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1. 发明申请

US20060205672A1 Novel peptides as NS3-serine protease inhibitors of hepatitis C virus 审中-公开
公开(公告)号：US20060205672A1
公开(公告)日：2006-09-14
申请号：US11241656
申请日：2005-09-30
申请人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
IPC分类号： A61K38/05 , C07K5/06
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

2. 发明申请

US20070032433A1 Novel peptides as NS3-serine protease inhibitors of hepatitis C virus 有权
标题翻译：新型肽作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂
公开(公告)号：US20070032433A1
公开(公告)日：2007-02-08
申请号：US10052386
申请日：2002-01-18
申请人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping Mc Cormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse Wong , Latha Nair
发明人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping Mc Cormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse Wong , Latha Nair
IPC分类号： A61K38/06 , A61K38/04 , C07K17/00 , C07K16/00 , C07K7/00 , C07K5/00 , A61K38/00
CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译：本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

3. 发明申请

US20050176648A1 Novel peptides as NS3-serine protease inhibitors of hepatitis C virus 有权
标题翻译：新型肽作为丙型肝炎病毒的NS3-丝氨酸蛋白酶抑制剂
公开(公告)号：US20050176648A1
公开(公告)日：2005-08-11
申请号：US11089192
申请日：2005-03-24
申请人： Anil Saksena , Viyyoor Girijavallabhan , Stephane Bogen , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Yi-Tsung Liu , Tin-Yau Chan , Zhaoning Zhu , Ashok Arasappan , Kevin Chen , Srikanth Venkatraman , Tejal Parekh , Patrick Pinto , Bama Santhanam , F. Njoroge , Ashit Ganguly , Henry Vaccaro , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura
发明人： Anil Saksena , Viyyoor Girijavallabhan , Stephane Bogen , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Yi-Tsung Liu , Tin-Yau Chan , Zhaoning Zhu , Ashok Arasappan , Kevin Chen , Srikanth Venkatraman , Tejal Parekh , Patrick Pinto , Bama Santhanam , F. Njoroge , Ashit Ganguly , Henry Vaccaro , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura
IPC分类号： C12N9/99 , A61K31/16 , A61K31/195 , A61K31/27 , A61K31/357 , A61K31/385 , A61K31/403 , A61K31/4164 , A61K31/445 , A61K31/7052 , A61K38/00 , A61K38/05 , A61K38/21 , A61K38/55 , A61K45/00 , A61P1/16 , A61P31/12 , A61P31/14 , A61P43/00 , C07C205/51 , C07C229/00 , C07D209/02 , C07K5/02 , C07K5/103 , C07K7/02 , C07K7/04 , C07K7/06 , A61K38/06 , A61K31/165 , A61K38/08
CPC分类号： C07K7/06 , A61K31/16 , A61K31/195 , A61K31/27 , A61K31/357 , A61K31/385 , A61K31/403 , A61K31/4164 , A61K31/445 , A61K38/05 , C07C205/51 , C07K5/101 , C07K7/02 , A61K2300/00
摘要： The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译：本发明公开了具有HCV蛋白酶抑制活性的新型肽化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

4. 发明申请

US20060122240A1 Benzotriazoles and methods of prophylaxis or treatment of metabolic-related disorders thereof 审中-公开
标题翻译：苯并三唑及其代谢相关疾病的预防或治疗方法
公开(公告)号：US20060122240A1
公开(公告)日：2006-06-08
申请号：US10533799
申请日：2003-11-04
申请人： Graeme Semple , Philip Skinner , Martin Cherrier , Peter Webb , Susan Tamura
发明人： Graeme Semple , Philip Skinner , Martin Cherrier , Peter Webb , Susan Tamura
IPC分类号： C07D249/16 , A61K31/4192
CPC分类号： C07D405/06 , A61K31/4192 , C07D249/18
摘要： The present invention relates to certain benzotriazole carboxylic acid or ester derivatives of Formula (I), pharmaceutically acceptable salts and solvates thereof, which exhibit useful pharmaceutical properties, for example, as agonists for the GPCR referred to as hRUP38. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the prophylaxis or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of -glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.
摘要翻译：本发明涉及一些表现出有用的药物性质的式（I）的苯并三唑羧酸或酯衍生物，其药学上可接受的盐和溶剂化物，例如被称为hRUP38的GPCR的激动剂。本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物预防或治疗代谢相关疾病（包括血脂异常，动脉粥样硬化，冠心病，胰岛素抵抗，类型 2型糖尿病，综合征X等。此外，本发明还提供本发明化合物与其它活性剂如属于葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成抑制剂，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂等。

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