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1. 发明授权

US08715269B2 Devices and methods for intraoral controlled drug release 有权
标题翻译：口服药物释放的装置和方法
公开(公告)号：US08715269B2
公开(公告)日：2014-05-06
申请号：US13406514
申请日：2012-02-27
申请人： Andy Wolff , Ben Z Beiski , Simon Herrlich , Axel Schumacher , Sven Spieth , Stephan Messner , Rachid Nouna
发明人： Andy Wolff , Ben Z Beiski , Simon Herrlich , Axel Schumacher , Sven Spieth , Stephan Messner , Rachid Nouna
IPC分类号： A61K9/22 , A61M37/00 , A61C17/00 , A61C17/02 , A61G17/02 , A61C5/00
CPC分类号： A61C19/06 , A61C5/70 , A61C13/00 , A61M31/002 , B33Y70/00 , B33Y80/00
摘要： Embodiments of the invention disclose a system for controlled oral drug delivery. The system comprising a removable device comprising a drug to be delivered, wherein the drug is delivered based on osmotic pressure generated in the removable device. Further, the system comprises a receptacle to hold the removable device in an oral cavity, and a base station configured to dock the removable device for determining information about one or more characteristics of the removable device.
摘要翻译：本发明的实施方案公开了一种用于受控口服药物递送的系统。该系统包括可移除装置，其包括待递送的药物，其中基于在可移除装置中产生的渗透压输送药物。此外，该系统包括用于将可移除装置保持在口腔中的插座，以及被配置为对准可移除装置以确定关于可移除装置的一个或多个特性的信息的基站。

2. 发明授权

US5927249A Electromotive adjustment device 失效
标题翻译：电动调节装置
公开(公告)号：US5927249A
公开(公告)日：1999-07-27
申请号：US985983
申请日：1997-12-05
申请人： Bernd Ackermann , Axel Schumacher
发明人： Bernd Ackermann , Axel Schumacher
IPC分类号： F02D9/02 , F02D11/10 , H01F7/14 , H02K26/00 , H02K33/02 , F16K31/08
CPC分类号： F02D11/10 , F02D11/107 , H01F7/14 , H02K26/00 , F02D2011/102
摘要： The invention relates to an electromotive adjustment device with a rotor (9) comprising a magnetized rotary body (8) and with a single-strand, electrically excitable U-shaped stator (11) whose legs (13, 14) form the pole shoes (26, 27) and whose yoke (15) interconnects the two legs (13, 14) and acts as a support for the exciter coil (16), the angular position of the rotor (9) being adjustable by means of the stator current, while the maximum range of the angle of rotation of the rotor is smaller than 180.degree.. Such adjustment devices can be used in particular for the adjustment of a throttle plate in the suction line of an internal combustion engine. To create such an electromotive adjustment device which can be manufactured by a simple technology with small dimensions and low weights, it is provided that the U-shaped stator (11) comprises at least three parts, in that the first part essentially forms the yoke (15) of the stator (11), in that the second and the third part essentially form the legs (13, 14) of the stator (11), and in that the first part (15) is made from an anisotropic material whose preferred direction is substantially aligned with the direction of the magnetic flux in the yoke (15).
摘要翻译：本发明涉及一种具有转子（9）的电动调节装置，转子（9）包括磁化旋转体（8）和具有单股，可电激发的U形定子（11），其腿部（13,14）形成极靴 26,27），并且其轭（15）将两个腿部（13,14）互连并且用作激励器线圈（16）的支撑件，转子（9）的角位置可通过定子电流调节，而转子旋转角度的最大范围小于180°。这种调节装置可以特别用于调节内燃机的吸入管路中的节流板。为了制造这样的电动调节装置，其可以通过具有小尺寸和低重量的简单技术制造，其中U形定子（11）包括至少三个部分，其中第一部分基本上形成轭定子（11）的第一部分（15）由于第二和第三部分基本上形成定子（11）的腿部（13,14），并且第一部分（15）由各向异性材料制成，方向基本上与磁轭（15）中的磁通量的方向一致。

3. 发明申请

US20080064030A1 Cpg-Amplicon and Array Protocol 有权
标题翻译： Cpg-Amplicon和Array Protocol
公开(公告)号：US20080064030A1
公开(公告)日：2008-03-13
申请号：US10598140
申请日：2005-02-18
申请人： Arturas Petronis , Axel Schumacher
发明人： Arturas Petronis , Axel Schumacher
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q2525/191 , C12Q2523/125 , C12Q2521/331
摘要： The invention can be summarized as follows. There is provided a method for amplifying hypomethylated genomic nucleotide sequences and/or hypermethylated genomic nucleotide sequences and comparing the methylation state between different samples, for example control and test samples. Also disclosed is a microarray based method for analysing hypo and/or hypermethylated genomic nucleotide sequence. Further, kits comprising reagents for practising the method are provided.
摘要翻译：本发明可概括如下。提供了用于扩增低甲基化基因组核苷酸序列和/或超甲基化基因组核苷酸序列并比较不同样品之间的甲基化状态的方法，例如对照和测试样品。还公开了用于分析低和/或超甲基化的基因组核苷酸序列的基于微阵列的方法。此外，提供了包含用于实施该方法的试剂的试剂盒。

