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1. 发明申请

US20110033464A1 IMMUNOGLOBULIN FUSION PROTEIN FORMULATIONS 审中-公开
标题翻译：免疫球蛋白融合蛋白制剂
公开(公告)号：US20110033464A1
公开(公告)日：2011-02-10
申请号：US12910146
申请日：2010-10-22
申请人： Anthony BARRY , Thomas Crowley , Daniel Dixon , Jennifer Juneau , Ajay Kumar , Li Li , Nicholas Luksha , Michael Shamashkin , Erin Soley , Nicholas Warne , Chandra Webb
发明人： Anthony BARRY , Thomas Crowley , Daniel Dixon , Jennifer Juneau , Ajay Kumar , Li Li , Nicholas Luksha , Michael Shamashkin , Erin Soley , Nicholas Warne , Chandra Webb
IPC分类号： A61K39/395
CPC分类号： C07K14/7155 , A61K38/1774 , C07K14/705 , C07K2319/30 , C07K2319/31
摘要： The present invention provides compositions of Ig fusion proteins, especially compositions including an Ig fusion protein, a bulking agent, a disaccharide, a surfactant, and a buffer. In one aspect, these compositions are stable under long-term storage or at least one freeze/thaw cycle. The invention also provides methods of preparation of the Ig fusion protein compositions. In one aspect, compositions of the invention are lyophilized. In a further aspect, the compositions are lyophilized by a process that includes an annealing step.
摘要翻译：本发明提供Ig融合蛋白的组合物，特别是包含Ig融合蛋白，填充剂，二糖，表面活性剂和缓冲液的组合物。在一个方面，这些组合物在长期储存或至少一个冷冻/融化循环下是稳定的。本发明还提供了Ig融合蛋白组合物的制备方法。在一个方面，本发明的组合物被冻干。在另一方面，组合物通过包括退火步骤的方法冻干。

2. 发明申请

US20070237758A1 IMMUNOGLOBULIN FUSION PROTEIN FORMULATIONS 审中-公开
标题翻译：免疫球蛋白融合蛋白制剂
公开(公告)号：US20070237758A1
公开(公告)日：2007-10-11
申请号：US11562299
申请日：2006-11-21
申请人： Anthony Barry , Thomas Crowley , Daniel Dixon , Jennifer Juneau , Ajay Kumar , Li Li , Nicholas Luksha , Michael Shamashkin , Erin Soley , Nicholas Warne , Chandra Webb
发明人： Anthony Barry , Thomas Crowley , Daniel Dixon , Jennifer Juneau , Ajay Kumar , Li Li , Nicholas Luksha , Michael Shamashkin , Erin Soley , Nicholas Warne , Chandra Webb
IPC分类号： A61K39/395
CPC分类号： C07K14/7155 , A61K38/1774 , C07K14/705 , C07K2319/30 , C07K2319/31
摘要： The present invention provides compositions of Ig fusion proteins, especially compositions including an Ig fusion protein, a bulking agent, a disaccharide, a surfactant, and a buffer. In one aspect, these compositions are stable under long-term storage or at least one freeze/thaw cycle. The invention also provides methods of preparation of the Ig fusion protein compositions. In one aspect, compositions of the invention are lyophilized. In a further aspect, the compositions are lyophilized by a process that includes an annealing step.
摘要翻译：本发明提供Ig融合蛋白的组合物，特别是包含Ig融合蛋白，填充剂，二糖，表面活性剂和缓冲液的组合物。在一个方面，这些组合物在长期储存或至少一个冷冻/融化循环下是稳定的。本发明还提供了Ig融合蛋白组合物的制备方法。在一个方面，本发明的组合物被冻干。在另一方面，组合物通过包括退火步骤的方法冻干。

3. 发明申请

US20090324586A1 LYOPHILIZATION CYCLE ROBUSTNESS STRATEGY 审中-公开
标题翻译： LYOPHILIZATION CYCLE ROBUSTNESS策略
公开(公告)号：US20090324586A1
公开(公告)日：2009-12-31
申请号：US12492052
申请日：2009-06-25
申请人： Serguei Tchessalov , Daniel Dixon , Anthony Barry , Nicholas Warne
发明人： Serguei Tchessalov , Daniel Dixon , Anthony Barry , Nicholas Warne
IPC分类号： A61K39/395 , F26B5/06 , G01N33/48 , A61K38/16 , A61K38/43
CPC分类号： F26B5/06
摘要： The present invention provides methods for assessing and optimizing lyophilization cycle robustness. In particular, the present invention provides rapid assessment of cycle robustness with respect to a variety of lyophilization process deviations by varying a relatively small number of parameters.
摘要翻译：本发明提供了评估和优化冻干循环鲁棒性的方法。特别地，本发明通过改变相对较少数量的参数来提供关于各种冻干过程偏差的循环鲁棒性的快速评估。

