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1. 发明申请

US20100076535A1 LEADS WITH NON-CIRCULAR-SHAPED DISTAL ENDS FOR BRAIN STIMULATION SYSTEMS AND METHODS OF MAKING AND USING 审中-公开
标题翻译：用于脑刺激系统的非圆形远端的引线及其制造和使用方法
公开(公告)号：US20100076535A1
公开(公告)日：2010-03-25
申请号：US12237888
申请日：2008-09-25
申请人： Anne M. Pianca , Courtney Lane , James C. Makous , Andrew DiGiore , Ellis Garai
发明人： Anne M. Pianca , Courtney Lane , James C. Makous , Andrew DiGiore , Ellis Garai
IPC分类号： A61N1/05
CPC分类号： A61N1/0534 , A61N1/0472 , A61N1/0529 , A61N1/36082
摘要： A lead is configured and arranged for brain stimulation. The lead includes a proximal end and a distal end. The proximal end includes a plurality of terminals disposed at the proximal end. The distal end has a non-circular transverse cross-sectional shape and includes a plurality of electrodes disposed at the distal end. A plurality of conductive wires electrically couple at least one of the plurality of electrodes to at least one of the plurality of terminals.
摘要翻译：铅的配置和排列用于脑刺激。引线包括近端和远端。近端包括设置在近端的多个端子。前端具有非圆形横截面形状，并且包括设置在远端的多个电极。多个导线将多个电极中的至少一个电连接到多个端子中的至少一个。

2. 发明授权

US07857819B2 Implant tool for use with a microstimulator 失效
标题翻译：用于微型刺激仪的植入物工具
公开(公告)号：US07857819B2
公开(公告)日：2010-12-28
申请号：US11565564
申请日：2006-11-30
申请人： Kristen N. Jaax , Rafael Carbunaru , James C. Makous , Todd K. Whitehurst , Meredith L. Anderson , Anne M. Pianca
发明人： Kristen N. Jaax , Rafael Carbunaru , James C. Makous , Todd K. Whitehurst , Meredith L. Anderson , Anne M. Pianca
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/0558 , A61N1/36071
摘要： A stimulation system is described that includes an implantable microstimulator. A tail may be coupled to a distal end of the implantable microstimulator. In one embodiment, the stimulation system includes an implantation tool that includes an insertion cannula, a handle, a bushing, and a detachable blunt dissector tip. The bushing is situated within the insertion cannula and may position the implantable microstimulator longitudinally within the insertion cannula when the implantable microstimulator is placed within the insertion cannula. The detachable blunt dissector tip may be attached to the tail of the implantable microstimulator. The stimulation system may further comprise an end cap that includes an upper portion and a base portion conformable over at least a portion of curved tissue. An open trough extends through the base upper portions and may be configured to guide the implantation tool through the tissue at various angles.
摘要翻译：描述了包括可植入微型刺激器的刺激系统。尾部可以联接到可植入微型刺激器的远端。在一个实施例中，刺激系统包括植入工具，其包括插入套管，手柄，衬套和可拆卸的钝性解剖器尖端。衬套位于插入套管内，并且当可植入微型刺激器放置在插入套管内时，可以将可植入的微型刺激器纵向定位在插入套管内。可拆卸的钝性解剖器尖端可以附接到可植入微型刺激器的尾部。所述刺激系统还可以包括端盖，所述端盖包括在至少一部分弯曲组织上的上部和基部。开口槽延伸穿过基底上部，并且可构造成以各种角度引导植入工具穿过组织。

