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1. 发明授权

US06485500B1 Emboli protection system 有权
标题翻译： Emboli保护系统
公开(公告)号：US06485500B1
公开(公告)日：2002-11-26
申请号：US09531740
申请日：2000-03-21
申请人： Arkady Kokish , Daryush Mirzaee , Eric J. Penn , Benjamin C. Huter , Kent C. B. Stalker , Gregg A. Jackson
发明人： Arkady Kokish , Daryush Mirzaee , Eric J. Penn , Benjamin C. Huter , Kent C. B. Stalker , Gregg A. Jackson
IPC分类号： A61M2900
CPC分类号： A61M25/104 , A61M2025/0079 , A61M2025/1013 , A61M2025/105 , A61M2025/1052 , A61M2025/1093 , A61M2025/1095
摘要： The emboli protection system provides one or more inflatable blocking balloons for isolation of a section of a blood vessel to prevent migration of emboli from the section during an interventional procedure, and fluid infusion and evacuation ports for flushing emboli from the isolated section. One embodiment provides for a distal blocking balloon catheter, over which an interventional device can be introduced, and a proximal blocking balloon catheter to be introduced over the interventional device for isolating a portion of a blood vessel to be treated. The blocking balloons can be perforated to provide the infusion ports, and thrombolytic inflation fluid may be used to break down and dissolve thrombus and plaque in the isolated portion of the blood vessel. The interventional therapeutic device such as an angioplasty balloon catheter may be incorporated into the distal blocking balloon catheter, or the distal and blocking proximal balloon catheters can be incorporated with the interventional therapeutic device together in one device. Infusion ports may also be provided in either or both of the distal and proximal blocking catheters.
摘要翻译：栓塞保护系统提供一个或多个可膨胀的阻塞气球，用于隔离血管的一部分，以防止在介入手术过程中栓塞从该部分移位，以及用于从隔离部分冲洗栓塞的流体输注和排出口。一个实施例提供远端阻塞气囊导管，介入装置可以在其上引入，以及近端阻塞气囊导管，其被引入到介入装置上，用于隔离待治疗血管的一部分。阻塞气囊可以被穿孔以提供输注口，并且可以使用溶栓膨胀流体来分解和溶解血管的孤立部分中的血栓和斑块。诸如血管成形术气囊导管的介入治疗装置可以并入到远端阻塞气囊导管中，或者远端和阻塞近端球囊导管可以与介入治疗装置并入一个装置中。输液口也可以设置在远端和近端阻塞导管中的一个或两者中。

2. 发明授权

US08845583B2 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US08845583B2
公开(公告)日：2014-09-30
申请号：US11651667
申请日：2007-01-10
申请人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
发明人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
IPC分类号： A61M29/00 , A61F2/01
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guidewire and is deployed within the patient's vasculature as the guidewire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guidewire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译：一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。在一个实施例中，过滤组件附接到导丝的远端，并且当导线被操纵进入治疗区域时，其部署在患者的脉管系统内。以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

3. 发明授权

US06695813B1 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US06695813B1
公开(公告)日：2004-02-24
申请号：US09476159
申请日：1999-12-30
申请人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
发明人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device includes a filtering assembly having a self-expanding strut assembly and a filter element. The filtering assembly can be attached to a guidewire and deployed within the patient's vasculature into an area of treatment. A restraining sheath maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Interventional devices can be delivered over the guidewire and any embolic debris created and released into the blood stream will enter the filtering assembly. The filtering assembly can be rotatably mounted on the guide wire and may include a dampening element which helps to prevent some shock force that may be transmitted along the guide to the deployed filtering assembly.
摘要翻译：栓塞保护装置包括具有自扩张支柱组件和过滤元件的过滤组件。过滤组件可以附接到导丝并且部署在患者的脉管系统内进入治疗区域。限制护套将过滤组件保持在其折叠位置，直到其准备好被医生部署为止。介入装置可以通过导线传送，并且产生并释放到血流中的任何栓塞碎片将进入过滤组件。过滤组件可以可旋转地安装在导丝上，并且可以包括阻尼元件，该阻尼元件有助于防止可能沿着引导件传递到部署的过滤组件的一些冲击力。

