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1. 发明申请

US20100050742A1 INTEGRATED AIRBORNE SUBSTANCE COLLECTION AND DETECTION SYSTEM 有权
标题翻译：一体化航空物质收集和检测系统
公开(公告)号：US20100050742A1
公开(公告)日：2010-03-04
申请号：US11510073
申请日：2006-08-24
申请人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
发明人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
IPC分类号： G01N7/00
CPC分类号： G01N1/2202 , G01N1/2273 , G01N15/14 , G01N2015/0046
摘要： A collection and detection system is directed to a combined system in which a detect to warn system is integrated with a detect to treat system. Such a combined system provides multi-levels of detection to determine the presence and identity of one or more different types of specific particles. In some applications, the combined system is configured to detect and identify one or more different types of specific biological particles such as toxins and pathogens. The combined system includes a first level detection device, in which the presence of one or more toxins and/or pathogens are detected, and a second level detection device. Upon detection by the first level detection device, the second level detection device performs a second level of detection in which the one or more toxins and/or pathogens are identified.
摘要翻译：收集和检测系统被引导到组合系统，其中警报系统的检测与检测处理系统集成。这样的组合系统提供多级检测以确定一种或多种不同类型的特定颗粒的存在和身份。在一些应用中，组合系统被配置为检测和识别一种或多种不同类型的特定生物颗粒，例如毒素和病原体。组合系统包括其中检测到一种或多种毒素和/或病原体的存在的第一级检测装置和第二级检测装置。在被第一级检测装置检测到时，第二级别检测装置执行其中识别出一种或多种毒素和/或病原体的第二检测水平。

2. 发明授权

US07858366B2 Integrated airborne substance collection and detection system 有权
标题翻译：综合空气中物质收集和检测系统
公开(公告)号：US07858366B2
公开(公告)日：2010-12-28
申请号：US11509969
申请日：2006-08-24
申请人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
发明人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
IPC分类号： C12M1/34 , C12M3/00 , C12M1/00 , G08B21/00
CPC分类号： G01N1/22 , G01N1/2273 , G01N1/24 , G01N33/54366 , G01N33/56911
摘要： An integrated collection and detection system is configured to monitor the ambient air for specific particles, such as toxins and pathogens. An air collector captures airborne particles and outputs a fluid sample including the captured particles in a fluid solution. The collection and detection system includes a control module configured to control the processing of the fluid sample such that detection of one or more types of particles is fully automated within the integrated system. The types of particles to be processed and detected include, but are not limited to, cells, bacteria, viruses, nucleic acids, toxins, and other pathogens. If one or more specific types of particles are detected, a system alarm is triggered. The system alarm triggers a local audio/visual alarm and/or is transmitted over a communications network to either a local or central monitoring location. More than one collection and detection system can be coupled to the network and monitored by the central monitoring location.
摘要翻译：集成收集和检测系统被配置为监测特定颗粒（例如毒素和病原体）的环境空气。空气收集器捕获空气中的颗粒并将包含所捕获的颗粒的流体样品输出在流体溶液中。收集和检测系统包括控制模块，该控制模块被配置为控制流体样品的处理，使得一个或多个类型的颗粒的检测在集成系统内完全自动化。待加工和检测的颗粒的类型包括但不限于细胞，细菌，病毒，核酸，毒素和其他病原体。如果检测到一种或多种特定类型的颗粒，则会触发系统报警。系统报警触发本地音频/视频报警和/或通过通信网络传输到本地或中央监控位置。多个收集和检测系统可以耦合到网络并由中央监控位置监控。

