网络操作NetOp智能的分析组件。报告组件可以管理接收和汇总的网络操作数据，并将其部分传达给可以产生竞争情报并开发战略网络规划的规划工具。规划工具可以请求特定的网络操作数据或NetOp智能。可以采用汇总的网络运营数据来识别服务提供商相对于竞争对手的室内覆盖优势或劣势，以集中与网络服务相关的销售活动以及网络改进工作。

10. 发明申请

US20070034646A1 Foil monomer container and dispenser 审中-公开
标题翻译：箔单体容器和分配器
公开(公告)号：US20070034646A1
公开(公告)日：2007-02-15
申请号：US11202785
申请日：2005-08-12
申请人： Paul Higham , Robert Klein
发明人： Paul Higham , Robert Klein
IPC分类号： B65D35/00
CPC分类号： B65D35/06 , B65D51/223 , B65D75/5805 , B65D75/5811 , B65D2251/0015 , B65D2251/0096
摘要： A metallic container for storing the liquid monomer component of bone cement and a method of packaging same are disclosed. The container is preferably aluminum and has an interior wall, a dispensing end, a reservoir for housing the liquid monomer, and a filling end for receiving the liquid monomer. The container is sealed by a welded seam near the filling end of the container, which secures a section of the top portion and lower portion of the interior wall of the container together.
摘要翻译：公开了一种用于储存骨水泥的液体单体成分的金属容器及其包装方法。容器优选为铝，并且具有内壁，分配端，用于容纳液体单体的储存器和用于接收液体单体的填充端。容器通过在容器的填充端附近的焊缝密封，其将容器的内壁的顶部和下部的一部分固定在一起。

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