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1. 再颁专利

USRE41949E1 System and method for tomographic imaging of dynamic properties of a scattering medium 有权
标题翻译：散射介质动态特性断层成像系统及方法
公开(公告)号：USRE41949E1
公开(公告)日：2010-11-23
申请号：US11525188
申请日：2000-09-14
申请人： Randall L. Barbour , Christoph H. Schmitz
发明人： Randall L. Barbour , Christoph H. Schmitz
IPC分类号： G01N21/47
CPC分类号： G01N21/4795
摘要： A system and method for the detection and three dimensional imaging of absorption and scattering properties of a medium such as human tissue is described. According to one embodiment of the invention, the system directs optical energy toward a turbid medium from at least one source and detects optical energy emerging from the turbid medium at a plurality of locations using at least one detector. The optical energy emerging from the medium and entering the detector originates from the source is scattered by the medium. The system then generates an image representing interior structure of the turbid medium based on the detected optical energy emerging from the medium. Generating the image includes a time-series analysis.
摘要翻译：描述了用于诸如人体组织的介质的吸收和散射性质的检测和三维成像的系统和方法。根据本发明的一个实施例，系统将光能从至少一个源引导到混浊介质，并使用至少一个检测器检测在多个位置处从混浊介质出射的光能。从介质出来的进入检测器的光能源源自介质散射。然后，系统基于从介质中出现的检测到的光能产生表示混浊介质的内部结构的图像。生成图像包括时间序列分析。

2. 发明授权

US07728986B2 Systems and methods for digital detection of a tomographic signal 有权
标题翻译：断层信号的数字检测系统和方法
公开(公告)号：US07728986B2
公开(公告)日：2010-06-01
申请号：US12257825
申请日：2008-10-24
申请人： Joseph M. Lasker , Andreas H. Hielscher , James Masciotti , Christoph H. Schmitz , Matthew Schoenecker
发明人： Joseph M. Lasker , Andreas H. Hielscher , James Masciotti , Christoph H. Schmitz , Matthew Schoenecker
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01N21/4795
摘要： Systems and methods for digital detection of an analog tomographic signal are described. The methods include receiving an amplitude-modulated analog signal containing tomographic information, the analog signal having a modulation frequency, fλi; and converting the analog signal into a digital signal at a sampling frequency, fs, to produce a number of samples, K. The digital signal is multiplied by an in-phase reference signal to obtain an in-phase signal component, the in-phase reference signal having the frequency, fλi; and the digital signal is multiplied by a quadrature reference signal to obtain a quadrature signal component, the quadrature reference signal having the frequency, fλi. The in-phase signal component and the quadrature signal component are passed through the K-point averaging filter. A signal amplitude is computed based on the filtered in-phase signal component and the filtered quadrature signal component, the signal amplitude being representative of the tomographic information.
摘要翻译：描述了用于模拟断层信号的数字检测的系统和方法。所述方法包括接收包含断层图像信息的幅度调制模拟信号，所述模拟信号具有调制频率fλi; 并以采样频率fs将模拟信号转换为数字信号，以产生多个采样值K.将数字信号乘以同相参考信号以获得同相信号分量，同相信号参考信号具有频率fλi; 并且数字信号乘以正交参考信号以获得正交信号分量，正交参考信号具有频率fλi。同相信号分量和正交信号分量通过K点平均滤波器。基于滤波的同相信号分量和滤波的正交信号分量来计算信号幅度，信号振幅代表层析信息。

