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1. 发明专利

JP2014015471A Cyclosporin compositions 审中-公开
标题翻译：环磷酰胺组合物
公开(公告)号：JP2014015471A
公开(公告)日：2014-01-30
申请号：JP2013184232
申请日：2013-09-05
申请人： Allergan Inc , アラーガン、インコーポレイテッドAllergan,Incorporated
发明人： RICHARD S GRAHAM , AILEEN MORGAN , MAYSSA ATTAR , WALTER TIEN , SCHIFFMAN RHETT M
IPC分类号： A61K38/00 , A61P27/02
CPC分类号： A61K38/13 , A61K9/0048 , A61K9/08 , A61K47/02 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/44
摘要： PROBLEM TO BE SOLVED: To provide therapeutic methods, compositions, and medicaments related to cyclosporine for abnormalities associated with lacrimal gland functions or with tearing, such as dry eye disease.SOLUTION: A pharmaceutical composition is provided comprising cyclosporin A at a concentration from about 0.0001% (w/v) to less than about 0.05% (w/v). The composition is topically administered to eyes to treat ocular rosacea of mammals. The pharmaceutical composition does not contain hyaluronic acid, alcohol, cyclodextrin A or the like, and is administered once a day.
摘要翻译：要解决的问题：提供与环孢素有关的治疗方法，组合物和药物，用于与泪腺功能相关的异常或撕裂如干眼病。解决方案：提供药物组合物，其包含浓度为约0.0001的环孢菌素A ％（w / v）至小于约0.05％（w / v）。将组合物局部施用于眼睛以治疗哺乳动物的眼红斑痤疮。药物组合物不含透明质酸，醇，环糊精A等，每天一次。

2. 发明专利

JP2014144983A Enhanced bimatoprost ophthalmic solution 有权
标题翻译：增强双歧杆菌OPHTHALMIC解决方案
公开(公告)号：JP2014144983A
公开(公告)日：2014-08-14
申请号：JP2014103678
申请日：2014-05-19
申请人： Allergan Inc , アラーガンインコーポレイテッドAllergan,Incorporated
发明人： CHANG CHIN-MING , CHANG JAMES N , SCHIFFMAN RHETT M , JORDAN R SCOTT , CHANG-LIN JOAN-EN
IPC分类号： A61K31/5575 , A61K9/08 , A61K47/02 , A61K47/12 , A61K47/18 , A61P27/02 , A61P27/06
CPC分类号： A61K31/5575 , A01N33/12 , A61K9/0048 , A61K31/14 , A61K31/165 , A61K31/557 , A61K47/02 , A61K47/12
摘要： PROBLEM TO BE SOLVED: To provide a formulation for ophthalmic administration that comprises bimatoprost and improves the membrane permeability of bimatoprost, and a method useful for treating glaucoma or ocular hypertension related thereto.SOLUTION: A composition comprises bimatoprost of 0.005- 0.02 wt% and benzalkonium chloride of 100-250 ppm, where the composition is an aqueous liquid which is formulated for ophthalmic administration.
摘要翻译：要解决的问题：提供包含比马前列素并改善比马前列素的膜通透性的眼用给药制剂和用于治疗与其相关的青光眼或高眼压症的方法。溶液：组合物包含0.005-0.02重量％的比马前列素和苯扎氯铵氯化物为100-250ppm，其中组合物是配制用于眼部给药的水性液体。

