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1. 发明授权

US08117005B2 Optimization and control of the freeze-drying process of pharmaceutical products 有权
标题翻译：药品冷冻干燥过程的优化与控制
公开(公告)号：US08117005B2
公开(公告)日：2012-02-14
申请号：US12296802
申请日：2007-04-10
申请人： Antonello Barresi , Giancarlo Baldi , Marco Parvis , Alberto Vallan , Salvatore Velardi , Hassan Hammouri
发明人： Antonello Barresi , Giancarlo Baldi , Marco Parvis , Alberto Vallan , Salvatore Velardi , Hassan Hammouri
IPC分类号： G01K17/00 , G01K3/00
CPC分类号： G01K1/024 , F26B5/06 , G01N33/15
摘要： A system for monitoring the lyophilization process of a product in containers (4, 4a, 4b) arranged inside a lyophilization chamber, including a temperature measurement system (6) associated with each container housed inside (10) the lyophilization chamber, capable of surveying local temperature data for each container. The system includes a wireless communication system (8) for the surveyed temperature data and a processing module (16) for said data, located externally to the lyophilization chamber, programmed to determine at least one parameter indicative of the progress of the lyophilization process not measured by the measurement system, through the use of a predetermined representation model of the process, capable of correlating a local temperature value of the container with the parameter.
摘要翻译：一种用于监测设置在冻干室内的容器（4,4a，4b）中的产品的冷冻干燥过程的系统，包括与容纳在所述冻干室内的每个容器（10）相关联的温度测量系统（6），所述容器能够测量局部每个容器的温度数据。该系统包括用于测量温度数据的无线通信系统（8）和位于冻干室外部的用于所述数据的处理模块（16），被编程为确定指示未测量的冻干过程进展的至少一个参数通过测量系统，通过使用能够使容器的局部温度值与参数相关联的该过程的预定表示模型。

2. 发明申请

US20090276179A1 OPTIMIZATION AND CONTROL OF THE FREEZE-DRYING PROCESS OF PHARMACEUTICAL PRODUCTS 有权
标题翻译：药用产品冷冻干燥过程的优化与控制
公开(公告)号：US20090276179A1
公开(公告)日：2009-11-05
申请号：US12296802
申请日：2007-04-10
申请人： Antonello Barresi , Giancarlo Baldi , Marco Parvis , Alberto Vallan , Salvatore Velardi , Hassan Hammouri
发明人： Antonello Barresi , Giancarlo Baldi , Marco Parvis , Alberto Vallan , Salvatore Velardi , Hassan Hammouri
IPC分类号： G06F15/00 , G01K13/00
CPC分类号： G01K1/024 , F26B5/06 , G01N33/15
摘要： A system is described for monitoring the lyophilisation process of a product in containers (4, 4a, 4b) arranged inside a lyophilisation chamber, comprising a temperature measurement system (6) associated with each container housed inside (10) said lyophilisation chamber, capable of surveying local temperature data for each container. The system includes: a wireless communication system (8) for the surveyed temperature data; and a processing module (16) for said data, located externally to the lyophilisation chamber, programmed to determine at least one parameter indicative of the progress of the lyophilisation process not measured by the measurement system, by means of a predetermined representation model of the process, capable of correlating a local temperature value of the container with said parameter.
摘要翻译：描述了一种用于监测设置在冻干室内的容器（4,4a，4b）中的产品的冻干过程的系统，其包括与容纳在所述冻干室内的每个容器（10）相关联的温度测量系统（6），所述温度测量系统能够测量每个容器的当地温度数据。该系统包括：用于测量温度数据的无线通信系统（8）以及位于所述冻干室外部的用于所述数据的处理模块（16），其被编程为通过所述过程的预定表示模型来确定指示所述冻干过程未被所述测量系统测量的进展的至少一个参数能够将容器的局部温度值与所述参数相关联。

3. 发明申请

US20070253000A1 System and method for measuring distances, displacement and mechanical actions 审中-公开
标题翻译：用于测量距离，位移和机械作用的系统和方法
公开(公告)号：US20070253000A1
公开(公告)日：2007-11-01
申请号：US11786254
申请日：2007-04-11
申请人： Alberto Vallan , Silvio Abrate , Guido Perrone
发明人： Alberto Vallan , Silvio Abrate , Guido Perrone
IPC分类号： G01B9/02
CPC分类号： G01D5/35351
摘要： An optical transducer adapted to detect external mechanical actions or forces acting comprising at least one sensing optical path (5) adapted to transmit at least one sensing optical signal (b′) and to emit at least one sensing output electrical signal (d) along with at least one reference path (4) adapted to emit at least one output electrical reference signal (e). Moreover, at least one portion (5′) of the at least one optical path (5) is adapted to be exposed to external mechanical actions or forces, so that the transmission of the sensing optical signal (b′) through the sensing optical path can be modified as a result of the mechanical actions or forces, so that a phase shift between the sensing electrical signal (d) and the reference electrical signal (e) is generated. Furthermore, the at least one reference path (4) comprises phase shifting means (11) adapted to maintain the phase shift between the at least one output sensing electrical signal (d) and the at least one output reference electrical signal (e) at a constant value in absence of any mechanical action or force exerted on the at least one sensing optical path (5), resulting in the working point or operating range of the transducer being kept within a range centered on a predefined phase shift, thus allowing improved sensitivity of the transducer.
摘要翻译：一种适于检测外部机械作用或力的光学传感器，其包括适于传输至少一个感测光信号（b'）的至少一个感测光路（5）并且发射至少一个感测输出电信号（d）以及与适于发射至少一个输出电参考信号（e）的至少一个参考路径（4）。此外，至少一个光路（5）的至少一部分（5'）适于暴露于外部机械动作或力，使得感测光信号（b'）通过传感光路可以由于机械动作或力而被修改，从而产生感测电信号（d）和参考电信号（e）之间的相移。此外，所述至少一个参考路径（4）包括相移装置（11），适于在至少一个输出感测电信号（d）和所述至少一个输出参考电信号（e）之间保持相移不存在施加在至少一个感测光路（5）上的任何机械作用或力的恒定值，导致换能器的工作点或操作范围保持在以预定相移为中心的范围内，从而允许改善的灵敏度的传感器。

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