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1. 发明申请

WO2006101839A3 ENHANCED BIMATOPROST OPHTHALMIC SOLUTION 审中-公开
标题翻译：增强双歧杆菌OPHTHALMIC解决方案
公开(公告)号：WO2006101839A3
公开(公告)日：2006-12-07
申请号：PCT/US2006009124
申请日：2006-03-14
申请人： ALLERGAN INC , CHANG CHIN-MING , CHANG JAMES N , SCHIFFMAN RHETT M , JORDAN R SCOTT , CHANG-LIN JOAN-EN
发明人： CHANG CHIN-MING , CHANG JAMES N , SCHIFFMAN RHETT M , JORDAN R SCOTT , CHANG-LIN JOAN-EN
IPC分类号： A61K31/5575 , A61K9/00 , A61K47/18 , A61P27/06
CPC分类号： A61K31/5575 , A01N33/12 , A61K9/0048 , A61K31/14 , A61K31/165 , A61K31/557 , A61K47/02 , A61K47/12
摘要： A composition comprising from 0.005% to 0.02% bimatoprost by weight and from 100 ppm to 250 ppm benzalkonium chloride, wherein said composition is an aqueous liquid which is formulated for ophthalmic administration is disclosed herein. A method which is useful in treating glaucoma or ocular hypertension related thereto is also disclosed herein.
摘要翻译：本文公开了包含0.005％至0.02％的比马前列素和100ppm至250ppm苯扎氯铵的组合物，其中所述组合物是配制用于眼部给药的水性液体。本文还公开了可用于治疗与其有关的青光眼或高眼压症的方法。

2. 发明申请

WO2005105067A3 AQUEOUS SOLUTIONS COMPRISING PREDNISOLONE AND A CYCLODEXTRIN DERIVATIVE 审中-公开
标题翻译：包含PREDNISOLONE和CYCLODEXTRIN DERIVATIVE的水溶液
公开(公告)号：WO2005105067A3
公开(公告)日：2006-04-27
申请号：PCT/US2005011960
申请日：2005-04-11
申请人： ALLERGAN INC , LYONS ROBERT T , CHANG CHIN-MING , CHANG-LIN JOAN-EN , CHANG JAMES , OLEJNIK OREST
发明人： LYONS ROBERT T , CHANG CHIN-MING , CHANG-LIN JOAN-EN , CHANG JAMES , OLEJNIK OREST
IPC分类号： A61K9/00 , A61K31/00 , A61K31/57 , A61K31/573 , A61K31/724 , A61K47/38 , A61K47/40 , A61K47/48 , A61P27/02
CPC分类号： A61K9/0014 , A61K9/0048 , A61K31/57 , A61K31/573 , A61K31/724 , A61K47/38 , A61K47/40
摘要： Disclosed herein are methods of delivering drugs or therapeutically active agents to the back of the eye via topical administration of compositions comprising cyclodextrin derivatives. Compositions related thereto are also disclosed herein.
摘要翻译：本文公开了通过局部施用包含环糊精衍生物的组合物将药物或治疗活性剂递送至眼睛后部的方法。本文还公开了与其相关的组合物。

3. 发明申请

WO2009111418A3 KETOROLAC TROMETHAMINE COMPOSITIONS FOR TREATING OR PREVENTING OCULAR PAIN 审中-公开
标题翻译：用于治疗或预防眼痛的KETOROLAC TROMETHAMINE组合物
公开(公告)号：WO2009111418A3
公开(公告)日：2010-04-01
申请号：PCT/US2009035787
申请日：2009-03-03
申请人： ALLERGAN INC , FARNES ELDON QUINN , ATTAR MAYSSA , SCHIFFMAN RHETT M , CHANG CHIN-MING , GRAHAM RICHARD S , WELTY DEVIN F
发明人： FARNES ELDON QUINN , ATTAR MAYSSA , SCHIFFMAN RHETT M , CHANG CHIN-MING , GRAHAM RICHARD S , WELTY DEVIN F
IPC分类号： A61K9/08 , A61K31/14
CPC分类号： A61K31/14 , A61K9/0048 , A61K31/407 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/186 , A61K47/38
摘要： The present invention provides an aqueous ophthalmic solution comprising an effective amount of ketorolac which comprises carboxymethyl cellulose in an aqueous solution wherein said concentration of carboxymethyl cellulose is selected to provide an increased absorption of ketorolac in the eye of a patient that is at least 130% greater than the absorption of a comparative aqueous ketorolac ophthalmic solution having the same concentration of ketorolac.
摘要翻译：本发明提供了一种含有有效量的酮咯酸的水性眼用溶液，所述酮咯酸在水溶液中包含羧甲基纤维素，其中所述羧甲基纤维素的浓度选择为提高患者眼睛中酮咯酸的吸收，所述吸光度至少为130％比吸收具有相同浓度的酮咯酸的对比的水性酮咯酸眼科溶液。

