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1. 发明授权

US5954661A Tissue characterization and treatment using pacing 失效
标题翻译：使用起搏组织表征和治疗
公开(公告)号：US5954661A
公开(公告)日：1999-09-21
申请号：US831489
申请日：1997-03-31
申请人： Arnold J. Greenspon , David K. Swanson , Dorin Panescu , Steve S. Hsu , James G. Whayne
发明人： Arnold J. Greenspon , David K. Swanson , Dorin Panescu , Steve S. Hsu , James G. Whayne
IPC分类号： A61B5/042 , A61B5/0452 , A61N1/362 , A61B5/04
CPC分类号： A61B5/6858 , A61B5/0422 , A61B2562/0209 , A61B2562/043 , A61B5/0452 , A61B5/7217 , A61N1/3621
摘要： Heart tissue is characterized by using pacing without inducing ventricular tachycardia (VT). With the tissue characterization, a patient's risk of developing VT can be determined and a slow conduction zone in the patient's heart can be determined. The characterization involves applying pacing signals with varying pacing cycle intervals to a chamber of the patient's heart to pace the patient's heart. The response signals generated by the paced heart are received and used as the basis for characterizing the patient's heart tissue.
摘要翻译：心脏组织的特征是使用起搏而不引起室性心动过速（VT）。通过组织表征，可以确定患者发生VT的风险，并且可以确定患者心脏中的缓慢传导区域。表征包括将具有不同起搏周期间隔的起搏信号应用于患者心脏的室以对患者的心脏进行加速。接收由起搏心脏产生的响应信号并用作表征病人心脏组织的基础。

2. 发明授权

US06824515B2 Ultrasound-guided ablation catheter and methods of use 有权
标题翻译：超声引导消融导管及使用方法
公开(公告)号：US06824515B2
公开(公告)日：2004-11-30
申请号：US10305256
申请日：2002-11-25
申请人： Veijo T. Suorsa , David K. Swanson , Dorin Panescu , Harm TenHoff , James G. Whayne
发明人： Veijo T. Suorsa , David K. Swanson , Dorin Panescu , Harm TenHoff , James G. Whayne
IPC分类号： A61B812
CPC分类号： A61B18/1492 , A61B2017/00106 , A61B2018/0016 , A61B2018/00351 , A61B2018/00577 , A61B2018/00654 , A61B2018/124 , A61B2090/065 , A61B2090/3784 , A61N7/02 , A61N2007/0078
摘要： The present invention provides ultrasound-guided ablation catheters and methods for their use. In one embodiment, a tissue ablation apparatus (2) includes a flexible elongate body (12) having proximal (14) and distal (12) ends. A plurality of spaced-apart electrodes (24) are operably attached to the flexible body near the distal end. A plurality of transducer elements (28) are disposed between at least some of the electrodes. Transducers assist the physician in determining whether or not the ablation elements are in contact with the tissue to be ablated.
摘要翻译：本发明提供超声引导消融导管及其使用方法。在一个实施例中，组织消融装置（2）包括具有近端（14）和远端（12）端部的柔性细长体（12）。多个间隔开的电极（24）在远端附近可操作地附接到柔性体。多个换能器元件（28）设置在至少一些电极之间。传感器帮助医师确定消融元件是否与要消融的组织接触。

3. 发明授权

US06542773B2 Interactive systems and methods for controlling the use of diagnostic or therapeutic instruments in interior body regions 有权
标题翻译：用于控制在内部身体区域使用诊断或治疗仪器的交互式系统和方法
公开(公告)号：US06542773B2
公开(公告)日：2003-04-01
申请号：US09848182
申请日：2001-05-02
申请人： Daniel A. Dupree , Tuan Nguyen , Dorin Panescu , James G. Whayne , David McGee , David K. Swanson
发明人： Daniel A. Dupree , Tuan Nguyen , Dorin Panescu , James G. Whayne , David McGee , David K. Swanson
IPC分类号： A61B50402
CPC分类号： A61B5/0422 , A61B5/0464 , A61B5/06 , A61B5/063 , A61B5/6858 , A61B5/7435 , A61B5/7445 , A61B5/7475 , A61B18/1492 , A61B2018/00214 , A61B2018/00898 , G06F19/00 , G06F19/3481 , G16H10/60 , G16H40/63
摘要： An interface is associated with a structure which, in use, is deployed in an interior body region of a patient. The structure includes an operative element coupled to a controller, which establishes an operating condition for the operative element to perform a diagnostic or therapeutic procedure in the interior body region. The interface generates a first display comprising an image of the structure at least partially while the operative element performs the procedure. The interface also generates a second display comprising one or more data fields reflecting the operating condition of the controller. The interface enables selection of the first display or the second display for viewing on a display screen.
摘要翻译：界面与在使用中部署在患者的内部身体区域中的结构相关联。该结构包括耦合到控制器的操作元件，其建立操作元件在内部身体区域中执行诊断或治疗过程的操作条件。该接口在操作元件执行该过程时至少部分地生成包括该结构的图像的第一显示器。接口还产生包括反映控制器的操作条件的一个或多个数据字段的第二显示器。该接口使得能够选择第一显示器或第二显示器以在显示屏幕上观看。