4. 发明授权

US07726184B2 Surface acoustic wave sensor and package 有权
标题翻译：表面声波传感器和封装
公开(公告)号：US07726184B2
公开(公告)日：2010-06-01
申请号：US12239363
申请日：2008-09-26
申请人： James D. Cook , Brian J. Marsh , Mohammed A J Qasimi , Daniel Dixon , Sachin Kumar
发明人： James D. Cook , Brian J. Marsh , Mohammed A J Qasimi , Daniel Dixon , Sachin Kumar
IPC分类号： B60C23/02 , G01M1/14
CPC分类号： H04Q9/00 , G01L9/0025 , H04Q2209/47 , H04Q2209/84 , H04Q2209/88
摘要： The SAW sensor in a stainless steel button package having a diaphragm and mounted on a threaded port. Package can hermetically seal a sensor and RFID-antenna assemblies from media. Sensor diaphragm is exposable to media. Sensor and RFID antennas communicate electrically with SAW sensor and RFID device, respectively, for sensor measurements and identification. Antennas receive RF interrogation signal from a nearby interrogator/transceiver and send reflected RF signals back to the interrogator unit containing sensor measurement and sensor ID. TRF signal excites a SAW resonator inside the sensor and causes the SAW to resonate wherein resonant frequency changes with pressure and temperature applied to the sensor. Antennas could be printed circuit board antennas, helical antennas, loop antennas, any other commercially available off-the-shelf antennas or a combination of these.
摘要翻译： SAW传感器采用不锈钢按钮包装，具有隔膜并安装在螺纹端口上。封装可以从介质密封传感器和RFID天线组件。传感器隔膜可暴露于介质。传感器和RFID天线分别与SAW传感器和RFID设备进行通信，用于传感器测量和识别。天线从附近的询问器/收发器接收RF询问信号，并将反射的RF信号发送回包含传感器测量和传感器ID的询问器单元。 TRF信号激发传感器内的SAW谐振器，并使SAW谐振，其中谐振频率随施加到传感器的压力和温度而变化。天线可以是印刷电路板天线，螺旋天线，环形天线，任何其他市售的现成天线或这些天线的组合。

5. 发明授权

US07730772B2 Surface acoustic wave sensor and package 有权
标题翻译：表面声波传感器和封装
公开(公告)号：US07730772B2
公开(公告)日：2010-06-08
申请号：US11966076
申请日：2007-12-28
申请人： James D. Cook , Brian J. Marsh , Mohammed A J Qasimi , Daniel Dixon , Sachin Kumar
发明人： James D. Cook , Brian J. Marsh , Mohammed A J Qasimi , Daniel Dixon , Sachin Kumar
IPC分类号： B60C23/02 , G01L9/00
CPC分类号： B60C23/0449 , B60C23/0496
摘要： A wireless and batteryless pressure sensor apparatus comprises of a SAW sensor and an antenna mounted on a printed circuit board. Optionally, and RFID tag in used in combination with the SAW sensor. A sensor antenna and a RFID antenna can be located on the printed circuit board such that the antennas communicate electrically with the sensor and the RFID device. The sensor can be interrogated utilizing a radio frequency, which is used to excite a SAW crystal inside the sensor. The interrogation signal causes the SAW to resonate wherein a resonant frequency changes with the pressure and temperature that is applied to the sensor. An interrogator can receive a return (echo) signal representing a change in SAW sensor properties (e.g., diaphragm change). A printed circuit board can be mounted on a stainless steel port and overpackaged with standard processes for hermetically sealing the sensor, or sensor and RFID device with at least one antenna.
摘要翻译：无线和无电池压力传感器装置包括SAW传感器和安装在印刷电路板上的天线。可选地，RFID标签与SAW传感器结合使用。传感器天线和RFID天线可以位于印刷电路板上，使得天线与传感器和RFID设备电气通信。传感器可以利用射频来询问，该射频用于激发传感器内的SAW晶体。询问信号使SAW谐振，其中谐振频率随施加到传感器的压力和温度而变化。询问器可以接收表示SAW传感器特性（例如膜片变化）的变化的返回（回波）信号。印刷电路板可以安装在不锈钢端口上，并采用标准工艺进行封装，以密封传感器，或传感器和RFID设备至少有一个天线。

