专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060131762A1 Method for metal-organic production of organic intermediate products by means of aryl lithium-bases 审中-公开
标题翻译：通过芳基锂基金属有机生产有机中间产物的方法
公开(公告)号：US20060131762A1
公开(公告)日：2006-06-22
申请号：US10526237
申请日：2003-08-21
申请人： Andreas Meudt , Bernd Lehnemann , Michael Erbes , Klaus Forstinger
发明人： Andreas Meudt , Bernd Lehnemann , Michael Erbes , Klaus Forstinger
IPC分类号： C07D333/22 , C07D213/63 , C07F1/02
CPC分类号： C07F5/025
摘要： The invention relates to a method for the production of substituted aromatic compounds by producing lithium arylene and by reacting it with suitable electrophiles. The method comprises the following steps (step 1); an aryl lithium compound ( auxiliary base”) is initially produced by reacting a halogen aromatic compound with lithium metal; said compound is subsequently (step 2) reacted for deprotonation of the aromatic substrate in order to form the corresponding lithium aromatic compound which is subsequently (step 3) reacted with a corresponding electrophile to form the desired substituted aromatic compound, see page 2 of the description.
摘要翻译：本发明涉及通过生产锂亚芳基并通过与合适的亲电体反应来制备取代的芳族化合物的方法。该方法包括以下步骤（步骤1）; 最初通过卤素芳族化合物与锂金属反应制备芳基锂化合物（辅助碱“）;随后（步骤2）使所述化合物反应进行芳族底物的去质子化，以形成相应的锂芳族化合物，随后（步骤3）与相应的亲电子试剂反应以形成所需的取代的芳族化合物，参见说明书的第2页。

2. 发明申请

US20050258553A1 Method for the organometallic production of organic intermediate products comprising carbon-heteroatom bonds achieved by the deprotonation of heteroatoms 审中-公开
标题翻译：通过杂原子脱质子实现的包含碳 - 杂原子键的有机中间产物的有机金属生产方法
公开(公告)号：US20050258553A1
公开(公告)日：2005-11-24
申请号：US10526327
申请日：2003-08-21
申请人： Andreas Meudt , Bernd Lehnemann , Michael Erbes , Klaus Forstinger
发明人： Andreas Meudt , Bernd Lehnemann , Michael Erbes , Klaus Forstinger
IPC分类号： C07B41/00 , C07B43/00 , C07B61/00 , C07C249/16 , C07C251/86 , C07C269/04 , C07C271/28 , C07C281/04 , C07C303/40 , C07C311/53 , C07C319/14 , C07C321/14 , C07D307/42 , C07F9/02 , C07F1/02
CPC分类号： C07D307/42 , C07B41/00 , C07B43/00 , C07C249/16 , C07C269/04 , C07C303/40 , C07C319/14 , C07C321/14 , C07C311/53 , C07C271/28 , C07C251/86
摘要： The invention relates to a method for binding heteroatom-carbon bonds. According to said method, a lithium compound (II) is first generated by reacting aliphatic or aromatic halogen compounds (I) with lithium metal, said compound is then used for the deprotonation of the compounds (III) or (V). The lithium salts of formulas (IV) or (VI) obtained by said deprotonation are subsequently reacted with suitable carbon electrophiles (equation I), said process binding the heteroatom-carbon bond and forming the products (VIII) or (VIII), (equation I).
摘要翻译：本发明涉及一种结合杂原子 - 碳键的方法。根据所述方法，首先通过使脂族或芳族卤素化合物（I）与锂金属反应生成锂化合物（II），然后将所述化合物用于化合物（III）或（V）的去质子化。随后通过所述去质子化获得的式（Ⅳ）或（Ⅵ）的锂盐与合适的碳亲电子（式I）反应，所述方法结合杂原子 - 碳键并形成产物（Ⅷ）或（Ⅷ），一世）。

