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1. 发明申请

US20050013733A1 Trace incorporation of fluorescent monomer facilitating quality control of polymerization reactions 审中-公开
标题翻译：微量掺入荧光单体促进聚合反应的质量控制
公开(公告)号：US20050013733A1
公开(公告)日：2005-01-20
申请号：US10850698
申请日：2004-05-21
申请人： Arkadi Krainev , Wenxi Huang , Charanjit Saini
发明人： Arkadi Krainev , Wenxi Huang , Charanjit Saini
IPC分类号： G01N20060101 , G01N21/64 , G01N21/76
CPC分类号： G01N33/542 , G01N33/545
摘要： The present invention provides a polymer that includes a trace amount of a luminescent moiety. The polymers have unique properties that make them ideally suited for use in diverse analyses, including desorption/ionization mass spectrometry of analytes. The invention also provides a device that incorporates the polymeric compositions of the inventions, methods of using the device to detect, quantify and identify analytes, and a method of preparing a device of the invention. The luminescent moiety provides a detectable tracer that allows for a rapid, simple quality control assay of devices that incorporate the polymer.
摘要翻译：本发明提供了包含微量发光部分的聚合物。聚合物具有独特的性质，使其非常适合用于多种分析，包括分析物的解吸/电离质谱分析。本发明还提供了结合本发明的聚合物组合物的装置，使用该装置检测，定量和鉴定分析物的方法以及制备本发明的装置的方法。发光部分提供可检测的示踪剂，其允许对掺入聚合物的装置进行快速，简单的质量控制测定。

2. 发明申请

US20070077596A1 TRACE INCORPORATION OF FLUORESCENT MONOMER FACILITATING QUALITY CONTROL OF POLYMERIZATION REACTIONS 审中-公开
标题翻译：追踪荧光单体促进聚合反应的质量控制
公开(公告)号：US20070077596A1
公开(公告)日：2007-04-05
申请号：US11465942
申请日：2006-08-21
申请人： Arkadi Krainev , Wenxi Huang , Charanjit Saini
发明人： Arkadi Krainev , Wenxi Huang , Charanjit Saini
IPC分类号： G01N33/53 , C12M1/34 , G01N33/50
CPC分类号： G01N33/542 , G01N33/545
摘要： The present invention provides a polymer that includes a trace amount of a luminescent moiety. The polymers have unique properties that make them ideally suited for use in diverse analyses, including desorption/ionization mass spectrometry of analytes. The invention also provides a device that incorporates the polymeric compositions of the inventions, methods of using the device to detect, quantify and identify analytes, and a method of preparing a device of the invention. The luminescent moiety provides a detectable tracer that allows for a rapid, simple quality control assay of devices that incorporate the polymer.
摘要翻译：本发明提供了包含微量发光部分的聚合物。聚合物具有独特的性质，使其非常适合用于多种分析，包括分析物的解吸/电离质谱分析。本发明还提供了结合本发明的聚合物组合物的装置，使用该装置检测，定量和鉴定分析物的方法以及制备本发明的装置的方法。发光部分提供可检测的示踪剂，其允许对掺入聚合物的装置进行快速，简单的质量控制测定。

3. 发明申请

US20130295586A1 PREPARATION OF NANOCRYSTALS WITH MIXTURES OF ORGANIC LIGANDS 审中-公开
标题翻译：用有机配体混合物制备纳米晶体
公开(公告)号：US20130295586A1
公开(公告)日：2013-11-07
申请号：US13976621
申请日：2011-12-23
申请人： Joseph August Bartel , Yongfen Chen , Noah Lermer , Timothy Carter , Scott Sweeney , Chad Teters , Wenxi Huang
发明人： Joseph August Bartel , Yongfen Chen , Noah Lermer , Timothy Carter , Scott Sweeney , Chad Teters , Wenxi Huang
IPC分类号： G01N33/533 , H01L51/00
CPC分类号： H01L29/0665 , B82Y20/00 , B82Y30/00 , B82Y40/00 , C30B7/00 , C30B29/40 , C30B29/48 , C30B29/60 , G01N33/533 , G01N33/588 , H01L21/02628 , H01L31/035209 , H01L33/04 , H01L51/0007
摘要： Semiconductor nanocrystals prepared using a mixture of organic ligands (e.g., oxoacids), as well as compositions, kits, and methods of using such semiconductor nanocrystals are disclosed.
摘要翻译：公开了使用有机配体（例如含氧酸）的混合物制备的半导体纳米晶体，以及组合物，试剂盒和使用这种半导体纳米晶体的方法。