3. 发明专利

JP2012082231A Clostridial neurotoxins for treating uterine disorders 审中-公开
标题翻译：用于治疗尿失禁的闭合神经毒素
公开(公告)号：JP2012082231A
公开(公告)日：2012-04-26
申请号：JP2012015604
申请日：2012-01-27
申请人： Allergan Inc , アラーガン、インコーポレイテッドAllergan,Incorporated
发明人： SCHIFFMAN RHETT M
IPC分类号： A61K38/00 , A61K38/48 , A61P15/00 , A61P21/02 , A61P35/00
CPC分类号： A61K38/4893
摘要： PROBLEM TO BE SOLVED: To provide means for treating, preventing the development of, and causing the regression or remission of uterine tissues, including atypical tissues, such as hyperplastic tissues, fibroids, and uterine neoplasms (including tumors and cancers), for treating uterine disorders, both benign and cancerous, as well as for treating hyperplastic and/or hypertonic uterine gland cells.SOLUTION: The uterine disorders, including hyperplastic, hypertonic, cystic and/or neoplastic uterine gland tissue, are treated by local administration of a botulinum toxin to or to the vicinity of the afflicted uterine tissue.
摘要翻译：要解决的问题：提供治疗，预防子宫组织，包括非典型组织如增生组织，子宫肌瘤和子宫赘瘤（包括肿瘤和癌症）的发展和退化或缓解的手段，用于治疗良性和癌性的子宫疾病，以及用于治疗增生性和/或高渗性子宫腺细胞。解决方案：子宫疾病，包括增生性，高渗性，囊性和/或肿瘤性子宫腺组织，通过局部施用肉毒杆菌毒素到受影响的子宫组织或其附近来治疗。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2011148827A Enhanced bimatoprost ophthalmic solution 有权
标题翻译：增强双歧杆菌OPHTHALMIC解决方案
公开(公告)号：JP2011148827A
公开(公告)日：2011-08-04
申请号：JP2011099657
申请日：2011-04-27
申请人： Allergan Inc , アラーガンインコーポレイテッドAllergan,Incorporated
发明人： CHANG CHIN-MING , CHANG JAMES N , SCHIFFMAN RHETT M , JORDAN R SCOTT , CHANG-LIN JOAN-EN
IPC分类号： A61K31/5575 , A61K9/08 , A61K47/02 , A61K47/18 , A61P27/02
CPC分类号： A61K31/5575 , A01N33/12 , A61K9/0048 , A61K31/14 , A61K31/165 , A61K31/557 , A61K47/02 , A61K47/12
摘要： PROBLEM TO BE SOLVED: To provide a formulation for ophthalmic administration, which includes bimatoprost and improves membrane permeability of bimatoprost; and to provide a useful method for treating glaucoma or ocular hypertension related thereto. SOLUTION: A composition comprises from 0.005 wt.% to 0.02 wt.% of bimatoprost and from 100 ppm to 250 ppm of benzalkonium chloride, wherein the composition is an aqueous liquid which is formulated for ophthalmic administration. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供一种眼用给药制剂，其包括比马前列素并改善比马前列素的膜通透性; 并提供治疗与之有关的青光眼或高眼压症的有用方法。解决方案：组合物包含0.005重量％至0.02重量％的比马前列素和100ppm至250ppm的苯扎氯铵，其中该组合物是配制用于眼部给药的水性液体。版权所有（C）2011，JPO＆INPIT

5. 发明申请

WO2006104760A2 OPHTHALMIC COMPOSITIONS COMPRISING dDC 审中-公开
标题翻译：包含dDC的透明组合物
公开(公告)号：WO2006104760A2
公开(公告)日：2006-10-05
申请号：PCT/US2006010176
申请日：2006-03-21
申请人： ALLERGAN INC , HUGHES PATRICK M , SCHIFFMAN RHETT M , JENSEN HAROLD G , CHANG-LIN JOAN-EN
发明人： HUGHES PATRICK M , SCHIFFMAN RHETT M , JENSEN HAROLD G , CHANG-LIN JOAN-EN
CPC分类号： A61K9/0048 , A61K31/7068
摘要： A composition comprising dDC and a polymer, wherein the composition is an aqueous liquid with a viscosity which increases upon contact with a surface of an eye is disclosed herein. An aqueous composition comprising a therapeutically effective concentration of dDC, wherein the concentration of dDC is less than 1% is also disclosed. An eye drop comprising a therapeutically effective amount of dDC, wherein the amount of dDC is less than 300 µg is also disclosed. A method comprising administering an effective amount of dDC topically to an eye of a person suffering from viral conjunctivitis a viral infection, wherein less than 300 µL of dDC is administered to said eye is also disclosed. A kit comprising a composition and a dispenser, wherein said dispenser dispenses a drop comprising a therapeutically effective amount of dDC, wherein the amount of dDC is less than 300 µg is also disclosed.
摘要翻译：包含dDC和聚合物的组合物，其中所述组合物是具有在与眼表面接触时增加的粘度的水性液体。还公开了包含治疗有效浓度的dDC的水性组合物，其中dDC的浓度小于1％。还公开了包含治疗有效量的dDC的滴眼剂，其中dDC的量小于300μg。还公开了一种将有效量的dDC局部施用于患有病毒性结膜炎的人的眼睛的病毒感染的方法，其中向所述眼睛施用小于300μL的dDC。一种包含组合物和分配器的试剂盒，其中所述分配器分配包含治疗有效量的dDC的液滴，其中dDC的量小于300μg也被公开。

6. 发明申请

WO2008014200A2 CYCLOSPORIN COMPOSITIONS 审中-公开
标题翻译：环磷酰胺组合物
公开(公告)号：WO2008014200A2
公开(公告)日：2008-01-31
申请号：PCT/US2007074079
申请日：2007-07-23
申请人： ALLERGAN INC , GRAHAM RICHARD S , MORGAN AILEEN , ATTAR MAYSSA , TIEN WALTER , SCHIFFMAN RHETT M
发明人： GRAHAM RICHARD S , MORGAN AILEEN , ATTAR MAYSSA , TIEN WALTER , SCHIFFMAN RHETT M
IPC分类号： A61K9/00 , A61K38/13
CPC分类号： A61K38/13 , A61K9/0048 , A61K9/08 , A61K47/02 , A61K47/10 , A61K47/26 , A61K47/32 , A61K47/44
摘要： Disclosed herein are therapeutic methods, compositions, and medicaments related to cyclosporine.
摘要翻译：本文公开了与环孢菌素相关的治疗方法，组合物和药物。

