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1. 发明申请

US20120220986A1 DEVICES AND METHODS FOR INTRAORAL CONTROLLED DRUG RELEASE 有权
标题翻译：用于内部控制药物释放的装置和方法
公开(公告)号：US20120220986A1
公开(公告)日：2012-08-30
申请号：US13406514
申请日：2012-02-27
申请人： Andy Wolff , Ben Z Beiski , Simon Herrlich , Axel Schumacher , Sven Spieth , Stephan Messner , Rachid Nouna
发明人： Andy Wolff , Ben Z Beiski , Simon Herrlich , Axel Schumacher , Sven Spieth , Stephan Messner , Rachid Nouna
IPC分类号： A61M37/00
CPC分类号： A61C19/06 , A61C5/70 , A61C13/00 , A61M31/002 , B33Y70/00 , B33Y80/00
摘要： Embodiments of the invention disclose a system for controlled oral drug delivery. The system comprising a removable device comprising a drug to be delivered, wherein the drug is delivered based on osmotic pressure generated in the removable device. Further, the system comprises a receptacle to hold the removable device in an oral cavity, and a base station configured to dock the removable device for determining information about one or more characteristics of the removable device.
摘要翻译：本发明的实施方案公开了一种用于受控口服药物递送的系统。该系统包括可移除装置，其包括待递送的药物，其中基于在可移除装置中产生的渗透压输送药物。此外，该系统包括用于将可移除装置保持在口腔中的插座，以及被配置为对准可移除装置以确定关于可移除装置的一个或多个特性的信息的基站。

2. 发明授权

US08715269B2 Devices and methods for intraoral controlled drug release 有权
标题翻译：口服药物释放的装置和方法
公开(公告)号：US08715269B2
公开(公告)日：2014-05-06
申请号：US13406514
申请日：2012-02-27
申请人： Andy Wolff , Ben Z Beiski , Simon Herrlich , Axel Schumacher , Sven Spieth , Stephan Messner , Rachid Nouna
发明人： Andy Wolff , Ben Z Beiski , Simon Herrlich , Axel Schumacher , Sven Spieth , Stephan Messner , Rachid Nouna
IPC分类号： A61K9/22 , A61M37/00 , A61C17/00 , A61C17/02 , A61G17/02 , A61C5/00
CPC分类号： A61C19/06 , A61C5/70 , A61C13/00 , A61M31/002 , B33Y70/00 , B33Y80/00
摘要： Embodiments of the invention disclose a system for controlled oral drug delivery. The system comprising a removable device comprising a drug to be delivered, wherein the drug is delivered based on osmotic pressure generated in the removable device. Further, the system comprises a receptacle to hold the removable device in an oral cavity, and a base station configured to dock the removable device for determining information about one or more characteristics of the removable device.
摘要翻译：本发明的实施方案公开了一种用于受控口服药物递送的系统。该系统包括可移除装置，其包括待递送的药物，其中基于在可移除装置中产生的渗透压输送药物。此外，该系统包括用于将可移除装置保持在口腔中的插座，以及被配置为对准可移除装置以确定关于可移除装置的一个或多个特性的信息的基站。

3. 发明授权

US5050616A Universal collector for submandibular-sublingual saliva 失效
标题翻译：颌下舌下唾液的通用收集器
公开(公告)号：US5050616A
公开(公告)日：1991-09-24
申请号：US493538
申请日：1990-03-14
申请人： Andy Wolff , Ronald L. Davis
发明人： Andy Wolff , Ronald L. Davis
IPC分类号： A61B10/00 , A61M1/00
CPC分类号： A61M1/0001 , A61B10/0051 , A61M1/0047 , A61M2202/0466
摘要： A fluid sampling device for sampling and collecting biological fluids from membrane bounded areas of a subject includes a buffering chamber to which a vacuum is applied, a sampling tube connector, a storage tube connector and a vent. In operation the vent is closed to apply the vacuum to a sampling tube connected to the sample tube connector to draw a sample into the buffering chamber. The drawn fluid flows under gravitational force into a storage tube attached to the storage tube connector. The device is particularly useful for sampling and collecting submandibular and sublingual saliva.
摘要翻译：用于从受试者的膜界限区域取样和收集生物流体的流体取样装置包括：施加真空的缓冲室，取样管连接器，储存管连接器和排气口。在操作中，通风口关闭，以将真空施加到连接到样品管连接器的采样管上，以将样品吸入缓冲室。抽出的流体在重力作用下流入连接到储存管连接器的储存管。该装置对采集和收集颌下和舌下唾液特别有用。