3. 发明申请

US20080048874A1 Integrated airborne substance collection and detection system 有权
标题翻译：综合空气中物质收集和检测系统
公开(公告)号：US20080048874A1
公开(公告)日：2008-02-28
申请号：US11509872
申请日：2006-08-24
申请人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
发明人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
IPC分类号： G08B21/00 , C12M3/00
CPC分类号： G08B21/12 , G01N1/2273 , G01N2001/2217
摘要： A collection and detection system is configured as a detect to warn system in which the presence of specific types of particles are detected, and may or may not be identified. An air collection module intakes ambient air, detect the presence of one or more different types of airborne particles within the ambient air, and collect the airborne particles, such as within a fluid. A triggering mechanism is positioned to continuously monitor the airflow, to determine one or more characteristics of the airborne particles. If those measured characteristics match specific known characteristics, a trigger signal is generated. In response, a confirmation device performs a detection method on a fluid solution including the airflow particles to determine the presence of one or more different types of specific biological particles.
摘要翻译：收集和检测系统被配置为检测到警告系统，其中检测到特定类型的粒子的存在，并且可以或可以不被识别。空气收集模块进入环境空气，检测在环境空气中存在一种或多种不同类型的空气中的颗粒，并收集空气中的颗粒，例如在流体内。定位触发机构以连续监测气流，以确定空气中的颗粒的一个或多个特性。如果这些测量特性符合特定的已知特性，则产生触发信号。作为响应，确认装置对包括气流颗粒的流体溶液执行检测方法以确定一种或多种不同类型的特定生物颗粒的存在。

4. 发明申请

US20080050803A1 Integrated airborne substance collection and detection system 有权
标题翻译：综合空气中物质收集和检测系统
公开(公告)号：US20080050803A1
公开(公告)日：2008-02-28
申请号：US11509969
申请日：2006-08-24
申请人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
发明人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
IPC分类号： C12M1/34
CPC分类号： G01N1/22 , G01N1/2273 , G01N1/24 , G01N33/54366 , G01N33/56911
摘要： An integrated collection and detection system is configured to monitor the ambient air for specific particles, such as toxins and pathogens. An air collector captures airborne particles and outputs a fluid sample including the captured particles in a fluid solution. The collection and detection system includes a control module configured to control the processing of the fluid sample such that detection of one or more types of particles is fully automated within the integrated system. The types of particles to be processed and detected include, but are not limited to, cells, bacteria, viruses, nucleic acids, toxins, and other pathogens. If one or more specific types of particles are detected, a system alarm is triggered. The system alarm triggers a local audio/visual alarm and/or is transmitted over a communications network to either a local or central monitoring location. More than one collection and detection system can be coupled to the network and monitored by the central monitoring location.
摘要翻译：集成收集和检测系统被配置为监测特定颗粒（例如毒素和病原体）的环境空气。空气收集器捕获空气中的颗粒并将包含所捕获的颗粒的流体样品输出在流体溶液中。收集和检测系统包括控制模块，该控制模块被配置为控制流体样品的处理，使得一个或多个类型的颗粒的检测在集成系统内完全自动化。待加工和检测的颗粒的类型包括但不限于细胞，细菌，病毒，核酸，毒素和其他病原体。如果检测到一种或多种特定类型的颗粒，则会触发系统报警。系统报警触发本地音频/视频报警和/或通过通信网络传输到本地或中央监控位置。多个收集和检测系统可以耦合到网络并由中央监控位置监控。

5. 发明授权

US07705739B2 Integrated airborne substance collection and detection system 有权
标题翻译：综合空气中物质收集和检测系统
公开(公告)号：US07705739B2
公开(公告)日：2010-04-27
申请号：US11510073
申请日：2006-08-24
申请人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
发明人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
IPC分类号： G08B21/00
CPC分类号： G01N1/2202 , G01N1/2273 , G01N15/14 , G01N2015/0046
摘要： A collection and detection system is directed to a combined system in which a detect to warn system is integrated with a detect to treat system. Such a combined system provides multi-levels of detection to determine the presence and identity of one or more different types of specific particles. In some applications, the combined system is configured to detect and identify one or more different types of specific biological particles such as toxins and pathogens. The combined system includes a first level detection device, in which the presence of one or more toxins and/or pathogens are detected, and a second level detection device. Upon detection by the first level detection device, the second level detection device performs a second level of detection in which the one or more toxins and/or pathogens are identified.
摘要翻译：收集和检测系统被引导到组合系统，其中警报系统的检测与检测处理系统集成。这样的组合系统提供多级检测以确定一种或多种不同类型的特定颗粒的存在和身份。在一些应用中，组合系统被配置为检测和识别一种或多种不同类型的特定生物颗粒，例如毒素和病原体。组合系统包括其中检测到一种或多种毒素和/或病原体的存在的第一级检测装置和第二级检测装置。在被第一级检测装置检测到时，第二级别检测装置执行其中识别出一种或多种毒素和/或病原体的第二检测水平。