4. 发明授权

US07045366B2 Photocrosslinked hydrogel blend surface coatings 失效
标题翻译：光交联水凝胶共混物表面涂层
公开(公告)号：US07045366B2
公开(公告)日：2006-05-16
申请号：US10802039
申请日：2004-03-17
申请人： Wenxi Huang , Pil-je Um
发明人： Wenxi Huang , Pil-je Um
IPC分类号： G01N33/544 , C07C221/00
CPC分类号： C08L101/14 , B01D15/1807 , B01J20/286 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , C07K1/22 , C40B40/10 , G01N33/6848
摘要： Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.
摘要翻译：水凝胶聚合物共混物包括前体和组合物的交联形式。共混物提供了一种改进的方法，以实现比其他方法（包括共聚）更好的商业生命力的高质量，均匀的涂层。应用包括生物分子分析物如蛋白质的质谱分析。葡聚糖和丙烯酰胺体系是优选的。二苯甲酮基团可用作光交联基团。光引发剂不需要。包括可选择性结合生物分子分析物的功能。

5. 发明申请

US20060183863A1 Zwitterionic polymers 审中-公开
标题翻译：两性离子聚合物
公开(公告)号：US20060183863A1
公开(公告)日：2006-08-17
申请号：US11058330
申请日：2005-02-14
申请人： Wenxi Huang , Sarah Ngola , Kamen Voivodov
发明人： Wenxi Huang , Sarah Ngola , Kamen Voivodov
IPC分类号： C08L9/02
CPC分类号： C08F220/38 , B01D15/364 , B01J20/264 , B01J20/3276 , B01J2220/54 , C08F220/36
摘要： Zwitterionic polymers bearing positive and negative charges are readily prepared from easily accessible precursors. The polymers show enhanced binding affinities for analytes under high salt conditions, compared to similar polymers bearing a charge of a single polarity. The polymers can also include an energy absorbing moiety for use in matrix assisted laser desorption/ionization mass spectrometry. The polymer can also include a photo-curable group, which can be used to form cross-links within the bulk polymer or between the polymer and a surface functionalized with a polymerizable moiety. The polymers are incorporated into devices of use for the analysis, capture, separation, or purification of an analyte. In an exemplary embodiment, the invention provides a substrate coated with a polymer of the invention, the substrate being adapted for use as a probe for a mass spectrometer.
摘要翻译：带有正电荷和负电荷的两性离子聚合物易于从容易获得的前体制备。与具有单一极性电荷的类似聚合物相比，聚合物在高盐条件下显示出增强的分析物的结合亲和力。聚合物还可以包括用于基质辅助激光解吸/电离质谱的能量吸收部分。聚合物还可以包括可光固化基团，其可以用于在本体聚合物内形成交联，或者在聚合物与用可聚合部分官能化的表面之间形成交联。将聚合物并入用于分析，捕获，分离或纯化分析物的装置中。在一个示例性实施方案中，本发明提供涂覆有本发明的聚合物的基材，所述基材适于用作质谱仪的探针。

6. 发明申请

US20060183242A1 Phthalate polymers 审中-公开
标题翻译：邻苯二甲酸酯聚合物
公开(公告)号：US20060183242A1
公开(公告)日：2006-08-17
申请号：US11057880
申请日：2005-02-14
申请人： Wenxi Huang , Aaron Chen , Sarah Ngola , Kamen Voivodov
发明人： Wenxi Huang , Aaron Chen , Sarah Ngola , Kamen Voivodov
IPC分类号： G01N31/22
CPC分类号： B01J20/26 , B01J20/265 , B01J20/285 , B01J20/3265 , B01J2220/54 , C07K1/22
摘要： Polymers bearing metal chelating groups are readily prepared from easily accessible precursors. The polymers are readily converted to the corresponding metal chelates. The polymers can also include an energy absorbing moiety for use in matrix assisted laser desorption/ionization mass spectrometry. The polymer can also include a photo-curable group, which can be used to form cross-links within the bulk polymer or between the polymer and a surface functionalized with a polymerizable moiety. The polymers are incorporated into devices of use for the analysis, capture, separation, or purification of an analyte. In an exemplary embodiment, the invention provides a substrate coated with a polymer of the invention, the substrate being adapted for use as a probe for a mass spectrometer.
摘要翻译：具有金属螯合基团的聚合物可以容易地从容易获得的前体制备。聚合物容易转化为相应的金属螯合物。聚合物还可以包括用于基质辅助激光解吸/电离质谱法中的能量吸收部分。聚合物还可以包括可光固化基团，其可以用于在本体聚合物内形成交联，或者在聚合物与用可聚合部分官能化的表面之间形成交联。将聚合物并入用于分析，捕获，分离或纯化分析物的装置中。在一个示例性实施方案中，本发明提供涂覆有本发明的聚合物的基材，所述基材适于用作质谱仪的探针。