3. 发明申请

US20080132961A1 IMPLANT TOOL FOR USE WITH A MICROSTIMULATOR 失效
标题翻译：用微型计算机使用的植入式工具
公开(公告)号：US20080132961A1
公开(公告)日：2008-06-05
申请号：US11565564
申请日：2006-11-30
申请人： Kristen N. Jaax , Rafael Carbunaru , James C. Makous , Todd K. Whitehurst , Meredith L. Anderson , Anne M. Pianca
发明人： Kristen N. Jaax , Rafael Carbunaru , James C. Makous , Todd K. Whitehurst , Meredith L. Anderson , Anne M. Pianca
IPC分类号： A61N1/05
CPC分类号： A61N1/0551 , A61N1/0558 , A61N1/36071
摘要： A stimulation system is described that includes an implantable microstimulator. A tail may be coupled to a distal end of the implantable microstimulator. In one embodiment, the stimulation system includes an implantation tool that includes an insertion cannula, a handle, a bushing, and a detachable blunt dissector tip. The bushing is situated within the insertion cannula and may position the implantable microstimulator longitudinally within the insertion cannula when the implantable microstimulator is placed within the insertion cannula. The detachable blunt dissector tip may be attached to the tail of the implantable microstimulator. The stimulation system may further comprise an end cap that includes an upper portion and a base portion conformable over at least a portion of curved tissue. An open trough extends through the base upper portions and may be configured to guide the implantation tool through the tissue at various angles.
摘要翻译：描述了包括可植入微型刺激器的刺激系统。尾部可以联接到可植入微型刺激器的远端。在一个实施例中，刺激系统包括植入工具，其包括插入套管，手柄，衬套和可拆卸的钝性解剖器尖端。衬套位于插入套管内，并且当可植入微型刺激器放置在插入套管内时，可以将可植入的微型刺激器纵向定位在插入套管内。可拆卸的钝性解剖器尖端可以附接到可植入微型刺激器的尾部。所述刺激系统还可以包括端盖，所述端盖包括在至少一部分弯曲组织上的上部和基部。开口槽延伸穿过基底上部，并且可构造成以各种角度引导植入工具穿过组织。

4. 发明授权

US08688218B2 Lead connector for an implantable electric stimulation system and methods of making and using 失效
标题翻译：用于可植入电刺激系统的引线连接器及其制造和使用方法
公开(公告)号：US08688218B2
公开(公告)日：2014-04-01
申请号：US13281257
申请日：2011-10-25
申请人： Anne M. Pianca
发明人： Anne M. Pianca
IPC分类号： A61N1/372
CPC分类号： A61N1/05 , A61N1/3752
摘要： A lead-connection system includes a lead and a connector. The lead includes a distal end, a proximal end, a plurality of electrodes disposed at the distal end, a plurality of terminals disposed at the proximal end, and a plurality of conductor wires electrically coupling each of the plurality of electrodes to a different one of the plurality of terminals. The connector defines a port for receiving the proximal end of the lead and a plurality of connector contacts. The number of connector contacts is greater than the number of terminals disposed on the proximal end of the lead. When the connector receives the proximal end of the lead, each of the terminals disposed on the proximal end of the lead makes electrical contact with at least one of the connector contacts of the connector and no two terminals make electrical contact with a same one of the connector contacts.
摘要翻译：引线连接系统包括引线和连接器。引线包括远端，近端，设置在远端的多个电极，设置在近端的多个端子，以及将多个电极中的每一个电连接到不同的电极的多个导体线多个终端。连接器限定用于接收引线的近端的端口和多个连接器触点。连接器触点的数量大于设置在引线的近端上的端子的数量。当连接器接收引线的近端时，设置在引线的近端的每个端子与连接器的至少一个连接器触点电接触，并且没有两个端子与相同的一个连接器触点

5. 发明授权

US08646172B2 Electrode array assembly and method of making same 有权
标题翻译：电极阵列组装及其制作方法
公开(公告)号：US08646172B2
公开(公告)日：2014-02-11
申请号：US13013599
申请日：2011-01-25
申请人： Janusz A. Kuzma , Anne M. Pianca
发明人： Janusz A. Kuzma , Anne M. Pianca
IPC分类号： H01R43/00 , A61N1/00
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/0553 , Y10T29/49117 , Y10T29/49204 , Y10T29/49208 , Y10T29/4922
摘要： A method of manufacturing a stimulation lead includes providing a lead body having an insulation section that defines a central lumen extending along the insulation section and conductor lumens extending along the insulation section and arranged around, and external to, the central lumen. The lead body also includes conductive contacts located along an axial end of the lead body and conductor wires with each conductor wire disposed within one of the conductor lumens and each of the conductor lumens having at least one of the conductor wires disposed therein. After providing the lead body, conductively at least one of the conductor wires to each of the conductive contacts; and placing non-conductive material into a portion of at least one of the conductor lumens of the lead body. A portion of the conductor lumens and at least a portion of the non-conductive material are disposed radially beneath the conductive contacts.
摘要翻译：制造刺激引线的方法包括提供引线本体，该引线本体具有绝缘部分，该绝缘部分限定沿着绝缘部分延伸的中心管腔和沿着绝缘部分延伸并且布置在中心管腔周围和外部的导体管腔。引线体还包括位于引线主体的轴向端部的导电触点和导体布线，导体布线设置在导体腔内的一个内，并且每个导体流明具有布置在其中的至少一个导线。在提供引线体之后，导电地将至少一根导线连接到每个导电触头; 以及将非导电材料放置在所述引线体的导体腔中的至少一个的一部分中。导体内腔的一部分和非导电材料的至少一部分径向设置在导电触头下方。