4. 发明授权

US06471699B1 Systems and methods for forming elongated lesion patterns in body tissue using straight or curvilinear electrode elements 失效
标题翻译：使用直线或曲线电极元件在身体组织中形成细长病变图案的系统和方法
公开(公告)号：US06471699B1
公开(公告)日：2002-10-29
申请号：US09579730
申请日：2000-05-26
申请人： Sidney D. Fleischman , Thomas Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
发明人： Sidney D. Fleischman , Thomas Bourne , Dorin Panescu , David K. Swanson , James G. Whayne
IPC分类号： A61B1818
CPC分类号： A61B5/0422 , A61B5/6855 , A61B5/6857 , A61B5/6858 , A61B18/1402 , A61B18/1492 , A61B18/1815 , A61B2017/00084 , A61B2017/00088 , A61B2017/00092 , A61B2017/00292 , A61B2017/003 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00357 , A61B2018/00577 , A61B2018/00755 , A61B2018/00791 , A61B2018/00839 , A61B2018/00869 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1435 , A61B2018/1497 , A61B2018/1861 , A61B2562/0209 , A61B2562/043 , A61L29/085 , A61L29/145 , A61L31/10 , A61L31/145 , A61M25/0041 , A61M2025/09141 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , G01K1/026 , G01K3/14 , C08L1/02
摘要： Systems and associated methods position arrays of multiple emitters of ablating energy in straight or curvilinear positions in contact with tissue to form elongated lesion patterns. The elongated lesion patterns can continuous or interrupted, depending upon the orientation of the energy emitters.
摘要翻译：系统和相关方法将多个发射器的阵列放置在与组织接触的直线或曲线位置中，以形成细长的病变图案。取决于能量发射器的取向，细长的损伤图案可以连续或中断。

5. 发明授权

US06289239B1 Interactive systems and methods for controlling the use of diagnostic or therapeutic instruments in interior body regions 有权
标题翻译：用于控制在内部身体区域使用诊断或治疗仪器的交互式系统和方法
公开(公告)号：US06289239B1
公开(公告)日：2001-09-11
申请号：US09538133
申请日：2000-03-29
申请人： Dorin Panescu , David McGee , James G. Whayne , Robert R. Burnside , David K. Swanson , Daniel A. Dupree
发明人： Dorin Panescu , David McGee , James G. Whayne , Robert R. Burnside , David K. Swanson , Daniel A. Dupree
IPC分类号： A61B5044
CPC分类号： A61B5/0422 , A61B5/0464 , A61B5/06 , A61B5/063 , A61B5/6858 , A61B5/7435 , A61B5/7445 , A61B5/7475 , A61B18/1492 , A61B2018/00214 , A61B2018/00898 , G06F19/00 , G06F19/3481 , G16H10/60 , G16H40/63
摘要： An interface is associated with a structure which, in use, is deployed in an interior body region of a patient. The structure includes an operative element coupled to a controller, which establishes an operating condition for the operative element to perform a diagnostic or therapeutic procedure in the interior body region. The interface generates a first display comprising an image of the structure at least partially while the operative element performs the procedure. The interface also generates a second display comprising one or more data fields reflecting the operating condition of the controller. The interface enables selection of the first display or the second display for viewing on a display screen.
摘要翻译：界面与在使用中部署在患者的内部身体区域中的结构相关联。该结构包括耦合到控制器的操作元件，其建立操作元件在内部身体区域中执行诊断或治疗过程的操作条件。该接口在操作元件执行该过程时至少部分地生成包括该结构的图像的第一显示器。接口还产生包括反映控制器的操作条件的一个或多个数据字段的第二显示器。该接口使得能够选择第一显示器或第二显示器以在显示屏幕上观看。