7. 发明申请

US20050059086A1 Photocrosslinked hydrogel blend surface coatings 失效
标题翻译：光交联水凝胶共混物表面涂层
公开(公告)号：US20050059086A1
公开(公告)日：2005-03-17
申请号：US10802039
申请日：2004-03-17
申请人： Wenxi Huang , Pil-je Um
发明人： Wenxi Huang , Pil-je Um
IPC分类号： B01D15/18 , B01J20/286 , C07K1/22 , C40B40/10 , G01N33/53 , A61K31/785 , C08G63/48
CPC分类号： C08L101/14 , B01D15/1807 , B01J20/286 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , C07K1/22 , C40B40/10 , G01N33/6848
摘要： Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.
摘要翻译：水凝胶聚合物共混物包括前体和组合物的交联形式。共混物提供了一种改进的方法，以实现比其他方法（包括共聚）更好的商业生命力的高质量，均匀的涂层。应用包括生物分子分析物如蛋白质的质谱分析。葡聚糖和丙烯酰胺体系是优选的。二苯甲酮基团可用作光交联基团。光引发剂不需要。包括可选择性结合生物分子分析物的功能。

8. 发明授权

US6031067A Soluble polyimide resin and process of preparation of the same 失效
标题翻译：可溶性聚酰亚胺树脂及其制备方法
公开(公告)号：US6031067A
公开(公告)日：2000-02-29
申请号：US86387
申请日：1998-05-29
申请人： Kil-Yeong Choi , Mi-Hie Yi , Wenxi Huang
发明人： Kil-Yeong Choi , Mi-Hie Yi , Wenxi Huang
IPC分类号： C08G73/00 , C08G73/10 , C08G69/26
CPC分类号： C08G73/10
摘要： The invention herein relates to a soluble polyimide resin and the process of preparation of the same, wherein aromatic tetracarboxylic dianhydride and aromatic diamine having an alicyclic group with various structures of substituted alkyl groups are used to yield a novel form of a polyimide resin, which has superior heat-resistance, solubility and transparency.More specifically, the invention herein relates to a novel polyimide resin having excellent heat-resistance and solubility, which is prepared by means of reacting aromatic diamine monomers having a novel chemical structure with various types of aromatic tetracarboxilic acid dianhydrides, in stead of aromatic diamine used for the preparation of the conventional polyimide resin. As a result, the polymers so obtained had the glass transition temperature of 250.degree. C..about.400.degree. C. and showed a increase in solubility in proportion to the increase in volume of the alkyl group. Further, the polymers herein showed superior solubility at room temperature in various types of organic solvents, e.g., THF.
摘要翻译：本发明涉及一种可溶性聚酰亚胺树脂及其制备方法，其中使用芳族四羧酸二酐和具有各种取代烷基结构的脂环族基团的芳族二胺以产生新型的聚酰亚胺树脂，其具有优异的耐热性，溶解性和透明度。更具体地说，本发明涉及具有优异的耐热性和溶解性的新型聚酰亚胺树脂，其通过使具有新型化学结构的芳族二胺单体与各种类型的芳族四羧酸二酐反应而制备，而不是使用芳族二胺用于制备常规的聚酰亚胺树脂。结果，如此获得的聚合物的玻璃化转变温度为250℃，差异为400℃，并且与烷基体积的增加成比例地显示出溶解度增加。此外，本文的聚合物在各种类型的有机溶剂例如THF中在室温下表现出优异的溶解度。

9. 发明申请

US20060292701A1 Photocrosslinked hydrogel blend surface coatings 审中-公开
公开(公告)号：US20060292701A1
公开(公告)日：2006-12-28
申请号：US11407357
申请日：2006-04-20
申请人： Wenxi Huang , Pil-je Um
发明人： Wenxi Huang , Pil-je Um
IPC分类号： G01N33/558 , C08G59/68 , C08F2/46
CPC分类号： G01N33/548 , C08B37/0021 , C08J3/246 , C08J7/047 , C08J2405/00 , C08L5/02 , C08L2205/02 , C09D105/02 , C08L2666/26
摘要： Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.

10. 发明申请

US20060252159A1 Photocrosslinked hydrogel blend surface coatings 审中-公开
公开(公告)号：US20060252159A1
公开(公告)日：2006-11-09
申请号：US11407347
申请日：2006-04-20
申请人： Wenxi Huang , Pil-Je Um
发明人： Wenxi Huang , Pil-Je Um
IPC分类号： G01N33/543 , C08G59/68
CPC分类号： C08L101/14 , B01D15/1807 , B01J20/286 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00702 , B01J2219/00725 , B01J2219/0074 , C07K1/22 , C40B40/10 , G01N33/6848
摘要： Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.

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