6. 发明授权

US08364279B2 Electrical stimulation leads having RF compatibility and methods of use and manufacture 有权
公开(公告)号：US08364279B2
公开(公告)日：2013-01-29
申请号：US12238039
申请日：2008-09-25
申请人： Matthew Lee McDonald , Anne M. Pianca
发明人： Matthew Lee McDonald , Anne M. Pianca
IPC分类号： A61N1/00
CPC分类号： A61N1/36128 , A61N1/0551 , A61N1/086 , A61N1/3718
摘要： A neurostimulation lead or lead extension includes a lead body having a proximal end and a distal end. A plurality of first contacts are disposed on the distal end of the lead body. A plurality of second contacts are disposed on a proximal end of the lead body. A plurality of conductors extend along the lead body. Each of the plurality of conductors electrically couples at least one of the first contacts to at least one of the second contacts. At least one of the conductors includes at least one switch disposed along a length of the conductor. The at least one switch is configured and arranged to separate the conductor into a plurality of individual segments when the at least one switch is opened.

7. 发明授权

US07672734B2 Non-linear electrode array 失效
标题翻译：非线性电极阵列
公开(公告)号：US07672734B2
公开(公告)日：2010-03-02
申请号：US11396309
申请日：2006-03-31
申请人： Meredith L. Anderson , Anne M. Pianca
发明人： Meredith L. Anderson , Anne M. Pianca
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0529 , A61N1/0551 , A61N1/0553
摘要： A system for stimulation includes an implantable pulse generator, a lead, and conductors. The lead includes an array body disposed at a distal end of the lead and electrodes concentrically arranged on the array body. A center electrode may also be disposed on the array body. The electrodes may be arranged in more than one concentric ring. A method of using an implantable stimulator includes implanting an implantable stimulator and providing an electrical signal to at least one electrode of the implantable stimulator to stimulate a tissue. The electrical signal may be provided between diametrically opposed electrodes or between electrodes that are not diametrically opposed. If the implantable stimulator has a center electrode, the electrical signal may be provided between the center electrode and at least one concentrically arranged electrode.
摘要翻译：用于刺激的系统包括可植入脉冲发生器，引线和导体。引线包括设置在引线的远端的阵列体和同心地布置在阵列体上的电极。中心电极也可以设置在阵列体上。电极可以布置在多于一个的同心环中。使用可植入刺激器的方法包括植入可植入刺激器并且向可植入刺激器的至少一个电极提供电信号以刺激组织。电信号可以设置在直径相对的电极之间或不直径相对的电极之间。如果植入式刺激器具有中心电极，则可以在中心电极和至少一个同心布置的电极之间提供电信号。

