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1. 发明授权

US06524808B1 Enzyme inhibition immunoassay 有权
公开(公告)号：US06524808B1
公开(公告)日：2003-02-25
申请号：US09603646
申请日：2000-06-26
申请人： Allan R. Dorn , Salvatore J. Salamone , Mitali Ghoshal , Eva Hoess , Erasmus Huber , Ronald C. Hawley , John W. Patterson
发明人： Allan R. Dorn , Salvatore J. Salamone , Mitali Ghoshal , Eva Hoess , Erasmus Huber , Ronald C. Hawley , John W. Patterson
IPC分类号： C12Q132
CPC分类号： G01N33/5735 , G01N33/78 , G01N2333/904 , Y10S435/975
摘要： The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.

2. 发明授权

US06811998B2 Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase 失效
标题翻译：肌苷单磷酸脱氢酶的竞争性抑制剂的结合物
公开(公告)号：US06811998B2
公开(公告)日：2004-11-02
申请号：US10341692
申请日：2003-01-14
申请人： Mitali Ghoshal , Gerald Sigler , Raymond A. Hui , Ronald Hawley , Eva Hoess , Erasmus J. Huber , John W. Patterson , Salvatore J. Salamone , Allan Dorn
发明人： Mitali Ghoshal , Gerald Sigler , Raymond A. Hui , Ronald Hawley , Eva Hoess , Erasmus J. Huber , John W. Patterson , Salvatore J. Salamone , Allan Dorn
IPC分类号： C12Q132
CPC分类号： C07D405/12 , C07D307/88 , C07D473/08 , C07H15/20 , C07H15/22 , C07H15/24 , C07J17/00 , C07J19/005 , C07J41/0005 , C07J41/0055 , C07J43/003 , G01N33/53 , G01N33/535 , G01N33/5735 , G01N33/581 , G01N33/78 , G01N33/9453 , G01N2333/904
摘要： The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
摘要翻译：本发明提供了一种用于测量生物样品中分析物的方法，由此使非竞争性抑制剂与配体偶联并用于均匀测定。分析物可以是药物或药物衍生物，激素，多肽或寡核苷酸。本发明还提供了可用于进行这种测量的新型化合物，测定试剂和包装的试剂盒。

3. 发明授权

US07476727B2 Conjugates of mycophenolic acid 失效
标题翻译：霉酚酸的结合物
公开(公告)号：US07476727B2
公开(公告)日：2009-01-13
申请号：US11673180
申请日：2007-02-09
申请人： Mitali Ghoshal , Gerald Sigler , Raymond A. Hui , Ronald Hawley , Eva Hoess , Erasmus J. Huber , John W. Patterson , Salvatore J. Salamone , Allan Dorn
发明人： Mitali Ghoshal , Gerald Sigler , Raymond A. Hui , Ronald Hawley , Eva Hoess , Erasmus J. Huber , John W. Patterson , Salvatore J. Salamone , Allan Dorn
IPC分类号： C07G3/00 , C07H15/20 , C07D233/00 , C07D473/00 , C07D211/72
CPC分类号： C07D405/12 , C07D307/88 , C07D473/08 , C07H15/20 , C07H15/22 , C07H15/24 , C07J17/00 , C07J19/005 , C07J41/0005 , C07J41/0055 , C07J43/003 , G01N33/53 , G01N33/535 , G01N33/5735 , G01N33/581 , G01N33/78 , G01N33/9453 , G01N2333/904
摘要： The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide.The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
摘要翻译：本发明提供了一种用于测量生物样品中分析物的方法，由此使非竞争性抑制剂与配体偶联并用于均匀测定。分析物可以是药物或药物衍生物，激素，多肽或寡核苷酸。本发明还提供了可用于进行这种测量的新型化合物，测定试剂和包装的试剂盒。

4. 发明授权

US07235675B2 Conjugates of mycophenolic acid 失效
标题翻译：霉酚酸的结合物
公开(公告)号：US07235675B2
公开(公告)日：2007-06-26
申请号：US10900447
申请日：2004-07-27
申请人： Mitali Ghoshal , Gerald Sigler , Raymond A. Hui , Ronald Hawley , Eva Hoess , Erasmus J. Huber , John W. Patterson , Salvatore J. Salamone , Allan Dorn
发明人： Mitali Ghoshal , Gerald Sigler , Raymond A. Hui , Ronald Hawley , Eva Hoess , Erasmus J. Huber , John W. Patterson , Salvatore J. Salamone , Allan Dorn
IPC分类号： C07D307/00 , C07D407/00
CPC分类号： C07D405/12 , C07D307/88 , C07D473/08 , C07H15/20 , C07H15/22 , C07H15/24 , C07J17/00 , C07J19/005 , C07J41/0005 , C07J41/0055 , C07J43/003 , G01N33/53 , G01N33/535 , G01N33/5735 , G01N33/581 , G01N33/78 , G01N33/9453 , G01N2333/904
摘要： The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide.The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
摘要翻译：本发明提供了一种用于测量生物样品中分析物的方法，由此使非竞争性抑制剂与配体偶联并用于均匀测定。分析物可以是药物或药物衍生物，激素，多肽或寡核苷酸。本发明还提供了可用于进行这种测量的新型化合物，测定试剂和包装的试剂盒。

