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1. 发明申请

US20060057023A1 Chemical arrays assemblies and devices and methods for fabricating the same 审中-公开
标题翻译：化学阵列组件及其制造方法
公开(公告)号：US20060057023A1
公开(公告)日：2006-03-16
申请号：US10941968
申请日：2004-09-14
申请人： Allen Thompson , Jacqueline Tso
发明人： Allen Thompson , Jacqueline Tso
IPC分类号： B01J19/00
CPC分类号： B01L3/50853 , B01J19/0046 , B01J2219/00286 , B01J2219/00315 , B01J2219/00378 , B01J2219/00509 , B01J2219/00549 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00657 , B01J2219/00659 , B01J2219/00662 , B01J2219/00664 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01L2300/0636 , B82Y30/00 , C12Q1/6837 , C40B40/06 , C40B40/10 , C40B40/12 , C40B50/14 , C40B60/14
摘要： The subject invention provides array assemblies that include at least one array of an addressable set of probes and devices, as well as methods for fabricating and using the same. Embodiments include array assemblies that include a base supporting a plurality of prongs wherein at least one prong includes an array of an addressable set of probes. Embodiments of the subject methods include generating at least one chemical array on a surface of at least one prong of a device that includes a base supporting a plurality of prongs. The subject invention also includes methods for performing array assays. Systems and kits for practicing the subject methods are also provided.
摘要翻译：本发明提供了阵列组件，其包括可寻址组的探针和装置的至少一个阵列，以及用于制造和使用它们的方法。实施例包括阵列组件，其包括支撑多个插脚的基座，其中至少一个插脚包括可寻址探针组的阵列。本发明方法的实施例包括在包括支撑多个插脚的基座的装置的至少一个插脚的表面上产生至少一个化学阵列。本发明还包括进行阵列测定的方法。还提供了用于实践主题方法的系统和套件。

2. 发明授权

US06613560B1 PCR microreactor for amplifying DNA using microquantities of sample fluid 失效
标题翻译： PCR微反应器用于使用样品液体的微量来扩增DNA
公开(公告)号：US06613560B1
公开(公告)日：2003-09-02
申请号：US09502597
申请日：2000-02-11
申请人： Jacqueline Tso , Sally A. Swedberg , Paul K. Wolber
发明人： Jacqueline Tso , Sally A. Swedberg , Paul K. Wolber
IPC分类号： C12M140
CPC分类号： B01L3/5027 , B01L3/502707 , B01L7/52 , B01L7/54 , B01L2300/0816 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/163 , B01L2300/1805 , B01L2300/1822 , B01L2300/1838 , B01L2300/1872 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B01L2400/0442 , B01L2400/0481 , B01L2400/0487 , B29C66/549 , G01N27/44721 , G01N27/44773 , G01N27/44791 , G01N30/02 , G01N30/60 , G01N30/6052 , G01N30/606 , G01N30/6095 , G01N2030/285 , G01N2030/0035 , B29C65/00
摘要： A microanalytical device is provided for conducting chemical processes using small amounts of fluid. The devices include microstructures, e.g., microcavities, microchannels and the like, that are laser ablated or otherwise formed in a support substrate, and can be used in a variety of chemical and biochemical methods, including chromatographic, electrophoretic and electrochromatographic separations, screening and diagnostics, and chemical and biochemical synthesis. The devices are formed from a material that is thermally and chemically stable and resistant to biofouling, significantly reducing electroosmotic flow and unwanted adsorption of solute. Preferred materials are polymeric.
摘要翻译：提供了一种微量分析装置，用于使用少量流体进行化学过程。这些器件包括在支撑衬底中激光烧蚀或以其他方式形成的微结构，例如微腔，微通道等，并且可以用于各种化学和生物化学方法，包括色谱，电泳和电色谱分离，筛选和诊断，以及化学和生物化学合成。这些装置由热和化学稳定的材料形成，并且能抵抗生物污损，显着减少电渗流和不想要的溶质吸附。优选的材料是聚合物。