3. 发明授权

US06657093B2 Preparation of substituted aromatic compounds 有权
标题翻译：取代芳族化合物的制备
公开(公告)号：US06657093B2
公开(公告)日：2003-12-02
申请号：US10171444
申请日：2002-06-13
申请人： Andreas Meudt , Michael Erbes , Klaus Forstinger
发明人： Andreas Meudt , Michael Erbes , Klaus Forstinger
IPC分类号： C07B3704
CPC分类号： C07D307/12 , C07B37/04 , C07C1/26 , C07C41/16 , C07C41/26 , C07C41/30 , C07C45/59 , C07C45/68 , C07C319/20 , C07D213/50 , C07C15/44 , C07C323/22 , C07C43/23 , C07C43/205
摘要： A process for preparing compounds of the formula (II), where the substituents R1 to R5 are each independently H, CH3, straight-chain or branched C1-C8-alkyl, CH(OC1-C5-alkyl)2, CH(C1-C5-alkyl)(OC1-C5-alkyl), CH2(OC1-C5-alkyl), CH(CH3)(OC1-C5-alkyl), C1-C8-alkoxy, N(C1-C5-alkyl)2, phenyl, substituted phenyl, aryl, heteroaryl, S(C1-C5-alkyl) or a radical Caryl, alkyl, and the symbols X1 to 5 are each carbon.
摘要翻译：一种制备式（II）化合物的方法，其中取代基R 1至R 5各自独立地为H，CH 3，直链或支链C 1 -C 8 - 烷基，CH（OC 1 -C 5 - 烷基） 2，CH（C1-C5-烷基）（OC1-C5-烷基），CH2（OC1-C5-烷基），CH（CH3）（OC1-C5-烷基），C1-C8-烷氧基，N（C1-C5 - 烷基）2，苯基，取代的苯基，芳基，杂芳基，S（C 1 -C 5 - 烷基）或基团羧基，烷基，符号X 1至5>各自为碳。

4. 发明授权

US07022857B2 Preparation of substituted aromatic compounds 失效
标题翻译：取代芳族化合物的制备
公开(公告)号：US07022857B2
公开(公告)日：2006-04-04
申请号：US10677412
申请日：2003-10-02
申请人： Andreas Meudt , Michael Erbes , Klaus Forstinger
发明人： Andreas Meudt , Michael Erbes , Klaus Forstinger
IPC分类号： C07D213/02
CPC分类号： C07D307/12 , C07B37/04 , C07C1/26 , C07C41/16 , C07C41/26 , C07C41/30 , C07C45/59 , C07C45/68 , C07C319/20 , C07D213/50 , C07C15/44 , C07C323/22 , C07C43/23 , C07C43/205
摘要： A process for preparing compounds of the formula (II), where the substituents R1 to R5 are each independently H, CH3, straight-chain or branched C1–C8-alkyl, CH(OC1–C5-alkyl)2, CH(C1–C5-alkyl)(OC1–C5-alkyl), CH2(OC1–C5-alkyl), CH(CH3)(OC1–C5-alkyl), C1–C8-alkoxy, N(C1–C5-alkyl)2, phenyl, substituted phenyl, aryl, heteroaryl, S(C1–C5-alkyl) or a radical Caryl, alkyl, and the symbols X1 to 5 are each carbon or a maximum of two neighboring X1-5 are nitrogen or X1R1 and X2R2 together are O, NH, N(C1–C5-alkyl), N(C═O—C1–C5-alkyl), N(SiR3)2 or S, or where neighboring radicals R1 to R5 form the following structural unit, where X6 to X9 and R6 to R9 have the same meaning as X1 to X5 and R1 to R5 which comprises reacting chloro- or fluoroaromatics of the formula (I) with carbon electrophiles and lithium metal.
摘要翻译：制备式（II）化合物的方法，其中取代基R 1至R 5各自独立地为H，CH 3，直链链或支链C 1 -C 8 - 烷基，CH（OC 1 -C 5 - 烷基） CH 2（C 1 -C 5 - 烷基）（OC 1 -C 5 - 烷基）（OC 1 -C 5 - 烷基） CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH 2 CH（CH 3 CH 3））（OC 1 -C 5 - 烷基），C 1 -C 8 - 烷氧基，N（ C 1 -C 5烷基）2，苯基，取代的苯基，芳基，杂芳基，S（C 1 -C 12烷基） C 1 -C 5 - 烷基）或基团C 1 -C 6烷基，符号X 1至5各自为碳或最大为两个相邻的X 1-5是氮或X 1 R 1和X 2 R 2， O，NH，N（C 1 -C 5 - 烷基），N（C 1 -C 5 - 烷基），N（C 1 -C 5 - 5个 - 烷基），N（SiR 3 N）2 S或S，或其中相邻基团R 0 > 1 至R 5形成以下结构单元，其中X 6至X 9和R 6，与R 9相同的含义与X 1至X 5和R 1至R 0的含义相同。其包括使式（I）的氯代或氟代芳族化合物与碳亲电体和锂金属反应。

