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1. 发明申请

US20100152410A1 HIGH MOLECULAR WEIGHT POLYMERS, DEVICES AND METHOD FOR MAKING AND USING SAME 有权
标题翻译：高分子量聚合物，制备和使用它们的装置和方法
公开(公告)号：US20100152410A1
公开(公告)日：2010-06-17
申请号：US12500438
申请日：2009-07-09
申请人： Anthony East , Alan Letton , Suseela Kanamathareddy , Bryant J. Pudil , Stephen Goodrich , Michael B. Hicks , Yun Choe
发明人： Anthony East , Alan Letton , Suseela Kanamathareddy , Bryant J. Pudil , Stephen Goodrich , Michael B. Hicks , Yun Choe
IPC分类号： C08G63/682
CPC分类号： A61K9/0024 , A61K47/34 , A61L27/34 , A61L27/54 , A61L2300/21 , A61L2300/41 , A61L2300/416 , A61L2300/604
摘要： Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from the controlled release of an agent(s) over a period of time. The polymers are prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The polymers are suitable as delivery systems, either by themselves, as compositions, formulations or devices.
摘要翻译：释放活性或可活化剂的酐聚合物具有预先选择的性质，例如分子量，柔韧性，硬度，粘合性和其它有价值的性质。聚合物适用于在一段时间内受益于试剂的受控释放的组合物，制剂，涂料，装置等中。聚合物通过涉及各种替代和顺序步骤的方法制备，其允许先验地设计具有特定特征的产品。聚合物本身适合作为递送系统，作为组合物，制剂或装置。

2. 发明授权

US08232322B2 High molecular weight polymers, devices and method for making and using same 有权
标题翻译：高分子量聚合物，其制备和使用方法
公开(公告)号：US08232322B2
公开(公告)日：2012-07-31
申请号：US12500438
申请日：2009-07-09
申请人： Anthony East , Alan Letton , Suseela Kanamathareddy , Bryant J. Pudil , Stephen Goodrich , Michael B. Hicks , Yun Choe
发明人： Anthony East , Alan Letton , Suseela Kanamathareddy , Bryant J. Pudil , Stephen Goodrich , Michael B. Hicks , Yun Choe
IPC分类号： A61K47/32 , A61K31/43
CPC分类号： A61K9/0024 , A61K47/34 , A61L27/34 , A61L27/54 , A61L2300/21 , A61L2300/41 , A61L2300/416 , A61L2300/604
摘要： Anhydride polymers that release active or activatable agent(s) have pre-selected properties such as molecular weight, flexibility, hardness, adhesiveness, and other valuable properties. The polymers are suitable for use in compositions, formulations, coatings, devices, and the like that benefit from the controlled release of an agent(s) over a period of time. The polymers are prepared by a process involving various alternative and sequential steps that allow the design a priori of products with specific characteristics. The polymers are suitable as delivery systems, either by themselves, as compositions, formulations or devices.
摘要翻译：释放活性或可活化剂的酐聚合物具有预先选择的性质，例如分子量，柔韧性，硬度，粘合性和其它有价值的性质。聚合物适用于在一段时间内受益于试剂的受控释放的组合物，制剂，涂料，装置等中。聚合物通过涉及各种替代和顺序步骤的方法制备，其允许先验地设计具有特定特征的产品。聚合物本身适合作为递送系统，作为组合物，制剂或装置。

3. 发明授权

US10857277B2 Modular hemodialysis system 有权
公开(公告)号：US10857277B2
公开(公告)日：2020-12-08
申请号：US13586824
申请日：2012-08-15
申请人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
发明人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
IPC分类号： A61M1/16 , A61M1/36
摘要： Apparatuses, systems, and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge, and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. A first sorbent cartridge is provided for use in a portable treatment module having activated carbon and zirconium oxide. The system also provides for the monitoring of an inlet and outlet conductivity of a sorbent cartridge containing urease to provide a facility to quantify or monitor the removal of urea by a detachable urea removal module.

4. 发明授权

US08956642B2 Bupivacaine formulation in a polyorthoester carrier 有权
标题翻译：布比卡因配方在聚原酸酯载体中
公开(公告)号：US08956642B2
公开(公告)日：2015-02-17
申请号：US12426005
申请日：2009-04-17
申请人： Christopher M. Hobot , Michael E. Benz , Keith R. Hildebrand , Bryant J. Pudil
发明人： Christopher M. Hobot , Michael E. Benz , Keith R. Hildebrand , Bryant J. Pudil
IPC分类号： A61F2/00 , A01N43/40 , A61K31/445 , A61L31/16
CPC分类号： A61K31/445 , A61K9/0024 , A61K9/0085 , A61K9/1641 , A61K9/1694 , A61K9/5031 , A61L31/16 , A61L2300/402 , A61L2300/602
摘要： Effective treatments of pain, such as chronic pelvic pain, for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of bupivacaine formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least thirty days, at least sixty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译：提供有效的治疗疼痛，如慢性盆腔疼痛，延长时间。治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的布比卡因。通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及手术附带的疼痛。在一些实施例中，浮雕可以是至少三十天，至少六十天，至少一百天或至少一百三十五天。