6. 发明授权

US07633606B2 Integrated airborne substance collection and detection system 有权
标题翻译：综合空气中物质收集和检测系统
公开(公告)号：US07633606B2
公开(公告)日：2009-12-15
申请号：US11509872
申请日：2006-08-24
申请人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
发明人： Allen Northrup , Farzad Pourahmadi , Bob Yuan , Amy J. Devitt
IPC分类号： G01N21/00
CPC分类号： G08B21/12 , G01N1/2273 , G01N2001/2217
摘要： A collection and detection system is configured as a detect to warn system in which the presence of specific types of particles are detected, and may or may not be identified. An air collection module intakes ambient air, detect the presence of one or more different types of airborne particles within the ambient air, and collect the airborne particles, such as within a fluid. A triggering mechanism is positioned to continuously monitor the airflow, to determine one or more characteristics of the airborne particles. If those measured characteristics match specific known characteristics, a trigger signal is generated. In response, a confirmation device performs a detection method on a fluid solution including the airflow particles to determine the presence of one or more different types of specific biological particles.
摘要翻译：收集和检测系统被配置为检测到警告系统，其中检测到特定类型的粒子的存在，并且可以或可以不被识别。空气收集模块进入环境空气，检测在环境空气中存在一种或多种不同类型的空气中的颗粒，并收集空气中的颗粒，例如在流体内。定位触发机构以连续监测气流，以确定空气中的颗粒的一个或多个特性。如果这些测量特性符合特定的已知特性，则产生触发信号。作为响应，确认装置对包括气流颗粒的流体溶液执行检测方法以确定一种或多种不同类型的特定生物颗粒的存在。

7. 发明授权

US07785868B2 Apparatus to automatically lyse a sample 有权
标题翻译：用于自动裂解样品的装置
公开(公告)号：US07785868B2
公开(公告)日：2010-08-31
申请号：US11290653
申请日：2005-11-29
申请人： Bob Yuan , Allen Northrup , Farzad Pourahmadi
发明人： Bob Yuan , Allen Northrup , Farzad Pourahmadi
IPC分类号： C12M1/42
CPC分类号： C12M47/06 , B01F11/0266
摘要： A standalone bench top laboratory instrument designed to disrupt, or lyse, cells, spores and tissue samples using ultrasonic energy. The lysing device is programmable, allowing the user control over the sample volume, sonication power level, and lysing duration in order to optimize lysing protocols for specific targets. Once a lysing protocol is entered, the device automatically lyses the sample according to the entered lysing protocol. The lysing device also provides a cooling feature, enabled by a heat exchanging sub-assembly, to prevent the sample from exceeding a maximum set temperature.
摘要翻译：一种独立的台式实验室仪器，旨在利用超声波能量破坏或溶解细胞，孢子和组织样品。裂解装置是可编程的，允许用户控制样品体积，超声功率水平和裂解持续时间，以优化特定靶标的裂解方案。一旦输入了裂解协议，设备将根据输入的裂解协议自动分析样品。裂解装置还提供通过热交换子组件实现的冷却特征，以防止样品超过最大设定温度。

8. 发明申请

US20060121603A1 Apparatus to automatically lyse a sample 有权
标题翻译：用于自动裂解样品的装置
公开(公告)号：US20060121603A1
公开(公告)日：2006-06-08
申请号：US11290653
申请日：2005-11-29
申请人： Bob Yuan , Allen Northrup , Farzad Pourahmadi
发明人： Bob Yuan , Allen Northrup , Farzad Pourahmadi
IPC分类号： C12M1/33
CPC分类号： C12M47/06 , B01F11/0266
摘要： A standalone bench top laboratory instrument designed to disrupt, or lyse, cells, spores and tissue samples using ultrasonic energy. The lysing device is programmable, allowing the user control over the sample volume, sonication power level, and lysing duration in order to optimize lysing protocols for specific targets. Once a lysing protocol is entered, the device automatically lyses the sample according to the entered lysing protocol. The lysing device also provides a cooling feature, enabled by a heat exchanging sub-assembly, to prevent the sample from exceeding a maximum set temperature.
摘要翻译：一种独立的台式实验室仪器，旨在利用超声波能量破坏或溶解细胞，孢子和组织样品。裂解装置是可编程的，允许用户控制样品体积，超声功率水平和裂解持续时间，以优化特定靶标的裂解方案。一旦输入了裂解协议，设备将根据输入的裂解协议自动分析样品。裂解装置还提供通过热交换子组件实现的冷却特征，以防止样品超过最大设定温度。