5. 发明申请

US20050001333A1 Method for producing, via organometallic compounds, organic intermediate products 审中-公开
标题翻译：通过有机金属化合物生产有机中间体产品的方法
公开(公告)号：US20050001333A1
公开(公告)日：2005-01-06
申请号：US10491967
申请日：2002-10-02
申请人： Detlef Wehle , Klaus Forstinger , Andreas Meudt
发明人： Detlef Wehle , Klaus Forstinger , Andreas Meudt
IPC分类号： C07B61/00 , C07C45/00 , C07C45/45 , C07C51/15 , C07F1/02
CPC分类号： C07F1/02 , C07C45/00 , C07C45/45 , C07C51/15 , C07C49/80 , C07C63/70 , C07C63/06
摘要： The present invention provides a process for preparing aryllithium compounds by reacting haloaliphatics with lithium metal to form a lithium alkyl and reacting the lithium alkyl with aromatic halogen compounds of formula (III) in a halogen-metal exchange reaction to form the corresponding lithium aromatics of formula (IV).
摘要翻译：本发明提供了一种通过卤代色谱与锂金属反应形成烷基锂并通过卤代 - 金属交换反应将烷基锂与芳族卤化物（III）卤化物反应形成相应的式（四）。

6. 发明申请

US20080188671A1 Method for Producing 2-Formylfuran-4-Boronic Acid by the Metalation of 4-Halofurfural Acetals in the Presence of Suitable Boronic Acid Esters or Anhydrides 审中-公开
标题翻译：在合适的硼酸酯或酸酐存在下通过4-卤代呋喃醛缩合生产2-甲基呋喃-4-硼酸的方法
公开(公告)号：US20080188671A1
公开(公告)日：2008-08-07
申请号：US11912157
申请日：2006-05-10
申请人： Andreas Meudt , Sven Nerdinger , Michael Erbes , William Vogt
发明人： Andreas Meudt , Sven Nerdinger , Michael Erbes , William Vogt
IPC分类号： C07F5/02
CPC分类号： C07F5/025
摘要： Methods for producing furfural-4-boronic acid by the reaction of furfural acetals (I), which are substituted by halogen in position 4, with boronic acid esters or anhydrides, by the subsequent metalation of compound (I) and the simultaneous or subsequent reaction with a boronic acid ester or anhydride to form an acetal-protected furfural-4-boronic acid ester. This product is subjected to acid hydrolysis to form furfural-4-boronic acid. In the formulae: X represents chlorine, bromine or iodine; R represents a branched, unbranched and/or cyclic, optionally substituted C1-C20 alkyl group, an optionally substituted C6-C12 aryl group or an optionally substituted C3-C8 cycloalkyl group, the two groups R together can form a ring; R′, R″, R′″ independently of one another represent acylic or cyclic, branched or unbranched, optionally substituted C1-C20 alkyl groups, or optionally substituted aryl groups, optionally two of the groups R′, R″ and R′″ together form a ring, or represent additional groups B(OR)3.
摘要翻译：通过随后的化合物（I）的金属化和通过化合物（I）的金属化以及同时或随后的反应，通过由位置4的卤素取代的糠醛缩醛（I）与硼酸酯或酸酐反应制备糠醛-4-硼酸的方法与硼酸酯或酸酐形成缩醛保护的糠醛-4-硼酸酯。将该产物进行酸水解形成糠醛-4-硼酸。式中X表示氯，溴或碘; R表示支链，非支链和/或环状的任选取代的C 1 -C 20烷基，任选取代的C 6 -C 20烷基，芳基或任选取代的C 3 -C 8环烷基，两个基团R一起可以形成环; R'，R“，R”'彼此独立地表示酰基或环状，支链或非支链的任选取代的C 1 -C 20烷基，或任选地取代的芳基，任选地两个基团R'，R“和R”'一起形成环，或代表另外的基团B（OR）3。

