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1. 发明公开

EP1856714A2 METHOD AND APPARATUS FOR IMPROVED SENSITIVITY IN A MASS SPECTROMETER 有权转让
标题翻译：方法和设备，用于质谱仪灵敏度增益
公开(公告)号：EP1856714A2
公开(公告)日：2007-11-21
申请号：EP06717665.1
申请日：2006-01-05
申请人： Applera Corporation , MDS Inc. , Loboda, Alexandre, V.
发明人： COLLINGS, Bruce, A. , COVEY, Thomas, R. , GUNA, Mircea , JAVAHERI, Hassan , SCHNEIDER, Bradley, B. , THOMSON, Bruce A.
IPC分类号： H01J49/04
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.

2. 发明申请

WO2006076228A2 METHOD AND APPARATUS FOR IMPROVED SENSITIVITY IN A MASS SPECTROMETER 审中-公开
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：WO2006076228A2
公开(公告)日：2006-07-20
申请号：PCT/US2006/000492
申请日：2006-01-05
申请人： APPLERA CORPORATION , MDS INC. , LOBODA, Alexandre, V. , COLLINGS, Bruce, A. , COVEY, Thomas, R. , GUNA, Mircea , JAVAHERI, Hassan , SCHNEIDER, Bradley, B. , THOMSON, Bruce A.
发明人： COLLINGS, Bruce, A. , COVEY, Thomas, R. , GUNA, Mircea , JAVAHERI, Hassan , SCHNEIDER, Bradley, B. , THOMSON, Bruce A.
IPC分类号： H01J49/04
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以基本上径向限制超音速自由射流膨胀的离子导向器可将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

3. 发明申请

WO2007090282A1 RADIO FREQUENCY ION GUIDE 审中-公开
标题翻译：无线电频率指南
公开(公告)号：WO2007090282A1
公开(公告)日：2007-08-16
申请号：PCT/CA2007/000185
申请日：2007-02-08
申请人： MDS INC., doing business as MDS SCIEX , APPLERA CORPORATION , SCHNEIDER, Bradley, B. , COVEY, Thomas, R.
发明人： SCHNEIDER, Bradley, B. , COVEY, Thomas, R.
IPC分类号： H01J37/147 , H01J49/06 , H01J49/10
CPC分类号： H01J49/062
摘要： An ion guide with two or more ion focusing elements and a gas channeling sleeve is described. An ion transport space within the gas channeling sleeve is in fluid communication with a pumping port. A suction device is used to suction gas out of the ion transport space through the pumping port establishing a gas flow. Ions in the ion transport space are transported from an ion entry end to an ion exit end of the ion guide by the gas flow. Several examples include a multipole ion guide in which rods are used as ion focusing elements. The gas channeling sleeve is fitted about the rods. In another example, toroidal or ring shaped ion focusing elements are used as ion focusing elements. In another example, a set of ion focusing rings are mounted between insulators to form a cylinder with a gas impermeable side wall. The cylinder is itself used as the gas channeling sleeve.
摘要翻译：描述了具有两个或更多离子聚焦元件和气体导引套筒的离子导向器。气体通道套管内的离子传输空间与泵送口流体连通。抽吸装置用于通过建立气流的泵送端口将气体排出离子传输空间。离子传输空间中的离子通过气流从离子入口端输送到离子导向器的离子出口端。几个实例包括其中杆用作离子聚焦元件的多极离子导向器。气体通道套筒围绕杆安装。在另一示例中，使用环形或环形离子聚焦元件作为离子聚焦元件。在另一示例中，一组离子聚焦环安装在绝缘体之间以形成具有不透气侧壁的圆筒。气缸本身用作气体导引套筒。

4. 发明公开

EP1984934A1 RADIO FREQUENCY ION GUIDE 审中-公开
标题翻译：高频离子引导
公开(公告)号：EP1984934A1
公开(公告)日：2008-10-29
申请号：EP07701774.7
申请日：2007-02-08
申请人： MDS Analytical Technologies, a business unit Of MDS Inc., doing busi. through its SCIEX div. , Applera Corporation
发明人： SCHNEIDER, Bradley, B. , COVEY, Thomas, R.
IPC分类号： H01J37/147 , H01J49/06 , H01J49/10
CPC分类号： H01J49/062
摘要： An ion guide with two or more ion focusing elements and a gas channeling sleeve is described. An ion transport space within the gas channeling sleeve is in fluid communication with a pumping port. A suction device is used to suction gas out of the ion transport space through the pumping port establishing a gas flow. Ions in the ion transport space are transported from an ion entry end to an ion exit end of the ion guide by the gas flow. Several examples include a multipole ion guide in which rods are used as ion focusing elements. The gas channeling sleeve is fitted about the rods. In another example, toroidal or ring shaped ion focusing elements are used as ion focusing elements. In another example, a set of ion focusing rings are mounted between insulators to form a cylinder with a gas impermeable side wall. The cylinder is itself used as the gas channeling sleeve.