9. 发明授权

US07988935B2 Handheld and portable microfluidic device to automatically prepare nucleic acids for analysis 有权
标题翻译：手持式和便携式微流体装置自动制备核酸进行分析
公开(公告)号：US07988935B2
公开(公告)日：2011-08-02
申请号：US11223095
申请日：2005-09-09
申请人： Bob Yuan , Nima Aflaatooni
发明人： Bob Yuan , Nima Aflaatooni
IPC分类号： B01D24/02 , B01L3/02
CPC分类号： G01N1/40 , B01L3/0217 , B01L3/0293 , B01L3/502 , B01L3/5027 , B01L9/527 , B01L2300/0681 , B01L2400/0478 , B01L2400/0487 , G01N1/14 , G01N1/405
摘要： A handheld and portable extraction device is directed to a microfluidic-based system to be used in the field to extract and purify an analyte, preferably a nucleic acid, from a fluid-based sample. Preferably, the fluid-based sample is water-based. The fluid-based sample can also be a biological fluid sample. The handheld and portable extraction device includes a syringe-like device coupled to a purification chip. The purification chip is preferably included within a chip block which is removable from the remaining portion of the handheld and portable extraction device. The analyte collected within the purification chip can be later removed and collected for analysis.
摘要翻译：手持和便携式提取装置被引导到在本领域中使用的基于微流体的系统，以从基于流体的样品中提取和纯化分析物，优选核酸。优选地，基于流体的样品是水基的。基于流体的样品也可以是生物流体样品。手持和便携式提取装置包括耦合到净化芯片的注射器状装置。净化芯片优选地包括在可从手持式和便携式提取装置的其余部分移除的芯片块内。收集在净化芯片内的分析物可以随后被去除并收集用于分析。

10. 发明申请

US20100104485A1 Flow-through thermal cycling device 审中-公开
标题翻译：流通热循环装置
公开(公告)号：US20100104485A1
公开(公告)日：2010-04-29
申请号：US12290249
申请日：2008-10-28
申请人： Bob Yuan
发明人： Bob Yuan
IPC分类号： B01J19/00
CPC分类号： B01J19/0013 , B01J2219/00096 , B01L3/5027 , B01L3/505 , B01L7/52 , B01L7/525 , B01L2300/0816 , B01L2300/0887 , B01L2300/1822 , B01L2400/0481 , B01L2400/0487
摘要： A thermally controlled device includes a flow-through expandable pouch with a fluid inlet, a fluid outlet, a first side surface, and a second side surface. A first thermoelectric cooler (TEC) is coupled to the first side surface and a second TEC is coupled to the second side surface. The first and second TECs are each tension-loaded to provide a compression force to the first and second side surfaces. When the fluid outlet is closed and a first fluid volume is input to the fluid chamber via the fluid inlet, the pouch expands from an initial state of zero volume to an expanded state of a second volume as the first side surface expands against the compression force of the first TEC to form a first thermal contact between the first side surface and the first TEC, and the second side surface expands against the compression force of the second TEC to form a second thermal contact between the second side surface and the second TEC.
摘要翻译：热控装置包括具有流体入口的流通可膨胀袋，流体出口，第一侧表面和第二侧表面。第一热电冷却器（TEC）耦合到第一侧表面，并且第二TEC耦合到第二侧表面。第一和第二TEC各自被加载以向第一和第二侧表面提供压缩力。当流体出口关闭并且经由流体入口将第一流体积输入到流体室时，当第一侧表面抵抗压缩力膨胀时，袋从零体积的初始状态膨胀到第二体积的膨胀状态的第一TEC以形成第一侧表面和第一TEC之间的第一热接触，并且第二侧表面抵抗第二TEC的压缩力膨胀以在第二侧表面和第二TEC之间形成第二热接触。

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