7. 发明授权

US06265607B1 Process for the preparation of 4-(4'-chlorobiphenyl-4-yl)-4-keto-2-methylenebutyric acid 失效
标题翻译：制备4-（4'-氯联苯-4-基）-4-酮-2-亚甲基丁酸的方法
公开(公告)号：US06265607B1
公开(公告)日：2001-07-24
申请号：US09366472
申请日：1999-08-03
申请人： Andreas Meudt , Wilfried Pressler , Antje Noerenberg , Steffen Haber , Michael Erbes , Robert Cosmo
发明人： Andreas Meudt , Wilfried Pressler , Antje Noerenberg , Steffen Haber , Michael Erbes , Robert Cosmo
IPC分类号： C07L5974
CPC分类号： C07C51/353 , C07C59/88
摘要： The invention relates to a process for the preparation of 4-(4′-chlorobiphenyl-4-yl)-4-keto-2-methylenebutyric acid of the formula (I) by Friedel-Crafts acylation of 4-chlorbiphenly with itaconic anhydride, which comprises carrying out the Friedel-Crafts acylation in aromatic solvents at a temperature from −20 to +80° C.
摘要翻译：本发明涉及通过Friedel-Crafts酰化4-氯乙烯与衣康酸酐制备式（I）的4-（4'-氯联苯-4-基）-4-酮-2-亚甲基丁酸的方法，其包括在-20至+ 80℃的温度下在芳族溶剂中进行Friedel-Crafts酰化。

8. 发明授权

US06833470B2 Method for producing formylphenylboronic acids 有权
公开(公告)号：US06833470B2
公开(公告)日：2004-12-21
申请号：US10433827
申请日：2003-06-05
申请人： Andreas Meudt , Stefan Scherer , Frank Vollmueller , Michael Erbes
发明人： Andreas Meudt , Stefan Scherer , Frank Vollmueller , Michael Erbes
IPC分类号： C07F502
CPC分类号： C07F5/025
摘要： A process for preparing formylphenylboronic acids of the formula (I) by reaction of protected chlorobenzaldehydes of the formula (II) with lithium in an inert solvent to form compounds of the formula (III) and subsequent reaction with a boron compound of the formula BY3 to give compounds of the formula (I).

9. 发明授权

US08598386B2 Process for producing lacosamide 有权
标题翻译：制备漆酶的方法
公开(公告)号：US08598386B2
公开(公告)日：2013-12-03
申请号：US13274718
申请日：2011-10-17
申请人： Richard Wisdom , Joerg Jung , Andreas Meudt
发明人： Richard Wisdom , Joerg Jung , Andreas Meudt
IPC分类号： C07C231/02 , C07C231/12 , C07C231/14 , C07C269/06
CPC分类号： C07C231/12 , C07B2200/07 , C07C231/14 , C07C231/18 , C07C269/06 , C07C237/22 , C07C271/22
摘要： The present invention relates to a method for producing (R)-2-acetamido-N-benzyl-3-methoxypropionamide (lacosamide), by methylation of (R)-2-acetamino-2-N-benzyl-3-hydroxy-propionamide (V), in which the methylation is carried out at a temperature below 20° C.
摘要翻译：本发明涉及通过（R）-2-乙酰氨基-2-N-苄基-3-羟基 - 丙酰胺的甲基化制备（R）-2-乙酰氨基-N-苄基-3-甲氧基丙酰胺（lacosamide）的方法（V），其中甲基化在低于20℃的温度下进行。

10. 发明授权

US07196219B2 Preparation of Anilineboronic acids and derivatives thereof 有权
标题翻译：苯胺硼酸及其衍生物的制备
公开(公告)号：US07196219B2
公开(公告)日：2007-03-27
申请号：US10846463
申请日：2004-05-14
申请人： Stefan Scherer , Andreas Meudt , Bernd Lehnemann , Alexei Kalinin , Victor Snieckus
发明人： Stefan Scherer , Andreas Meudt , Bernd Lehnemann , Alexei Kalinin , Victor Snieckus
IPC分类号： C07F5/02 , C07F5/04
CPC分类号： C07F5/025 , Y02P20/55
摘要： A process for preparing anilineboronic acid derivative of the formula I, by converting an aniline to a diprotected aniline by introducing two protecting groups, metalating the diprotected aniline with a metalating agent and simultaneously or subsequently reacting with a boronic ester B(OR1,2,3)3 to form a protected anilineboronic ester, which is converted, by detaching the protecting groups, to the anilineboronic esters of the formula (I).
摘要翻译：一种制备式I的苯胺硼酸衍生物的方法，

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式