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    • 1. 发明授权
    • Systems and methods for dynamic imaging of tissue using digital optical tomography
    • 使用数字光学层析成像的组织动态成像的系统和方法
    • US09037216B2
    • 2015-05-19
    • US12832780
    • 2010-07-08
    • Andreas H. HielscherYang LiAndres BurMolly FlexmanJames MasciottiChristopher J. Fong
    • Andreas H. HielscherYang LiAndres BurMolly FlexmanJames MasciottiChristopher J. Fong
    • A61B5/05A61B6/00G06K9/00A61B5/00
    • A61B5/0073A61B5/0053A61B5/0091A61B5/7225
    • A methods for imaging tissue using diffuse optical tomography with digital detection includes directing at the tissue a plurality of amplitude modulated optical signals from a plurality of optical signal sources illuminating the tissue at a plurality of locations; detecting a resulting plurality of attenuated optical signals exiting the tissue to obtain a plurality of analog signals containing diffuse optical tomographic information; converting the analog signals into digital signals; recovering the tomographic information from the digital signals using a digital signal processor-based detection module that performs digital detection, wherein the detection module includes a master digital signal processing subsystem and at least one slave digital signal processing subsystem that processes at least a portion of the digital signals and the master digital signal processing subsystem controls the at least one slave digital signal processing subsystem; and transmitting the recovered tomographic information in digital form to a host computer.
    • 使用具有数字检测的漫射光学层析成像对组织进行成像的方法包括在组织处引导来自在多个位置照射组织的多个光信号源的多个幅度调制光信号; 检测离开组织的所得多个衰减的光信号,以获得包含漫射光学层析信息的多个模拟信号; 将模拟信号转换为数字信号; 使用执行数字检测的基于数字信号处理器的检测模块从所述数字信号中恢复断层图像信息,其中所述检测模块包括主数字信号处理子系统和至少一个从属数字信号处理子系统,其处理至少一部分 数字信号和主数字信号处理子系统控制至少一个从属数字信号处理子系统; 并将恢复的数字形式的断层信息发送到主计算机。
    • 2. 发明申请
    • SYSTEMS AND METHODS FOR DYNAMIC IMAGING OF TISSUE USING DIGITAL OPTICAL TOMOGRAPHY
    • 使用数字光学成像技术动态成像组织的系统和方法
    • US20100292569A1
    • 2010-11-18
    • US12832780
    • 2010-07-08
    • Andreas H. HielscherYang LiAndrés BurMolly FlexmanJames MasciottiChristopher J. Fong
    • Andreas H. HielscherYang LiAndrés BurMolly FlexmanJames MasciottiChristopher J. Fong
    • A61B6/00G06K9/00
    • A61B5/0073A61B5/0053A61B5/0091A61B5/7225
    • A methods for imaging tissue using diffuse optical tomography with digital detection includes directing at the tissue a plurality of amplitude modulated optical signals from a plurality of optical signal sources illuminating the tissue at a plurality of locations; detecting a resulting plurality of attenuated optical signals exiting the tissue to obtain a plurality of analog signals containing diffuse optical tomographic information; converting the analog signals into digital signals; recovering the tomographic information from the digital signals using a digital signal processor-based detection module that performs digital detection, wherein the detection module includes a master digital signal processing subsystem and at least one slave digital signal processing subsystem that processes at least a portion of the digital signals and the master digital signal processing subsystem controls the at least one slave digital signal processing subsystem; and transmitting the recovered tomographic information in digital form to a host computer.
    • 使用具有数字检测的漫射光学层析成像对组织进行成像的方法包括在组织处引导来自在多个位置照射组织的多个光信号源的多个幅度调制光信号; 检测离开组织的所得多个衰减的光信号,以获得包含漫射光学层析信息的多个模拟信号; 将模拟信号转换为数字信号; 使用执行数字检测的基于数字信号处理器的检测模块从所述数字信号中恢复断层图像信息,其中所述检测模块包括主数字信号处理子系统和至少一个从属数字信号处理子系统,其处理至少一部分 数字信号和主数字信号处理子系统控制至少一个从属数字信号处理子系统; 并将恢复的数字形式的断层信息发送到主计算机。
    • 3. 发明授权
    • Systems and methods for digital detection of a tomographic signal
    • 断层信号的数字检测系统和方法
    • US07728986B2
    • 2010-06-01
    • US12257825
    • 2008-10-24
    • Joseph M. LaskerAndreas H. HielscherJames MasciottiChristoph H. SchmitzMatthew Schoenecker
    • Joseph M. LaskerAndreas H. HielscherJames MasciottiChristoph H. SchmitzMatthew Schoenecker
    • G01B9/02G01B11/02
    • G01N21/4795
    • Systems and methods for digital detection of an analog tomographic signal are described. The methods include receiving an amplitude-modulated analog signal containing tomographic information, the analog signal having a modulation frequency, fλi; and converting the analog signal into a digital signal at a sampling frequency, fs, to produce a number of samples, K. The digital signal is multiplied by an in-phase reference signal to obtain an in-phase signal component, the in-phase reference signal having the frequency, fλi; and the digital signal is multiplied by a quadrature reference signal to obtain a quadrature signal component, the quadrature reference signal having the frequency, fλi. The in-phase signal component and the quadrature signal component are passed through the K-point averaging filter. A signal amplitude is computed based on the filtered in-phase signal component and the filtered quadrature signal component, the signal amplitude being representative of the tomographic information.
    • 描述了用于模拟断层信号的数字检测的系统和方法。 所述方法包括接收包含断层图像信息的幅度调制模拟信号,所述模拟信号具有调制频率fλi; 并以采样频率fs将模拟信号转换为数字信号,以产生多个采样值K.将数字信号乘以同相参考信号以获得同相信号分量,同相信号 参考信号具有频率fλi; 并且数字信号乘以正交参考信号以获得正交信号分量,正交参考信号具有频率fλi。 同相信号分量和正交信号分量通过K点平均滤波器。 基于滤波的同相信号分量和滤波的正交信号分量来计算信号幅度,信号振幅代表层析信息。