4. 发明申请

WO2007100984A3 BEADS CONTAINING PYRIDIN-SULFINYL BENZOIMIDAZOLE SULFONYL PHENOXY ACETATE DERIVATIVES 审中-公开
标题翻译：含有吡啶基 - 磺酰基苯甲酰亚胺磺酰苯氧基乙酸酯衍生物的珠
公开(公告)号：WO2007100984A3
公开(公告)日：2007-11-15
申请号：PCT/US2007062173
申请日：2007-02-15
申请人： ALLERGAN INC , CHANG CHIN-MING , CHANG JAMES N , FARNES QUINN E
发明人： CHANG CHIN-MING , CHANG JAMES N , FARNES QUINN E
IPC分类号： A61K9/16 , A61K9/48 , A61K31/00
CPC分类号： A61K9/1676 , A61K9/4808 , A61K9/5078
摘要： Dosage forms comprising therapeutically active compounds are disclosed herein.
摘要翻译：包含治疗活性化合物的剂型在本文中公开。

5. 发明申请

WO2005014046A3 COMPOSITIONS FOR DELIVERY OF THERAPEUTICS INTO THE EYES AND METHODS FOR MAKING AND USING THE SAME 审中-公开
标题翻译：将治疗方法输送到眼睛中的组合物及其制备和使用方法
公开(公告)号：WO2005014046A3
公开(公告)日：2006-06-01
申请号：PCT/US2004025540
申请日：2004-08-05
申请人： ALLERGAN INC , VEHIGE JOSEPH G , CHANG JAMES N , GRAHAM RICHARD , LYONS ROBERT T , KUAN TERESA H , CHANG CHIN-MING
发明人： VEHIGE JOSEPH G , CHANG JAMES N , GRAHAM RICHARD , LYONS ROBERT T , KUAN TERESA H , CHANG CHIN-MING
IPC分类号： A61K9/00 , A61K31/00
CPC分类号： A61K31/407 , A61K9/0048 , A61K31/00 , A61K47/38
摘要： The present invention provides for compositions for administering a therapeutically effective amount of a therapeutic component. The compositions may include an ophthalmically acceptable carrier component; a therapeutically effective amount of a therapeutic component; and a retention component which may be effective to reduce wettability, induce viscosity, increase mucoadhesion, increase meniscus height on a cornea of an eye and/or increase physical apposition to a cornea of an eye of a composition.
摘要翻译：本发明提供了用于施用治疗有效量的治疗成分的组合物。组合物可以包括眼科可接受的载体组分; 治疗有效量的治疗成分; 以及可以有效降低润湿性，诱导粘度，增加粘膜粘附，增加眼睛角膜上的弯液面高度和/或增加与组合物的眼睛的角膜的物理连接的保留组分。

6. 发明申请

WO2005072745A3 AQUEOUS SOLUTIONS COMPRISING PREDNISOLONE AND A CYCLODEXTRIN DERIVATIVE 审中-公开
标题翻译：包含PREDNISOLONE和CYCLODEXTRIN DERIVATIVE的水溶液
公开(公告)号：WO2005072745A3
公开(公告)日：2006-01-05
申请号：PCT/US2005001582
申请日：2005-01-20
申请人： ALLERGAN INC , CHANG CHIN-MING , CHANG JAMES N , LUU MICHELLE , LYONS ROBERT T , OLEJNIK OREST
发明人： CHANG CHIN-MING , CHANG JAMES N , LUU MICHELLE , LYONS ROBERT T , OLEJNIK OREST
IPC分类号： A61K9/00 , A61K9/08 , A61K31/57 , A61K31/573 , A61K47/02 , A61K47/40 , A61K47/48 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/08 , A61K31/57 , A61K31/573 , A61K47/02 , A61K47/40 , A61K47/6951 , B82Y5/00
摘要： Disclosed herein are compositions comprising cyclodextrin derivatives and prednisolone and prodrugs thereof, and methods related thereto. The use of soluble polyanionic polymers such as hydroxypropylmethylcellulose and others in relation to these compositions is also disclosed. Delivery of these prednisolone-related compounds to the back of the eye via topical ophthalmic administration is also disclosed.
摘要翻译：本文公开了包含环糊精衍生物和泼尼松龙及其前药的组合物及其相关方法。还公开了与这些组合物相关的可溶性聚阴离子聚合物如羟丙基甲基纤维素等的用途。还公开了通过局部眼科给药将这些泼尼松龙相关化合物递送至眼睛后部。