5. 发明申请

WO2011094529A2 MASS ANALYSIS SYSTEM WITH LOW PRESSURE DIFFERENTIAL MOBILITY SPECTROMETER 审中-公开
标题翻译：具有低压差分移动光谱仪的质量分析系统
公开(公告)号：WO2011094529A2
公开(公告)日：2011-08-04
申请号：PCT/US2011/022905
申请日：2011-01-28
申请人： MDS ANALYTICAL TECHNOLOGIES, A BUSINESS UNIT OF MDS INC. , APPLIED BIOSYSTEMS (CANADA) LIMITED , COVEY, Thomas, R. , SCHNEIDER, Bradley, B.
发明人： COVEY, Thomas, R. , SCHNEIDER, Bradley, B.
IPC分类号： H01J49/00
CPC分类号： H01J49/26 , G01N27/624 , H01J49/004 , Y10T436/24
摘要： A mass analysis system including a low pressure dissociation region and a differential mobility spectrometer. The differential mobility spectrometer including at least one pair of filter electrodes defining an ion flow path where the filter electrodes generate an electric field for passing through a selected portion of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, an ion inlet that receives sample ions that have passed through the low pressure dissociation region, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.
摘要翻译：质量分析系统，包括低压解离区域和差动迁移谱仪。差动迁移谱仪包括至少一对限定离子流路的过滤电极对，其中过滤电极基于样品离子的迁移率特性产生用于通过选定部分样品离子的电场。差分迁移率光谱仪还包括电压源，其向至少一个滤光器电极提供DC和RF电压以产生电场;接收经过低压解离区域的样品离子的离子入口和离子出口其输出所选择的样本离子部分。质谱仪接收部分或全部选定部分的样品离子。

6. 发明申请

WO2007075856A2 LASER DESORPTION ION SOURCE WITH ION GUIDE COUPLING FOR ION MASS SPECTROSCOPY 审中-公开
标题翻译：带离子导向的激光吸附离子源用于离子质谱
公开(公告)号：WO2007075856A2
公开(公告)日：2007-07-05
申请号：PCT/US2006/048732
申请日：2006-12-19
申请人： MDS SCIEX, INC. , APPLERA CORPORATION , COVEY, Thomas, R. , JAVAHERI, Hassan , SCHNEIDER, Bradley, B.
发明人： COVEY, Thomas, R. , JAVAHERI, Hassan , SCHNEIDER, Bradley, B.
IPC分类号： H01J49/42
CPC分类号： H01J49/063 , H01J49/164
摘要： A laser desorption ion source provides enhanced ion sampling efficiency and measurement sensitivity by using one or more ion guides to effectively capture ions in a plume emitted from the ion target and guide the ions through an aperture into a downstream vacuum chamber. In one configuration using two RF multipole ion guides, a first RF multipole ion guide disposed next to the ion target is selected to be sufficiently large to capture a substantial portion of the plume, while the second RF multipole ion guide disposed between the first multipole ion guide and the aperture has a smaller dimension to assist focusing of ions into the aperture. The first RF multipole ion guides the ions in the plume into the second RF multipole ion guide, which then focuses the ions so that they pass through the aperture into the downstream vacuum chamber.
摘要翻译：激光解吸离子源通过使用一个或多个离子引导件有效地捕获从离子靶发射的羽流中的离子并将离子引导通过孔进入下游真空室来提供增强的离子采样效率和测量灵敏度。在使用两个RF多极离子引导件的一种配置中，选择邻近离子靶设置的第一RF多极离子导向器足够大以捕获大部分羽流，而第二射频多极离子导向器设置在第一多极离子导向件和孔径具有较小的尺寸以辅助将离子聚焦到孔中。第一RF多极离子将羽流中的离子引导到第二射频多极离子导向器中，然后将离子聚焦以使它们通过孔进入下游真空室。

7. 发明公开

EP2529387A2 MASS ANALYSIS SYSTEM WITH LOW PRESSURE DIFFERENTIAL MOBILITY SPECTROMETER 审中-公开
标题翻译：低压差分迁移谱仪的质量分析系统
公开(公告)号：EP2529387A2
公开(公告)日：2012-12-05
申请号：EP11704506.2
申请日：2011-01-28
申请人： MDS Analytical Technologies, a business unit of MDS INC., doing business through its SCIEX Division , Applied Biosystems (Canada) Limited
发明人： COVEY, Thomas, R. , SCHNEIDER, Bradley, B.
IPC分类号： H01J49/00
CPC分类号： H01J49/26 , G01N27/624 , H01J49/004 , Y10T436/24
摘要： A mass analysis system including a low pressure dissociation region and a differential mobility spectrometer. The differential mobility spectrometer including at least one pair of filter electrodes defining an ion flow path where the filter electrodes generate an electric field for passing through a selected portion of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, an ion inlet that receives sample ions that have passed through the low pressure dissociation region, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.