3. 发明申请

US20050049796A1 Methods for encoding non-biological information on microarrays 审中-公开
标题翻译：编码微阵列非生物信息的方法
公开(公告)号：US20050049796A1
公开(公告)日：2005-03-03
申请号：US10817115
申请日：2004-04-02
申请人： Peter Webb , Joseph Fredrick , Jacqueline Tso
发明人： Peter Webb , Joseph Fredrick , Jacqueline Tso
IPC分类号： B01J19/00 , C12M1/34 , C12Q1/68 , C40B40/08 , C40B70/00 , G01N33/48 , G01N33/50 , G06F19/20 , G06F19/00
CPC分类号： C40B70/00 , B01J19/0046 , B01J2219/00527 , B01J2219/0054 , B01J2219/00542 , B01J2219/00545 , B01J2219/00547 , B01J2219/00576 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00662 , B01J2219/00693 , B01J2219/00722 , C40B40/08 , G16B25/00
摘要： Methods and compositions for encoding and decoding array information on an array are provided. The methods involve contacting an array containing one or more array information features with a sample containing target that binds to at least one of the one or more array information features to produce at least one signal that provides information about the array.
摘要翻译：提供了用于对阵列上的阵列信息进行编码和解码的方法和组合。所述方法包括将包含一个或多个阵列信息特征的阵列与包含目标的样本接触，所述样本包含与所述一个或多个阵列信息特征中的至少一个结合的至少一个阵列信息特征，以产生提供关于所述阵列的信息的至少

4. 发明申请

US20070127027A1 Photometer having multiple light paths 审中-公开
标题翻译：光度计具有多个光路
公开(公告)号：US20070127027A1
公开(公告)日：2007-06-07
申请号：US11291258
申请日：2005-12-01
申请人： John Kralik , Judith Thompson , Jay Bass , Jacqueline Tso
发明人： John Kralik , Judith Thompson , Jay Bass , Jacqueline Tso
IPC分类号： G01N21/59
CPC分类号： G01N21/31
摘要： A photometer for analyzing a plurality of samples. The photometer comprises a light source and a detector. An optical assembly defines two or more light paths, each light path arranged to carry light from the light source, through a separate sample location, and to the detector.
摘要翻译：用于分析多个样品的光度计。光度计包括光源和检测器。光学组件限定两个或更多个光路，每个光路布置成承载来自光源的光，通过单独的采样位置和检测器。

5. 发明申请

US20050048505A1 Methods to detect cross-contamination between samples contacted with a multi-array substrate 失效
标题翻译：检测与多阵列基板接触的样品之间的交叉污染的方法
公开(公告)号：US20050048505A1
公开(公告)日：2005-03-03
申请号：US10655430
申请日：2003-09-03
申请人： Joseph Fredrick , Jacqueline Tso
发明人： Joseph Fredrick , Jacqueline Tso
IPC分类号： C12M1/34 , C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6837 , C12Q2600/166 , C12Q2537/143
摘要： Methods and compositions for detecting cross-contamination between samples contacted with different arrays of a multi-array substrate are provided. The methods involve contacting sample to arrays of a multi-array substrate that contains cross-contamination probes in each of its arrays, and evaluating the resultant sample contacted arrays for cross-contamination between the samples. In many embodiments, the arrays of the multi-array substrate contain a set of cross-contamination probes for a corresponding set of cross-contamination targets in the sample(s). Kits and systems are provided for performing the invention. The subject methods may be used in a variety of different applications, such as gene expression analysis, DNA sequencing, mutation detection, as well as other genomics and proteomics applications.
摘要翻译：提供了用于检测与多阵列基板的不同阵列接触的样品之间的交叉污染的方法和组合物。该方法包括将样品接触到阵列中的多阵列基底，该阵列在其阵列中包含交叉污染探针，并评估所得样品接触的阵列以用于样品之间的交叉污染。在许多实施例中，多阵列基板的阵列包含用于样品中相应的一组交叉污染目标的一组交叉污染探针。提供了用于执行本发明的套件和系统。主题方法可用于各种不同的应用，如基因表达分析，DNA测序，突变检测以及其他基因组学和蛋白质组学应用。