4. 发明申请

US20190336762A1 SYSTEM FOR THE TREATMENT OF DRY MOUTH USING ELECTRICAL STIMULATION OF THE SALIVARY GLANDS 审中-公开
公开(公告)号：US20190336762A1
公开(公告)日：2019-11-07
申请号：US16404135
申请日：2019-05-06
申请人： Luis Miguel Ramírez Aristeguieta , Ben Zion Beiski , Diego José Luis Botia Valderrama , Andy Wolff , Jonathan Gallego Londoño , Luis Gabriel Lafaurie Ponce , Juan Felipe Ospina Mejía , Daniel Felipe Salazar Ramírez
发明人： Luis Miguel Ramírez Aristeguieta , Ben Zion Beiski , Diego José Luis Botia Valderrama , Andy Wolff , Jonathan Gallego Londoño , Luis Gabriel Lafaurie Ponce , Juan Felipe Ospina Mejía , Daniel Felipe Salazar Ramírez
IPC分类号： A61N1/36
摘要： A system for electrical stimulation of the salivary glands for the treatment of dry mouth is disclosed. In one embodiment, the system includes a headset with an electronic control module, placed on the back head, and a stimulating module, placed on the area to be stimulated. Both modules are connected by an elastic arm. The stimulating module provides one or more pairs of electrodes in contact with neuro-sensitive areas of a patient, and is anchored in the ear canal. The position of the electrodes is adjustable for optimized stimulation. The system may be operated by control bottoms that are part of the electronic control module or by a mobile device, such as a wireless remote control, a smartphone, or a tablet. A mobile device camera may be used for correcting the placement of the electrodes.

5. 发明申请

US20100312311A1 DEVICE AND METHOD FOR STIMULATING SALIVATION 审中-公开
标题翻译：用于刺激消化的装置和方法
公开(公告)号：US20100312311A1
公开(公告)日：2010-12-09
申请号：US12795421
申请日：2010-06-07
申请人： Andy Wolff , Ben Zion Beiski
发明人： Andy Wolff , Ben Zion Beiski
IPC分类号： A61N1/00
CPC分类号： A61N1/36014 , A61N1/0548
摘要： Embodiments of the invention provide a reusable intra-oral device for treating xerostomia. The device having a structure adaptable for oral cavities of multiple users. The hermitically sealed housing comprises of an electronic module having a signal generator configured to generate electrical signals based on one or more values of one or more predefined parameters. Further, the device comprises of electrodes connected to the electronic module. The electrodes are configured to apply the electric signals for stimulating lingual nerves in the oral cavities to induce salivation.
摘要翻译：本发明的实施例提供了一种用于治疗口腔干燥症的可重复使用的口腔内装置。该装置具有适用于多个使用者的口腔的结构。密封壳体包括具有信号发生器的电子模块，该信号发生器被配置为基于一个或多个预定义参数的一个或多个值产生电信号。此外，该装置包括连接到电子模块的电极。电极被配置为施加用于刺激口腔中的舌神经的电信号以诱导唾液分泌。