8. 发明授权

EP2529387B1 MASS ANALYSIS SYSTEM WITH LOW PRESSURE DIFFERENTIAL MOBILITY SPECTROMETER 有权
公开(公告)号：EP2529387B1
公开(公告)日：2018-08-01
申请号：EP11704506.2
申请日：2011-01-28
申请人： MDS Analytical Technologies, a business unit of MDS INC., doing business through its SCIEX Division , Applied Biosystems (Canada) Limited
发明人： COVEY, Thomas, R. , SCHNEIDER, Bradley, B.
IPC分类号： G01N27/62 , H01J49/00
CPC分类号： H01J49/26 , G01N27/624 , H01J49/004 , Y10T436/24
摘要： A mass analysis system including a low pressure dissociation region and a differential mobility spectrometer. The differential mobility spectrometer including at least one pair of filter electrodes defining an ion flow path where the filter electrodes generate an electric field for passing through a selected portion of the sample ions based on the mobility characteristics of the sample ions. The differential mobility spectrometer also includes a voltage source that provides DC and RF voltages to at least one of the filter electrodes to generate the electric field, an ion inlet that receives sample ions that have passed through the low pressure dissociation region, and an ion outlet that outputs the selected portion of the sample ions. A mass spectrometer receives some or all of the selected portion of the sample ions.

9. 发明授权

EP0739533B1 ION SPRAY WITH INTERSECTING FLOW 失效
标题翻译：芳基取代的5,5-稠合芳族氮化合物AGENTS抗炎
公开(公告)号：EP0739533B1
公开(公告)日：1999-04-28
申请号：EP95905498.2
申请日：1995-01-09
申请人： MDS Inc.
发明人： COVEY, Thomas, R. , ANACLETO, Joseph, F.
IPC分类号： H01J49/04 , G01N30/72
CPC分类号： H01J49/165 , G01N30/7246 , H01J49/044 , H01J49/0477
摘要： Liquid from a liquid chromatograph or other sample source, preferably assisted by a high velocity coaxial gas jet, is sprayed through a capillary tube (40') producing a flow in a first direction of charged droplets (50'). A flow of heated gas (60), in a second direction different from the first direction, intersects the droplet flow at a region (64) upstream of an orifice (20'). The flows mix turbulently, with the second flow helping to evaporate the droplets to produce ions and helping to move the evaporating droplets toward the orifice (20'), providing a focusing effect. Ions are drawn through the orifice (20') into a mass analyzer and analyzed. Alternatively the flows of liquid and heating gas can be directed toward each other and at right angles to the axis through the orifice, and the inhaling effect of the orifice can be used to draw droplets toward it, or a third gas flow can be used for this purpose. The heated intersecting gas flow typically provides an increase in sensitivity (ion counts per second) of between 10 and 100 times. Heating the droplet plume also allows controlled desaturation of ions and an increase in the number of charges on them, without degrading the ions.

10. 发明公开

EP1964156A2 LASER DESORPTION ION SOURCE WITH ION GUIDE COUPLING FOR ION MASS SPECTROSCOPY 审中-公开
标题翻译：离子导体耦合离子质谱分析的激光解吸离子源
公开(公告)号：EP1964156A2
公开(公告)日：2008-09-03
申请号：EP06845935.3
申请日：2006-12-19
申请人： MDS Sciex, Inc. , Applera Corporation
发明人： COVEY, Thomas, R. , JAVAHERI, Hassan , SCHNEIDER, Bradley, B.
IPC分类号： H01J49/42
CPC分类号： H01J49/063 , H01J49/164
摘要： A laser desorption ion source provides enhanced ion sampling efficiency and measurement sensitivity by using one or more ion guides to effectively capture ions in a plume emitted from the ion target and guide the ions through an aperture into a downstream vacuum chamber. In one configuration using two RF multipole ion guides, a first RF multipole ion guide disposed next to the ion target is selected to be sufficiently large to capture a substantial portion of the plume, while the second RF multipole ion guide disposed between the first multipole ion guide and the aperture has a smaller dimension to assist focusing of ions into the aperture. The first RF multipole ion guides the ions in the plume into the second RF multipole ion guide, which then focuses the ions so that they pass through the aperture into the downstream vacuum chamber.
摘要翻译：激光解吸离子源通过使用一个或多个离子导向器来有效地捕获从离子靶发射的羽流中的离子并将离子引导通过孔进入下游真空室来提供增强的离子取样效率和测量灵敏度。在使用两个RF多极离子导向器的一个配置中，选择与离子目标相邻布置的第一RF多极离子导向器足够大以捕获羽流的大部分，而第二RF多极离子导向器布置在第一多极离子导向器导向，并且光圈具有较小的尺寸以帮助将离子聚焦到光圈中。第一个RF多极离子将羽流中的离子引导到第二个RF多极离子导向器中，然后聚焦离子，使它们通过孔进入下游真空室。

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