5. 发明申请

US20050009076A1 Enzyme inhibition immunoassay 失效
标题翻译：酶抑制免疫测定
公开(公告)号：US20050009076A1
公开(公告)日：2005-01-13
申请号：US10900447
申请日：2004-07-27
申请人： Mitali Ghoshal , Gerald Sigler , Raymond Hui , Ronald Hawley , Eva Hoess , Erasmus Huber , John Patterson , Salvatore Salamone , Allan Dorn
发明人： Mitali Ghoshal , Gerald Sigler , Raymond Hui , Ronald Hawley , Eva Hoess , Erasmus Huber , John Patterson , Salvatore Salamone , Allan Dorn
IPC分类号： G01N33/531 , C07D307/88 , C07D405/12 , C07D473/08 , C07J19/00 , C07J41/00 , C07J43/00 , G01N33/53 , G01N33/535 , G01N33/573 , G01N33/58 , G01N33/78 , G01N33/94 , C12Q1/68 , C07H15/24 , C07H21/04 , C07J17/00
CPC分类号： C07D405/12 , C07D307/88 , C07D473/08 , C07H15/20 , C07H15/22 , C07H15/24 , C07J17/00 , C07J19/005 , C07J41/0005 , C07J41/0055 , C07J43/003 , G01N33/53 , G01N33/535 , G01N33/5735 , G01N33/581 , G01N33/78 , G01N33/9453 , G01N2333/904
摘要： The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
摘要翻译：本发明提供了一种用于测量生物样品中分析物的方法，由此使非竞争性抑制剂与配体偶联并用于均匀测定。分析物可以是药物或药物衍生物，激素，多肽或寡核苷酸。本发明还提供了可用于进行这种测量的新型化合物，测定试剂和包装的试剂盒。

6. 发明申请

US20070142631A1 ENZYME INHIBITON IMMUNOASSAY 失效
公开(公告)号：US20070142631A1
公开(公告)日：2007-06-21
申请号：US11673180
申请日：2007-02-09
申请人： Mitali Ghoshal , Gerald Sigler , Raymond Hui , Ronald Hawley , Eva Hoess , Erasmus Huber , John Patterson , Salvatore Salamone , Allan Dorn
发明人： Mitali Ghoshal , Gerald Sigler , Raymond Hui , Ronald Hawley , Eva Hoess , Erasmus Huber , John Patterson , Salvatore Salamone , Allan Dorn
IPC分类号： C07J17/00 , C07H15/22 , C07D473/04 , C07H15/24 , C07H15/20
CPC分类号： C07D405/12 , C07D307/88 , C07D473/08 , C07H15/20 , C07H15/22 , C07H15/24 , C07J17/00 , C07J19/005 , C07J41/0005 , C07J41/0055 , C07J43/003 , G01N33/53 , G01N33/535 , G01N33/5735 , G01N33/581 , G01N33/78 , G01N33/9453 , G01N2333/904
摘要： The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The analyte can be a drug or drug derivative, hormone, polypeptide, or oligonucleotide. The present invention also provides novel compounds, assay reagents and packaged kits useful for performing such measurements.
摘要翻译：本发明提供了一种用于测量生物样品中分析物的方法，由此使非竞争性抑制剂与配体偶联并用于均匀测定。分析物可以是药物或药物衍生物，激素，多肽或寡核苷酸。本发明还提供了可用于进行这种测量的新型化合物，测定试剂和包装的试剂盒。

7. 发明授权

US5521319A Biotinylation reagent and method of use thereof 失效
标题翻译：生物素化试剂及其使用方法
公开(公告)号：US5521319A
公开(公告)日：1996-05-28
申请号：US295793
申请日：1994-09-14
申请人： Erasmus Huber , Bruno Zink , Helmut Lenz , Eva Hoess
发明人： Erasmus Huber , Bruno Zink , Helmut Lenz , Eva Hoess
IPC分类号： G01N33/53 , C07D495/04 , C07K1/13 , C07K16/00 , C12N9/00 , G01N33/532
CPC分类号： C07D495/04 , C12N9/00 , G01N33/532
摘要： The invention concerns a compound of the general formula (I): ##STR1## in which Bi denotes a residue derived by cleavage of a carboxyl group from biotin or from a biotin derivative, R.sup.1 and R.sup.2 denote independently of one another hydrogen or C.sub.1 --C.sub.4 alkyl,n denotes an integer from 4 to 10 andX denotes an alkylene residue with a chain length of 5 to 20 atoms substituted by one or several O or/and S atoms and a conjugate of this compound with a substance that has at least one primary or/and secondary amino group NHR.sup.3.
摘要翻译： PCT No.PCT / EP94 / 00195 Sec。 371日期1994年9月14日 102（e）1994年9月14日PCT 1994年1月25日PCT公布。公开号WO94 / 17072 日期：1994年8月4日本发明涉及通式（I）的化合物：其中Bi表示通过从生物素或生物素衍生物R 1和R 2切割羧基衍生的残基彼此独立地表示氢或C 1 -C 4烷基，n表示4至10的整数，X表示链长为5至20个原子的一个或多个O或/和S原子的亚烷基，该化合物与具有至少一个伯或仲氨基NHR 3的物质形成。