6. 发明申请

US20090210032A1 MANUFACTURING METHODS, TESTING METHODS, AND TESTERS FOR INTRA-ORAL ELECTRONICALLY EMBEDDED DEVICES 审中-公开
标题翻译：内部电子嵌入式器件的制造方法，测试方法和测试
公开(公告)号：US20090210032A1
公开(公告)日：2009-08-20
申请号：US11572527
申请日：2005-07-20
申请人： Ben Zion Beiski , Andy Wolff
发明人： Ben Zion Beiski , Andy Wolff
IPC分类号： A61N1/08 , B29C39/02 , A61N1/36 , G06F19/00
CPC分类号： A61N1/0548 , A61F5/56 , A61N1/3601 , A61N1/36014 , Y02A90/26
摘要： The invention is directed to manufacturing and testing methods of electronic intraoral devices for diagnose, monitor and treat local and systemic diseases and conditions for humans and animals. More specifically, the current invention deals with manufacturing techniques, testing methods and a testing apparatus of mainly three types of intra-oral devices: (a) electro-stimulators for various applications such as treatment of dry mouth by stimulating saliva secretion, apnea, sleeping disorders, eating disorders (obesity, anorexia, etc.) dysphagia and others, (b) drug delivery devices; and (c) bio-sensing and monitoring devices. The common parts or the devices are: (1) art electronic module embedded in the device: (2) or a power source being embedded in the device; (3) the devices (or part of them) being placed in the oral cavity.
摘要翻译：本发明涉及用于诊断，监测和治疗人和动物的局部和全身疾病和病症的电子口腔内装置的制造和测试方法。更具体地说，本发明涉及三种类型的口腔内装置的制造技术，测试方法和测试装置：（a）用于各种应用的电刺激剂，例如通过刺激唾液分泌来治疗口干，呼吸暂停，睡眠障碍，饮食失调（肥胖，厌食等）吞咽困难等，（b）药物输送装置; 和（c）生物传感和监测装置。公共部件或设备是：（1）嵌入设备中的艺术电子模块：（2）或嵌入在设备中的电源; （3）装置（或其中的一部分）放置在口腔中。

7. 发明申请

US20070106138A1 Intraoral apparatus for non-invasive blood and saliva monitoring & sensing 审中-公开
标题翻译：用于非侵入性血液和唾液监测和感测的口腔内装置
公开(公告)号：US20070106138A1
公开(公告)日：2007-05-10
申请号：US11603897
申请日：2006-11-24
申请人： Ben Beiski , Andy Wolff
发明人： Ben Beiski , Andy Wolff
IPC分类号： A61B5/05 , A61B5/00 , A61B5/02
CPC分类号： A61B10/0051 , A61B5/682 , A61C8/0048 , A61C13/26 , A61C13/267
摘要： Controlled-specimen-sampling oral devices are described, implanted or inserted into an oral cavity, built onto a prosthetic tooth crown, a denture plate, braces, a dental implant, or the like. The devices are replaced as needed. The controlled specimen sampling may be passive, based on a dosage form, or electro-mechanically controlled, for a high-precision, intelligent, specimen sampling. Additionally, the controlled sampling may be any one of the following: sampling in accordance with a preprogrammed regimen, sampling at a controlled rate, delayed sampling, pulsatile sampling, chronotherapeutic sampling, closed-loop sampling, responsive to a sensor's input, sampling on demand from a personal extracorporeal system, sampling regimen specified by a personal extracorporeal system, sampling on demand from a monitoring center, via a personal extracorporeal system, and sampling regimen specified by a monitoring center, via a personal extracorporeal system. Specimen collection in the oral cavity may be assisted or induced by a transport mechanism, such as any one of, or a combination of iontophoresis, electroosmosis, electrophoresis, electroporation, sonophoresis, and ablation. The oral devices require replacement at relatively long intervals of weeks or months. The oral devices and methods for controlled specimen sampling apply to humans and animals.
摘要翻译：受控样本采集口腔装置被描述，植入或插入口腔中，内置于假牙齿冠，假牙板，支架，牙植入物等上。根据需要更换设备。受控样本采样可以是基于剂型或电机械控制的被动样品，用于高精度，智能的样品采样。此外，受控采样可以是以下任何一种：根据预编程方案进行采样，以受控速率采样，延迟采样，脉冲采样，定时采样，闭环采样，响应传感器输入，按需采样通过个人体外系统，通过个人体外系统指定的抽样方案，通过个人体外系统从监测中心抽样，以及由监测中心指定的抽样方案，通过个人体外系统。可以通过运输机制来辅助或诱导口腔中的标本收集，例如离子电渗疗法，电渗，电泳，电穿孔，超声波和消融中的任何一种或组合。口服装置需要以相对较长的周或数月进行更换。用于受控样本取样的口服装置和方法适用于人和动物。