4. 发明授权

US06599267B1 Transluminal injection device for intravascular drug delivery 有权
标题翻译：用于血管内药物输送的腔内注射装置
公开(公告)号：US06599267B1
公开(公告)日：2003-07-29
申请号：US09746862
申请日：2000-12-22
申请人： Pinaki Ray , Henri A. Gaudoin , Lyudmila K. Kokish , Arkady Kokish , Daryush Mirzaee
发明人： Pinaki Ray , Henri A. Gaudoin , Lyudmila K. Kokish , Arkady Kokish , Daryush Mirzaee
IPC分类号： A61M2500
CPC分类号： A61M25/0074 , A61B2017/22061 , A61B2017/22077 , A61B2017/22082 , A61B2017/22084 , A61M25/0075 , A61M25/0084 , A61M25/1002 , A61M2025/0086 , A61M2025/0087 , A61M2025/1059 , A61M2210/0693
摘要： A catheter including an injection port at or near the distal end thereof and a mechanism for causing the injection port to move between a first position and a second position. In the first position the injection port is substantially aligned with a central axis of the catheter. Upon activation of the mechanism, the injection port moves between the first position and the second position perpendicular to the central axis of the catheter. The mechanism also causes the injection port to move away from the central axis of the catheter and into a wall of the vasculature.
摘要翻译：包括在其远端处或其远端附近的注射口的导管和用于使注射口在第一位置和第二位置之间移动的机构。在第一位置，注射口基本上与导管的中心轴对准。在启动机构时，注射口在垂直于导管的中心轴线的第一位置和第二位置之间移动。该机构还使得注射端口远离导管的中心轴线并进入脉管系统的壁。

5. 发明申请

US20100055295A1 Apparatus and Method for Selectively Coating a Medical Article 有权
标题翻译：选择性涂覆医疗用品的设备和方法
公开(公告)号：US20100055295A1
公开(公告)日：2010-03-04
申请号：US12616651
申请日：2009-11-11
申请人： Syed F.A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
发明人： Syed F.A. Hossainy , Gordon Stewart , Srinivasan Sridharan , Arkady Kokish , Klaus Kleine , Benjamyn Serna , Bjorn G. Svensson
IPC分类号： B05D7/00 , B05C11/00
CPC分类号： B05D1/32 , B05B12/20 , B05B13/0442 , B05D1/02 , Y10T428/13
摘要： A mask for masking a stent during a coating procedure may include a mask body that has a negative pattern or an approximate negative pattern of a stent pattern being masked by the mask body. An apparatus for selectively coating a predetermined portion of a medical article may include a dispenser of a coating composition, a mask, a device for creating a relative movement between the mask and the medical article.
摘要翻译：用于在涂覆过程中遮蔽支架的掩模可以包括掩模体，其具有由掩模体遮蔽的支架图案的负图案或近似负图案。用于选择性地涂覆医疗用品的预定部分的设备可以包括涂料组合物的分配器，掩模，用于在面罩和医疗制品之间产生相对运动的装置。

6. 发明申请

US20080004569A1 Expandable Introducer Sheath to Preserve Guidewire Access 有权
标题翻译：可扩展的介绍者护套来保护指导者的访问
公开(公告)号：US20080004569A1
公开(公告)日：2008-01-03
申请号：US11767947
申请日：2007-06-25
申请人： Kelly McCrystle , Arkady Kokish
发明人： Kelly McCrystle , Arkady Kokish
IPC分类号： A61M29/00
CPC分类号： A61M25/0017 , A61B17/0057 , A61B17/3439 , A61B2017/3445 , A61B2090/037 , A61M2025/0024
摘要： An introducer sheath. The introducer sheath includes a tubular body. The tubular body extends from a distal end toward a proximal end. The tubular body includes a lumen. The lumen is defined at least partially by a wall. The tubular body includes a secondary channel. The secondary channel is disposed within the wall. The secondary channel is configured to receive a guidewire.
摘要翻译：导引鞘。导引鞘包括管状体。管状体从远端朝向近端延伸。管状体包括内腔。管腔至少部分地由壁限定。管状体包括第二通道。第二通道设置在壁内。辅助通道被配置为接收导丝。

7. 发明申请

US20070178223A1 Apparatus And Method For Coating And Drying Multiple Stents 失效
公开(公告)号：US20070178223A1
公开(公告)日：2007-08-02
申请号：US11690097
申请日：2007-03-22
申请人： Arkady Kokish , Yung-Ming Chen , Jason Van Sciver , Roberto Listek
发明人： Arkady Kokish , Yung-Ming Chen , Jason Van Sciver , Roberto Listek
IPC分类号： A61L33/00
CPC分类号： A61F2/82 , B05B13/0242
摘要： A coating and drying apparatus for the application of a coating substance to a stent and drying the stent is provided.