6. 发明授权

US06188924B1 Systems and methods for acquiring making time-sequential measurements of biopotentials sensed in myocardial tissue 有权
标题翻译：用于获取在心肌组织中感测的生物电位的时间顺序测量的系统和方法
公开(公告)号：US06188924B1
公开(公告)日：2001-02-13
申请号：US09247442
申请日：1999-02-10
申请人： David K. Swanson , James G. Whayne , Dorin Panescu
发明人： David K. Swanson , James G. Whayne , Dorin Panescu
IPC分类号： A61B50402
CPC分类号： A61B5/6855 , A61B1/0051 , A61B5/0422 , A61B5/04525 , A61B5/6858 , A61B18/1492 , A61N1/056 , G06F19/00 , G16H15/00 , G16H40/63
摘要： Systems and methods for generating a composite signal derived from biopotentials sensed in myocardial tissue are disclosed and described. One such method includes inputting a first set of signals comprising biopotentials sensed at a first group of tissue sites during a first time interval; inputting a second set of signals comprising biopotentials sensed at a second group of tissue sites during a second time interval sequentially after the first time interval, wherein at least one of the biopotentials sensed as part of the first set of signals is not sensed as part of the second set of signals, and at least one of the biopotentials sensed as part of the second set of signals is not sensed as part of the first set of signals; and time aligning the first and second sets of signals using biopotentials sensed at the same site as part of both the first and second sets of signals, thereby generating the composite signal arranged for analysis as if all biopotentials were sensed during a common time interval, whereby the composite signal provides a diagnostic indicator.
摘要翻译：公开和描述了用于产生从心肌组织中感测的生物电位得到的复合信号的系统和方法。一种这样的方法包括在第一时间间隔期间输入包括在第一组组织位点处感测的生物电位的第一组信号; 在所述第一时间间隔之后，在第二时间间隔期间输入包括在第二组组织位置处感测的生物电位的第二组信号，其中作为所述第一组信号的一部分感测到的所述生物电位中的至少一个未被感测为所述第二组信号以及作为所述第二组信号的一部分感测到的所述生物电位中的至少一个未被感测为所述第一组信号的一部分; 以及使用在同一位点处感测的生物电位作为第一组信号和第二组信号的一部分的时间对齐第一组信号和第二组信号，从而生成布置成用于分析的复合信号，好像在公共时间间隔期间感测到所有生物电位一样，由此复合信号提供诊断指示器。

7. 发明授权

US06179835B2 Expandable-collapsible electrode structures made of electrically conductive material 失效
标题翻译：由导电材料制成的可膨胀 - 可折叠电极结构
公开(公告)号：US06179835B2
公开(公告)日：2001-01-30
申请号：US09300936
申请日：1999-04-27
申请人： Dorin Panescu , David K. Swanson , James G. Whayne , Thomas F. Kordis
发明人： Dorin Panescu , David K. Swanson , James G. Whayne , Thomas F. Kordis
IPC分类号： A61B1814
CPC分类号： A61N1/06 , A61B18/1492 , A61B2017/00053 , A61B2017/00243 , A61B2017/22051 , A61B2017/22061 , A61B2018/00065 , A61B2018/00083 , A61B2018/00095 , A61B2018/00107 , A61B2018/00113 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00839 , A61B2018/1253 , A61B2018/1472 , A61B2218/002 , A61L29/085 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/056 , C08L1/02
摘要： Electrode assemblies and associated systems employ a nonporous wall having an exterior for contacting tissue. The exterior peripherally surrounds an interior area. The wall is essentially free of electrically conductive material. The wall is adapted to assume an expanded geometry having a first maximum diameter and a collapsed geometry having a second maximum diameter less than the first maximum diameter. The assemblies and systems include a lumen that conveys a medium containing ions into the interior area. An element free of physical contact with the wall couples the medium within the interior area to a source of electrical energy to enable ionic transport of electrical energy from the source through the medium to the wall for capacitive coupling to tissue contacting the exterior of the wall.
摘要翻译：电极组件和相关系统采用具有用于接触组织的外部的无孔壁。外部外围围绕着内部区域。该壁基本上不含导电材料。壁适于呈现具有第一最大直径和具有小于第一最大直径的第二最大直径的折叠几何形状的扩展几何形状。组件和系统包括将含有离子的介质输送到内部区域的内腔。与壁物理接触的元件将内部区域内的介质耦合到电能源，以使电能从源通过介质到壁的电能离子传输，用于电容耦合到与壁的外部接触的组织。