5. 发明申请

US20140190876A1 SORBENT CARTRIDGE TO MEASURE SOLUTE CONCENTRATIONS 有权
标题翻译： SORBENT CARTRIDGE测量解决方案
公开(公告)号：US20140190876A1
公开(公告)日：2014-07-10
申请号：US13791755
申请日：2013-03-08
申请人： Thomas E. Meyer , David B. Lura , Bryant J. Pudil , Martin T. Gerber
发明人： Thomas E. Meyer , David B. Lura , Bryant J. Pudil , Martin T. Gerber
IPC分类号： A61M1/16 , B01D15/08 , B01D15/36 , A61M1/34 , A61M1/28
CPC分类号： A61M1/1696 , A61M1/284 , A61M1/287 , A61M1/288 , A61M1/3413 , A61M1/3472 , A61M1/3679 , A61M2205/3303 , A61M2205/3317 , A61M2205/3334 , A61M2205/50 , B01D15/08 , B01D15/361 , B01J20/0292 , B01J20/048 , B01J20/06 , B01J20/08 , B01J20/20 , B01J20/28052 , B01J39/10 , B01J39/12 , B01J39/18 , B01J41/10 , B01J41/12 , B01J47/012 , B01J47/026 , B01J47/14 , B01J2220/49
摘要： A sorbent based monitoring system for measuring the solute concentration of at least one component of a fluid. The system has a sorbent regeneration system for regeneration of the fluid and has a sorbent cartridge that has at least one material layer. The fluid is conveyed through the sorbent cartridge and contacts at least one sensor after having contacted at least one material layer.
摘要翻译：一种用于测量流体至少一种组分的溶质浓度的基于吸附剂的监测系统。该系统具有用于再生流体的吸附剂再生系统，并具有至少一个材料层的吸附剂盒。流体通过吸附剂药筒输送，并且在接触至少一个材料层之后接触至少一个传感器。

6. 发明授权

US09144640B2 Sorbent cartridge configurations for improved dialysate regeneration 有权
标题翻译：吸附剂盒配置，用于改善透析液再生
公开(公告)号：US09144640B2
公开(公告)日：2015-09-29
申请号：US13836973
申请日：2013-03-15
申请人： Bryant J. Pudil , Thomas E. Meyer , David B. Lura , Martin T. Gerber
发明人： Bryant J. Pudil , Thomas E. Meyer , David B. Lura , Martin T. Gerber
IPC分类号： A61M1/16
CPC分类号： A61M1/1656 , A61M1/1654 , A61M1/1668 , A61M1/167 , A61M1/1696 , A61M1/287 , A61M1/3486 , A61M2205/02 , B01D15/08
摘要： A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance.
摘要翻译：一种再生系统，其具有包含第一选择再生物质的第一再生模块; 包含第一选择再生物质的第二再生模块; 和第一混合室。流体的第一出口流顺序地离开第一混合室，流过第一再生模块与第一选择的再生物质流体连通并返回到第一混合室，并且流体的第二出口流依次离开第一混合并且与第一选择的再生物质流体连通地流过第二再生模块。

7. 发明授权

US08940315B2 Benzodiazepine formulation in a polyorthoester carrier 有权
标题翻译：苯并二氮类制剂在聚原酸酯载体中
公开(公告)号：US08940315B2
公开(公告)日：2015-01-27
申请号：US12426031
申请日：2009-04-17
申请人： Christopher M. Hobot , Michael E. Benz , Keith R. Hildebrand , Bryant J. Pudil
发明人： Christopher M. Hobot , Michael E. Benz , Keith R. Hildebrand , Bryant J. Pudil
IPC分类号： A61F13/00 , A01N43/62 , A61K31/55 , A61K31/197 , A61K9/00 , A61K47/34
CPC分类号： A61K31/197 , A61K9/0024 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译：提供长时间有效的疼痛治疗。治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及手术附带的疼痛。在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。