6. 发明申请

US20090167503A1 WIRELESS AND BATTERYLESS SENSOR 有权
标题翻译：无线和无电池传感器
公开(公告)号：US20090167503A1
公开(公告)日：2009-07-02
申请号：US12239363
申请日：2008-09-26
申请人： James D. Cook , Brian J. Marsh , Mohammed A J Qasimi , Daniel Dixon , Sachin Kumar
发明人： James D. Cook , Brian J. Marsh , Mohammed A J Qasimi , Daniel Dixon , Sachin Kumar
IPC分类号： H04Q5/22
CPC分类号： H04Q9/00 , G01L9/0025 , H04Q2209/47 , H04Q2209/84 , H04Q2209/88
摘要： The SAW sensor in a stainless steel button package having a diaphragm and mounted on a threaded port. Package can hermetically seal a sensor and RFID-antenna assemblies from media. Sensor diaphragm is exposable to media. Sensor and RFID antennas communicate electrically with SAW sensor and RFID device, respectively, for sensor measurements and identification. Antennas receive RF interrogation signal from a nearby interrogator/transceiver and send reflected RF signals back to the interrogator unit containing sensor measurement and sensor ID. TRF signal excites a SAW resonator inside the sensor and causes the SAW to resonate wherein resonant frequency changes with pressure and temperature applied to the sensor. Antennas could be printed circuit board antennas, helical antennas, loop antennas, any other commercially available off-the-shelf antennas or a combination of these.
摘要翻译： SAW传感器采用不锈钢按钮包装，具有隔膜并安装在螺纹端口上。封装可以从介质密封传感器和RFID天线组件。传感器隔膜可暴露于介质。传感器和RFID天线分别与SAW传感器和RFID设备进行通信，用于传感器测量和识别。天线从附近的询问器/收发器接收RF询问信号，并将反射的RF信号发送回包含传感器测量和传感器ID的询问器单元。 TRF信号激发传感器内的SAW谐振器，并使SAW谐振，其中谐振频率随施加到传感器的压力和温度而变化。天线可以是印刷电路板天线，螺旋天线，环形天线，任何其他市售的现成天线或这些天线的组合。

7. 发明申请

US20090165546A1 WIRELESS AND BATTERYLESS SENSOR 有权
标题翻译：无线和无电池传感器
公开(公告)号：US20090165546A1
公开(公告)日：2009-07-02
申请号：US11966076
申请日：2007-12-28
申请人： James D. Cook , Brian J. Marsh , Mohammed A.J Qasimi , Daniel Dixon , Sachin Kumar
发明人： James D. Cook , Brian J. Marsh , Mohammed A.J Qasimi , Daniel Dixon , Sachin Kumar
IPC分类号： B60C23/04
CPC分类号： B60C23/0449 , B60C23/0496
摘要： A wireless and batteryless pressure sensor apparatus comprises of a SAW sensor and an antenna mounted on a printed circuit board. Optionally, and RFID tag in used in combination with the SAW sensor. A sensor antenna and a RFID antenna can be located on the printed circuit board such that the antennas communicate electrically with the sensor and the RFID device. The sensor can be interrogated utilizing a radio frequency, which is used to excite a SAW crystal inside the sensor. The interrogation signal causes the SAW to resonate wherein a resonant frequency changes with the pressure and temperature that is applied to the sensor. An interrogator can receive a return (echo) signal representing a change in SAW sensor properties (e.g., diaphragm change). A printed circuit board can be mounted on a stainless steel port and overpackaged with standard processes for hermetically sealing the sensor, or sensor and RFID device with at least one antenna.
摘要翻译：无线和无电池压力传感器装置包括SAW传感器和安装在印刷电路板上的天线。可选地，RFID标签与SAW传感器结合使用。传感器天线和RFID天线可以位于印刷电路板上，使得天线与传感器和RFID设备电气通信。传感器可以利用射频来询问，该射频用于激发传感器内的SAW晶体。询问信号使SAW谐振，其中谐振频率随施加到传感器的压力和温度而变化。询问器可以接收表示SAW传感器特性（例如膜片变化）的变化的返回（回波）信号。印刷电路板可以安装在不锈钢端口上，并采用标准工艺进行封装，以密封传感器，或传感器和RFID设备至少有一个天线。

8. 发明申请

US20070088105A1 Low molecular weight cellulose mixed esters and their use as low viscosity binders and modifiers in coating compositions 有权
标题翻译：低分子量纤维素混合酯及其作为涂料组合物中低粘度粘合剂和改性剂的用途
公开(公告)号：US20070088105A1
公开(公告)日：2007-04-19
申请号：US11394008
申请日：2006-03-30
申请人： Michael Shelton , Jessica Posey-Dowty , Luis Perdomo , Daniel Dixon , Paul Lucas , Alan Wilson , Kenneth Walker , Jonathan Lawniczak , Roy Foulk , Hieu Phan , Charlie Freeman , John Booton
发明人： Michael Shelton , Jessica Posey-Dowty , Luis Perdomo , Daniel Dixon , Paul Lucas , Alan Wilson , Kenneth Walker , Jonathan Lawniczak , Roy Foulk , Hieu Phan , Charlie Freeman , John Booton
IPC分类号： C08L1/00
CPC分类号： C08B3/18 , C08B3/16 , C08G18/6484 , C09D101/14 , C09D201/00 , C08L2666/02 , C08L2666/26
摘要： Cellulose mixed esters are disclosed having low molecular weights and low degrees of polymerization. These new cellulose mixed esters include cellulose acetate propionate and cellulose acetate butyrate. The esters exhibit solubility in a wide range of organic solvents with minimal viscosity increase, are compatible with a wide variety of resins, and are useful in coatings and inks compositions as binder resins and rheology modifiers.
摘要翻译：公开了具有低分子量和低聚合度的纤维素混合酯。这些新的纤维素混合酯包括乙酸丙酸纤维素和乙酸丁酸纤维素。该酯在宽范围的有机溶剂中表现出溶解性，粘度增加最小，与多种树脂相容，并且可用作涂料和油墨组合物作为粘合剂树脂和流变改性剂。

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