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1. 发明授权

US5455332A Carcinoma-marking monoclonal antibodies elicited with synthetic Asialo-GM1 antigen 失效
标题翻译：用合成的Asialo-GM1抗原引起的癌标记单克隆抗体
公开(公告)号：US5455332A
公开(公告)日：1995-10-03
申请号：US353162
申请日：1989-05-12
申请人： Connie J. Turner , Bryan M. Longenecker , David J. Willans , Antoine A. Noujaim , Grant MacLean
发明人： Connie J. Turner , Bryan M. Longenecker , David J. Willans , Antoine A. Noujaim , Grant MacLean
IPC分类号： C07K16/28 , G01N33/574
CPC分类号： C07K16/28
摘要： Monoclonal antibodies produced after immunization with a synthetic antigen bearing the structure Gal (beta 1-3) GalNac beta-glycosidically linked to a carrier moiety are useful as carcinoma markers. Radioimmunoimaging agents are described in which such antibodies are tagged with radiometals or radiohalogens. Radiolabeled monoclonal antibody 155H.7, elicited by this antigen, rapidly localizes and persists in tumor tissues, demonstrating its utility as a tumor imaging agent.
摘要翻译：用携带结构Gal（β1-3））的合成抗原产生的单克隆抗体，其与载体部分糖苷连接的GalNac可用作癌标记物。描述了放射免疫成像剂，其中这些抗体用放射性金属或放射性卤素标记。由该抗原引起的放射性标记的单克隆抗体155H.7快速定位并持续存在于肿瘤组织中，证明其作为肿瘤成像剂的效用。

2. 发明授权

US4990326A Method for detecting blood platelets 失效
标题翻译：检测血小板的方法
公开(公告)号：US4990326A
公开(公告)日：1991-02-05
申请号：US170447
申请日：1988-03-15
申请人： Antoine A. Noujaim , Bryan M. Longenecker
发明人： Antoine A. Noujaim , Bryan M. Longenecker
IPC分类号： A61K49/16 , A61K51/10 , G01N33/569
CPC分类号： A61K51/1018 , A61K49/16 , G01N33/56966 , A61K2123/00 , Y10S530/808 , Y10S530/809
摘要： Use of labeled monoclonal antibody 50 H.19 to detect the location and concentration of blood platelets in a host is disclosed. MAb 50 H.19 labeled with a label which can be detected from without the host (e.g. a radiolabel or NMR-label) is intravenously injected to immunoreact with platelets in vivo or is first immunoreacted in vitro with platelets, which are then intravenously injected into the host. By means of the labeled MAb 50 H.19 bound platelets it is possible to detect and locate thrombi, emboli, atherosclerotic obstructions, bacterial endocarditis and to do spleen imaging. In another embodiment of the invention, the MAb 50 H.19 is bound to an enzymatic thrombolytic agent and injected intravenously to permit the therapeutic application of the agent directly to thrombi.
摘要翻译：公开了使用标记的单克隆抗体50H.19来检测宿主血小板的位置和浓度。静脉内注射可从体内检测无标记物（如放射性标记或核磁共振标记）的标记的MAb 50 H.19，与血小板体内免疫反应或首先在血小板上进行体外免疫反应，然后静脉注射主人。通过标记的MAb 50 H.19结合血小板，可以检测和定位血栓，栓塞，动脉粥样硬化障碍，细菌性心内膜炎，并做脾脏成像。在本发明的另一个实施方案中，MAb 50H.19与酶溶血栓剂结合并静脉内注射以允许药物直接治疗性施用于血栓。

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