8. 发明授权

US5573922A Immunological detection method for triazines 失效
标题翻译：三嗪免疫检测方法
公开(公告)号：US5573922A
公开(公告)日：1996-11-12
申请号：US235393
申请日：1994-04-29
申请人： Eva Hoess , Erasmus Huber , Christine Markert-Hahn , Wolfgang Rollinger
发明人： Eva Hoess , Erasmus Huber , Christine Markert-Hahn , Wolfgang Rollinger
IPC分类号： G01N33/53 , G01N33/545
CPC分类号： G01N33/5308 , Y10S436/815
摘要： An immunological method for the determination of triazine and triazine derivatives by a competitive immunoassay in which the sample and labelled atrazine compete for a polyclonal antibody which is bound to a solid phase before, during or after the immunological reaction, the immunological complex binds to the solid phase, the solid phase and unbound labelled atrazine are separated and the label in the solid or liquid phase is determined as a measure of the content of triazine and triazine derivatives, which is characterized in that polyclonal antibodies which were obtained by immunization with a 4-alkylamino-S-triazine are used and a conjugate of a label and 4-amino-S-triazine which is bound to the label via the 6 position is used as the labelled atrazine. Triazine and triazine derivatives can be determined simultaneously using this method.
摘要翻译：通过竞争性免疫测定法测定三嗪和三嗪衍生物的免疫学方法，其中样品和标记的莠去津竞争在免疫反应之前，期间或之后与固相结合的多克隆抗体，免疫复合物结合固体分离固相和未结合标记的莠去津，固定或液相中的标记作为三嗪和三嗪衍生物含量的量度来确定，其特征在于通过用4- 使用烷基氨基-S-三嗪，并且通过6位与标记结合的标记物和4-氨基-S-三嗪的缀合物用作标记的莠去津。可以使用该方法同时测定三嗪和三嗪衍生物。

9. 发明授权

US5601824A Homobidental, trifunctional linkers used in immunologically active conjugates 失效
标题翻译：用于免疫活性缀合物的偶联的三官能连接体
公开(公告)号：US5601824A
公开(公告)日：1997-02-11
申请号：US606098
申请日：1996-02-23
申请人： Eva Hoess , Erasmus Huber , Christine Markert-Hahn , Beatus Ofenloch-Haehnle
发明人： Eva Hoess , Erasmus Huber , Christine Markert-Hahn , Beatus Ofenloch-Haehnle
IPC分类号： C07D207/44 , C07D207/452 , G01N33/532 , G01N33/535 , G01N33/543 , A61K39/40 , A61K39/44
CPC分类号： C07D207/452 , G01N33/532 , G01N33/535 , G01N33/54353
摘要： Compound of the general formula ##STR1## wherein R is an ester-activating group, m and n are identical or different and 0-6, p =0, 2-4, and q and s=1, p=0 if s=0 and p=2-4 if s=1. The compound is novel and suitable for the reproducible coupling of immunological substances at a high yield.
摘要翻译：通式“IMAGE”的化合物，其中R是酯活化基团，m和n相同或不同，并且0-6，p = 0,2-4和q和s = 1，p = 0，如果s = 0和p = 2-4，如果s = 1。该化合物是新颖的，适合于以高产率可重复地偶联免疫物质。

10. 发明授权

US5519142A Homobidental, trifunctional linkers, method for their preparation and use in immunologically active conjugates 失效
标题翻译：亲和，三功能接头，其制备方法和用于免疫活性缀合物
公开(公告)号：US5519142A
公开(公告)日：1996-05-21
申请号：US219469
申请日：1994-03-29
申请人： Eva Hoess , Erasmus Huber , Christine Markert-Hahn , Beatus Ofenloch-Haehnle
发明人： Eva Hoess , Erasmus Huber , Christine Markert-Hahn , Beatus Ofenloch-Haehnle
IPC分类号： C07D207/44 , C07D207/452 , G01N33/532 , G01N33/535 , G01N33/543 , C07D401/14 , C07D403/14
CPC分类号： C07D207/452 , G01N33/532 , G01N33/535 , G01N33/54353
摘要： Compound of the general formula ##STR1## wherein R is an ester-activating group, m and n are identical or different and 0-6, p=0, 2-4, and q and s=1, p=0 if s=0 and p=2-4 if s=1. The compound is novel and suitable for the reproducible coupling of immunological substances at a high yield.
摘要翻译：通式 + TR（CONH）s（CH 2）p COOR的化合物，其中R是酯活化基团，m和n相同或不同，并且0-6，p = 0,2-4和q和 s = 1，如果s = 0，p = 0，如果s = 1，则p = 2-4。该化合物是新颖的，适合于以高产率可重复地偶联免疫物质。

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