7. 发明申请

WO2006101839A3 ENHANCED BIMATOPROST OPHTHALMIC SOLUTION 审中-公开
标题翻译：增强双歧杆菌OPHTHALMIC解决方案
公开(公告)号：WO2006101839A3
公开(公告)日：2006-12-07
申请号：PCT/US2006009124
申请日：2006-03-14
申请人： ALLERGAN INC , CHANG CHIN-MING , CHANG JAMES N , SCHIFFMAN RHETT M , JORDAN R SCOTT , CHANG-LIN JOAN-EN
发明人： CHANG CHIN-MING , CHANG JAMES N , SCHIFFMAN RHETT M , JORDAN R SCOTT , CHANG-LIN JOAN-EN
IPC分类号： A61K31/5575 , A61K9/00 , A61K47/18 , A61P27/06
CPC分类号： A61K31/5575 , A01N33/12 , A61K9/0048 , A61K31/14 , A61K31/165 , A61K31/557 , A61K47/02 , A61K47/12
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein. A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
摘要翻译：本文公开了包含0.005％至0.02％的比马前列素和100ppm至250ppm苯扎氯铵的组合物，其中所述组合物是配制用于眼部给药的水性液体。本文还公开了可用于治疗与其有关的青光眼或高眼压症的方法。

8. 发明申请

WO2009111418A3 KETOROLAC TROMETHAMINE COMPOSITIONS FOR TREATING OR PREVENTING OCULAR PAIN 审中-公开
标题翻译：用于治疗或预防眼痛的KETOROLAC TROMETHAMINE组合物
公开(公告)号：WO2009111418A3
公开(公告)日：2010-04-01
申请号：PCT/US2009035787
申请日：2009-03-03
申请人： ALLERGAN INC , FARNES ELDON QUINN , ATTAR MAYSSA , SCHIFFMAN RHETT M , CHANG CHIN-MING , GRAHAM RICHARD S , WELTY DEVIN F
发明人： FARNES ELDON QUINN , ATTAR MAYSSA , SCHIFFMAN RHETT M , CHANG CHIN-MING , GRAHAM RICHARD S , WELTY DEVIN F
IPC分类号： A61K9/08 , A61K31/14
CPC分类号： A61K31/14 , A61K9/0048 , A61K31/407 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/186 , A61K47/38
摘要： The present invention provides an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose in an aqueous solution wherein said concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient that is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.
摘要翻译：本发明提供了一种含有有效量的酮咯酸的水性眼用溶液，所述酮咯酸在水溶液中包含羧甲基纤维素，其中所述羧甲基纤维素的浓度选择为提高患者眼睛中酮咯酸的吸收，所述吸光度至少为130％比吸收具有相同浓度的酮咯酸的对比的水性酮咯酸眼科溶液。

9. 发明申请

WO2007103765A2 TREATMENT WITH CYCLOSPORIN A 审中-公开
标题翻译：环孢菌素A治疗
公开(公告)号：WO2007103765A2
公开(公告)日：2007-09-13
申请号：PCT/US2007063126
申请日：2007-03-02
申请人： ALLERGAN INC , SCHIFFMAN RHETT M
发明人： SCHIFFMAN RHETT M
IPC分类号： A61K38/13 , A61P27/02
CPC分类号： A61K38/13
摘要： Disclosed herein is a method comprising administering cyclosporin A topically to an eye of a person for the purpose of treating or preventing loss of vision from keratoconus.
摘要翻译：本文公开了一种方法，其包括将环孢菌素A局部给药至人的眼睛以治疗或预防圆锥形角膜的视力丧失。

10. 发明专利

CA2796071C KETOROLAC COMPOSITIONS FOR CORNEAL WOUND HEALING 未知
公开(公告)号：CA2796071C
公开(公告)日：2018-06-26
申请号：CA2796071
申请日：2011-04-06
申请人： ALLERGAN INC
发明人： GRAHAM RICHARD S , HOLLANDER DAVID , VILLANUEVA LINDA , FARNES ELDON QUINN , ATTAR MAYSSA , SCHIFFMAN RHETT M , CHANG CHIN-MING , WELTY DEVIN F
IPC分类号： A61K31/407 , A61P27/02
摘要： The present invention is directed to an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose which promotes epithelial wound healing in a patients cornea.

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