7. 发明申请

WO2008058220A2 TRANSDERMAL DRUG DELIVERY SYSTEM 审中-公开
标题翻译：转基因药物递送系统
公开(公告)号：WO2008058220A2
公开(公告)日：2008-05-15
申请号：PCT/US2007083995
申请日：2007-11-07
申请人： ALLERGAN INC , LIKITLERSUANG SUKHON , CHANG CHIN-MING , CHANG JAMES , OLEJNIK OREST
发明人： LIKITLERSUANG SUKHON , CHANG CHIN-MING , CHANG JAMES , OLEJNIK OREST
IPC分类号： A61K9/70 , A61K31/13 , A61K47/08 , A61K47/26
CPC分类号： A61K9/7084 , A61K9/0009 , A61K47/08 , A61K47/16 , A61K47/26 , A61N1/044 , A61N1/0444 , A61N1/0448 , A61N1/327
摘要： A transdermal drug delivery system includes a drug source, an adhesive for applying the system to a skin surface, a penetration enhancer for enhancing penetration of the drug into the skin surface, an energy source and a contact for conveying energy from said energy source through said adhesive and the penetrating enhancer.
摘要翻译：透皮药物递送系统包括药物源，用于将系统施用于皮肤表面的粘合剂，用于增强药物渗入皮肤表面的渗透促进剂，能量源和用于将能量从所述能量源传递通过所述皮肤表面的接触件粘合剂和渗透增强剂。

8. 发明申请

WO2006031658A3 THERAPEUTIC LACRIMAL CANALICULAR INSERTS AND RELATED METHODS 审中-公开
标题翻译：治疗性食管癌和相关方法
公开(公告)号：WO2006031658A3
公开(公告)日：2006-04-13
申请号：PCT/US2005032222
申请日：2005-09-07
申请人： ALLERGAN INC , CHANG CHIN-MING , SCHIFFMAN RHETT , CHANG JAMES , JORDAN ROBERT S
发明人： CHANG CHIN-MING , SCHIFFMAN RHETT , CHANG JAMES , JORDAN ROBERT S
IPC分类号： A61K9/00
CPC分类号： A61K9/0051 , A61F9/00772
摘要： Lacrimal canalicular inserts include a polymeric component and a therapeutic component. The therapeutic component is released from the inserts for extended periods of time, such as for more than about 2 weeks after placement in a lacrimal canaliculus of an individual. The polymeric component may include one or more non-biodegradable polymers, one or more biodegradable polymers, or combinations thereof. The therapeutic component may include one or more therapeutic agents. Therapeutically effective amounts of the therapeutic component are released from the insert and provide sustained drug delivery to the eye and/or the nasolacrimal system of the individual.
摘要翻译：泪小管插入物包括聚合物组分和治疗组分。治疗组分从插入物中延长的时间段释放，例如放置在个体的泪小管中超过约2周。聚合物组分可以包括一种或多种不可生物降解的聚合物，一种或多种可生物降解的聚合物，或其组合。治疗组分可以包括一种或多种治疗剂。治疗成分的治疗有效量从插入物释放并提供持续的药物递送到个体的眼睛和/或鼻泪管系统。

9. 发明专利

GB2278059B Syringe disposal system 未知
公开(公告)号：GB2278059B
公开(公告)日：1997-02-26
申请号：GB9310498
申请日：1993-05-21
申请人： CHANG CHIN MING
发明人： CHANG CHIN-MING
IPC分类号： A61M5/32
摘要： A syringe disposal system includes a frame body and a separation device which includes an upper cover that is mounted on the frame body and that is formed with a needle guiding port. A driving gear is rotatably mounted on the frame body below the cover. A driven gear is rotatably mounted on the frame body below the cover and is positioned parallel to the driving gear. The teeth on the driven gear mesh with the teeth on the driving gear. A container is disposed below the driving and driven gears. The syringe disposal system also includes a fragmentation device which includes an inclined cutting plate, which has an outer side that is fixed on the frame body and an inner side that extends downwardly and inwardly and that is formed with spaced cutting teeth. A cutting wheel is rotatably mounted on the frame body below the inclined cutting plate and has spaced rows of axially-aligned cutting teeth extending radially. The cutting teeth on each row are able to mesh with the cutting teeth on the inclined cutting plate. A receptacle is disposed in the frame body below the cutting wheel.

10. 发明专利

GB2278059A Syringe disposal system 未知
公开(公告)号：GB2278059A
公开(公告)日：1994-11-23
申请号：GB9310498
申请日：1993-05-21
申请人： CHANG CHIN MING
发明人： CHANG CHIN-MING
IPC分类号： A61M5/32
摘要： A syringe disposal system to separate a needle from a barrel includes a separation device (20a) which includes an upper cover (201a) that has a needle guiding port. A driving gear (22) is rotatably mounted below the cover. A driven gear (23) is also rotatably mounted below the cover and is positioned parallel to the driving gear. The teeth on the driven gear mesh with the teeth on the driving gear to pull the needle from the barrel. The syringe disposal system also includes a fragmentation device to fragment the barrel portion after separation. The separated needle and fragmented barrel portion can be collected respectively for reuse.

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