8. 发明授权

US11969593B2 System for the treatment of dry mouth using electrical stimulation of the salivary glands 有权
公开(公告)号：US11969593B2
公开(公告)日：2024-04-30
申请号：US16404135
申请日：2019-05-06
申请人： Luis Miguel Ramírez Aristeguieta , Ben Zion Beiski , Diego José Luis Botia Valderrama , Andy Wolff , Jonathan Gallego Londoño , Luis Gabriel Lafaurie Ponce , Juan Felipe Ospina Mejía , Daniel Felipe Salazar Ramírez
发明人： Luis Miguel Ramírez Aristeguieta , Ben Zion Beiski , Diego José Luis Botia Valderrama , Andy Wolff , Jonathan Gallego Londoño , Luis Gabriel Lafaurie Ponce , Juan Felipe Ospina Mejía , Daniel Felipe Salazar Ramírez
IPC分类号： A61N1/36 , A61N1/04
CPC分类号： A61N1/36014 , A61N1/0456
摘要： A system for electrical stimulation of the salivary glands for the treatment of dry mouth is disclosed. In one embodiment, the system includes a headset with an electronic control module, placed on the back head, and a stimulating module, placed on the area to be stimulated. Both modules are connected by an elastic arm. The stimulating module provides one or more pairs of electrodes in contact with neuro-sensitive areas of a patient, and is anchored in the ear canal. The position of the electrodes is adjustable for optimized stimulation. The system may be operated by control bottoms that are part of the electronic control module or by a mobile device, such as a wireless remote control, a smartphone, or a tablet. A mobile device camera may be used for correcting the placement of the electrodes.

9. 发明授权

US09566432B2 Device and method for stimulating salivation 有权
标题翻译：刺激唾液分泌的装置和方法
公开(公告)号：US09566432B2
公开(公告)日：2017-02-14
申请号：US12795421
申请日：2010-06-07
申请人： Andy Wolff , Ben Zion Beiski
发明人： Andy Wolff , Ben Zion Beiski
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36014 , A61N1/0548
摘要： Embodiments of the invention provide a reusable intra-oral device for treating xerostomia. The device having a structure adaptable for oral cavities of multiple users. The hermitically sealed housing comprises of an electronic module having a signal generator configured to generate electrical signals based on one or more values of one or more predefined parameters. Further, the device comprises of electrodes connected to the electronic module. The electrodes are configured to apply the electric signals for stimulating lingual nerves in the oral cavities to induce salivation.
摘要翻译：本发明的实施例提供了一种用于治疗口腔干燥症的可重复使用的口腔内装置。该装置具有适用于多个使用者的口腔的结构。密封壳体包括具有信号发生器的电子模块，该信号发生器被配置为基于一个或多个预定义参数的一个或多个值产生电信号。此外，该装置包括连接到电子模块的电极。电极被配置为施加用于刺激口腔中的舌神经的电信号以诱导唾液分泌。

10. 发明授权

US09521973B1 Method of monitoring patients with mental and/or behavioral disorders using their personal mobile devices 有权
标题翻译：使用其个人移动设备监测精神和/或行为障碍患者的方法
公开(公告)号：US09521973B1
公开(公告)日：2016-12-20
申请号：US14624548
申请日：2015-02-17
申请人： Ben Beiski , Eytan Ofry , Andy Wolff
发明人： Ben Beiski , Eytan Ofry , Andy Wolff
IPC分类号： A61B5/00 , A61B5/16 , A61B5/0205 , A61B5/11 , A61B5/145 , A61B5/0476 , A61B5/0402 , A61B5/021 , A61B5/024
CPC分类号： A61B5/168 , A61B5/165 , A61B5/6898 , A61B5/7282
摘要： A monitoring system embodying a monitoring system embodying a method of this invention for monitoring predetermined patients with mental and/or behavioral disorders by accessing, analyzing and monitoring their measured input through a plurality of sensors inherent in most personal mobile devices is provided. The measured input may represents values attributed to at least one physical behavior of the patient that is representative of a symptom of at least one mental/behavior health condition. The measured input can be used to establish a baseline and thresholds thereof that separates the at least one physical behavior into normative from ab-normative behavior for each predetermined patient.
摘要翻译：提供了一种体现本发明方法的监测系统，用于通过访问，分析和监测其通过大多数个人移动设备中固有的多个传感器的测量输入来监测精神和/或行为障碍的预定患者。测量的输入可以表示归因于代表至少一个心理/行为健康状况的症状的患者的至少一个身体行为的值。所测量的输入可用于建立其基线和阈值，其将至少一个物理行为与每个预定患者的规范性行为分离为规范性。

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