3. 发明申请

US20090103102A1 SYSTEMS AND METHODS FOR DIGITAL DETECTION OF A TOMOGRAPHIC SIGNAL 有权
标题翻译：用于数字检测图像信号的系统和方法
公开(公告)号：US20090103102A1
公开(公告)日：2009-04-23
申请号：US12257825
申请日：2008-10-24
申请人： Joseph M. LASKER , Andreas HIELSCHER , James M. MASCIOTTI , Christoph H. SCHMITZ , Matthew SCHOENECKER
发明人： Joseph M. LASKER , Andreas HIELSCHER , James M. MASCIOTTI , Christoph H. SCHMITZ , Matthew SCHOENECKER
IPC分类号： G01B11/02
CPC分类号： G01N21/4795
摘要： Systems and methods for digital detection of an analog tomographic signal are described. The methods include receiving an amplitude-modulated analog signal containing tomographic information, the analog signal having a modulation frequency, fλi; and converting the analog signal into a digital signal at a sampling frequency, fs, to produce a number of samples, K. The digital signal is multiplied by an in-phase reference signal to obtain an in-phase signal component, the in-phase reference signal having the frequency, fλi; and the digital signal is multiplied by a quadrature reference signal to obtain a quadrature signal component, the quadrature reference signal having the frequency, fλi. The in-phase signal component and the quadrature signal component are passed through the K-point averaging filter. A signal amplitude is computed based on the filtered in-phase signal component and the filtered quadrature signal component, the signal amplitude being representative of the tomographic information.
摘要翻译：描述了用于模拟断层信号的数字检测的系统和方法。所述方法包括接收包含断层图像信息的幅度调制模拟信号，所述模拟信号具有调制频率flambdai; 并以采样频率fs将模拟信号转换为数字信号，以产生多个采样K.将数字信号乘以同相参考信号以获得同相信号分量，同相信号参考信号具有频率，flambdai; 并且数字信号乘以正交参考信号以获得正交信号分量，正交参考信号具有频率，flambdai。同相信号分量和正交信号分量通过K点平均滤波器。基于滤波的同相信号分量和滤波的正交信号分量来计算信号幅度，信号振幅代表层析信息。

4. 发明授权

US07463362B2 Digital signal processor-based detection system, method, and apparatus for optical tomography 有权
标题翻译：用于光学层析成像的基于数字信号处理器的检测系统，方法和装置
公开(公告)号：US07463362B2
公开(公告)日：2008-12-09
申请号：US11106348
申请日：2005-04-13
申请人： Joseph M. Lasker , Andreas Hielscher , James M. Masciotti , Christoph H. Schmitz , Mathew Schoenecker
发明人： Joseph M. Lasker , Andreas Hielscher , James M. Masciotti , Christoph H. Schmitz , Mathew Schoenecker
IPC分类号： G01B11/02 , G01B9/02
CPC分类号： G01N21/4795
摘要： The present invention provides systems, methods and apparatuses that perform digital detection for use in optical tomography. Methods and systems are provided in which digital lock-in detection is performed using an algorithm that employs a phase-independent quadrature technique. Methods and systems are provided in which a unique manipulation of an ordinary averaging filter optimized for sources discrimination and the consequent sampling constraints is presented as a novel filtering scheme for the lock-in detection. Systems and apparatuses are provided which include a digital signal processor which performs digital lock-in detection and an integrated complex programmable logic device for timing control. Apparatuses are provided which include an instrument having an integrated digital signal processor for performing digital processing and detection for use in optical tomography.
摘要翻译：本发明提供了在光学层析成像中使用数字检测的系统，方法和装置。提供了使用采用相位独立正交技术的算法执行数字锁定检测的方法和系统。提供了方法和系统，其中针对源鉴别和随后的采样约束优化的普通均值滤波器的唯一操作被呈现为用于锁定检测的新型滤波方案。提供了包括执行数字锁定检测的数字信号处理器和用于定时控制的集成复杂可编程逻辑器件的系统和装置。提供了包括具有集成的数字信号处理器的仪器，用于执行用于光学层析成像的数字处理和检测。

5. 发明授权

US06795195B1 System and method for tomographic imaging of dynamic properties of a scattering medium 有权
标题翻译：散射介质动态特性断层成像系统及方法
公开(公告)号：US06795195B1
公开(公告)日：2004-09-21
申请号：US10088254
申请日：2002-08-29
申请人： Randall L. Barbour , Christoph H. Schmitz
发明人： Randall L. Barbour , Christoph H. Schmitz
IPC分类号： G01N2147
CPC分类号： G01N21/4795
摘要： A system and method for the detection and three dimensional imaging of absorption and scattering properties of a medium such as human tissue is described. According to one embodiment of the invention, the system directs optical energy toward a turbid medium from at least one source and detects optical energy emerging from the turbid medium at a plurality of locations using at least one detector. The optical energy emerging from the medium and entering the detector originates from the source is scattered by the medium. The system then generates an image representing interior structure of the turbid medium based on the detected optical energy emerging from the medium. Generating the image includes a time-series analysis.
摘要翻译：描述了用于诸如人体组织的介质的吸收和散射性质的检测和三维成像的系统和方法。根据本发明的一个实施例，系统将光能从至少一个源引导到混浊介质，并使用至少一个检测器检测在多个位置处从混浊介质出射的光能。从介质出来的进入检测器的光能源源自介质散射。然后，系统基于从介质中出现的检测到的光能产生表示混浊介质的内部结构的图像。生成图像包括时间序列分析。

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