6. 发明授权

US07105295B2 Methods for applying small volumes of reagents 失效
公开(公告)号：US07105295B2
公开(公告)日：2006-09-12
申请号：US10229812
申请日：2002-08-27
申请人： Jay K. Bass , Jacqueline Tso
发明人： Jay K. Bass , Jacqueline Tso
IPC分类号： C12Q1/68
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00385 , B01J2219/00427 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B05B17/0607 , C07B2200/11 , C40B40/06 , C40B60/14
摘要： Methods, devices and apparatus are disclosed for carrying out multiple chemical reactions, such as in situ synthesis of polynucleotides, on a surface comprising an array of discrete sites. Molecules are deposited at a predetermined number of the discrete sites on the surface for reaction at the discrete sites. The surface is positioned relative to an outlet of a fluid ejection device, which is activated to dispense a small volume of a fluid through the outlet to the surface to provide uniform coating of a continuous region of the surface comprising a multiple of the discrete sites. The fluid is dispensed as uniform particles having a diameter such that the uniform particles form a sheet to coat the continuous region of the surface. In one embodiment of the present invention, liquid is dispensed as uniform particles through a fluid ejection device activated by means of ultrasonic energy. The invention has particular application to the in situ synthesis of polynucleotides in arrays on a surface.

7. 发明授权

US06635226B1 Microanalytical device and use thereof for conducting chemical processes 有权
标题翻译：微量分析装置及其用于进行化学过程的用途
公开(公告)号：US06635226B1
公开(公告)日：2003-10-21
申请号：US09502593
申请日：2000-02-11
申请人： Jacqueline Tso , Sally A. Swedberg , Paul K Wolber
发明人： Jacqueline Tso , Sally A. Swedberg , Paul K Wolber
IPC分类号： B01J1000
CPC分类号： G01N30/6095 , B01L3/5027 , B01L3/502707 , B01L7/52 , B01L7/54 , B01L2300/0816 , B01L2300/0883 , B01L2300/0887 , B01L2300/12 , B01L2300/163 , B01L2300/1805 , B01L2400/0415 , B01L2400/0418 , B01L2400/0421 , B01L2400/0481 , B01L2400/0487 , B29C66/549 , G01N27/44721 , G01N27/44773 , G01N27/44791 , G01N30/02 , G01N30/60 , G01N30/6052 , G01N30/606 , G01N2030/285 , G01N2030/0035 , B29C65/00
摘要： A microanalytical device is provided for conducting chemical processes using small amounts of fluid. The devices include microstructures, e.g., microcavities, microchannels and the like, that are laser ablated or otherwise formed in a support substrate, and can be used in a variety of chemical and biochemical methods, including chromatographic, electrophoretic and electrochromatographic separations, screening and diagnostics, and chemical and biochemical synthesis. The devices are formed from a material that is thermally and chemically stable and resistant to biofouling, significantly reducing electroosmotic flow and unwanted adsorption of solute. Preferred materials are polymeric.
摘要翻译：提供了一种微量分析装置，用于使用少量流体进行化学过程。这些器件包括在支撑衬底中激光烧蚀或以其他方式形成的微结构，例如微腔，微通道等，并且可以用于各种化学和生物化学方法，包括色谱，电泳和电色谱分离，筛选和诊断，以及化学和生物化学合成。这些装置由热和化学稳定的材料形成，并且能抵抗生物污损，显着减少电渗流和不想要的溶质吸附。优选的材料是聚合物。

8. 发明申请

US20060257922A1 Methods to detect cross-contamination between samples contacted with a multi-array substrate 审中-公开
公开(公告)号：US20060257922A1
公开(公告)日：2006-11-16
申请号：US11490635
申请日：2006-07-21
申请人： Joseph Fredrick , Jacqueline Tso
发明人： Joseph Fredrick , Jacqueline Tso
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6876 , C12Q1/6837 , C12Q2600/166 , C12Q2537/143
摘要： Methods and compositions for detecting cross-contamination between samples contacted with different arrays of a multi-array substrate are provided. The methods involve contacting sample to arrays of a multi-array substrate that contains cross-contamination probes in each of its arrays, and evaluating the resultant sample contacted arrays for cross-contamination between the samples. In many embodiments, the arrays of the multi-array substrate contain a set of cross-contamination probes for a corresponding set of cross-contamination targets in the sample(s). Kits and systems are provided for performing the invention. The subject methods may be used in a variety of different applications, such as gene expression analysis, DNA sequencing, mutation detection, as well as other genomics and proteomics applications.