8. 发明申请

US20070167975A1 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US20070167975A1
公开(公告)日：2007-07-19
申请号：US11651667
申请日：2007-01-10
申请人： William Boyle , David Burkett , Andy Denison , Benjamin Huter , Scott Huter , Arkady Kokish , Kent Stalker , Chicheng Wang , John Whitfield
发明人： William Boyle , David Burkett , Andy Denison , Benjamin Huter , Scott Huter , Arkady Kokish , Kent Stalker , Chicheng Wang , John Whitfield
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guidewire and is deployed within the patient's vasculature as the guidewire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guidewire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译：一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。在一个实施例中，过滤组件附接到导丝的远端，并且当导线被操纵进入治疗区域时，其部署在患者的脉管系统内。以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好被医师部署为止。此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

9. 发明申请

US20070068216A1 Assembly for crimping an intraluminal device and method of use 失效
标题翻译：用于压缩管腔内装置的装置和使用方法
公开(公告)号：US20070068216A1
公开(公告)日：2007-03-29
申请号：US11606423
申请日：2006-11-30
申请人： Arkady Kokish
发明人： Arkady Kokish
IPC分类号： B21D41/00
CPC分类号： A61F2/958 , A61F2/01 , A61F2/95 , A61F2002/9522 , B25B27/10 , B25B27/146 , Y10T29/49927 , Y10T29/53657 , Y10T29/53987 , Y10T29/53996
摘要： An assembly is provided which can crimp or compress an intraluminal device or measure the radial strength of an intraluminal device. The crimping assembly includes at least two moving-element subassemblies, each with a pair of moving elements. The moving elements having a first side and a second side joining at a tip. The moving-element subassembly is able to move in such a way that the moving elements move relative to each other from a first position with the tips offset from each other by a first distance, to a second position with the tips offset from each other by a second distance different than the first distance. The assembly also includes a movement assembly that interfaces with each of the moving-element subassemblies. The movement assembly moves the pairs of moving elements between the first position and the second position.
摘要翻译：提供了一种可压缩或压缩管腔内装置或测量管腔内装置的径向强度的组件。压接组件包括至少两个移动元件子组件，每个具有一对移动元件。移动元件具有在尖端处连接的第一侧和第二侧。移动元件子组件能够以这样一种方式移动，使得移动元件从第一位置相对移动，其中尖端彼此偏移第一距离，到第二位置，其中尖端彼此偏移了第二距离不同于第一距离。组件还包括与每个移动元件子组件接合的移动组件。移动组件在第一位置和第二位置之间移动一对移动元件。

10. 发明授权

US06391002B1 Balloon with the variable radial force distribution 有权
标题翻译：具有可变径向力分布的气球
公开(公告)号：US06391002B1
公开(公告)日：2002-05-21
申请号：US09457124
申请日：1999-12-07
申请人： Arkady Kokish
发明人： Arkady Kokish
IPC分类号： A61M2900
CPC分类号： A61M25/1027 , A61M25/10 , A61M25/1002 , A61M25/1029 , A61M25/1034
摘要： A balloon catheter having an elongated shaft and a balloon mounted on the distal portion of the shaft, the balloon having a working section and proximal and distal end portions that extend inwardly with respect to the working section and which are secured to the catheter shaft within the working section. The end portions are therefore inverted recesses on each end of the balloon. A stent may be disposed about the balloon to form a stent deploying system. The proximal and distal end portions may contain a tapered portion, which tapers from the balloon working section to the catheter shaft with decreasing transverse dimension. The end portions may be connected to the working section with connecting fibers. This design allows for improved expansion and stent placement in the vasculature.
摘要翻译：一种气囊导管，其具有细长轴和安装在所述轴的远端部分上的气囊，所述球囊具有工作部分和相对于所述工作部分向内延伸并且在所述工作部分内固定到所述导管轴内的近端部分和远端部分工作部分。因此，端部在气球的每一端都是倒置的凹槽。可以围绕气囊设置支架以形成支架展开系统。近端部分和远端部分可以包含锥形部分，该锥形部分随着横向尺寸的减小而从气囊工作部分向导管轴逐渐变细。端部可以用连接纤维连接到工作部分。这种设计允许在脉管系统中改进扩张和支架放置。

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