8. 发明授权

US07313444B2 Self-anchoring coronary sinus lead 有权
标题翻译：自固定冠状动脉窦导联
公开(公告)号：US07313444B2
公开(公告)日：2007-12-25
申请号：US10081457
申请日：2002-02-21
申请人： Anne M. Pianca , Kevin L. Morgan , Gene A. Bornzin , Joseph J. Florio , David J. Vachon
发明人： Anne M. Pianca , Kevin L. Morgan , Gene A. Bornzin , Joseph J. Florio , David J. Vachon
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N1/056 , A61N2001/0578 , A61N2001/0585
摘要： An implantable cardiac lead system suitable for placement in the coronary sinus region of the heart. The lead system comprises a lead having two or more non-helical bends in its distal portion. The two or more non-helical bends cooperate to prevent the lead from dislodgment or displacement inside the coronary sinus. The lead system may further comprise a stylet suitable for steering the lead into at least one of the coronary sinus vein, great cardiac vein, left marginal vein, left posterior ventricular vein, and small cardiac vein. The stylet is tapered in its distal portion to provide enhanced maneuverability and steerability inside the coronary sinus region. The lead system may also comprise an introducer which aids in introducing the lead into the heart.
摘要翻译：适用于放置在心脏冠状静脉窦区域的可植入心脏引导系统。引导系统包括在其远端部分中具有两个或多个非螺旋形弯曲部的引线。两个或更多个非螺旋形弯曲合作以防止铅在冠状窦内发生移位或移位。引导系统还可以包括适于将引线引导到冠状静脉窦静脉，大心静脉，左边缘静脉，左后脑室静脉和小心静脉中的至少一个的探针。探针在其远端部分逐渐变细，以在冠状窦区域内提供增强的机动性和可操纵性。引导系统还可以包括有助于将引入引入心脏的导引器。

9. 发明授权

US06466821B1 AC/DC multi-axis accelerometer for determining patient activity and body position 失效
标题翻译：用于确定患者活动和身体位置的AC / DC多轴加速度计
公开(公告)号：US06466821B1
公开(公告)日：2002-10-15
申请号：US09457451
申请日：1999-12-08
申请人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
发明人： Anne M. Pianca , Gene A. Bornzin , Euljoon Park , Joseph J. Florio , Alan B. Vogel , Lee Jay Mandell , Junyu Mai
IPC分类号： A61N1362
CPC分类号： A61N1/36542
摘要： An implantable cardiac stimulation device which determines stimulation based upon the patient's body position and activity level while eliminating special implantation or calibration procedures. To eliminate such special implantation and calibration procedures, the stimulation device correlates the patient's body position using a multi-axis DC accelerometer or other sensor during times of high activity and determines a patient's standing position value. During other times, the stimulation device compares the signals from the accelerometer to the standing position value to determine the patient's current body position. Based upon the current body position and the activity level, the stimulation device determines the necessary stimulation to deliver to the patient.
摘要翻译：一种可植入心脏刺激装置，其基于患者的身体位置和活动水平确定刺激，同时消除特殊植入或校准过程。为了消除这种特殊的植入和校准过程，刺激装置在高活动时间期间使用多轴DC加速度计或其他传感器来关联患者的身体位置并且确定患者的站立位置值。在其他时间，刺激装置将来自加速度计的信号与站立位置值进行比较，以确定患者的当前身体位置。基于当前身体位置和活动水平，刺激装置确定必要的刺激以递送给患者。

10. 发明申请

US20130023972A1 ELECTRODE ARRAY ASSEMBLY AND METHOD OF MAKING SAME 有权
标题翻译：电极阵列组件及其制造方法
公开(公告)号：US20130023972A1
公开(公告)日：2013-01-24
申请号：US13620099
申请日：2012-09-14
申请人： Janusz A. Kuzma , Anne M. Pianca
发明人： Janusz A. Kuzma , Anne M. Pianca
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/0553 , Y10T29/49117 , Y10T29/49204 , Y10T29/49208 , Y10T29/4922
摘要： A lead assembly and a method of making a lead are provided. The method of making a multi-contact lead assembly comprises placing monofilament placed in the void spaces not occupied by the plurality of conductor wires and, in one embodiment, thermally fusing the monofilament to the like material spacer by applying heat just below the melting temperature of the monofilament and spacer material. Alternatively, the monofilament and spacer may be of different materials and heat is applied to cause at least one material to thermally reflow or melt. The conductive contacts may be located at either the distal end and/or proximal end of the lead. Oversized spacers may be used in order to provide extra material to fill voids during the thermal fusion/reflow process.
摘要翻译：提供引线组件和引线的方法。制造多接触引线组件的方法包括放置放置在未被多根导线占据的空隙空间中的单丝，并且在一个实施例中，通过施加刚好低于熔融温度单丝和间隔材料。或者，单丝和间隔件可以是不同的材料，并且施加热量以使至少一种材料热回流或熔化。导电触点可以位于引线的远端和/或近端处。可以使用超大间隔物，以便在热熔/回流过程期间提供额外的材料以填充空隙。

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