4. 发明授权

US06929102B1 Method for actuating a wheel brake device 失效
标题翻译：用于致动车轮制动装置的方法
公开(公告)号：US06929102B1
公开(公告)日：2005-08-16
申请号：US10019269
申请日：2000-06-23
申请人： Axel Schumacher
发明人： Axel Schumacher
IPC分类号： B60T7/12 , B60T13/74 , F16D65/14 , F16D65/38
CPC分类号： B60T13/741 , B60T7/12
摘要： The invention relates to a method for actuating a wheel brake assembly, in particular an electromechanical wheel brake assembly (10) or a mechanical system involving friction and having spring elasticity. To increase a braking force once a quasi-static terminal state of the wheel brake assembly (10) is reached, the invention proposes actuating the wheel brake assembly (10) for a brief period of time in the release direction and then to re-tighten it; the period of time of the actuation in the release direction is selected to be so brief that the braking force is reduced, if at all, only imperceptibly.
摘要翻译：本发明涉及一种用于致动车轮制动器组件，特别是机电车轮制动器组件（10）或涉及摩擦并具有弹簧弹性的机械系统的方法。为了在达到车轮制动器组件（10）的准静态末端状态时增加制动力，本发明提出在释放方向上短时间内驱动车轮制动器组件（10），然后重新紧固它; 选择在释放方向上的致动的时间段是如此短暂的，使得制动力如果完全不可察觉地减小。

5. 发明授权

US06891345B2 Actuator with an electric motor 失效
标题翻译：带电动执行机构
公开(公告)号：US06891345B2
公开(公告)日：2005-05-10
申请号：US10311953
申请日：2001-05-22
申请人： Axel Schumacher
发明人： Axel Schumacher
IPC分类号： G05D3/12 , G05B19/25 , H02P6/08 , H02P7/00
CPC分类号： G05B19/255 , G05B2219/42093 , G05B2219/42228
摘要： An actuating drive including an electronically commutated electric motor which operates with a position-dependent summed torque and which, using a torque controller and a controlled system, is able to be adjusted to a selectable, torque-dependent setpoint value according to a continuously increasing torque-time characteristic curve. The torque controller is able to have supplied to it a torque-dependent actual value of the electric motor in addition to the set point value to derive a control signal. A positioning control is subordinate the torque control, the positioning control providing that the minima between the maxima of the summed torque are rapidly and reliably passed and the electric motor is stopped in the region of a maximum.
摘要翻译：一种致动驱动器，包括电子换向电动机，其以位置相关的相加转矩运行，并且使用转矩控制器和受控系统能够根据连续增加的转矩将其调节到可选择的与转矩相关的设定值时间特征曲线。除了设定值以外，转矩控制器能够向其提供电动机的与转矩相关的实际值，以得出控制信号。定位控制从属于转矩控制，定位控制使得总和转矩的最大值之间的最小值能够快速可靠地通过，电动机在最大范围内停止。

6. 发明申请

US20120220986A1 DEVICES AND METHODS FOR INTRAORAL CONTROLLED DRUG RELEASE 有权
标题翻译：用于内部控制药物释放的装置和方法
公开(公告)号：US20120220986A1
公开(公告)日：2012-08-30
申请号：US13406514
申请日：2012-02-27
申请人： Andy Wolff , Ben Z Beiski , Simon Herrlich , Axel Schumacher , Sven Spieth , Stephan Messner , Rachid Nouna
发明人： Andy Wolff , Ben Z Beiski , Simon Herrlich , Axel Schumacher , Sven Spieth , Stephan Messner , Rachid Nouna
IPC分类号： A61M37/00
CPC分类号： A61C19/06 , A61C5/70 , A61C13/00 , A61M31/002 , B33Y70/00 , B33Y80/00
摘要： Embodiments of the invention disclose a system for controlled oral drug delivery. The system comprising a removable device comprising a drug to be delivered, wherein the drug is delivered based on osmotic pressure generated in the removable device. Further, the system comprises a receptacle to hold the removable device in an oral cavity, and a base station configured to dock the removable device for determining information about one or more characteristics of the removable device.
摘要翻译：本发明的实施方案公开了一种用于受控口服药物递送的系统。该系统包括可移除装置，其包括待递送的药物，其中基于在可移除装置中产生的渗透压输送药物。此外，该系统包括用于将可移除装置保持在口腔中的插座，以及被配置为对准可移除装置以确定关于可移除装置的一个或多个特性的信息的基站。

7. 发明授权

US08043808B2 CpG-amplicon and array protocol 有权
标题翻译： CpG扩增子和阵列方案
公开(公告)号：US08043808B2
公开(公告)日：2011-10-25
申请号：US10598140
申请日：2005-02-18
申请人： Arturas Petronis , Axel Schumacher
发明人： Arturas Petronis , Axel Schumacher
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6858 , C12Q2525/191 , C12Q2523/125 , C12Q2521/331
摘要： The invention can be summarized as follows. There is provided a method for amplifying hypomethylated genomic nucleotide sequences and/or hypermethylated genomic nucleotide sequences and comparing the methylation state between different samples, for example control and test samples. Also disclosed is a microarray based method for analyzing hypo and/or hypermethylated genomic nucleotide sequence. Further, kits comprising reagents for practicing the method are provided.
摘要翻译：本发明可概括如下。提供了用于扩增低甲基化基因组核苷酸序列和/或超甲基化基因组核苷酸序列并比较不同样品之间的甲基化状态的方法，例如对照和测试样品。还公开了用于分析低和/或超甲基化的基因组核苷酸序列的基于微阵列的方法。此外，提供了包含用于实施该方法的试剂的试剂盒。

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