8. 发明申请

US20140217028A1 SORBENT CARTRIDGE CONFIGURATIONS FOR IMPROVED DIALYSATE REGENERATION 有权
标题翻译：用于改进的透析再生的SORBENT CARTRIDGE配置
公开(公告)号：US20140217028A1
公开(公告)日：2014-08-07
申请号：US13836973
申请日：2013-03-15
申请人： Bryant J. Pudil , Thomas E. Meyer , David B. Lura , Martin T. Gerber
发明人： Bryant J. Pudil , Thomas E. Meyer , David B. Lura , Martin T. Gerber
IPC分类号： A61M1/16
CPC分类号： A61M1/1656 , A61M1/1654 , A61M1/1668 , A61M1/167 , A61M1/1696 , A61M1/287 , A61M1/3486 , A61M2205/02 , B01D15/08
摘要： A regeneration system that has a first regeneration module containing a first chosen regenerative substance; a second regeneration module containing the first chosen regenerative substance; and a first mixing chamber. A first outlet stream of a fluid sequentially exits the first mixing chamber, flows through the first regeneration module in fluid communication with the first chosen regenerative substance and returns to the first mixing chamber, and a second outlet stream of the fluid sequentially exits the first mixing chamber and flows through the second regeneration module in fluid communication with the first chosen regenerative substance.
摘要翻译：一种再生系统，其具有包含第一选择再生物质的第一再生模块; 包含第一选择再生物质的第二再生模块; 和第一混合室。流体的第一出口流顺序地离开第一混合室，流过第一再生模块与第一选择的再生物质流体连通并返回到第一混合室，并且流体的第二出口流依次离开第一混合并且与第一选择的再生物质流体连通地流过第二再生模块。

9. 发明申请

US20140217027A1 SYSTEMS AND METHODS FOR MULTIFUNCTIONAL VOLUMETRIC FLUID CONTROL 有权
标题翻译：多功能体积流体控制系统与方法
公开(公告)号：US20140217027A1
公开(公告)日：2014-08-07
申请号：US13757709
申请日：2013-02-01
申请人： Thomas E. Meyer , David B. Lura , Bryant J. Pudil , Martin T. Gerber
发明人： Thomas E. Meyer , David B. Lura , Bryant J. Pudil , Martin T. Gerber
IPC分类号： A61M1/36 , A61M1/16
CPC分类号： A61M1/1621 , A61M1/16 , A61M1/1601 , A61M1/1605 , A61M1/165 , A61M1/1652 , A61M1/1656 , A61M1/1658 , A61M1/1664 , A61M1/1666 , A61M1/1668 , A61M1/1672 , A61M1/1676 , A61M1/169 , A61M1/1696 , A61M1/3413 , A61M1/3437 , A61M1/3609 , A61M1/3626 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/365 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/50 , A61M2205/502 , A61M2205/505 , A61M2209/06 , A61M2230/65
摘要： Systems and methods for controlling fluid movement and volumes of fluid between a subject and a controlled compliant flow path. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the controlled compliant flow path. An extracorporeal flow path is in fluid communication with the controlled compliant flow path across a semi-permeable membrane where the extracorporeal flow path has a first terminal end and a second terminal end.
摘要翻译：用于控制受试者和受控顺应流动路径之间的流体运动和流体体积的系统和方法。受控制的柔性流动路径具有用于选择性地计量来自受控制的顺应流动路径的流体的计量装置。体外流路与跨过半透膜的受控顺应性流动路径流体连通，其中体外流路具有第一末端和第二末端。

10. 发明申请

US20130199998A1 HEMODIALYSIS SYSTEM HAVING A FLOW PATH WITH A CONTROLLED COMPLIANT VOLUME 审中-公开
标题翻译：具有控制合格体积的流路的血液透析系统
公开(公告)号：US20130199998A1
公开(公告)日：2013-08-08
申请号：US13565733
申请日：2012-08-02
申请人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
发明人： Thomas D. Kelly , SuPing Lyu , Bryant J. Pudil , Thomas E. Meyer
IPC分类号： A61M1/16
CPC分类号： A61M1/3482 , A61M1/1696 , A61M2202/0021 , A61M2202/0413
摘要： Systems and methods for the performance of kidney replacement therapy having or using a dialyzer, control components, sorbent cartridge and fluid reservoirs configured to be of a weight and size suitable to be worn or carried by an individual requiring treatment are disclosed. The system for performing kidney replacement therapy has a controlled compliance dialysis circuit, where a control pump controls the bi-directional movement of fluid across a dialysis membrane. The dialysis circuit and an extracorporeal circuit for circulating blood are in fluid communication through the dialysis membrane. The flux of fluid moving between the extracorporeal circuit and the dialysis circuit is modified by the rate at which the control pump is operating such that a rate of ultrafiltration and convective clearance can be controlled. The system provides for the monitoring of an inlet and outlet conductivity of the sorbent cartridge to provide a facility to quantify or monitor the removal of urea by the sorbent cartridge.
摘要翻译：公开了用于执行肾脏替代疗法的系统和方法，其具有或使用透析器，控制组件，吸附剂盒和流体储存器，其被配置为适于被需要治疗的个体穿戴或携带的重量和尺寸。用于执行肾脏替代治疗的系统具有受控的依从性透析电路，其中控制泵控制流体穿过透析膜的双向运动。透析电路和用于循环血液的体外循环通过透析膜流体连通。在体外循环和透析回路之间移动的流体通量由控制泵运行的速率改变，从而可以控制超滤速率和对流间隙。该系统提供对吸附剂盒的入口和出口导电性的监测，以提供量化或监测吸附剂盒去除尿素的设施。

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