8. 发明授权

US6113591A Systems and methods for sensing sub-surface temperatures in body tissue 失效
标题翻译：用于感测身体组织中亚表面温度的系统和方法
公开(公告)号：US6113591A
公开(公告)日：2000-09-05
申请号：US942251
申请日：1997-10-01
申请人： James G. Whayne , David K. Swanson , Sidney D. Fleischman , Thomas M. Bourne , Dorin Panescu
发明人： James G. Whayne , David K. Swanson , Sidney D. Fleischman , Thomas M. Bourne , Dorin Panescu
IPC分类号： A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61N1/05 , A61N1/40 , A61B17/36
CPC分类号： A61B18/00 , A61B18/12 , A61B18/1206 , A61B18/1492 , A61N1/056 , A61N1/403 , A61B2017/00017 , A61B2017/00084 , A61B2017/00243 , A61B2018/00023 , A61B2018/00029 , A61B2018/00083 , A61B2018/00095 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/0066 , A61B2018/00666 , A61B2018/00684 , A61B2018/0069 , A61B2018/00791 , A61B2018/00815 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2018/1861 , A61M2230/50
摘要： Systems and methods supply ablation energy to an electrode in contact with tissue to form a tissue-electrode interface. The system and methods sense, simultaneously with ablation, at least two tissue temperature conditions using at least two tissue temperature sensing elements which are held within a carrier that is substantially isolated from thermal conductive contact with the electrode. The carrier holds the tissue temperature sensing elements in a spaced apart relationship in thermal conductive contact with tissue at different depths beneath the tissue-electrode interface. The systems and methods control the supply of ablation energy to the electrode based, at least in part, upon temperatures sensed by the tissue temperature sensing elements.
摘要翻译：系统和方法向与组织接触的电极提供消融能量以形成组织 - 电极界面。系统和方法同时消融，使用至少两个组织温度感测元件感测至少两个组织温度条件，所述组织温度感测元件保持在与电极的导热接触基本隔离的载体内。载体将组织温度感测元件以间隔开的关系保持在与组织 - 电极界面下方不同深度处的组织的导热接触中。系统和方法至少部分地基于由组织温度感测元件感测到的温度来控制向电极提供消融能量。

9. 发明授权

US6014590A Systems and methods employing structures having asymmetric mechanical properties to support diagnostic or therapeutic elements in contact with tissue in interior body regions 失效
标题翻译：使用具有不对称机械性能的结构以支持与内部身体区域中的组织接触的诊断或治疗元件的系统和方法
公开(公告)号：US6014590A
公开(公告)日：2000-01-11
申请号：US742564
申请日：1996-10-28
申请人： James G. Whayne , Sidney D. Fleischman , Dorin Panescu , Thomas F. Kordis , David K. Swanson
发明人： James G. Whayne , Sidney D. Fleischman , Dorin Panescu , Thomas F. Kordis , David K. Swanson
IPC分类号： A61B17/39
摘要： Structures having asymmetric mechanical properties provide enhanced ability to support therapeutic or diagnostic elements in contact with tissue in an interior body region. The support structure includes a first region, which exhibits a first mechanical property affecting tissue contact, and a second region spaced from the first region about the axis, which exhibits a second mechanical property, different than the first mechanical property, affecting tissue contact. In a preferred embodiment, the first and second mechanical properties correlate with stiffness of the respective first and second regions, with the first region being more flexible (i.e., less stiff) than the second region. The first region, due to its greater flexibility, is more conformal to tissue than the second region. The less flexible (i.e., more stiff) second region imparts greater force against the tissue to urge the more flexible first region toward intimate tissue contact. In a preferred embodiment, the more flexible first region carries at least one therapeutic or diagnostic element.
摘要翻译：具有不对称机械特性的结构提供增强的能力，以支持与内部身体区域中的组织接触的治疗或诊断元件。支撑结构包括表现出影响组织接触的第一机械特性的第一区域以及围绕轴线与第一区域隔开的第二区域，该第二区域具有影响组织接触的第二机械特性，该第二机械特性不同于第一机械特性。在优选实施例中，第一和第二机械特性与相应的第一和第二区域的刚度相关，其中第一区域比第二区域更加柔性（即，较不硬）。第一个区域由于其更大的灵活性，比第二个区域更适合组织。较不柔性（即更硬）的第二区域赋予组织更大的力以促使更柔性的第一区域朝向紧密的组织接触。在优选实施方案中，更灵活的第一区域携带至少一种治疗或诊断元件。

10. 发明授权

US5961513A Tissue heating and ablation systems and methods using porous electrode structures 失效
标题翻译：组织加热和消融系统和使用多孔电极结构的方法
公开(公告)号：US5961513A
公开(公告)日：1999-10-05
申请号：US631575
申请日：1996-04-12
申请人： David K. Swanson , Dorin Panescu , James G. Whayne , Patrick M. Owens , Russell B. Thompson
发明人： David K. Swanson , Dorin Panescu , James G. Whayne , Patrick M. Owens , Russell B. Thompson
IPC分类号： A61B17/22 , A61B18/14 , A61B17/39
CPC分类号： A61B18/1492 , A61B2017/22061 , A61B2018/00083 , A61B2018/00095 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022
摘要： Porous electrode assemblies for tissue heating and ablation systems and methods enable ionic transport of electrical energy to occur substantially free of liquid perfusion.
摘要翻译：用于组织加热和消融系统和方法的多孔电极组件使得电能的离子转运基本上不含液体灌注。

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