9. 发明申请

US20050048506A1 Methods for encoding non-biological information on microarrays 审中-公开
标题翻译：编码微阵列非生物信息的方法
公开(公告)号：US20050048506A1
公开(公告)日：2005-03-03
申请号：US10655477
申请日：2003-09-03
申请人： Joseph Fredrick , Jacqueline Tso
发明人： Joseph Fredrick , Jacqueline Tso
IPC分类号： B01J19/00 , C12M1/34 , C12Q1/68 , C40B40/08 , C40B70/00 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： B01J19/0046 , B01J2219/00527 , B01J2219/00542 , B01J2219/00545 , B01J2219/00576 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00693 , B01J2219/00722 , C40B40/08 , C40B70/00
摘要： Methods and compositions for encoding array information on an array are provided. The methods involve contacting an array containing one or more array information features with a sample containing target that binds to at least one of the one or more array information features to produce at least one signal that provides information about the array. In many embodiments the signal is a symbol or a code, such as binary-code or non-binary-code, that provides the information about the array. Kits and systems are provided for performing the invention.
摘要翻译：提供了用于编码阵列上阵列信息的方法和组合。所述方法包括将包含一个或多个阵列信息特征的阵列与包含目标的样本接触，所述样本包含与所述一个或多个阵列信息特征中的至少一个结合的至少一个阵列信息特征，以产生提供关于所述阵列的信息的至少在许多实施例中，信号是提供关于阵列的信息的符号或代码，例如二进制代码或非二进制代码。提供了用于执行本发明的套件和系统。

10. 发明授权

US06440669B1 Methods for applying small volumes of reagents 失效
标题翻译：应用小体积试剂的方法
公开(公告)号：US06440669B1
公开(公告)日：2002-08-27
申请号：US09437990
申请日：1999-11-10
申请人： Jay K. Bass , Jacqueline Tso
发明人： Jay K. Bass , Jacqueline Tso
IPC分类号： C12Q168
CPC分类号： C07H21/00 , B01J19/0046 , B01J2219/0036 , B01J2219/00378 , B01J2219/00385 , B01J2219/00427 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , B05B17/0607 , C07B2200/11 , C40B40/06 , C40B60/14
摘要： Methods, devices and apparatus are disclosed for carrying out multiple chemical reactions, such as in situ synthesis of polynucleotides, on a surface comprising an array of discrete sites. Molecules are deposited at a predetermined number of the discrete sites on the surface for reaction at the discrete sites. The surface is positioned relative to an outlet of a fluid ejection device, which is activated to dispense a small volume of a fluid through the outlet to the surface to provide uniform coating of a continuous region of the surface comprising a multiple of the discrete sites. The fluid is dispensed as uniform particles having a diameter such that the uniform particles form a sheet to coat the continuous region of the surface. In one embodiment of the present invention, liquid is dispensed as uniform particles through a fluid ejection device activated by means of ultrasonic energy. The invention has particular application to the in situ synthesis of polynucleotides in arrays on a surface.
摘要翻译：公开了用于在包括离散位置阵列的表面上进行多重化学反应的方法，装置和装置，例如原位合成多核苷酸。分子沉积在表面上的预定数目的离散位置以在离散位置反应。表面相对于流体喷射装置的出口定位，其被激活以将小体积的流体通过出口分配到表面，以提供包括多个离散位置的表面的连续区域的均匀涂覆。流体被分配为具有使得均匀颗粒形成片以涂覆表面的连续区域的直径的均匀颗粒。在本发明的一个实施例中，通过超声能量激活的流体喷射装置将液体作为均匀颗粒分配。本发明特别适用于表面上阵列中多核苷酸的原位合成。

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